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Gagan D. Flora
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Journal Articles

Impaired Platelet Function in Ehlers-Danlos Syndrome: Insights from Human Subjects and a Murine Model

Mariia Kumskova, Gagan D. Flora, Manasa K. Nayak, Ivan Budnik, Madankumar Ghatge, Neelam Chauhan, Aditi Jain, Janice Staber, Steven R. Lentz, Anil K. Chauhan
Journal: Blood
Blood (2024) 144 (Supplement 1): 551.
https://doi.org/10.1182/blood-2024-204028
Published: 2024
Journal Articles

Platelets from Ehlers-Danlos Syndrome Patients Exhibit Reduced GPVI Levels and Impaired Integrin αIIbβ3 inside-out Signaling

Mariia Kumskova, Gagan D. Flora, Manasa K. Nayak, Ivan Budnik, Aditi Jain, Rakeshkumar B. Patel, Steven R. Lentz, Anil K. Chauhan
Journal: Blood
Blood (2023) 142 (Supplement 1): 1191.
https://doi.org/10.1182/blood-2023-179466
Published: 2023
Journal Articles

PKM2 promotes neutrophil activation and cerebral thromboinflammation: therapeutic implications for ischemic stroke

Nirav Dhanesha, Rakesh B. Patel, Prakash Doddapattar, Madankumar Ghatge, Gagan D. Flora, Manish Jain, Daniel Thedens, Heena Olalde, Mariia Kumskova, Enrique C. Leira, Anil K. Chauhan
Journal: Blood
Blood (2022) 139 (8): 1234–1245.
https://doi.org/10.1182/blood.2021012322
Published: 2022
Includes: Supplemental data
Journal Articles

The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis

Manasa K. Nayak, Madankumar Ghatge, Gagan D. Flora, Nirav Dhanesha, Manish Jain, Kathleen R. Markan, Matthew J. Potthoff, Steven R. Lentz, Anil K. Chauhan
Journal: Blood
Blood (2021) 137 (12): 1658–1668.
https://doi.org/10.1182/blood.2020007140
Published: 2021
Includes: Supplemental data
Journal Articles

Structural, functional, and mechanistic insights uncover the fundamental role of orphan connexin-62 in platelets

Khaled A. Sahli, Gagan D. Flora, Parvathy Sasikumar, Ali H. Maghrabi, Lisa-Marie Holbrook, Sarah K. AlOuda, Amro Elgheznawy, Tanya Sage, Alexander R. Stainer, Recep Adiyaman, Mohammad AboHassan, Marilena Crescente, Neline Kriek, Sakthivel Vaiyapuri, Alexander P. Bye, Amanda J. Unsworth, Chris I. Jones, Liam J. McGuffin, Jonathan M. Gibbins
Journal: Blood
Blood (2021) 137 (6): 830–843.
https://doi.org/10.1182/blood.2019004575
Published: 2021
Includes: Supplemental data
Journal Articles

Targeting myeloid-cell specific integrin α9β1 inhibits arterial thrombosis in mice

Brief Report
Nirav Dhanesha, Manasa K. Nayak, Prakash Doddapattar, Manish Jain, Gagan D. Flora, Shigeyuki Kon, Anil K. Chauhan
Journal: Blood
Blood (2020) 135 (11): 857–861.
https://doi.org/10.1182/blood.2019002846
Published: 2020
Includes: Supplemental data
Journal Articles

Targeting Metabolic Enzyme Pyruvate Kinase M2: A Novel Strategy to Inhibit Platelet Function and Arterial Thrombosis

Manasa K Nayak, PhD, Madankumar Ghatge, PhD, Nirav Dhanesha, PhD, Gagan D Flora, PhD, Manish Jain, PhD, Omar Rodriguez, MD BS, Kathleen Markan, PhD, Mathhhew Potthoff, PhD, Steven R. Lentz, MD PhD, Anil K Chauhan, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1056.
https://doi.org/10.1182/blood-2019-129027
Published: 2019