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Journal Articles

Data Coming out of the Human Inhibitor PUP Study (HIPS) Reveal 4 Subgroups of Patients with Distinct Antibody Signatures

Blood (2018) 132 (Supplement 1): 3774.

https://doi.org/10.1182/blood-2018-99-115979

Published: 2018

Journal Articles

Bispecific Antibodies with Native Human IgG Structure As Mimetics for FVIII Activity

Sabine Knappe, PhD, Nicolas Fischer, Patrice Robert Douillard, Rudolf Hartmann, PhD, Gerald Schrenk, PhD, Ulla Ravn, Giovanni Magistrelli, Franck Gueneau, Gerard Didelot, Krzysztof Masternak, Marie Kosco-Vilbois, Friedrich Scheiflinger, PhD, Michael Dockal, PhD

Blood (2017) 130 (Supplement 1): 1083.

https://doi.org/10.1182/blood.V130.Suppl_1.1083.1083

Published: 2017

Journal Articles

A Bispecific Antibody Lacks Measurability in Routine Coagulation Assays and Comparability to Factor VIII

Rudolf Hartmann, PhD, Tjerk Feenstra, MSc, Sabine Knappe, PhD, Gerald Schrenk, PhD, Friedrich Scheiflinger, PhD, Michael Dockal, PhD

Blood (2017) 130 (Supplement 1): 1080.

https://doi.org/10.1182/blood.V130.Suppl_1.1080.1080

Published: 2017

Journal Articles

Elucidating the Excessive Pro-Coagulant Effect of a Sequence Identical Analogue to ACE910 in Combination with Bypassing Agents

Rudolf Hartmann, PhD, Tjerk Feenstra, MSc, Sabine Knappe, PhD, Michael Dockal, PhD, Friedrich Scheiflinger, PhD

Blood (2017) 130 (Supplement 1): 90.

https://doi.org/10.1182/blood.V130.Suppl_1.90.90

Published: 2017

Journal Articles

Influence of Obesity on Factor IX Expression after Gene Therapy in a Mouse Model of Hemophilia B

Sogué Coulibaly, Markus Weiller, Alexander Bauer, Johannes Lengler, Stefan Romeder-Finger, Alexandra Kopić, Karima Benamara, Paul Monahan, Hanspeter Rottensteiner, Friedrich Scheiflinger, PhD, Marietta Turecek, Werner Hoellriegl, MD

Blood (2017) 130 (Supplement 1): 4878.

https://doi.org/10.1182/blood.V130.Suppl_1.4878.4878

Published: 2017

Journal Articles

Synergistic Effects of a Procoagulant Bispecific Antibody and Rescue Therapies on Thrombin Generation- a Potential Safety Risk

Sabine Knappe, Rudolf Hartmann, Brahm Goldstein, MD, Bruce M. Ewenstein, Leonard Valentino, Friedrich Scheiflinger, PhD

Blood (2016) 128 (22): 4952.

https://doi.org/10.1182/blood.V128.22.4952.4952

Published: 2016

Journal Articles

Lethality of Mouse Tissue Factor Pathway Inhibitor Gene Disruption Is Rescued By Transgenic Human Tissue Factor Pathway Inhibitor Knock in

Robert Pachlinger, Rudolf Hartmann, Andrea Kolm, Erwin Panholzer, Nadja Ullrich, Fabian Knofl, Maria Schuster, Werner Hoellriegl, DVM, Friedrich Scheiflinger, PhD, Michael Dockal

Blood (2015) 126 (23): 3495.

https://doi.org/10.1182/blood.V126.23.3495.3495

Published: 2015

Journal Articles

The Application of Thrombin Generation Test Is Compromised By Antithrombin III Deficiency

Sabine Knappe, Susanne Till, Gabriele Gerstenbauer, Friedrich Scheiflinger, PhD, Michael Dockal

Blood (2015) 126 (23): 4663.

https://doi.org/10.1182/blood.V126.23.4663.4663

Published: 2015

Journal Articles

Development of BAX 826, a Polysialylated Full-Length rFVIII with Significantly Improved PK Properties

Peter L. Turecek, PhD, Juergen Siekmann, PhD, Artur Mitterer, PhD, Michael Graninger, PhD, Gerald Schrenk, PhD, Peter Matthiessen, PhD, Hanspeter Rottensteiner, PhD, Werner Hoellriegl, DVM, Marietta Putz, MS, Hans Peter Schwarz, MD, Friedrich Scheiflinger, PhD

Blood (2015) 126 (23): 3536.

https://doi.org/10.1182/blood.V126.23.3536.3536

Published: 2015

Journal Articles

Pharmacokinetics of BAX 826, a Polysialylated Full-Length rFVIII, in Hemophilia a Mice, Rats, and Cynomolgus Monkeys

Alexandra Schiviz, DVM, Gerald Hoebarth, Martin Wolfsegger, Paolo Rossato, Alfred Weber, Herbert Gritsch, Hanspeter Rottensteiner, PhD, Peter L. Turecek, PhD, Friedrich Scheiflinger, PhD, Werner Hoellriegl, DVM, Marietta Putz, MS

Blood (2015) 126 (23): 1073.

https://doi.org/10.1182/blood.V126.23.1073.1073

Published: 2015

Journal Articles

Non-Proteolytic Regulation of the Multimerization of Von Willebrand Factor By ADAMTS13 Based on a Novel Cysteine Thiol Redundancy

Hanspeter Rottensteiner, PhD, Susanna Skalicky, Birgit Seyfried, PhD, Stefan Kaufmann, Christian Fiedler, Meinhard Hasslacher, PhD, Jing-fei Dong, MD PhD, X. Long Zheng, MD PhD, Barbara Plaimauer, PhD, Friedrich Scheiflinger, PhD

Blood (2015) 126 (23): 2236.

https://doi.org/10.1182/blood.V126.23.2236.2236

Published: 2015

Journal Articles

Temperature-Dependent Irreversible Conformational Change of ADAMTS13 upon Metal Ion Chelation

Rana Grillberger, PhD, Stefan Kaufmann, Barbara Kink, Peter Matthiessen, PhD, Barbara Plaimauer, PhD, Friedrich Scheiflinger, PhD, Hanspeter Rottensteiner, PhD

Blood (2015) 126 (23): 2238.

https://doi.org/10.1182/blood.V126.23.2238.2238

Published: 2015

Journal Articles

Tissue Factor Pathway Inhibitor Isoforms of Macro- and Microvascular Endothelial Cells

Michael Dockal, PhD, Robert Pachlinger, PhD, Angelina Baldin-Stoyanova, Fabian Knofl, Nadja Ullrich, Friedrich Scheiflinger, PhD

Blood (2014) 124 (21): 4167.

https://doi.org/10.1182/blood.V124.21.4167.4167

Published: 2014

Journal Articles

A TFPI Inhibitory Half Life Extended Fusion Peptide Proves Efficacy in FVIII Knock out Mice and Marmoset Monkeys

Michael Dockal, PhD, Rudolf Hartmann, PhD, Thomas Polakowski, PhD, Erwin Panholzer, Willibald Kammlander, Frank Osterkamp, PhD, Ulrich Reineke, PhD, Alexandra Schiviz, PhD, Werner Hoellriegl, PhD, Friedrich Scheiflinger, PhD

Blood (2014) 124 (21): 1469.

https://doi.org/10.1182/blood.V124.21.1469.1469

Published: 2014

Journal Articles

Low ADAMTS13 Activity Is a Strong Risk Factor for Ischemic Stroke: A Prospective Cohort Study - the Rotterdam Study

Michelle Alida Helena Sonneveld, MD, Moniek de Maat, PhD, Marileen L.P. Portegies, MD, Albert Hofman, MD PhD, Peter L Turecek, PhD, Hanspeter Rottensteiner, PhD, Friedrich Scheiflinger, PhD, Peter J. Koudstaal, MD PhD, Mohammed A. Ikram, MD PhD, Frank Leebeek, MD PhD

Blood (2014) 124 (21): 113.

https://doi.org/10.1182/blood.V124.21.113.113

Published: 2014

Journal Articles

Recombinant VWF Promotes Platelet Adhesion Under Shear Stress Dependent on Its Multimer Size

Gerald Schrenk, PhD, Jutta Schreiner, Herbert Gritsch, Peter L Turecek, PhD, Michael Dockal, PhD, Friedrich Scheiflinger, PhD

Blood (2014) 124 (21): 1442.

https://doi.org/10.1182/blood.V124.21.1442.1442

Published: 2014

Journal Articles

Molecular Characterization of the Synergistic Effect on TFPI Inhibition By Fusion of Two Inhibitory Peptides

Michael Dockal, PhD, Rudolf Hartmann, PhD, Thomas Polakowski, PhD, Christoph Redl, Erwin Panholzer, Willibald Kammlander, Frank Osterkamp, PhD, Ulrich Reineke, PhD, Hans Brandstetter, Prof., Friedrich Scheiflinger, PhD

Blood (2014) 124 (21): 1484.

https://doi.org/10.1182/blood.V124.21.1484.1484

Published: 2014

Journal Articles

Concomitant Administration Of Activated Prothrombin Complex Concentrate and Recombinant Activated Factor VII At Low Doses Are Efficacious and Safe In Hemophilic Mice

Michael Dockal, PhD, Sabine Knappe, PhD, Peter Leidenmuehler, Christina Piskernik, DVM, Sylvia Tippl, Marlene Resch, DVM, Dagmar Verdino, DVM, Alexander Bauer, Werner Hoellriegl, PhD, Friedrich Scheiflinger, PhD

Blood (2013) 122 (21): 2353.

https://doi.org/10.1182/blood.V122.21.2353.2353

Published: 2013

Journal Articles

TFPI Expresses Anticoagulant Activity Independent Of TF-FVIIa

Stella Thomassen, PhD, Alexandra Heinzmann, PhD, Linda Herfs, Jan Rosing, PhD, Tilman M. Hackeng, PhD, Rudolf Hartmann, PhD, Friedrich Scheiflinger, PhD, Michael Dockal, PhD

Blood (2013) 122 (21): 3563.

https://doi.org/10.1182/blood.V122.21.3563.3563

Published: 2013

Journal Articles

Design Of a Most Efficient Inhibitor Of TFPI By Molecular Fusion Of Two Inhibitory Peptides

Michael Dockal, PhD, Rudolf Hartmann, PhD, Thomas Polakowski, PhD, Johannes Brandstetter, PhD, Willibald Kammlander, Erwin Panholzer, Christoph Redl, Frank Osterkamp, PhD, Jan Rosing, PhD, Friedrich Scheiflinger, PhD

Blood (2013) 122 (21): 3564.

https://doi.org/10.1182/blood.V122.21.3564.3564

Published: 2013

NARROW

Data Coming out of the Human Inhibitor PUP Study (HIPS) Reveal 4 Subgroups of Patients with Distinct Antibody Signatures

Bispecific Antibodies with Native Human IgG Structure As Mimetics for FVIII Activity

A Bispecific Antibody Lacks Measurability in Routine Coagulation Assays and Comparability to Factor VIII

Elucidating the Excessive Pro-Coagulant Effect of a Sequence Identical Analogue to ACE910 in Combination with Bypassing Agents

Influence of Obesity on Factor IX Expression after Gene Therapy in a Mouse Model of Hemophilia B

Synergistic Effects of a Procoagulant Bispecific Antibody and Rescue Therapies on Thrombin Generation- a Potential Safety Risk

Lethality of Mouse Tissue Factor Pathway Inhibitor Gene Disruption Is Rescued By Transgenic Human Tissue Factor Pathway Inhibitor Knock in

The Application of Thrombin Generation Test Is Compromised By Antithrombin III Deficiency

Development of BAX 826, a Polysialylated Full-Length rFVIII with Significantly Improved PK Properties

Pharmacokinetics of BAX 826, a Polysialylated Full-Length rFVIII, in Hemophilia a Mice, Rats, and Cynomolgus Monkeys

Non-Proteolytic Regulation of the Multimerization of Von Willebrand Factor By ADAMTS13 Based on a Novel Cysteine Thiol Redundancy

Temperature-Dependent Irreversible Conformational Change of ADAMTS13 upon Metal Ion Chelation

Tissue Factor Pathway Inhibitor Isoforms of Macro- and Microvascular Endothelial Cells

A TFPI Inhibitory Half Life Extended Fusion Peptide Proves Efficacy in FVIII Knock out Mice and Marmoset Monkeys

Low ADAMTS13 Activity Is a Strong Risk Factor for Ischemic Stroke: A Prospective Cohort Study - the Rotterdam Study

Recombinant VWF Promotes Platelet Adhesion Under Shear Stress Dependent on Its Multimer Size

Molecular Characterization of the Synergistic Effect on TFPI Inhibition By Fusion of Two Inhibitory Peptides

Concomitant Administration Of Activated Prothrombin Complex Concentrate and Recombinant Activated Factor VII At Low Doses Are Efficacious and Safe In Hemophilic Mice

TFPI Expresses Anticoagulant Activity Independent Of TF-FVIIa

Design Of a Most Efficient Inhibitor Of TFPI By Molecular Fusion Of Two Inhibitory Peptides

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American Society of Hematology

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American Society of Hematology

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