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Journal Articles

Irs1 S57X Heterozygous Mutant Mice Display Normal Hematopoiesis and Phenotypic Features, While Homozygous Knockout Exhibit High Fetal or Postnatal Lethality

Bruna Alves Fenerich, BSc, Jaqueline Cristina Fernandes, BSc, MSc, Cleide Lúcia Araújo Silva, MSc, Juan L Coelho-Silva, BSc, MSc, Antonio Bruno Alves Silva, BSc, MSc, Natasha Peixoto Fonseca, B.Sc., M.Sc., João Agostinho Machado-Neto, PhD, Fabiola Traina, MD PhD

Blood (2020) 136 (Supplement 1): 33–34.

https://doi.org/10.1182/blood-2020-139422

Published: 2020

Journal Articles

Cytopenia Management in Patients With Newly Diagnosed Acute Myeloid Leukemia Treated With Venetoclax Plus Azacitidine in the VIALE-A Study

Blood (2020) 136 (Supplement 1): 51–53.

https://doi.org/10.1182/blood-2020-134832

Published: 2020

Journal Articles

Analysis of Metformin Effects on Bone Marrow Fibrosis and Disease Progression in Primary Myelofibrosis Patients: Preliminary Results of an Open Label Phase II Trial (FIBROMET)

Paula De Melo Campos, MD, Katia B Pagnano, MD PhD, Rubia Mancuso, Francisco Breno S. Teófilo, Juan L Coelho-Silva, BSc, MSc, Fernanda I Della Via, MSc, Leandro Luiz Lopes Freitas, MD PhD, Hernandes F. Carvalho, PhD, Fernando Ferreira Costa, MD PhD, Fabiola Traina, MD PhD, Sara T Olalla Saad, PhD

Blood (2019) 134 (Supplement_1): 554.

https://doi.org/10.1182/blood-2019-130648

Published: 2019

Journal Articles

Metformin Suppress Cellular and Molecular Processes Related to Maintenance and Proliferation of Myeloproliferative Neoplasm Stem Cell

Juan L Coelho-Silva, BSc, MSc, Thiago Mantello Bianco, MSc, Antonio Bruno Alves Silva, BSc, Diego Antonio Pereira-Martins, M.Sc., Natasha Peixoto Fonseca, B.Sc., M.Sc., Isabel Weinhäuser, MSc, Eduardo M Rego, MD PhD, Fernando Chahud, MD PhD, João Agostinho Machado-Neto, PhD, Lorena Lobo Figueiredo-Pontes, MD PhD, Fabiola Traina, MD PhD

Blood (2019) 134 (Supplement_1): 1682.

https://doi.org/10.1182/blood-2019-132115

Published: 2019

Journal Articles

MN1 Expression Is an Indepedent Prognostic Marker in FLT3-Mutated Acute Myeloid Leukemia and Is Involved in the Resistance to FLT3 Inhibitors

Diego A Pereira-Martins, MSc, Juan L Coelho-Silva, BSc, MSc, Isabel Weinhäuser, MSc, Carol Hassibe Thomé, César Alexander Ortiz Rojas, BSc, Luíse A A Simões, BSc, Fabiola Traina, MD PhD, Michael Heuser, MD, Arnold Ganser, MD, Antonio R. Lucena-Araujo, PhD, Eduardo M Rego, MD PhD

Blood (2019) 134 (Supplement_1): 1403.

https://doi.org/10.1182/blood-2019-131542

Published: 2019

Journal Articles

Efficacy of the Pan-Bcl-2 Inhibitor (Obatoclax) As a Single Agent to Treat Myeloproliferative Neoplasm in JAK2V617F Murine Transplantation Model

Thiago Mantello Bianco, MSc, Juan L Coelho-Silva, BSc, MSc, Diego A Pereira-Martins, MSc, Priscila Santos Scheucher, PhD, Isabel Weinhäuser, MSc, Antonio Bruno Alves Silva, BSc, Cleide Lucia Silva, MSc, Ann Mullally, MD, Susumu S Kobayashi, MD PhD, Eduardo M Rego, MD PhD, Fabiola Traina, MD PhD, Lorena Lobo Figueiredo-Pontes, MD PhD

Blood (2019) 134 (Supplement_1): 2977.

https://doi.org/10.1182/blood-2019-131023

Published: 2019

Journal Articles

Combining Clinical Features with Genetic Factors Improves Survival Prediction for Adults with Acute Myeloid Leukemia: Validation of a New Score System in 3 Cohorts

Douglas R. A. Silveira, Lynn Quek, MD PhD, Anna Corby, B.Sc., Juan L Coelho-Silva, BSc, MSc, Diego A Pereira-Martins, MSc, Grant Vallance, B.Sc., PhD, Benjamin Brown, B.Sc., PhD, Luciana Nardinelli, M.Sc, Wellington F Silva, MD, Elvira DRP Velloso, MD PhD, Fabiola Traina, MD PhD, Andy Peniket, MD, Paresh Vyas, MD PhD, Eduardo M Rego, MD PhD, Israel Bendit, MD PhD, Vanderson Rocha, MD PhD

Blood (2019) 134 (Supplement_1): 2602.

https://doi.org/10.1182/blood-2019-130726

Published: 2019

Journal Articles

Molecular-Based Score Inspired on Metabolic Signature Improves Prognostic Stratification for Myelodysplastic Syndrome

Juan L Coelho-Silva, BSc, MSc, Douglas R. A. Silveira, Diego A Pereira-Martins, MSc, César Alexander Ortiz Rojas, BSc, Antonio R. Lucena-Araujo, PhD, Eduardo M Rego, MD PhD, João Agostinho Machado-Neto, PhD, Israel Bendit, MD PhD, Vanderson Rocha, MD PhD, Fabiola Traina, MD PhD

Blood (2019) 134 (Supplement_1): 4257.

https://doi.org/10.1182/blood-2019-132141

Published: 2019

Journal Articles

Experience of Generic Imatinib As a First Line Therapy for Patients with Chronic Myeloid Leukemia in a Single Reference Institution

Gabriel Carvalho Pereira, MD, Fernanda B da Silva, BSc and MSc, Luisa Espirito Santo Oliveira, Pedro Marques Garibaldi, MD, Lorena Lobo Figueiredo-Pontes, MD PhD, Belinda Pinto Simões, MD PhD, Leonardo Carvalho Palma, MD PhD, Fabiola Traina, MD PhD

Blood (2019) 134 (Supplement_1): 5916.

https://doi.org/10.1182/blood-2019-132045

Published: 2019

Journal Articles

IGF1R-IRS1/2 Signaling Pathway Is a Potential Target for FLT3-Mutated Acute Myeloid Leukemia

Juan L Coelho-Silva, BSc, MSc, Diego A Pereira-Martins, MSc, Virginia Campos Silvestrini, BSc, MSc, Eduardo M Rego, MD PhD, Vitor Marcel Faca, PhD, João Agostinho Machado-Neto, PhD, Fabiola Traina, MD PhD

Blood (2019) 134 (Supplement_1): 2689.

https://doi.org/10.1182/blood-2019-132129

Published: 2019

Journal Articles

NSD1 and NSD2 Transcriptional Levels Might Predict Clinical Outcome in AML Patients

Virginia Mara De Deus Wagatsuma, PhD, Diego Antonio Pereira-Martins, MSc, Mariane Cristina Do Nascimento, BSc, Silvia Elena Sanchez Mendoza, Antonio R. Lucena-Araujo, PhD, Aleide Lima, MSc, Felipe Saldanha-Araujo, PhD, Fabio Pitella, PhD, Fabiola Traina, MD PhD, Maria Isabel A Madeira, MSc, MD, Lorena Lobo Figueiredo-Pontes, MD PhD, Eduardo Magalhães Rego, MD PhD

Blood (2018) 132 (Supplement 1): 5257.

https://doi.org/10.1182/blood-2018-99-119411

Published: 2018

Journal Articles

Clinical Impact and Therapeutic Opportunity of Insulin Receptor Substrates 1/2 in Acute Myeloid Leukemia

Juan Luiz Coelho-Silva, BSc, MSc, Diego Antonio Pereira-Martins, MSc, Josiane Lilian Schiavinato, PhD, Eduardo Magalhães Rego, MD PhD, João Agostinho Machado-Neto, BSc, Fabiola Traina, MD PhD

Blood (2018) 132 (Supplement 1): 1512.

https://doi.org/10.1182/blood-2018-99-119156

Published: 2018

Journal Articles

Autophagy Inhibition Potentiates Ruxolitinib-Induced Apoptosis in JAK2 V617F Cells

João Agostinho Machado-Neto, BSc, Juan Luiz Coelho-Silva, BSc, MSc, Fábio Pires de Souza Santos, MD PhD, Priscila Santos Scheucher, PhD, Paulo Vidal Campregher, MD PhD, Nelson Hamerschlak, MD PhD, Eduardo Magalhães Rego, MDPhD, Fabiola Traina, MD PhD

Blood (2018) 132 (Supplement 1): 1788.

https://doi.org/10.1182/blood-2018-99-119651

Published: 2018

Journal Articles

Metformin Reduces Tumor Burden and Splenomegaly in JAK2 V617F Murine Models

João Agostinho Machado-Neto, BSc, Renata Scopim Ribeiro, BSc, MSc, Juan Luiz Coelho-Silva, BSc, MSc, Christopher A. Eide, Bruna Alves Fenerich, BSc, Jaqueline Cristina Fernandes, BSc, MSc, Ana Paula Nunes Rodrigues Alves, MSc, Priscila S Scheucher, PhD, Cristina E. Tognon, PhD, Lorena Lobo Figueiredo-Pontes, MD PhD, Brian J. Druker, MD, Eduardo Magalhães Rego, MDPhD, Fabiola Traina, MD PhD

Blood (2017) 130 (Supplement 1): 4222.

https://doi.org/10.1182/blood.V130.Suppl_1.4222.4222

Published: 2017

Journal Articles

Stathmin 1 Is Highly Expressed in Acute Promyelocytic Leukemia and Microtubule Dynamics Is a Potential Target for ATRA-Resistant APL Cells

João Agostinho Machado-Neto, BSc, Juan Luiz Coelho-Silva, BSc, MSc, Antonio R. Lucena-Araujo, PhD, Priscila S Scheucher, PhD, Raul Antônio Morais Melo, MD PhD, Rosane Bittencourt, MD, Ricardo Pasquini, MD, Katia B B Pagnano, MD PhD, Evandro Maranhão Fagundes, MD, Maria de Lourdes Chauffaille, MD PhD, Carlos Chiattone, MD, Eduardo Magalhães Rego, MDPhD, Fabiola Traina, MD PhD

Blood (2017) 130 (Supplement 1): 2514.

https://doi.org/10.1182/blood.V130.Suppl_1.2514.2514

Published: 2017

Journal Articles

IGF Signaling Predicts Outcomes and Is a Promising Target Therapy for Acute Myeloid Leukemia

Juan Luiz Coelho-Silva, BSc, MSc, João Agostinho Machado-Neto, BSc, Jaqueline Cristina Fernandes, BSc, MSc, Ana Silvia G de Lima, PhD, Priscila Santos Scheucher, PhD, Eduardo Magalhães Rego, MDPhD, Fabiola Traina, MD PhD

Blood (2017) 130 (Supplement 1): 3966.

https://doi.org/10.1182/blood.V130.Suppl_1.3966.3966

Published: 2017

Journal Articles

DNMT3A Is Highly Expressed in Bone Marrow Cells from Acute Myeloid Leukemia Patients

Renata Scopim Ribeiro, BSc, MSc, João Agostinho Machado-Neto, BSc, Paula De Melo Campos, MD PhD, Christopher A. Eide, Samantha L Savage, Irene Lorand-Metze, MD PhD, Cristina E. Tognon, PhD, Fernando Ferreira Costa, MD PhD, Brian J. Druker, MD, Sara Teresinha Olalla Saad, MD PhD, Fabiola Traina, MD PhD

Blood (2017) 130 (Supplement 1): 3969.

https://doi.org/10.1182/blood.V130.Suppl_1.3969.3969

Published: 2017

Journal Articles

The Pharmacological IGF1R-IRS1/2 Inhibitor NT157 Presents Multiple Anti-Neoplastic Effects in Myeloproliferative Neoplasms

Bruna Alves Fenerich, BSc, João Agostinho Machado-Neto, BSc, Ana Paula Nunes Rodrigues Alves, MSc, Paula De Melo Campos, MD PhD, Jaqueline Cristina Fernandes, BSc, MSc, Juan Luiz Coelho-Silva, BSc, MSc, Renata Scopim Ribeiro, BSc, MSc, Fernanda B da Silva, BSc and MSc, Priscila Santos Scheucher, PhD, Lorena Lobo Figueiredo-Pontes, MD PhD, Eduardo Magalhães Rego, MDPhD, Fabiola Traina, MD PhD

Blood (2017) 130 (Supplement 1): 1253.

https://doi.org/10.1182/blood.V130.Suppl_1.1253.1253

Published: 2017

Journal Articles

Nuclear SET Domain (NSD) Protein Lysine Methyltransferases (KMT) Family Members Expression in Acute Myeloid Leukemia

Virginia Mara De Deus Wagatsuma, PhD, Luisa C A Koury, MD, Silvia Elena Sánchez, MSc, Lorena Lobo Figueiredo Pontes, MD; PhD, Fernanda Borges da Silva, MSc, Adriana Ines Dore, Biologist, Ana Silvia Gouvêa de Lima, PhD, Antonio R. Lucena-Araujo, PhD, Luciana Yamamoto Almeida, PhD, Fabiola Traina, MD, PhD, Felipe Saldanha-Araújo, PhD, Fabio Pittella-Silva, PhD, Eduardo Magalhães Rego, MD, PhD

Blood (2016) 128 (22): 5097.

https://doi.org/10.1182/blood.V128.22.5097.5097

Published: 2016

Journal Articles

Pharmacological IRS1/2 Inhibition Induces Apoptosis in BCR-ABL1 T315I mutant Cells

Renata Scopim-Ribeiro, M.Sc., João Agostinho Machado-Neto, PhD, Christopher A. Eide, Paula de Melo Campos, PhD, Priscila Santos Scheucher, PhD, Sara Teresinha Olalla Saad, MD PhD, Eduardo Magalhães Rego, MD, PhD, Cristina E. Tognon, Brian J. Druker, MD, Fabiola Traina, MD, PhD

Blood (2016) 128 (22): 1886.

https://doi.org/10.1182/blood.V128.22.1886.1886

Published: 2016

NARROW

Irs1 S57X Heterozygous Mutant Mice Display Normal Hematopoiesis and Phenotypic Features, While Homozygous Knockout Exhibit High Fetal or Postnatal Lethality

Cytopenia Management in Patients With Newly Diagnosed Acute Myeloid Leukemia Treated With Venetoclax Plus Azacitidine in the VIALE-A Study

Analysis of Metformin Effects on Bone Marrow Fibrosis and Disease Progression in Primary Myelofibrosis Patients: Preliminary Results of an Open Label Phase II Trial (FIBROMET)

Metformin Suppress Cellular and Molecular Processes Related to Maintenance and Proliferation of Myeloproliferative Neoplasm Stem Cell

MN1 Expression Is an Indepedent Prognostic Marker in FLT3-Mutated Acute Myeloid Leukemia and Is Involved in the Resistance to FLT3 Inhibitors

Efficacy of the Pan-Bcl-2 Inhibitor (Obatoclax) As a Single Agent to Treat Myeloproliferative Neoplasm in JAK2V617F Murine Transplantation Model

Combining Clinical Features with Genetic Factors Improves Survival Prediction for Adults with Acute Myeloid Leukemia: Validation of a New Score System in 3 Cohorts

Molecular-Based Score Inspired on Metabolic Signature Improves Prognostic Stratification for Myelodysplastic Syndrome

Experience of Generic Imatinib As a First Line Therapy for Patients with Chronic Myeloid Leukemia in a Single Reference Institution

IGF1R-IRS1/2 Signaling Pathway Is a Potential Target for FLT3-Mutated Acute Myeloid Leukemia

NSD1 and NSD2 Transcriptional Levels Might Predict Clinical Outcome in AML Patients

Clinical Impact and Therapeutic Opportunity of Insulin Receptor Substrates 1/2 in Acute Myeloid Leukemia

Autophagy Inhibition Potentiates Ruxolitinib-Induced Apoptosis in JAK2 V617F Cells

Metformin Reduces Tumor Burden and Splenomegaly in JAK2 V617F Murine Models

Stathmin 1 Is Highly Expressed in Acute Promyelocytic Leukemia and Microtubule Dynamics Is a Potential Target for ATRA-Resistant APL Cells

IGF Signaling Predicts Outcomes and Is a Promising Target Therapy for Acute Myeloid Leukemia

DNMT3A Is Highly Expressed in Bone Marrow Cells from Acute Myeloid Leukemia Patients

The Pharmacological IGF1R-IRS1/2 Inhibitor NT157 Presents Multiple Anti-Neoplastic Effects in Myeloproliferative Neoplasms

Nuclear SET Domain (NSD) Protein Lysine Methyltransferases (KMT) Family Members Expression in Acute Myeloid Leukemia

Pharmacological IRS1/2 Inhibition Induces Apoptosis in BCR-ABL1 T315I mutant Cells

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American Society of Hematology

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American Society of Hematology

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