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Journal Articles

Development of Exosome-Capturing Antibody-Conjugated Nucleic Acid Medicines Targeting Multiple Myeloma Cells

Emi Soma, Yuki Toda, PhD, Shigekuni Hosogi, MD PhD, Asako Yamayoshi, PhD, Eishi Ashihara, MD PhD

Blood (2019) 134 (Supplement_1): 3365.

https://doi.org/10.1182/blood-2019-121995

Published: 2019

Journal Articles

A Novel BRD4 Inhibitor CA2 Suppresses MM Cell Proliferation in an Orthotopic Myeloma Mouse Model

Natsuki Imayoshi, Makoto Yoshioka, PhD, Susumu Nakata, MD PhD, Jay Chauhan, PhD, Yoko Kado, BS, Yuki Toda, PhD, Steven Fletcher, PhD, Jeffrey Strovel, PhD, Kazuyuki Takata, PhD, Eishi Ashihara, MD PhD

Blood (2016) 128 (22): 4722.

https://doi.org/10.1182/blood.V128.22.4722.4722

Published: 2016

Journal Articles

Prediction of the Lenalidomide Toxicity and Its Therapeutic Efficacy in Japanese Multiple Myeloma Patients By Measuring Its Plasma Concentration.

Yoko Kado, BS, Fumiaki Kitazawa, MS, Masayuki Tsujimoto, PhD, Shin-ichi Fuchida, MD PhD, Akira Okano, MD PhD, Mayumi Hatsuse, MD, Satoshi Murakami, MD, Kumi Ueda, BS, Takatoshi Kokufu, BS, Shoichi Ozawa, Natsuko Ito, Satoe Morishita, Tetsuya Takada, BS, Tetsuya Minegaki, PhD, Kohshi Nishiguchi, PhD, Eishi Ashihara, MD PhD, Chihiro Shimazaki, MD PhD

Blood (2015) 126 (23): 3700.

https://doi.org/10.1182/blood.V126.23.3700.3700

Published: 2015

Journal Articles

Novel Bromodomain Inhibitors Suppress Proliferation of Multiple Myeloma Cells

Eishi Ashihara, MD PhD, Ryoko Oki, Natsuki Imayoshi, Makoto Yoshioka, PhD, Jeffrey Strovel, PhD, Ayako Honjo, Yumi Sakai, Tetsuya Takada, BS, Jay Chauhan, PhD, Mithun Raje, PhD, Steven Fletcher, PhD, Kazuyuki Takata, PhD

Blood (2015) 126 (23): 4432.

https://doi.org/10.1182/blood.V126.23.4432.4432

Published: 2015

Journal Articles

C/EBPβ Promotes Initial Expansion and Exhaustion of Hematopoietic Stem and Progenitor Cells in Response to Hematopoietic Stresses

Atsushi Sato, MD, Hideyo Hirai, MD PhD, Akihiro Tamura, MD, Asumi Yokota, PhD, Yoshihiro Hayashi, MD PhD, Hisayuki Yao, MD PhD, Masaki Iwasa, MD, Aya Fujishiro, MD, Eishi Ashihara, MD PhD, Yasuo Miura, MD PhD, Taira Maekawa, MD PhD

Blood (2014) 124 (21): 5126.

https://doi.org/10.1182/blood.V124.21.5126.5126

Published: 2014

Journal Articles

Microglia-Like Monocytic Cells Derived From Bone Marrow Cells Phagocytose Amyloid-β and Facilitate Phagocytosis Of Amyloid-β By Resident Microglia

Kazuyuki Takata, PhD, Yumiko Toji, Shohei Kawanishi, Tetsuya Takada, BA, Kitamura Yoshihisa, PhD, Eishi Ashihara, MD, PhD

Blood (2013) 122 (21): 3467.

https://doi.org/10.1182/blood.V122.21.3467.3467

Published: 2013

Journal Articles

Direct Interaction With Bone Marrow Mesenchymal Stromal/Stem Cells Is Required For Hematopoietic Expansion By Parathyroid Hormone

Hisayuki Yao, MD, PhD, Yasuo Miura, MD, PhD, Satoshi Yoshioka, MD, Masaki Iwasa, MD, Atsushi Sato, MD, Akihiro Tamura, MD, Asumi Yokota, PhD, Eishi Ashihara, MD, PhD, Tatsuo Ichinohe, MD, PhD, Hideyo Hirai, MD, PhD, Taira Maekawa, MD, PhD

Blood (2013) 122 (21): 3689.

https://doi.org/10.1182/blood.V122.21.3689.3689

Published: 2013

Journal Articles

Cell-Intrinsic and Cell-Extrinsic Involvement Of C/EBPβ In The Regulation Of Hematopoietic Stem Cells

Akihiro Tamura, MD, Hideyo Hirai, MD, PhD, Yoshihiro Hayashi, MD, PhD, Asumi Yokota, PhD, Atsushi Sato, MD, Satoshi Yoshioka, MD, Masaki Iwasa, MD, Eishi Ashihara, MD, PhD, Yasuo Miura, MD, PhD, Taira Maekawa, MD, PhD

Blood (2013) 122 (21): 1202.

https://doi.org/10.1182/blood.V122.21.1202.1202

Published: 2013

Journal Articles

Hypoxia-Adapted Myeloma Cells Possess Stem Cell Character

Eishi Ashihara, MD, PhD, Yoko Nakagawa, Hisayuki Yao, MD, PhD, Asumi Yokota, PhD, Yasuo Miura, MD, PhD, Kazuyuki Takata, PhD, Yoshihisa Kitamura, PhD, Hideyo Hirai, MD, PhD, Taira Maekawa, MD, PhD

Blood (2013) 122 (21): 3088.

https://doi.org/10.1182/blood.V122.21.3088.3088

Published: 2013

Journal Articles

Cytokine-STATs Signalings Upregulate C/EBPβ In BCR-ABL + Leukemic Cells Independently From BCR-ABL/JAK-STAT Pathway

Asumi Yokota, PhD, Hideyo Hirai, MD, PhD, Yoshihiro Hayashi, MD, PhD, Akihiro Tamura, MD, Atsushi Sato, MD, Hisayuki Yao, MD, PhD, Satoshi Yoshioka, MD, Masaki Iwasa, MD, Eishi Ashihara, MD, PhD, Yasuo Miura, MD, PhD, Taira Maekawa, MD, PhD

Blood (2013) 122 (21): 1468.

https://doi.org/10.1182/blood.V122.21.1468.1468

Published: 2013

Journal Articles

C/EBPβ-Mediated Expansion of Hematopoietic Stem/Progenitors Precedes ‘Emergency’ Granulopoiesis Induced by Candidemia.

Akihiro Tamura, MD, Hideyo Hirai, MD, PhD, Yoshihiro Hayashi, MD, Hisayuki Yao, MD, PhD, Satoshi Yoshioka, MD, Yasuo Miura, MD, PhD, Eishi Ashihara, MD, PhD, Taira Maekawa, MD, PhD

Blood (2012) 120 (21): 2336.

https://doi.org/10.1182/blood.V120.21.2336.2336

Published: 2012

Journal Articles

C/EBPβ Is Upregulated Through STAT5 and Accelerates Exhaustion of Leukemic Stem Cells During BCR-ABL-Mediated Myeloid Expansion

Yoshihiro Hayashi, MD, Hideyo Hirai, MD, PhD, Hisayuki Yao, MD, PhD, Satoshi Yoshioka, MD, Akihiro Tamura, MD, Yasuo Miura, MD, PhD, Eishi Ashihara, MD, PhD, Yoshihide Fujiyama, MD, PhD, Daniel G. Tenen, MD, Taira Maekawa, MD, PhD

Blood (2012) 120 (21): 907.

https://doi.org/10.1182/blood.V120.21.907.907

Published: 2012

Journal Articles

Leukemia Microenvironment-Specific Galectin-3 Expression of Leukemic Cells Promotes Malignant Niche Formation and Bone Marrow Lodgment of Leukemic Cells in Chronic Myelogenous Leukemia

Junya Kuroda, MD, PhD, Mio Yamamoto, Eishi Ashihara, MD, PhD, Hisao Nagoshi, MD, Tsutomu Kobayashi, MD, PhD, Yosuke Matsumoto, MD, PhD, Nasa Sasaki, Yuji Shimura, Miki Kiyota, Ryuko Nakayama, Shigeo Horiike, Taira Maekawa, MD, PhD, Masafumi Taniwaki

Blood (2011) 118 (21): 1678.

https://doi.org/10.1182/blood.V118.21.1678.1678

Published: 2011

Journal Articles

Targeting the Hedgehog Signaling Pathway in Therapy-Resistant BCR-ABL1 Positive Leukemia with Ponatinib

Seiichiro Katagiri, M.D., Tetsuzo Tauchi, M.D., Seiichi Okabe, M.D., Eishi Ashihara, MD, PhD, Shinya Kimura, MD, PhD, Taira Maekawa, MD, DMSci, Kazuma Ohyashiki, MD, PhD

Blood (2011) 118 (21): 63.

https://doi.org/10.1182/blood.V118.21.63.63

Published: 2011

Journal Articles

Combined Effects of a Pan-ABL1 Kinase Inhibitor, Ponatinib and Dasatinib Against T315I Mutant Forms of BCR-ABL1: In Vitro and In Vivo Studies

Tetsuzo Tauchi, M.D., Seiichiro Katagiri, M.D., Seiichi Okabe, M.D., Eishi Ashihara, MD, PhD, Shinya Kimura, MD, PhD, Taira Maekawa, MD, DMSci, Kazuma Ohyashiki, MD, PhD

Blood (2011) 118 (21): 2482.

https://doi.org/10.1182/blood.V118.21.2482.2482

Published: 2011

Journal Articles

Galectin-3 Is the Molecular Target for Overcoming Multidrug Resistance Due to the Cell Protection by Bone Marrow Leukemia Microenvironment in Chronic Myeloid Leukemia,

Mio Yamamoto, Junya Kuroda, MD, PhD, Tsutomu Kobayashi, MD, PhD, Nana Sasaki, MD, Hisao Nagoshi, Yuji Shimura, Miki Kiyota, Ryuko Nakayama, Shigeo Horiike, MD, PhD, Eishi Ashihara, MD, PhD, Kenichi Akaji, PhD, Masafumi Taniwaki, MD, PhD

Blood (2011) 118 (21): 3746.

https://doi.org/10.1182/blood.V118.21.3746.3746

Published: 2011

Journal Articles

BCR/ABL-Mediated Myeloid Expansion Is Promoted by C/EBPβ, a Regulator of Emergency Granulopoiesis,

Yoshihiro Hayashi, MD, Hideyo Hirai, MD, PhD, Hisayuki Yao, MD, Satoshi Yoshioka, MD, Sakiko Satake, MD, Naoka Kamio, MD, Yasuo Miura, MD, PhD, Eishi Ashihara, MD, PhD, Yoshihide Fujiyama, MD, PhD, Daniel G. Tenen, Taira Maekawa, MD, PhD

Blood (2011) 118 (21): 3747.

https://doi.org/10.1182/blood.V118.21.3747.3747

Published: 2011

Journal Articles

Candidemia-Induced Emergency Granulopoiesis Consists of Successive Dual Waves Triggered by the Shift From C/EBPalpha to C/EBPbeta Dependency.

Sakiko Satake, MD, Hideyo Hirai, MD, PhD, Nobuaki Shime, MD, PhD, Rina Nagao, Ruriko Tanaka, MMSc, Hisayuki Yao, MD, Yoshihiro Hayashi, MD, Eishi Ashihara, MD, PhD, Tohru Inaba, MD, PhD, Naohisa Fujita, MD, PhD, Jiro Imanishi, MD, PhD, Taira Maekawa, MD, DMSci

Blood (2010) 116 (21): 3778.

https://doi.org/10.1182/blood.V116.21.3778.3778

Published: 2010

Journal Articles

Activity of the Histone Deacetylase Inhibitor, Vorinostat, Against BCR-ABL Positive Leukemia Cells with Random Mutagenesis and In Combination with Nilotinib

Seiichi Okabe, M.D., Tetsuzo Tauchi, M.D., Eishi Ashihara, MD, PhD, Shinya Kimura, MD, PhD, Taira Maekawa, MD, DMSci, Kazuma Ohyashiki, MD, PhD

Blood (2010) 116 (21): 4460.

https://doi.org/10.1182/blood.V116.21.4460.4460

Published: 2010

Journal Articles

Isopentenyl Pyrophosphate (IPP), a Metabolite produced in Myeloma Cells Induces the Chemotaxis of γδT Cells

Eishi Ashihara, MD, PhD, Tatsuya Munaka, PhD, Shinya Kimura, MD, PhD, Masaki Kanai, PhD, Hirohisa Abe, Hideyo Hirai, MD, PhD, Shuichi Shoji, PhD, Taira Maekawa, MD, DMSci

Blood (2010) 116 (21): 2766.

https://doi.org/10.1182/blood.V116.21.2766.2766

Published: 2010

NARROW

Development of Exosome-Capturing Antibody-Conjugated Nucleic Acid Medicines Targeting Multiple Myeloma Cells

A Novel BRD4 Inhibitor CA2 Suppresses MM Cell Proliferation in an Orthotopic Myeloma Mouse Model

Prediction of the Lenalidomide Toxicity and Its Therapeutic Efficacy in Japanese Multiple Myeloma Patients By Measuring Its Plasma Concentration.

Novel Bromodomain Inhibitors Suppress Proliferation of Multiple Myeloma Cells

C/EBPβ Promotes Initial Expansion and Exhaustion of Hematopoietic Stem and Progenitor Cells in Response to Hematopoietic Stresses

Microglia-Like Monocytic Cells Derived From Bone Marrow Cells Phagocytose Amyloid-β and Facilitate Phagocytosis Of Amyloid-β By Resident Microglia

Direct Interaction With Bone Marrow Mesenchymal Stromal/Stem Cells Is Required For Hematopoietic Expansion By Parathyroid Hormone

Cell-Intrinsic and Cell-Extrinsic Involvement Of C/EBPβ In The Regulation Of Hematopoietic Stem Cells

Hypoxia-Adapted Myeloma Cells Possess Stem Cell Character

Cytokine-STATs Signalings Upregulate C/EBPβ In BCR-ABL + Leukemic Cells Independently From BCR-ABL/JAK-STAT Pathway

C/EBPβ-Mediated Expansion of Hematopoietic Stem/Progenitors Precedes ‘Emergency’ Granulopoiesis Induced by Candidemia.

C/EBPβ Is Upregulated Through STAT5 and Accelerates Exhaustion of Leukemic Stem Cells During BCR-ABL-Mediated Myeloid Expansion

Leukemia Microenvironment-Specific Galectin-3 Expression of Leukemic Cells Promotes Malignant Niche Formation and Bone Marrow Lodgment of Leukemic Cells in Chronic Myelogenous Leukemia

Targeting the Hedgehog Signaling Pathway in Therapy-Resistant BCR-ABL1 Positive Leukemia with Ponatinib

Combined Effects of a Pan-ABL1 Kinase Inhibitor, Ponatinib and Dasatinib Against T315I Mutant Forms of BCR-ABL1: In Vitro and In Vivo Studies

Galectin-3 Is the Molecular Target for Overcoming Multidrug Resistance Due to the Cell Protection by Bone Marrow Leukemia Microenvironment in Chronic Myeloid Leukemia,

BCR/ABL-Mediated Myeloid Expansion Is Promoted by C/EBPβ, a Regulator of Emergency Granulopoiesis,

Candidemia-Induced Emergency Granulopoiesis Consists of Successive Dual Waves Triggered by the Shift From C/EBPalpha to C/EBPbeta Dependency.

Activity of the Histone Deacetylase Inhibitor, Vorinostat, Against BCR-ABL Positive Leukemia Cells with Random Mutagenesis and In Combination with Nilotinib

Isopentenyl Pyrophosphate (IPP), a Metabolite produced in Myeloma Cells Induces the Chemotaxis of γδT Cells

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American Society of Hematology

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American Society of Hematology

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