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Journal Articles

Single Cell Transcriptomics Revealed AML and Non-AML Cell Clusters Relevant to Relapse and Remission in Pediatric AML

Beena E Thomas, Pruthvi Perumalla, MS, Swati S Bhasin, PhD, Debasree Sarkar, PhD, Bhakti Dwivedi, PhD, Sunita I Park, MD, Deborah DeRyckere, BS,PhD, Curtis J. Henry, PhD, Sunil S. Raikar, MD, Christopher C. Porter, MD, Melinda Pauly, MD, Ryan J Summers, MD, Sharon M. Castellino, MD MSc, Daniel S. Wechsler, MD PhD, Douglas K Graham, MD PhD, Manoj Bhasin, PhD

Blood (2020) 136 (Supplement 1): 24–25.

https://doi.org/10.1182/blood-2020-142513

Published: 2020

Journal Articles

Characterization of T-ALL-Specific Heterogenous Blast Populations Using High Resolution Single Cell Profiling

Swati S Bhasin, PhD, Ryan J Summers, MD, Beena E Thomas, Debasree Sarkar, PhD, Bhakti Dwivedi, PhD, Sunita I Park, MD, Deborah DeRyckere, BS,PhD, Sharon M. Castellino, MD MSc, Manoj Bhasin, PhD, Douglas K Graham, MD PhD

Blood (2020) 136 (Supplement 1): 11–12.

https://doi.org/10.1182/blood-2020-143017

Published: 2020

Journal Articles

Mertk Inhibition Promotes Anti-Leukemia Immunity By Reversing T Cell Suppression Via the PD-1 Axis

Alisa Lee-Sherick, MD, Kristen Jacobsen, PhD, Curtis J. Henry, PhD, Rebecca Parker, Xiaodong Wang, PhD, Stephen V Frye, PhD, H. Shelton Earp, MD, Deborah DeRyckere, PhD, Douglas K Graham, MD PhD

Blood (2018) 132 (Supplement 1): 4019.

https://doi.org/10.1182/blood-2018-99-119818

Published: 2018

Journal Articles

Mertk Is a Therapeutic Target in Early T-Precursor Acute Lymphoblastic Leukemia

Ryan J Summers, MD, Katherine A Minson, MD, Stephen V Frye, PhD, Xiaodong Wang, PhD, H. Shelton Earp, III, MD, Deborah DeRyckere, PhD, Douglas K. Graham, MD PhD

Blood (2017) 130 (Supplement 1): 2536.

https://doi.org/10.1182/blood.V130.Suppl_1.2536.2536

Published: 2017

Journal Articles

Bone Marrow Stromal Cell Mediated Resistance to Mertk Inhibition in Acute Myeloid Leukemia

Katherine A Minson, MD, Madeline G Huey, BA, Annie Qiu, Xiaodong Wang, PhD, Stephen V Frye, PhD, H. Shelton Earp, MD, Deborah DeRyckere, PhD, Douglas K Graham, MD PhD

Blood (2017) 130 (Supplement 1): 3823.

https://doi.org/10.1182/blood.V130.Suppl_1.3823.3823

Published: 2017

Journal Articles

Bone Marrow Stromal Cell Mediated Resistance to Mertk Inhibition in Acute Leukemia

Katherine A Minson, MD, Madeline G Huey, BS, Amanda A Hill, Irene Perez, Xiaodong Wang, PhD, Stephen Frye, PhD, H. Shelton Earp, III, MD, Deborah DeRyckere, PhD, Douglas K. Graham, MD PhD

Blood (2016) 128 (22): 2819.

https://doi.org/10.1182/blood.V128.22.2819.2819

Published: 2016

Journal Articles

UNC2025, a Small Molecule MerTK and Flt3 Tyrosine Kinase Inhibitor, Decreases Disease Burden, Prolongs Survival, and Promotes Sensitivity to Chemotherapy in Xenograft Models of Acute Leukemia

Deborah DeRyckere, PhD, Alisa B. Lee-Sherick, MD, Amanda A. Hill, Lauren Page, BS, Xiaodong Wang, PhD, Stephen V. Frye, PhD, H. Shelton Earp, MD, Douglas K. Graham, MD PhD

Blood (2014) 124 (21): 998.

https://doi.org/10.1182/blood.V124.21.998.998

Published: 2014

Journal Articles

MRX2843, a Novel Dual MerTK-FLT3 Inhibitor with Activity Against Resistance-Conferring FLT3 Mutations in Acute Myeloid Leukemia

Katherine A Minson, MD, Catherine C Smith, MD, Alisa B. Lee-Sherick, MD, Deborah DeRyckere, PhD, Elisabeth Lasater, PhD, Amanda A. Hill, Xiaodong Wang, PhD, Stephen V. Frye, PhD, H. Shelton Earp, MD, Neil P. Shah, MD PhD, Douglas K. Graham, MD PhD

Blood (2014) 124 (21): 3757.

https://doi.org/10.1182/blood.V124.21.3757.3757

Published: 2014

Journal Articles

Mer Receptor Tyrosine Kinase Is a Novel Therapeutic Target In Multiple Myeloma

Sandra Christoph, Silke Maag, Deborah DeRyckere, Douglas K. Graham, MD, PhD, Stephen V Frye, H. Shelton Earp, III, Jing Liu, Chao Yang, Weihe Zhang, Xiaodong Wang, Ahmet H. Elmaagacli, Dietrich Beelen, MD

Blood (2013) 122 (21): 1957.

https://doi.org/10.1182/blood.V122.21.1957.1957

Published: 2013

Journal Articles

Development Of a Novel Small Molecule Inhibitor Of The Mer Tyrosine Kinase For Treatment Of Acute Lymphoblastic Leukemia

Deborah DeRyckere, Xiaodong Wang, Amanda A Hill, Weihe Zhang, Michael A Stashko, Susan Sather, Christopher E Cummings, William P Janzen, Stephen V Frye, H. Shelton Earp, III, Douglas K. Graham, MD, PhD

Blood (2013) 122 (21): 2666.

https://doi.org/10.1182/blood.V122.21.2666.2666

Published: 2013

Journal Articles

Novel Small Molecule Inhibitors Of The Gas6/TAM Signaling Pathway Mediate Synergistic Inhibition Of Platelet Aggregation In Combination With ADP/P2Y Antagonists

Gilbert Acevedo, BS, Brian R. Branchford, MD, Luke Law, BS, Christine Brzezinski, Susan Sather, Gary Brodsky, PhD, Deborah DeRyckere, Ph.D., Weihe Zhang, H. Shelton Earp, III, Stephen V Frye, Douglas K. Graham, MD, PhD, Jorge Di Paola, MD

Blood (2013) 122 (21): 3507.

https://doi.org/10.1182/blood.V122.21.3507.3507

Published: 2013

Journal Articles

Novel Small Molecule Inhibitors Of The Gas6/TAM Signaling Pathway Inhibit Platelet Aggregation In Vitro and Protect Mice From Arterial and Venous Thrombosis In Vivo

Gilbert Acevedo, BS, Brian R. Branchford, MD, Christine Brzezinski, Susan Sather, Gary Brodsky, PhD, Deborah DeRyckere, Ph.D., Weihe Zhang, Jing Liu, H. Shelton Earp, III, Xiaodong Wang, Stephen V Frye, Douglas K. Graham, MD, PhD, Jorge Di Paola, MD

Blood (2013) 122 (21): 2296.

https://doi.org/10.1182/blood.V122.21.2296.2296

Published: 2013

Journal Articles

UNC1666, a Dual Mer and Flt-3 Tyrosine Kinase Small Molecule Inhibitor In Acute Myeloid Leukemia

Alisa B. Lee-Sherick, MD, Kelly Menachof, Amanda A Hill, Sean Rinella, MPH, Jing Liu, Deborah DeRyckere, Xiaodong Wang, Stephen V Frye, H. Shelton Earp, III, Douglas K. Graham, MD, PhD

Blood (2013) 122 (21): 3849.

https://doi.org/10.1182/blood.V122.21.3849.3849

Published: 2013

Journal Articles

A Small Molecule Inhibitor of the Gas6/Mer Pathway Inhibits Platelet Activation and Thrombosis with Equal Efficacy to, but Greater Potency Than, iMer, the Novel MerTK Splice Variant

Brian R. Branchford, MD, Luke Law, BS, Susan Sather, BS, Gary Brodsky, PhD, H. Shelton Earp, III, Xiaodong Wang, Stephen Frye, Douglas K. Graham, MD, PhD, Jorge A Di Paola, MD

Blood (2012) 120 (21): 3303.

https://doi.org/10.1182/blood.V120.21.3303.3303

Published: 2012

Journal Articles

Mer Receptor Tyrosine Kinase Is A Potential Therapeutic Target in Acute Myeloid Leukemia

Alisa B. Lee-Sherick, MD, Kelly Menachof, Kristen M. Eisenman, MD, Amy McGranahan, Colleen McGary, Sally A. Hunsucker, PhD, Jennifer Schlegel, Paul M Armistead, MD, PhD, Xiayuan Liang, MD, Dmitri Kireev, William Janzen, Jing Liu, Michael Stashko, Jacqueline Norris-Drouin, H. Shelton Earp, III, Xiaodong Wang, Stephen Frye, Deborah DeRyckere, PhD, Douglas K. Graham, MD, PhD

Blood (2012) 120 (21): 1317.

https://doi.org/10.1182/blood.V120.21.1317.1317

Published: 2012

Journal Articles

Imer Blocks Phosphorylation of the β 3 Integrin, Decreasing Platelet Activation Responses and Protecting Mice From Arterial Thrombosis

Brian R. Branchford, MD, Susan Sather, BS, Gary Brodsky, PhD, Tara C White-Adams, PhD, Deborah DeRyckere, Ph.D., Keith B Neeves, PhD, Katina M Wilson, BA, Steven R. Lentz, MD, PhD, Douglas K. Graham, MD, PhD, Jorge A Di Paola, MD

Blood (2011) 118 (21): 189.

https://doi.org/10.1182/blood.V118.21.189.189

Published: 2011

Journal Articles

Mer Receptor Tyrosine Kinase Is Over-Expressed In and Contributes to Oncogenesis In Acute Myeloid Leukemia

Alisa B. Lee-Sherick, MD, Kristen M. Eisenman, MD, Susan Sather, BS, Deborah DeRyckere, PhD, Jennifer Schlegel, Douglas K. Graham, MD, PhD

Blood (2011) 118 (21): 1390.

https://doi.org/10.1182/blood.V118.21.1390.1390

Published: 2011

Journal Articles

Lymphoblastic Leukemia/Lymphoma in Mice Overexpressing the Mer Receptor Tyrosine Kinase.

Dana B. Salzberg, MD, Amy K. Keating, MD, Adil Anwar, PhD, Kelly Sawczyn, MD, Kimberley Hill, Susan Sather, Jane Park, BS, Deborah DeRyckere, PhD, Doug Everett, PhD, Douglas K. Graham, MD, PhD

Blood (2005) 106 (11): 2619.

https://doi.org/10.1182/blood.V106.11.2619.2619

Published: 2005

Journal Articles

Ectopic Expression of Mer Receptor Tyrosine Kinase in Childhood T Cell Acute Lymphoblastic Leukemia.

Dana B. Salzberg, MD, Amy K. Keating, MD, Jian-zhe Cao, MA, Susan Sather, BS, Kimberley Hill, Adil Anwar, PhD, Douglas K. Graham, MD, PhD.

Blood (2004) 104 (11): 4310.

https://doi.org/10.1182/blood.V104.11.4310.4310

Published: 2004

Journal Articles

A Soluble Truncated Form of the Mer Tyrosine Kinase Inhibits Gas6 Activity in Platelets and Monocytes.

Douglas K. Graham, MD PhD, Susan Sather, BS

Blood (2004) 104 (11): 1561.

https://doi.org/10.1182/blood.V104.11.1561.1561

Published: 2004

NARROW

Single Cell Transcriptomics Revealed AML and Non-AML Cell Clusters Relevant to Relapse and Remission in Pediatric AML

Characterization of T-ALL-Specific Heterogenous Blast Populations Using High Resolution Single Cell Profiling

Mertk Inhibition Promotes Anti-Leukemia Immunity By Reversing T Cell Suppression Via the PD-1 Axis

Mertk Is a Therapeutic Target in Early T-Precursor Acute Lymphoblastic Leukemia

Bone Marrow Stromal Cell Mediated Resistance to Mertk Inhibition in Acute Myeloid Leukemia

Bone Marrow Stromal Cell Mediated Resistance to Mertk Inhibition in Acute Leukemia

UNC2025, a Small Molecule MerTK and Flt3 Tyrosine Kinase Inhibitor, Decreases Disease Burden, Prolongs Survival, and Promotes Sensitivity to Chemotherapy in Xenograft Models of Acute Leukemia

MRX2843, a Novel Dual MerTK-FLT3 Inhibitor with Activity Against Resistance-Conferring FLT3 Mutations in Acute Myeloid Leukemia

Mer Receptor Tyrosine Kinase Is a Novel Therapeutic Target In Multiple Myeloma

Development Of a Novel Small Molecule Inhibitor Of The Mer Tyrosine Kinase For Treatment Of Acute Lymphoblastic Leukemia

Novel Small Molecule Inhibitors Of The Gas6/TAM Signaling Pathway Mediate Synergistic Inhibition Of Platelet Aggregation In Combination With ADP/P2Y Antagonists

Novel Small Molecule Inhibitors Of The Gas6/TAM Signaling Pathway Inhibit Platelet Aggregation In Vitro and Protect Mice From Arterial and Venous Thrombosis In Vivo

UNC1666, a Dual Mer and Flt-3 Tyrosine Kinase Small Molecule Inhibitor In Acute Myeloid Leukemia

A Small Molecule Inhibitor of the Gas6/Mer Pathway Inhibits Platelet Activation and Thrombosis with Equal Efficacy to, but Greater Potency Than, iMer, the Novel MerTK Splice Variant

Mer Receptor Tyrosine Kinase Is A Potential Therapeutic Target in Acute Myeloid Leukemia

Imer Blocks Phosphorylation of the β 3 Integrin, Decreasing Platelet Activation Responses and Protecting Mice From Arterial Thrombosis

Mer Receptor Tyrosine Kinase Is Over-Expressed In and Contributes to Oncogenesis In Acute Myeloid Leukemia

Lymphoblastic Leukemia/Lymphoma in Mice Overexpressing the Mer Receptor Tyrosine Kinase.

Ectopic Expression of Mer Receptor Tyrosine Kinase in Childhood T Cell Acute Lymphoblastic Leukemia.

A Soluble Truncated Form of the Mer Tyrosine Kinase Inhibits Gas6 Activity in Platelets and Monocytes.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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