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Devon J Shedlock
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Journal Articles

Enhanced Potency of BCMA/CD19 Dual-Targeting Allogeneic CAR-T Cells for Relapsed/ Refractory Multiple Myeloma with 4-1BB/TACI Intracellular Domains

Steven Wang, Iris Pang, Claudia Chang, Michelle Burrascano, Nick DeMarco, Danny Mendoza, Sonia Reyes, Arturo Barcenas, Pastor Nieto, Jose Diaz, Garrett Arauz, Chris Lynn, Tony Nguyen, Connor Reed, Jeannette Connerney, Quy LE, Julia Coronella, Devon J Shedlock
Journal: Blood
Blood (2024) 144 (Supplement 1): 7093.
https://doi.org/10.1182/blood-2024-211463
Published: 2024
Journal Articles

A Phase 1 Study of P-BCMA-ALLO1, a Non-Viral, Allogeneic BCMA Directed CAR-T in Relapsed/Refractory Multiple Myeloma (RRMM): Results from Optimized Lymphodepletion Cohort

Bhagirathbhai Dholaria, Leyla O. Shune, Mehmet H. Kocoglu, Andrew Kin, Aravind Ramakrishnan, Ehsan Malek, Siddhartha Ganguly, Christopher Strouse, Jose Carlos Cruz, Edward Anthony Faber, Katherine McArthur, Jeff D Eskew, Joanne McCaigue, Samuel DePrimo, Chris E Martin, Sabrina Haag, Hamid Namini, Ellen Christie, Rajesh Belani, Syed Rizvi, Stacey A Cranert, Julia Coronella, Devon J Shedlock, Caitlin Costello
Journal: Blood
Blood (2024) 144 (Supplement 1): 4828.
https://doi.org/10.1182/blood-2024-207459
Published: 2024
Journal Articles

P-CD19CD20-ALLO1: Potent Fully Allogeneic CAR-T Therapy Targeting CD19 and CD20 with Superior Efficacy over Single-Target Products

Samy Jambon, Jennifer Ruiz, Andres Garcia-Maldonado, Meixuan Chen, Danny Mendoza, Garrett Arauz, Nicholas DeMarco, Mona Connerney, Jeff D Eskew, Rajesh Belani, Stacey A Cranert, Julia Coronella, Devon J Shedlock
Journal: Blood
Blood (2024) 144 (Supplement 1): 4805.
https://doi.org/10.1182/blood-2024-211441
Published: 2024
Journal Articles

Early Safety Results of P-BCMA-ALLO1, a Fully Allogeneic Chimeric Antigen Receptor T-Cell (CAR-T), in Patients with Relapsed / Refractory Multiple Myeloma (RRMM)

Bhagirathbhai Dholaria, Mehmet H. Kocoglu, Andrew Kin, Adam S. Asch, Aravind Ramakrishnan, Carlos Bachier, Tulio E. Rodriguez, Leyla Shune, Katherine McArthur, Joanne McCaigue, Samuel DePrimo, Chris Martin, Sabrina Haag, Maggie Zhang, Hamid Namini, Ellen Christie, Rajesh Belani, Stacey A Cranert, Julia Coronella, Devon J Shedlock, Caitlin L. Costello
Journal: Blood
Blood (2023) 142 (Supplement 1): 3479.
https://doi.org/10.1182/blood-2023-182430
Published: 2023
Journal Articles

A Tumor-Bearing Murine Xenograft Model As a Bioassay for Assessing CAR-T Product Potency Shows Positive Predictive Value for Clinical Performance

Stacey A Cranert, Hubert Tseng, Karl Marquez, Benjamin S Cho, Andrew Bacong, Danny Mendoza, Garrett Arauz, Nick DeMarco, Mona Connerney, Julia Coronella, Devon J Shedlock
Journal: Blood
Blood (2023) 142 (Supplement 1): 2293.
https://doi.org/10.1182/blood-2023-189837
Published: 2023
Journal Articles

Memory Phenotype in Allogeneic Anti-BCMA CAR-T Cell Therapy (P-BCMA-ALLO1) Correlates with In Vivo Tumor Control

Hubert Tseng, Yan Zhang, Stacey A Cranert, Maximilian Richter, Karl Marquez, Jing Qiu, Benjamin Cho, Yening Tan, Min Tong, Christine Domingo, Leslie Weiss, Elvira Argus, Jessica Sparks, Eric M. Ostertag, Julia Coronella, Devon J Shedlock
Journal: Blood
Blood (2021) 138 (Supplement 1): 4802.
https://doi.org/10.1182/blood-2021-154034
Published: 2021
Journal Articles

Phase 1/2 Study of the Safety and Response of P-BCMA-101 CAR-T Cells in Patients with Relapsed/Refractory (r/r) Multiple Myeloma (MM) (PRIME) with Novel Therapeutic Strategies

Caitlin L. Costello, MD, Adam D. Cohen, MD, Krina K. Patel, MD, Syed S Ali, MD, Jesus G. Berdeja, MD, Nina Shah, MD, Siddhartha Ganguly, MD, Mehmet Hakan Kocoglu, MD, Mehrdad Abedi, MD, Eric M. Ostertag, MD PhD, Chris E Martin, PhD, Majid Ghoddussi, PhD, Devon J Shedlock, PhD, Joanne McCaigue, M.S., Hamid Namini, PhD, Sreeni Yalamanchili, Matthew A. Spear, MD, Tara K. Gregory, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 29–30.
https://doi.org/10.1182/blood-2020-142695
Published: 2020
Journal Articles

Manufacture of an Allogeneic CAR-T Stem Cell Memory Product Candidate for Multiple Myeloma, P-Bcma-ALLO1, Is Robust, Reproducible and Highly Scalable

Stacey A Cranert, PhD, Maximilian Richter, PhD, Min Tong, MS, Leslie Weiss, MS, Yening Tan, MS, Eric M. Ostertag, MD PhD, Julia Coronella, PhD, Devon J Shedlock, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4445.
https://doi.org/10.1182/blood-2019-131839
Published: 2019
Journal Articles

Phase 2 Study of the Response and Safety of P-Bcma-101 CAR-T Cells in Patients with Relapsed/Refractory (r/r) Multiple Myeloma (MM) (PRIME)

Caitlin L. Costello, MD, Tara K. Gregory, MD, Syed Abbas Ali, MD, Jesus G. Berdeja, MD, Krina K. Patel, MDMSc, Nina D. Shah, MD, Eric Ostertag, Chris Martin, Majid Ghoddusi, PhD DVM, Devon J Shedlock, PhD, Matthew A. Spear, MD, Robert Z. Orlowski, MD, PhD, Adam D. Cohen, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3184.
https://doi.org/10.1182/blood-2019-129562
Published: 2019
Journal Articles

Efficacy and Safety of P-Bcma-101 CAR-T Cells in Patients with Relapsed/Refractory (r/r) Multiple Myeloma (MM)

Tara Gregory, MD, Adam D. Cohen, MD, Caitlin L. Costello, MD, Syed Abbas Ali, MD, Jesus G. Berdeja, MD, Eric M Ostertag, MD PhD, Christopher Martin, PhD, Devon J Shedlock, PhD, Michelle Lynn Resler, BS, Matthew A. Spear, MD, Robert Z. Orlowski, MD PhD, Krina K. Patel, MDMSc
Journal: Blood
Blood (2018) 132 (Supplement 1): 1012.
https://doi.org/10.1182/blood-2018-99-111419
Published: 2018
Journal Articles

The Application of ‘Drug-Reversible’ CAR-T Cells Directed Against Recipient Hematopoietic Cells As a Selective Conditioning Strategy for Stem Cell Transplantation

Nina Timberlake, Maximilian Richter, Xinxin Wang, PhD, Nicholas Cam, Yening Tan, Eric M Ostertag, Devon J Shedlock, Julian D Down
Journal: Blood
Blood (2017) 130 (Supplement 1): 1893.
https://doi.org/10.1182/blood.V130.Suppl_1.1893.1893
Published: 2017
Journal Articles

Production of Universal Anti-Bcma CAR-T Cells with Reduced Alloreactivity, but Potent Effector Function for the Treatment of Multiple Myeloma

Xinxin Wang, PhD, Burton Earle Barnett, PhD, Christopher Martin, David Hermanson, PhD, Xianghong Li, Jenessa Smith, Joann Wu, Stacey Cranert, PhD, Srinivas Rengarajan, MS, Yening Tan, Min Tong, Rebecca Codde, Julian D Down, Eric M Ostertag, Devon J Shedlock
Journal: Blood
Blood (2017) 130 (Supplement 1): 503.
https://doi.org/10.1182/blood.V130.Suppl_1.503.503
Published: 2017
Journal Articles

Development of Novel Non-Immunoglobulin Centyrin-Based Cars (CARTyrins) Targeting Human Bcma

Burton Earle Barnett, PhD, Xinxin Wang, PhD, David L. Hermanson, PhD, Yening Tan, B.S., Eric M. Osertag, MD PhD, Devon J. Shedlock, PhD
Journal: Blood
Blood (2016) 128 (22): 4557.
https://doi.org/10.1182/blood.V128.22.4557.4557
Published: 2016
Journal Articles

A Novel Bcma-Specific, Centyrin-Based CAR-T Product for the Treatment of Multiple Myeloma

David L. Hermanson, PhD, Burton Earle Barnett, PhD, Srinivas Rengarajan, M.S., Rebecca Codde, B.S., Xinxin Wang, PhD, Yening Tan, B.S., Christopher E. Martin, PhD, Jenessa Barbara Smith, PhD, Jin He, M.S., Rohit Mathur, PhD, Jing Yan, PhD, Sattva S. Neelapu, MD, Eric M. Osertag, MD PhD, Devon J. Shedlock, PhD
Journal: Blood
Blood (2016) 128 (22): 2127.
https://doi.org/10.1182/blood.V128.22.2127.2127
Published: 2016
Journal Articles

piggyBac TM -Produced CAR-T Cells Exhibit Stem-Cell Memory Phenotype

Burton Earle Barnett, PhD, David L. Hermanson, PhD, Jenessa Barbara Smith, PhD, Xinxin Wang, PhD, Yening Tan, B.S., Christopher E. Martin, PhD, Eric M. Osertag, MD PhD, Devon J. Shedlock, PhD
Journal: Blood
Blood (2016) 128 (22): 2167.
https://doi.org/10.1182/blood.V128.22.2167.2167
Published: 2016