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David Fajgenbaum
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Journal Articles

T follicular helper cells are mis-localized in idiopathic multicentric castleman disease

Free
Melanie Mumau, Katherine Forsyth, Michael Gonzalez, Joseph Zinski, Abiola Irvine, David Fajgenbaum
Journal: Blood
Blood (2025) 146 (Supplement 1): 1236.
https://doi.org/10.1182/blood-2025-1236
Published: 2025
Journal Articles

Xgboost profiling of quantitative lymph-node and symptom signatures distinguishes idiopathic multicentric castleman disease and its clinical subtypes

Free
Joseph Zinski, Larissa Borys, Michael Gonzalez, David Fajgenbaum
Journal: Blood
Blood (2025) 146 (Supplement 1): 1234.
https://doi.org/10.1182/blood-2025-1234
Published: 2025
Journal Articles

Somatic mutation discovery in idiopathic multicentric castleman disease (iMCD) lymph node tissue identifies dysregulated intracellular calcium signaling as a potential disease mechanism and therapeutic target

Free
Michael Gonzalez, Melanie Mumau, Joseph Zinski, Vikas Arige, Flore Castellan, Abiola Irvine, Katherine Forsyth, Ira Miller, Bridget Austin, Criswell Lavery, David Wu, David Yule, David Beck, David Fajgenbaum
Journal: Blood
Blood (2025) 146 (Supplement 1): 4789.
https://doi.org/10.1182/blood-2025-4789
Published: 2025
Journal Articles

Siltuximab-mediated suppression of CRP is associated with clinical response in idiopathic multicentric castleman disease

Free
Jean-Francois Rossi, Azhaar Ashraf, Yildiz Kelahmetoglu, David Fajgenbaum, Saishravan Shyamsundar, Frits van Rhee
Journal: Blood
Blood (2025) 146 (Supplement 1): 4788.
https://doi.org/10.1182/blood-2025-4788
Published: 2025
Journal Articles

Increased type I interferon signaling is a hallmark of idiopathic multicentric castleman disease

Free
Katherine Forsyth, Michael Gonzalez, Joseph Zinski, Melanie Mumau, David Fajgenbaum
Journal: Blood
Blood (2025) 146 (Supplement 1): 4786.
https://doi.org/10.1182/blood-2025-4786
Published: 2025
Journal Articles

Transcriptomic and pathological insights into PI3K–Akt pathway activation in idiopathic multicentric castleman disease, tafro and NOS subtypes

Free
Tomoka Haratake, Midori Filiz Nishimura, Asami Nishikori, Yoshito Nishimura, Michael Gonzalez, Daisuke Ennishi, Manaka Tsunoda, David Fajgenbaum, Frits van Rhee, Shuji Momose, Yasuharu Sato
Journal: Blood
Blood (2025) 146 (Supplement 1): 4782.
https://doi.org/10.1182/blood-2025-4782
Published: 2025
Journal Articles

Pediatric idiopathic multicentric castleman disease is often severe and responds to siltuximab

Free
Bridget Austin, Saishravan Shyamsundar, Mateo Sarmiento Bustamante, Sheila Pierson, Larissa Borys, Kayla McHugh, Abiola Irvine, Kelley Dacus, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan Lim, Gordan Srkalovic, Frits van Rhee, Joshua Brandstadter, David Fajgenbaum
Journal: Blood
Blood (2025) 146 (Supplement 1): 3009.
https://doi.org/10.1182/blood-2025-3009
Published: 2025
Journal Articles

Comparable response rates to therapies in idiopathic multicentric castleman disease patients with and without expert-confirmed diagnoses

Free
Larissa Borys, Bridget Austin, Mary Jo Lechowicz, Sheila Pierson, Kayla McHugh, Abiola Irvine, Kelley Dacus, Adam Bagg, Daisy Alapat, Amy Chadburn, Megan Lim, Gordan Srkalovic, Frits van Rhee, Joshua Brandstadter, David Fajgenbaum
Journal: Blood
Blood (2025) 146 (Supplement 1): 6569.
https://doi.org/10.1182/blood-2025-6569
Published: 2025
Journal Articles

Quantitative measures of imcd lymph nodes reveal distinguishing characteristics of imcd lymph nodes and clinical subtypes

Free
Michael Gonzalez, Joseph Zinski, Ira Miller, Abiola Irvine, Melanie Mumau, Sheila Pierson, David Fajgenbaum
Journal: Blood
Blood (2025) 146 (Supplement 1): 6568.
https://doi.org/10.1182/blood-2025-6568
Published: 2025
Journal Articles

Idiopathic multicentric castleman disease unresponsive to one IL-6 inhibitor may respond to another IL-6 inhibitor

Free
Kayla McHugh, Yuan Huang, Bridget Austin, Larissa Borys, Abiola Irvine, Daisy Alapat, Adam Bagg, Amy Chadburn, Mary Jo Lechowicz, Megan Lim, Gordan Srkalovic, Frits van Rhee, David Fajgenbaum, Lu Zhang, Joshua Brandstadter
Journal: Blood
Blood (2025) 146 (Supplement 1): 1228.
https://doi.org/10.1182/blood-2025-1228
Published: 2025
Journal Articles

Interferon-γ sparks inflammatory fire in Castleman disease

Free
Frits van Rhee, David Fajgenbaum
Journal: Blood
Blood (2025) 146 (1): 5–7.
https://doi.org/10.1182/blood.2025029270
Published: 2025
Journal Articles

Insights into the etiology of Castleman disease

Free
Frits van Rhee, David Fajgenbaum
Journal: Blood
Blood (2024) 143 (18): 1789–1790.
https://doi.org/10.1182/blood.2023023716
Published: 2024