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Daniel T. Starczynowski, PhD
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Journal Articles

Clonal Cytopenias of Undetermined Significance Are Common in Cytopenic Adults Evaluated for MDS in the National MDS Study

Johannes B Goll, MS, R. Coleman Lindsley, MD PhD, William F. Hooper, MS, Rafael Bejar, MD PhD, Jason Walker, Robert Fulton, MS, Gregory A. Abel, MDMPH, Tareq Al Baghdadi, MD, H. Joachim Deeg, MD, Amy E. DeZern, MD, Benjamin Ebert, MD, Pearlie Epling-Burnette, PhD PharmD, James M. Foran, MD, Edward J. Gorak, DO,MBA,MS, Steven D. Gore, MD, Rami S. Komrokji, MD, Jane Jijun Liu, MD, Jaroslaw P. Maciejewski, MD PhD, Eric Padron, MD, Wael Saber, MD MS, Daniel T. Starczynowski, PhD, Myron Waclawiw, PhD, Nancy DiFronzo, PhD, Mikkael A. Sekeres, MD MS, Ling Zhang, MD, Matthew J. Walter, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4271.
https://doi.org/10.1182/blood-2019-126978
Published: 2019
Journal Articles

SF3B1 Mutations Induce Oncogenic IRAK4 Isoforms and Activate Targetable Innate Immune Pathways in MDS and AML

Gaurav S Choudhary, PhD, Molly A Smith, PhD, Andrea Pellagatti, Tushar D Bhagat, PhD, Shanisha Gordon, Sanjay Pandey, PhD, Nishi Shah, MBBS, MPH, Srinivas Aluri, Robert N Booher, PhD, Murali Ramachandra, PhD, Maria Elena Samson, Kith Pradhan, PhD, Teresa V. Bowman, PhD, Manoj M Pillai, MD, Chandan Guha, MBBS, Amittha Wickrema, PhD, Britta Will, PhD, Aditi Shastri, MD, Ulrich G. Steidl, MD PhD, Jacqueline Boultwood, Daniel T. Starczynowski, PhD, Amit Verma, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 4224.
https://doi.org/10.1182/blood-2019-124458
Published: 2019
Journal Articles

Cell-Intrinsic Inflammation Drives Progression from Myelodysplastic Syndromes to Leukemia

Laura Barreyro, PhD, Avery Sampson, BSc, Kathleen Hueneman, Kwangmin Choi, PhD, Susanne Christie, BSc, Dehua Wang, MD, Gang Huang, PhD, Daniel T. Starczynowski, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2983.
https://doi.org/10.1182/blood-2019-127307
Published: 2019
Journal Articles

Overcoming Adaptive Therapy Resistance in AML By Targeting Immune Response Pathways

Katelyn M. Melgar, PhD, LaQuita M Jones, DO, Mackenzie Walker, Lyndsey C Bolanos, BSc, Kathleen Hueneman, Mark Wunderlich, MS, Jiang-Kang Jiang, Kelli Wilson, Xiaohu Zhang, Patrick Sutter, Xin Xu, Kwangmin Choi, PhD, Gregory Tawa, Donald Lorimer, Jan Abendroth, Eric O'Brien, BSc, Scott Hoyt, Ellin Berman, MD, Christopher Famulare, MS, James C Mulloy, Ross L. Levine, MD, Jan S Rosenbaum, John P Perentesis, Craig J Thomas, PhD, Daniel T. Starczynowski, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3934.
https://doi.org/10.1182/blood-2019-124178
Published: 2019
Journal Articles

The Inherited MDS Gene DDX41 Is Required for Ribosome Biogenesis and Cell Viability

Timothy M Chlon, PhD, Emily Stepanchick, Kwangmin Choi, PhD, Yi Zheng, PhD, Kathleen Hueneman, Ashley Davis, Daniel T. Starczynowski, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 773.
https://doi.org/10.1182/blood-2019-127471
Published: 2019
Journal Articles

Innate Immune Signaling Suppresses Acute Leukemia By Modifying MYC Oncogenic Activity

Tomoya Muto, MD PhD, Maria Guillamot, PhD, Jing Fang, MD PhD, Luna Zea Redondo, MS, Kwangmin Choi, PhD, Yixiao Gong, MSc, Callum S Walker, MSc, Kathleen Hueneman, Lyndsey C Bolanos, BSc, Laura Barreyro, PhD, Lynn Lee, MD, Kenneth D Greis, PhD, Alireza Khodadadi-Jamayran, M.Sc., Amaia Lujambio, PhD, Scott W. Lowe, PhD, Iannis Aifantis, PhD, Daniel T. Starczynowski, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 727.
https://doi.org/10.1182/blood-2019-121423
Published: 2019
Journal Articles

Chronic Innate Immune Signaling in Myelodysplasia

Daniel T. Starczynowski, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): SCI-33.
https://doi.org/10.1182/blood-2018-99-109492
Published: 2018
Journal Articles

Therapeutic Targeting of the Ubiquitin Conjugating Enzyme UBE2N in Myeloid Malignancies

Laura Barreyro, PhD, Avery Sampson, BSc, Kathleen Hueneman, BSc, Lyndsey C Bolanos, BSc, Mario Pujato, PhD, Somchai Chutipongtanate, MD PhD, Michael Wyder, MS, Wendy Haffey, PhD, Kwangmin Choi, PhD, Yaseswini Neelamraju, MS, Molly A Smith, BSc, Madeline Niederkorn, BSc, Vighnesh Ramesh, Tomoya Muto, MD PhD, Eric O'Brien, BSc, Cem Meydan, PhD, Susanne Christie, BSc, Xiaona Liu, Francine Garret-Bakelman, MD PhD, Boris Bartholdy, PhD, Britta Will, PhD, Matthew T. Weirauch, PhD, Zartash Gul, MD, Stephen Medlin, MD, John Peter Perentesis, MD, Kenneth D Greis, PhD, William Seibel, PhD, Daniel T. Starczynowski, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4050.
https://doi.org/10.1182/blood-2018-99-115359
Published: 2018
Journal Articles

Genomic Landscape of Multiple Myeloma with Elevated Lactate Dehydrogenase

Susan Bal, MBBS, Saulius K. Girnius, MD, Daniel T. Starczynowski, PhD, Heather J. Landau, MD, Kwangmin Choi, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 470.
https://doi.org/10.1182/blood-2018-99-115523
Published: 2018
Journal Articles

Clinical Outcomes of Newly Diagnosed Multiple Myeloma Patients with Elevated Lactate Dehydrogenase Who Underwent Autologous Hematopoietic Stem Cell Transplantation

Susan Bal, MBBS, Kwangmin Choi, PhD, Heather J. Landau, MD, Daniel T. Starczynowski, PhD, Saulius K. Girnius, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4623.
https://doi.org/10.1182/blood-2018-99-120077
Published: 2018
Journal Articles

Inhibition of UBE2N As a Therapeutic Approach in Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML)

Laura Barreyro, PhD, Avery M Sampson, BS, Lyndsey Bolanos, BSc, Madeline Niederkorn, BS, Mario Pujato, PhD, Molly A Smith, BS, Muto Tomoya, MD PhD, Wendy D Haffey, PhD, Susanne Christie, Xiaona Liu, MD MS, Matthew Weirauch, PhD, Ken Greis, PhD, William L Seibel, PhD, Daniel T Starczynowski, PhD
Journal: Blood
Blood (2016) 128 (22): 579.
https://doi.org/10.1182/blood.V128.22.579.579
Published: 2016
Journal Articles

TRAF6 Is Essential for Maintaining Hematopoietic Stem Cell Homeostasis

Jing Fang, MD PhD, Lyndsey Bolanos, BSc, Juana Serrano-Lopez, PhD, Susanne Christie, Jose A Cancelas, MD PhD, Daniel T Starczynowski, PhD
Journal: Blood
Blood (2016) 128 (22): 568.
https://doi.org/10.1182/blood.V128.22.568.568
Published: 2016
Journal Articles

Tifab , a Del(5q) MDS/AML Gene, Regulates USP15 Activity and p53

Madeline Niederkorn, BS, Melinda Varney, PhDBS, Molly A Smith, BS, Ruhikanta A. Meetei, PhD, Daniel T Starczynowski, PhD
Journal: Blood
Blood (2016) 128 (22): 1130.
https://doi.org/10.1182/blood.V128.22.1130.1130
Published: 2016
Journal Articles

Molecular Analysis and In Vivo Efficacy Studies on a Novel Chemical-Series of FLT3 Inhibitors in Human FLT3-ITD AML

Katelyn Melgar, MacKenzie Walker, Jiang-kang Jiang, Kelli Wison, Kwangmin Choi, PhD, James C. Mulloy, PhD, Craig J Thomas, PhD, Daniel T Starczynowski, PhD
Journal: Blood
Blood (2016) 128 (22): 36.
https://doi.org/10.1182/blood.V128.22.36.36
Published: 2016
Journal Articles

Alternative Splice Variants of IRAK4 That Activate Innate Immune Signaling Are Associated with U2AF1 Mutations in Myelodysplastic Syndrome and Acute Myeloid Leukemia

Molly A Smith, BS, Kwangmin Choi, PhD, Nathan Salomonis, PhD, Matthew J. Walter, MD, Kakajan Komurov, PhD, Daniel T Starczynowski, PhD
Journal: Blood
Blood (2016) 128 (22): 1531.
https://doi.org/10.1182/blood.V128.22.1531.1531
Published: 2016
Journal Articles

Novel Small Molecule FLT3 Inhibitors for the Treatment of FLT3-ITD AML

Katelyn Melgar, MacKenzie Walker, Jian-kang Jiang, PhD, Kelli Wilson, PhD, James C. Mulloy, PhD, Craig J Thomas, PhD, Daniel T Starczynowski, PhD
Journal: Blood
Blood (2015) 126 (23): 3690.
https://doi.org/10.1182/blood.V126.23.3690.3690
Published: 2015
Journal Articles

Systemic Inflammation Recruits Ccr7 + Dendritric-Biased Granulocyte-Macrophage Progenitors to Lymphatic Circulation in a Non-Canonical Traf6-Dependent Manner

Juana Serrano-Lopez, PhD, Josefina Serrano, Cuiping Zhang, MD PhD, Ashley Wellendorf, Jing Fang, MDPhD, Joaquin Sanchez-Garcia, H. Leighton Grimes, PhD, Daniel T Starczynowski, PhD, Jose A Cancelas, MD PhD
Journal: Blood
Blood (2015) 126 (23): 785.
https://doi.org/10.1182/blood.V126.23.785.785
Published: 2015
Journal Articles

Sqstm1 Is Required to Retain Hematopoietic Stem Cell/ Progenitors As a Negative Regulator of Macrophage-Dependent Inflammatory Signaling in the Bone Marrow Osteoblastic Niche

Kyung-Hee Chang, PhD, Amitava Sengupta, PhD, Ramesh C Nayak, Angeles Duran, Sang Jun Lee, Ronald Pratt, Ashley Wellendorf, Sarah Hill, Marcus Watkins, Roberto Civitelli, Daniel T Starczynowski, PhD, Maria T Diaz-Meco, Jorge Moscat, Jose A Cancelas, MD PhD
Journal: Blood
Blood (2014) 124 (21): 350.
https://doi.org/10.1182/blood.V124.21.350.350
Published: 2014
Journal Articles

A Calcium-Dependent Pathway Determines Response to Lenalidomide in Del(5q) Myelodysplastic Syndromes

Jing Fang, MD PhD, Xiaona Liu, BSc, Lyndsey Bolanos, BSc, Brenden Barker, BSc, Carmela Rigolino, BSc, Agostino Cortelezzi, MD, Esther Natalie Oliva, MD, Kyle J MacBeth, PhD, Kakajan Komurov, PhD, Daniel T Starczynowski, PhD
Journal: Blood
Blood (2014) 124 (21): 1898.
https://doi.org/10.1182/blood.V124.21.1898.1898
Published: 2014
Journal Articles

Deletion Of Tifab, a Novel Candidate Gene On Chromosome 5q, Results In Hematopoietic Defects By Changing The Dynamic Range Of Innate Immune Pathway Activation

Melinda Varney, PhD, Susanne Christie, Madeline Niederkorn, Jing Fang, MD, PhD, Andres Jerez, MD, PhD, Jaroslaw P. Maciejewski, MD, PhD, FACP, Jun-ichiro Inoue, PhD, Daniel T Starczynowski, PhD
Journal: Blood
Blood (2013) 122 (21): 102.
https://doi.org/10.1182/blood.V122.21.102.102
Published: 2013