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Journal Articles

Use of Multi-Omics Approach to Produce a Robust Serum-Free Media for the Expansion of T Cells

Sarya G. Mansour, M.A, Pei-Yi Lin, PhD, Anson Pierce, PhD, Curt I Civin, MD

Blood (2019) 134 (Supplement_1): 1053.

https://doi.org/10.1182/blood-2019-124393

Published: 2019

Journal Articles

Optimized Culture Medium for Enhanced Ex Vivo expansion of Human Hematopoietic Stem Cells

Janet J Sei, PhD, Blake S Moses, PhD, Abigail Harris-Becker, MS, MinJung Kim, PhD, Navjot Kaur, PhD, Mohan C Vemuri, PhD, Curt I Civin, MD

Blood (2019) 134 (Supplement_1): 1965.

https://doi.org/10.1182/blood-2019-126174

Published: 2019

Journal Articles

SIX1 Transcription Factor Enhances Human Erythropoiesis Via GATA1

Michael Creed, MSc, Christian Eberly, Jevon Cutler, PhD, MinJung Kim, PhD, Akhilesh Pandey, MD PhD, Curt I Civin, MD, Tami J Kingsbury, PhD

Blood (2019) 134 (Supplement_1): 3503.

https://doi.org/10.1182/blood-2019-131203

Published: 2019

Journal Articles

The 3-Drug Combination Treatment ART838, ABT199 Plus Sorafenib Is Effective Against AML Xenografts, Possibly Via Cooperative Targeting of MCL1

Blake S Moses, PhD, Jennifer Fox, PhD, Xiaochun Chen, PhD, Samantha McCullough, BS, Sang Ngoc Tran, BA, Allison Kirkpatrick, BS, Kalyani Kumar, BS, Jeffrey W. Tyner, PhD, Gary H. Posner, PhD, Curt I. Civin, MD

Blood (2018) 132 (Supplement 1): 4044.

https://doi.org/10.1182/blood-2018-99-113040

Published: 2018

Journal Articles

Artemisinins Synergize with BCL2 Inhibitors By Reducing MCL1 Protein Levels in Leukemia Cells

Blake S Moses, PhD, Jennifer Fox, PhD, Xiaochun Chen, PhD, Samantha McCullough, BS, Allison Kirkpatrick, BS, Kalyani Kumar, BS, Jeffrey W. Tyner, PhD, Gary H. Posner, PhD, Curt I. Civin, MD

Blood (2017) 130 (Supplement 1): 3827.

https://doi.org/10.1182/blood.V130.Suppl_1.3827.3827

Published: 2017

Journal Articles

DNA Demethylating Agents Generate a Brcaness Effect in Multiple Sporadic Tumor Types: Prediction for Sensitivity to PARP Inhibitors in AML

Aksinija A Kogan, BS, MS, Lena J Mclaughlin, BS, Michael Topper, BS, Nidal Muvarak, PhD, Lora Stojanovic, BS, T Michael Creed, BS, MS, Soren Bentzen, PhD DMSc, Curt I. Civin, MD, Maria R. Baer, MD, Tami J Kingsbury, PhD, Stephen Baylin, MD, Feyruz V. Rassool, BSc, PhD

Blood (2017) 130 (Supplement 1): 3347.

https://doi.org/10.1182/blood.V130.Suppl_1.3347.3347

Published: 2017

Journal Articles

Nrf2 Regulates Sensitivity of Leukemias to Artemisinins

Jennifer Bai, BA, Xiaochun Chen, PhD, Curt I. Civin, MD

Blood (2016) 128 (22): 2324.

https://doi.org/10.1182/blood.V128.22.2324.2324

Published: 2016

Journal Articles

RAB14 Regulates Human Erythropoiesis and Megakaryopoiesis

Minjung Kim, PhD, Tami J. Kingsbury, PhD, Curt I. Civin, MD

Blood (2016) 128 (22): 2661.

https://doi.org/10.1182/blood.V128.22.2661.2661

Published: 2016

Journal Articles

RAB14 and RAB5 Gtpases Regulate Human Erythropoiesis, Potentially Via Opposing Roles in Endosomal Recycling

MinJung Kim, PhD, Tami J. Kingsbury, PhD, Wen-Chih Cheng, PhD, Yee Sun Tan, PhD, Brittany M. Taylor, Sampada Koshatwar, Curt I. Civin, MD

Blood (2015) 126 (23): 937.

https://doi.org/10.1182/blood.V126.23.937.937

Published: 2015

Journal Articles

Gene Expression and Mutation Analysis (GEMA) –Guided Precision Medicine Targeting PARP1 to Induce Synthetic Lethality in DNA-PK –Deficient Quiescent and BRCA-Deficient Proliferating Leukemia Stem and Progenitor Cells

Margaret Nieborowska-Skorska, MD PhD, Katherine Sullivan, Paulina Podszywalow-Bartnicka, Grazyna Hoser, PhD, Elisabeth Bolton-Gillespie, Kimberly Cramer-Morales, Artur Slupianek, PhD, Chun Zhou, PhD, Sabine Cerny-Reiterer, DVM, Tomasz Stoklosa, MD PhD, Stephen M. Sykes, PhD, Peter Valent, MD, Curt I. Civin, MD, Markus Muschen, MD PhD, Mark D. Minden, MD PhD, Kolja Eppert, PhD, Tomasz Skorski, MD PhD

Blood (2014) 124 (21): 480.

https://doi.org/10.1182/blood.V124.21.480.480

Published: 2014

Journal Articles

Interleukin-6 Is a Significant Modifier of the Anemia Associated with Aging in Mice.

Bryan J. McCranor, PhD, Jacqueline M. Langdon, Olivier D. Prince, M.D., Qilu Yu, Ph.D., Alan E. Berger, PhD, Chris Cheadle, PhD, Curt I. Civin, MD, Jeremy D. Walston, M.D., Qian-Li Xue, PhD, Cindy N. Roy, PhD

Blood (2012) 120 (21): 2094.

https://doi.org/10.1182/blood.V120.21.2094.2094

Published: 2012

Journal Articles

FLT3-ITD Knock-in Impairs Hematopoietic Stem Cell Quiescence/Homeostasis, Leading to a Myeloproliferative Neoplasm

S. Haihua Chu, Diane Heiser, Li Li, PhD, Ian M Kaplan, PhD, David Huso, D.V.M., Ph.D., Curt I. Civin, MD, Donald Small, MD, PhD

Blood (2011) 118 (21): 46.

https://doi.org/10.1182/blood.V118.21.46.46

Published: 2011

Journal Articles

Shortened Erythrocyte Life Span and Increased Oxidative Stress In Erythroid Precursors Are Consistent with Normocytic Anemia In Mice with Chronic Inflammation

Andrew J. Layman, Jacqueline M. Langdon, Qilu Yu, Ph.D., Olivier D. Prince, M.D., Jeremy D. Walston, M.D., Curt I. Civin, MD, Cindy N. Roy, PhD

Blood (2010) 116 (21): 3205.

https://doi.org/10.1182/blood.V116.21.3205.3205

Published: 2010

Journal Articles

Sorafenib Treatment Reverses Depletion of Primitive Hematopoietic Stem Cells and Resolves FLT3-ITD Driven Myeloproliferative Disease In a Mouse Model.

Diane Heiser, S. Haihua Chu, Li Li, PhD, Ian M Kaplan, Curt I. Civin, MD, Donald Small, MD, PhD

Blood (2010) 116 (21): 1586.

https://doi.org/10.1182/blood.V116.21.1586.1586

Published: 2010

Journal Articles

The YAP Transcriptional Co-Activator Is Not Required for Mouse Hematopoiesis, at Steady State or After 5FU Treatment.

Wen-Chih Cheng, PhD, Osnat Bohana-Kashtan, Sebastien Morisot, PhD, Nailing Zhang, Qian Chen, Duojia Pan, Curt I. Civin, MD

Blood (2010) 116 (21): 1592.

https://doi.org/10.1182/blood.V116.21.1592.1592

Published: 2010

Journal Articles

The Mir-23a∼Mir-27a∼Mir-24 Cluster Acts as a Tumor Suppressor In Leukemias by Post-Transcriptional Regulation of 14-3-3 Proteins

Kara A. Scheibner, PhD, Brie Teaboldt, Mary Claire Hauer, Curt I. Civin, MD

Blood (2010) 116 (21): 3145.

https://doi.org/10.1182/blood.V116.21.3145.3145

Published: 2010

Journal Articles

MicroRNA Maestros of Hematopoiesis

Kara A. Scheibner, PhD, Diane Heiser, Ian M Kaplan, Wen-Chih Cheng, PhD, MinJung Kim, PhD, Shubhada Shashikant Bharne, PhD, Sebastien Morisot, PhD, Curt I. Civin, MD

Blood (2010) 116 (21): SCI-32.

https://doi.org/10.1182/blood.V116.21.SCI-32.SCI-32

Published: 2010

Journal Articles

The Hematopoietic Stem Cell (HSC) Compartment in Tristetraprolin (TTP) Knock-out Mice Is Abnormal Phenotypically but Normal Functionally.

Ian M Kaplan, BS, Sebastien Morisot, PhD, Diane Heiser, BA, Wen-Chih Cheng, PhD, Christina LaDana, Curt I. Civin, MD

Blood (2009) 114 (22): 2541.

https://doi.org/10.1182/blood.V114.22.2541.2541

Published: 2009

Journal Articles

FLT3 Internal Tandem Duplication (ITD) Mutations Disrupt Homeostasis in Hematopoietic Stem Cells.

S. Haihua Chu, BSE, Diane Heiser, BA, Li Li, MD, PhD, Ian M Kaplan, BS, Curt I. Civin, MD, Donald Small, MD, PhD

Blood (2009) 114 (22): 1420.

https://doi.org/10.1182/blood.V114.22.1420.1420

Published: 2009

Journal Articles

Leukemia Stem Cells (LSCs) Are Frequent in Childhood Precursor B Acute Lymphoblastic Leukemia (ALL).

Sebastien Morisot, MS, Alan S Wayne, MD, Osnat Bohana-Kashtan, PhD, Ian M Kaplan, BS, Richard Hildreth, MS, Patrick Brown, MD, Maryalice Stetler-Stevenson, MD, PhD, Curt I Civin, MD

Blood (2008) 112 (11): 1354.

https://doi.org/10.1182/blood.V112.11.1354.1354

Published: 2008

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Use of Multi-Omics Approach to Produce a Robust Serum-Free Media for the Expansion of T Cells

Optimized Culture Medium for Enhanced Ex Vivo expansion of Human Hematopoietic Stem Cells

SIX1 Transcription Factor Enhances Human Erythropoiesis Via GATA1

The 3-Drug Combination Treatment ART838, ABT199 Plus Sorafenib Is Effective Against AML Xenografts, Possibly Via Cooperative Targeting of MCL1

Artemisinins Synergize with BCL2 Inhibitors By Reducing MCL1 Protein Levels in Leukemia Cells

DNA Demethylating Agents Generate a Brcaness Effect in Multiple Sporadic Tumor Types: Prediction for Sensitivity to PARP Inhibitors in AML

Nrf2 Regulates Sensitivity of Leukemias to Artemisinins

RAB14 Regulates Human Erythropoiesis and Megakaryopoiesis

RAB14 and RAB5 Gtpases Regulate Human Erythropoiesis, Potentially Via Opposing Roles in Endosomal Recycling

Gene Expression and Mutation Analysis (GEMA) –Guided Precision Medicine Targeting PARP1 to Induce Synthetic Lethality in DNA-PK –Deficient Quiescent and BRCA-Deficient Proliferating Leukemia Stem and Progenitor Cells

Interleukin-6 Is a Significant Modifier of the Anemia Associated with Aging in Mice.

FLT3-ITD Knock-in Impairs Hematopoietic Stem Cell Quiescence/Homeostasis, Leading to a Myeloproliferative Neoplasm

Shortened Erythrocyte Life Span and Increased Oxidative Stress In Erythroid Precursors Are Consistent with Normocytic Anemia In Mice with Chronic Inflammation

Sorafenib Treatment Reverses Depletion of Primitive Hematopoietic Stem Cells and Resolves FLT3-ITD Driven Myeloproliferative Disease In a Mouse Model.

The YAP Transcriptional Co-Activator Is Not Required for Mouse Hematopoiesis, at Steady State or After 5FU Treatment.

The Mir-23a∼Mir-27a∼Mir-24 Cluster Acts as a Tumor Suppressor In Leukemias by Post-Transcriptional Regulation of 14-3-3 Proteins

MicroRNA Maestros of Hematopoiesis

The Hematopoietic Stem Cell (HSC) Compartment in Tristetraprolin (TTP) Knock-out Mice Is Abnormal Phenotypically but Normal Functionally.

FLT3 Internal Tandem Duplication (ITD) Mutations Disrupt Homeostasis in Hematopoietic Stem Cells.

Leukemia Stem Cells (LSCs) Are Frequent in Childhood Precursor B Acute Lymphoblastic Leukemia (ALL).

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