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Journal Articles

New Molecular Surrogate Assay for Genotoxicity Assessment of Gene Therapy Vectors (SAGA)

Adrian Schwarzer, MD PhD, Steven R Talbot, PhD, Oliver Dittrich-Breiholz, PhD, Adrian J Thrasher, MD PhD, Bobby Gaspar, MD, Ute Modlich, Christopher Baum, MD, Axel Schambach, MD PhD, Michael Rothe, PhD

Blood (2016) 128 (22): 4710.

https://doi.org/10.1182/blood.V128.22.4710.4710

Published: 2016

Journal Articles

Targeting Rac-Gtpases Reverses Stroma-Induced Resistance to Notch and mTOR-Inhibition in Acute T-Cell Leukemia

Adrian Schwarzer, MD PhD, Martin May, Harald Genth, Zhixiong Li, MD, Christopher Baum, MD, Axel Schambach, MD PhD

Blood (2015) 126 (23): 1326.

https://doi.org/10.1182/blood.V126.23.1326.1326

Published: 2015

Journal Articles

Investigating Synthetic Lethality Between mTOR Hyperactivation and Cap-Dependent mRNA Translation In a Receptor Tyrosine Kinase Driven Model Of Acute T-Cell Leukemia

Adrian Schwarzer, MD PhD, Helmut Holtmann, PhD, Celina Schauerte, M.Sc., Nomme Benn, Jan Völkel, Sabine Knöß, Johannes Zuber, MD, Zhixiong Li, MD, Axel Schambach, MD PhD, Christopher Baum, MD

Blood (2013) 122 (21): 3913.

https://doi.org/10.1182/blood.V122.21.3913.3913

Published: 2013

Journal Articles

Immune Reconstitution and Preliminary Safety Analysis Of 9 Patients Treated With Somatic Gene Therapy For X-Linked Severe Combined Immunodeficiency (SCID-X1) With a Self-Inactivating Gammaretroviral Vector

Blood (2013) 122 (21): 715.

https://doi.org/10.1182/blood.V122.21.715.715

Published: 2013

Journal Articles

Hematopoietic Stem Cell Gene Therapy For Wiskott- Aldrich Syndrome

Blood (2013) 122 (21): 718.

https://doi.org/10.1182/blood.V122.21.718.718

Published: 2013

Journal Articles

Lentivirally Transduced Human Cord Blood CD34 + FLT3-ITD + Cells Induce Murine Acute Leukemia in the NOD/SCID Transplantation Model.

Pawan Kaur Bollinger, PhD, Doris Steinemann, PhD, Rama Krishna Kancha, PhD, Leticia Quantanilla-Fend, MD, Stefan K Bohlander, MD, Christian Peschel, MD, Robert A.J. Oostendorp, PhD, Christopher Baum, MD, Katharina S. Goetze, MD

Blood (2012) 120 (21): 2984.

https://doi.org/10.1182/blood.V120.21.2984.2984

Published: 2012

Journal Articles

Gene Therapy Corrects the Lethal Bone Marrow Failure in a Mouse Model for RPS19-Deficient Diamond-Blackfan Anemia

Pekka Jaako, Shubhranshu Debnath, Karin Olsson, Axel Schambach, MD, PhD, Christopher Baum, MD, Johan Flygare, MD, PhD, Stefan Karlsson, MD, PhD

Blood (2012) 120 (21): 513.

https://doi.org/10.1182/blood.V120.21.513.513

Published: 2012

Journal Articles

Receptor Tyrosine Kinases, Notch Mutations and PTEN Loss Converge On mTOR in T-ALL and Cause Addiction to Cap Dependent mRNA Translation.

Adrian Schwarzer, MD, Helmut Holtmann, PhD, Martijn Brugman, PhD, Johann Meyer, PhD, Doris Steinemann, PhD, Brigitte Schlegelberger, Zhixiong Li, MD, Christopher Baum, MD

Blood (2012) 120 (21): 2415.

https://doi.org/10.1182/blood.V120.21.2415.2415

Published: 2012

Journal Articles

Somatic Gene Therapy for X-Linked Severe Combined Immunodeficiency Using a Self-Inactivating Modified Gammaretroviral Vector Results in An Improved Preclinical Safety Profile and Early Clinical Efficacy in a Human Patient

Blood (2011) 118 (21): 164.

https://doi.org/10.1182/blood.V118.21.164.164

Published: 2011

Journal Articles

Efficacy of Gene Therapy for Wiskott-Aldrich-Syndrome

Blood (2011) 118 (21): 165.

https://doi.org/10.1182/blood.V118.21.165.165

Published: 2011

Journal Articles

Lentiviral Vector Induced Insertional Haploinsufficiency of Ebf1 Causes Leukemia in a Murine Bone Marrow Transplantation Model

Dirk Heckl, PhD, Adrian Schwarzer, MD, Reinhard Haemmerle, Johann Meyer, PhD, Doris Steinemann, PhD, Cornelia Rudolph, PhD, Britta Skawran, PhD, Brigitte Schlegelberger, MD, Christopher Baum, MD, Ute Modlich, DVM, PhD

Blood (2011) 118 (21): 671.

https://doi.org/10.1182/blood.V118.21.671.671

Published: 2011

Journal Articles

Use of the in Vitro Immortalization Assay to Quantify the Impact of Integration Spectrum and Vector Design on Insertional Mutagenesis

Ute Modlich, DVM, PhD, Julia Sürth, Daniela Zychlinski, PhD, Johann Meyer, PhD, Christian Brendel, Manuel Grez, PhD, Paritha Arumugam, PhD, Punam Malik, MD, Elke Grassman, PhD, Axel Schambach, MD PhD, Christopher Baum, MD

Blood (2011) 118 (21): 3123.

https://doi.org/10.1182/blood.V118.21.3123.3123

Published: 2011

Journal Articles

Telomere Attrition and Chromosomal Instability During Long-Term Cultivation of Hematopoietic Stem Cells,

Kathrin Lange, Dipl. Biochem., Beate Kuhlmann, PhD, Andrea Schienke, Axel Schambach, MD PhD, Ute Modlich, DVM, PhD, Christopher Baum, MD, Brigitte Schlegelberger, M.D., Gudrun Göhring, MD

Blood (2011) 118 (21): 4001.

https://doi.org/10.1182/blood.V118.21.4001.4001

Published: 2011

Journal Articles

Generation of a Transgenic Mouse with Inducible Constitutively Active Stat5a,

Harini Nivarthi, Andriy Tsyrulnyk, Wolfgang Warsch, Zhengqi Wang, Susanne Winkler, Lukas Kenner, MD, Mathias Müller, DVM, Christopher Baum, MD, Kevin D. Bunting, PhD, Veronika Sexl, MD, Thomas Rülicke, D.V.M., Richard Moriggl, PhD

Blood (2011) 118 (21): 3399.

https://doi.org/10.1182/blood.V118.21.3399.3399

Published: 2011

Journal Articles

Doxycycline Regulatable Expression of Cytidine Deaminase Mediates Myeloprotection and Avoids Lymphotoxicity in a Murine Transplant Model

Nico Lachmann, Sebastian Brennig, Nils Pfaff, Heiko Schermeier, Axel Schambach, MD PhD, Christopher Baum, MD, Thomas Moritz, MD

Blood (2011) 118 (21): 2054.

https://doi.org/10.1182/blood.V118.21.2054.2054

Published: 2011

Journal Articles

Evi-1 Regulates Myelopoiesis and Hematopoietic Stem Cell Development in Zebrafish and Human Pluripotent Stem Cells

Martina Konantz, PhD, Matthias Grauer, Sarah Grzywna, Martijn Brugman, PhD, Lothar Kanz, MD, In-Hyun Park, PhD, George Q. Daley, MD, PhD, Christopher Baum, MD, Claudia Lengerke, MD

Blood (2011) 118 (21): 1281.

https://doi.org/10.1182/blood.V118.21.1281.1281

Published: 2011

Journal Articles

Evidence for Cooperation of Receptor Tyrosine Kinases and Activating NOTCH Mutations to Hyperactivate mTOR in T-Cell Leukemia: A Rationale Basis for Targeted Therapy

Adrian Schwarzer, MD, Johann Meyer, PhD, Martijn Brugman, PhD, Axel Schambach, MD PhD, Martin Stanulla, MD, MSc, Martin Schrappe, MD, Doris Steinemann, PhD, Brigitte Schlegelberger, M.D., Christopher Baum, MD, Zhixiong Li, MD

Blood (2011) 118 (21): 1381.

https://doi.org/10.1182/blood.V118.21.1381.1381

Published: 2011

Journal Articles

Retroviral Ectopic Expression of a Signaling-Defective Thrombopoietin Receptor (Mpl) Induces a Systemic Loss of Hematopoietic Stem Cells in Mice,

Sabine Wintterle, MD, Dirk Heckl, PhD, Adrian Schwarzer, MD, Guntram Buesche, MD, Christopher Baum, MD, Ute Modlich, DVM, PhD

Blood (2011) 118 (21): 4175.

https://doi.org/10.1182/blood.V118.21.4175.4175

Published: 2011

Journal Articles

EVI-1 Mediates Apoptosis Resistance Via CD261 Induction and Enhances Leukemogenic Potential in Human Acute Lymphoblastic Leukemia

Martina Konantz, PhD, Maya Caroline Andre, MD, Martin Ebinger, MD, Matthias Grauer, Hui Wang, Sarah Grzywna, Helmut R. Salih, MD, Rupert Handgretinger, MD, Olga S. Kustikova, PhD, Christopher Baum, MD, Lothar Kanz, MD, Klaus Schulze-Osthoff, PhD, Leticia Quintanilla-Martinez, MD, Frank Essmann, PhD, Claudia Lengerke, MD

Blood (2011) 118 (21): 1356.

https://doi.org/10.1182/blood.V118.21.1356.1356

Published: 2011

Journal Articles

The Zebrafish Homologue of the Murine Ecotropic Viral Integration Site-1 (. Evi-1 ) gene Regulates Zebrafish Embryonic Blood Development.

Martina Konantz, Martijn H. Brugman, Ph.D., In-Hyun Park, Ph.D., George Q. Daley, MD, PhD, Christiane Nuesslein-Volhard, Ph.D., Christopher Baum, MD, Claudia Lengerke, MD

Blood (2009) 114 (22): 1461.

https://doi.org/10.1182/blood.V114.22.1461.1461

Published: 2009

NARROW

New Molecular Surrogate Assay for Genotoxicity Assessment of Gene Therapy Vectors (SAGA)

Targeting Rac-Gtpases Reverses Stroma-Induced Resistance to Notch and mTOR-Inhibition in Acute T-Cell Leukemia

Investigating Synthetic Lethality Between mTOR Hyperactivation and Cap-Dependent mRNA Translation In a Receptor Tyrosine Kinase Driven Model Of Acute T-Cell Leukemia

Immune Reconstitution and Preliminary Safety Analysis Of 9 Patients Treated With Somatic Gene Therapy For X-Linked Severe Combined Immunodeficiency (SCID-X1) With a Self-Inactivating Gammaretroviral Vector

Hematopoietic Stem Cell Gene Therapy For Wiskott- Aldrich Syndrome

Lentivirally Transduced Human Cord Blood CD34 + FLT3-ITD + Cells Induce Murine Acute Leukemia in the NOD/SCID Transplantation Model.

Gene Therapy Corrects the Lethal Bone Marrow Failure in a Mouse Model for RPS19-Deficient Diamond-Blackfan Anemia

Receptor Tyrosine Kinases, Notch Mutations and PTEN Loss Converge On mTOR in T-ALL and Cause Addiction to Cap Dependent mRNA Translation.

Somatic Gene Therapy for X-Linked Severe Combined Immunodeficiency Using a Self-Inactivating Modified Gammaretroviral Vector Results in An Improved Preclinical Safety Profile and Early Clinical Efficacy in a Human Patient

Efficacy of Gene Therapy for Wiskott-Aldrich-Syndrome

Lentiviral Vector Induced Insertional Haploinsufficiency of Ebf1 Causes Leukemia in a Murine Bone Marrow Transplantation Model

Use of the in Vitro Immortalization Assay to Quantify the Impact of Integration Spectrum and Vector Design on Insertional Mutagenesis

Telomere Attrition and Chromosomal Instability During Long-Term Cultivation of Hematopoietic Stem Cells,

Generation of a Transgenic Mouse with Inducible Constitutively Active Stat5a,

Doxycycline Regulatable Expression of Cytidine Deaminase Mediates Myeloprotection and Avoids Lymphotoxicity in a Murine Transplant Model

Evi-1 Regulates Myelopoiesis and Hematopoietic Stem Cell Development in Zebrafish and Human Pluripotent Stem Cells

Evidence for Cooperation of Receptor Tyrosine Kinases and Activating NOTCH Mutations to Hyperactivate mTOR in T-Cell Leukemia: A Rationale Basis for Targeted Therapy

Retroviral Ectopic Expression of a Signaling-Defective Thrombopoietin Receptor (Mpl) Induces a Systemic Loss of Hematopoietic Stem Cells in Mice,

EVI-1 Mediates Apoptosis Resistance Via CD261 Induction and Enhances Leukemogenic Potential in Human Acute Lymphoblastic Leukemia

The Zebrafish Homologue of the Murine Ecotropic Viral Integration Site-1 (. Evi-1 ) gene Regulates Zebrafish Embryonic Blood Development.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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