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Journal Articles

NUP98-HOXA9 -Initiates Molecular and Biologic Features of Disease Progression in a Humanized Model of CML

Ivan Sloma, PharmD, PhD, Philip Beer, PhD FRCPath, MRCP, Christophe Desterke, PhD, Elizabeth Bulaeva, Misha Bilenky, Michelle Moksa, Kamini Raghuram, Cedric Brimacombe, Karen Lambie, Ali G Turhan, MD PhD, Orianne Wagner-Ballon, MD PhD, Philippe Gaulard, MD PhD, R. Keith Humphries, MD PhD, Martin Hirst, PhD BS, Connie J. Eaves, PhD

Blood (2019) 134 (Supplement_1): 4139.

https://doi.org/10.1182/blood-2019-127839

Published: 2019

Journal Articles

The Embryonic Program Activated during Blast Crisis of Chronic Myelogenous Leukemia (CML) Implicates a TCF7L2 and MYC Cooperative Chromatin Binding and Represents a Druggable Target

Christophe Desterke, PhD, Sarah Pagliaro, Pharm D, Patricia Hugues, Annelise Bennaceur-Griscelli, MD PhD, Ali G Turhan, MD PhD

Blood (2019) 134 (Supplement_1): 1632.

https://doi.org/10.1182/blood-2019-124796

Published: 2019

Journal Articles

DIS3 Mutation in RUNX1-Mutated AML1 Confers a Highly Dismal Prognosis in AML By Repressing Sister Chromatid Cohesion

Christophe Desterke, PhD, Annelise Bennaceur-Griscelli, MD PhD, Ali G Turhan, MD PhD

Blood (2019) 134 (Supplement_1): 1454.

https://doi.org/10.1182/blood-2019-123352

Published: 2019

Journal Articles

Accessible Chromatin Landscape Reveals a Proliferative Osteoprogenitor Transcriptional Program in Bone Marrow Mesenchymal Stromal Cells from Patients with Primary Myelofibrosis

Christophe Desterke, PhD, Nadira Ruzehaji, PhD, Bernadette Guerton, Johanna Konopacki, MD, Solene-Florence Kammerer-Jacquet, MD, Alessandro M. Vannucchi, MD PhD, Lisa Pieri, MD PhD, Christophe Martinaud, MD PhD, Marie-Caroline Le Bousse-Kerdiles, PhD

Blood (2016) 128 (22): 3135.

https://doi.org/10.1182/blood.V128.22.3135.3135

Published: 2016

Journal Articles

Pathological Heterotopic Ossifications in Brain or Spinal Cord Injured Patients: From Ectopic Bone to Hematopoietic Stem Cell Niche Development

Frédéric Torossian, PhD, Bernadette Guerton, Adrienne Anginot, PhD, Nassim Arouche, Laetitia Boutin, Denis Clay, Nathalie Rochet, PhD MD, Christophe Desterke, PhD, Erica Vlachos, Guillaume Genet, Philippe Denormandie, PhD MD, François Genet, PhD MD, Jean-Pierre Levesque, PhD, Jean-Jacques Lataillade, PhD MD, Marie-Caroline Le Bousse-Kerdiles, PhD

Blood (2016) 128 (22): 3889.

https://doi.org/10.1182/blood.V128.22.3889.3889

Published: 2016

Journal Articles

ETS1 Expression Is Upregulated in Chronic Myeloid Leukemia (CML) and the ETS1 Transcriptional Program Correlates with Disease Progression Towards Blast Crisis

Christophe Desterke, PhD, Maud Voldoire, MD, Nathalie Sorel, Marie Laure Bonnet, Sarah Pagliaro, PharmD, Annelise Bennaceur-Griscelli, MD PhD, Emilie Cayssials, MD, Jean-Claude Chomel, PharmD PhD, Ali G Turhan, MD, PhD

Blood (2016) 128 (22): 442.

https://doi.org/10.1182/blood.V128.22.442.442

Published: 2016

Journal Articles

Blast Crisis in a Dish: Generation of a Blast Crisis Model in Chronic Myeloid Leukemia (CML) Using Patient-Specific Induced Pluripotent Stem Cells ( iPSC)

Gladys Telliam, Christophe Desterke, PhD, Olivier Féraud, PhD, Frank Griscelli, PharmD, PhD, Noufissa Oudrhiri, Micheline Fontaine Arnoux, Radhia Najar, PhD, Herve Acloque, PhD, Annelise Bennaceur-Griscelli, MD PhD, Ali G Turhan, MD, PhD

Blood (2016) 128 (22): 933.

https://doi.org/10.1182/blood.V128.22.933.933

Published: 2016

Journal Articles

A Bio-Integrative Approach Identifies an Inflammatory Signature in Chronic Myeloid Leukemia (CML) Stem Cells That Is Highly Perturbed in CML Blast Crisis and Involves REL transcription Factor

Christophe Desterke, PhD, Ludovic Marie-Sainte, Amine Sbitti, PhD, Ali Naama, Annelise Bennaceur-Griscelli, MD PhD, Ali G Turhan, MD PhD, Ivan Sloma, PharmD,PhD

Blood (2015) 126 (23): 4017.

https://doi.org/10.1182/blood.V126.23.4017.4017

Published: 2015

Journal Articles

Inecalcitol, a Novel Adjuvant Therapy Inhibiting Chronic Myeloid Leukemia (CML) Stem Cells, Activates a Macrophage Differentiation Pathway in Leukemic Progenitors

Christophe Desterke, PhD, Hyacinthe Johnson-Ansa, MD, Patricia Hugues, Jean Francois Dufour-Lamartinie, MD, Remi Delansorne, PhD, Agnes Guerci, MD, Annelise BENNACEUR Griscelli, MD PhD, Ali G Turhan, MD PhD

Blood (2015) 126 (23): 4020.

https://doi.org/10.1182/blood.V126.23.4020.4020

Published: 2015

Journal Articles

Assessment of Sites of Marrow and Extramedullary Hematopoieis By Hybrid Imaging in Patients with Primary Myelofibrosis

Mario Ojeda-Uribe, MD, Constantin Ungureanu, MD, Olivier Morel, MD, Christophe Desterke, PhD, Marie-Caroline Le Bousse-Kerdiles, PhD, Hatem Boulahdour, MD PhD

Blood (2015) 126 (23): 2823.

https://doi.org/10.1182/blood.V126.23.2823.2823

Published: 2015

Journal Articles

Blood Traffic of Endothelial, Mesenchymal, Hematopoietic and Lin-/CD45-CD34+AC133+CXCR4+ Progenitor Cell Subsets Show Different Patterns in Pre-Fibrotic and Fibrotic Primary Myelofibrosis

Mario Ojeda-Uribe, MD, Christophe Desterke, PhD, Laura Jung, PhD, Pierre Bories, MD, Hanna Sovalat, PhD, Laurent Mauvieux, MD PhD, Jean Claude Eisenmann, Bruno Lioure, Marie-Caroline Le Bousse-Kerdiles, PhD

Blood (2014) 124 (21): 3230.

https://doi.org/10.1182/blood.V124.21.3230.3230

Published: 2014

Journal Articles

Endogenous TGF-beta1 Mediated Osteogenic Impairment of Medullar Mesenchymal Stromal Cells in Primary Myelofibrosis

Christophe Martinaud, MD, Christophe Desterke, PhD, Johanna Konopacki, MD, Lisa Pieri, MDPhD, Rachel Golub, PhD, Sandrine Schmutz, PhD, Adrienne Anginot, PhD, Bernadette Guerton, Nathalie Rochet, MD PhD, Patricia Albanese, PhD, Emilie Henault, Thierry De Revel, Marie-Françoise Bourgeade, PhD, Vanucchi Alessandro, MD, Jean-Jacques Lataillade, MD PhD, Marie-Caroline Le Bousse-Kerdilès, PhD

Blood (2014) 124 (21): 1873.

https://doi.org/10.1182/blood.V124.21.1873.1873

Published: 2014

Journal Articles

T315I-Mutated BCR-ABL Induces a Distinct and Specific Molecular Signature With High Expression Of Zinc Finger (ZNF) Transcription Factors

Christophe Desterke, PhD, Djamel Aggoune, Marie Laure Bonnet, Nais Prade, Jean-Claude Chomel, PharmD, PhD, Eric Delabesse, MD, PhD, Ali G Turhan, MD, PhD

Blood (2013) 122 (21): 4899.

https://doi.org/10.1182/blood.V122.21.4899.4899

Published: 2013

Journal Articles

Bloodstream Progenitor-Cell Traffic In Primary Myelofibrosis Reveals Cell Subsets Showing Some Features Of Very-Small Embryonnic-Like Stem Cells (VSELs), Along With Endothelial (PEC), Mesenchymal (MPC) and Hematopoietic (HPC) Progenitor Cells

Mario Ojeda-Uribe, MD, Hanna Sovalat, PhD, Laura Jung, PhD, Christophe Desterke, PhD, Sylvie Thiebault, MD, Pierre Bories, MD, Laurent Mauvieux, MD, PhD, Philippe Tropel, PhD, Jean-Claude Eisenmann, MD, Bruno Lioure, MD, Anne-Claire Voegeli, PhD, Eric Jeandidier, MD, Stephane Viville, PharmD, PhD, Valerie Rimelen, PhD, Marie-Caroline Le Bousse-Kerdiles, PhD

Blood (2013) 122 (21): 5265.

https://doi.org/10.1182/blood.V122.21.5265.5265

Published: 2013

Journal Articles

Impairment of Myeloid Dendritic Differentiation and Role in the Support of Splenic Dysmegakaryopoiesis in Patients with Primary Myelofibrosis

Christophe Desterke, PhD, Bernadette Guerton, Sophie Amsellem, PhD, Agnes Charpentier, MD, Brigitte Dupriez, MD, Jean-Loup Demory, MD, Christophe Martinaud, MD, Jean-Jacques Lataillade, Julien Giron-Michel, Bruno Azzarone, Marie-Caroline Le Bousse-Kerdiles, PhD

Blood (2012) 120 (21): 1762.

https://doi.org/10.1182/blood.V120.21.1762.1762

Published: 2012

Journal Articles

CXCR7 Functions Together with CXCR4 in SDF-1/CXCL12 Induced CD34 + Hematopoietic Progenitor Cell Cycling Through β-Arrestin 2-Dependent Akt Activation

Frederic Torossian, PhD, Aurélie Chabanon, PhD, Denis Clay, Bernadette Guerton, Adrienne Anginot, PhD, Richard Proust, Jean-Francois Ottavi, Emmanuel Dornier, Laetitia Boutin, Christophe Desterke, PhD, Mark Scott, PhD, Jean-Jacques Lataillade, MD, PhD, Marie-Caroline Le Bousse-Kerdiles, PhD

Blood (2012) 120 (21): 3448.

https://doi.org/10.1182/blood.V120.21.3448.3448

Published: 2012

Journal Articles

The Tetraspanin CD9 Is Involved in Primary Myelofibrosis Dysmegakaryopoiesis Through c-Myb Regulation and Stroma Interactions,

Christophe Desterke, PhD, Costanza Bogani, PhD, Lisa Pieri, MD, Alessandro M. Vannucchi, MD, PhD, Bernadette Guerton, Christophe Martinaud, MD, Denis Clay, Jean-Jacques Lataillade, MD, PhD, Hans Hasselbalch, MD, PhD, Heinz Gisslinger, MD, PhD, Sophie Amsellem, PhD, Jean-Loup Demory, MD, Agnès Charpentier, MD, Brigitte Dupriez, Claude Boucheix, MD, PhD, Eric Rubinstein, PhD, Marie-Caroline Le Bousse-Kerdiles, PhD

Blood (2011) 118 (21): 3834.

https://doi.org/10.1182/blood.V118.21.3834.3834

Published: 2011

Journal Articles

Abnormal Expression and Function of the Lnk Adaptor Protein in Myeloproliferative Neoplasms (MPN).

Jean-Jacques Kiladjian, MD, PhD, Fanny Baran-Marszak, MD, PhD, Christophe Desterke, PhD, Bruno Cassinat, Pharm.D, Hajer Magdoud, Elisabeth Mazoyer, MD, Pierre Fenaux, MD, PhD, Claude Gardin, Florence Cymbalista, MD, PhD, Marie-Caroline Le Bousse-Kerdiles, PhD, Nadine Varin-Blank, PhD, Laura Velazquez, PhD

Blood (2009) 114 (22): 2897.

https://doi.org/10.1182/blood.V114.22.2897.2897

Published: 2009

NARROW

NUP98-HOXA9 -Initiates Molecular and Biologic Features of Disease Progression in a Humanized Model of CML

The Embryonic Program Activated during Blast Crisis of Chronic Myelogenous Leukemia (CML) Implicates a TCF7L2 and MYC Cooperative Chromatin Binding and Represents a Druggable Target

DIS3 Mutation in RUNX1-Mutated AML1 Confers a Highly Dismal Prognosis in AML By Repressing Sister Chromatid Cohesion

Accessible Chromatin Landscape Reveals a Proliferative Osteoprogenitor Transcriptional Program in Bone Marrow Mesenchymal Stromal Cells from Patients with Primary Myelofibrosis

Pathological Heterotopic Ossifications in Brain or Spinal Cord Injured Patients: From Ectopic Bone to Hematopoietic Stem Cell Niche Development

ETS1 Expression Is Upregulated in Chronic Myeloid Leukemia (CML) and the ETS1 Transcriptional Program Correlates with Disease Progression Towards Blast Crisis

Blast Crisis in a Dish: Generation of a Blast Crisis Model in Chronic Myeloid Leukemia (CML) Using Patient-Specific Induced Pluripotent Stem Cells ( iPSC)

A Bio-Integrative Approach Identifies an Inflammatory Signature in Chronic Myeloid Leukemia (CML) Stem Cells That Is Highly Perturbed in CML Blast Crisis and Involves REL transcription Factor

Inecalcitol, a Novel Adjuvant Therapy Inhibiting Chronic Myeloid Leukemia (CML) Stem Cells, Activates a Macrophage Differentiation Pathway in Leukemic Progenitors

Assessment of Sites of Marrow and Extramedullary Hematopoieis By Hybrid Imaging in Patients with Primary Myelofibrosis

Blood Traffic of Endothelial, Mesenchymal, Hematopoietic and Lin-/CD45-CD34+AC133+CXCR4+ Progenitor Cell Subsets Show Different Patterns in Pre-Fibrotic and Fibrotic Primary Myelofibrosis

Endogenous TGF-beta1 Mediated Osteogenic Impairment of Medullar Mesenchymal Stromal Cells in Primary Myelofibrosis

T315I-Mutated BCR-ABL Induces a Distinct and Specific Molecular Signature With High Expression Of Zinc Finger (ZNF) Transcription Factors

Bloodstream Progenitor-Cell Traffic In Primary Myelofibrosis Reveals Cell Subsets Showing Some Features Of Very-Small Embryonnic-Like Stem Cells (VSELs), Along With Endothelial (PEC), Mesenchymal (MPC) and Hematopoietic (HPC) Progenitor Cells

Impairment of Myeloid Dendritic Differentiation and Role in the Support of Splenic Dysmegakaryopoiesis in Patients with Primary Myelofibrosis

CXCR7 Functions Together with CXCR4 in SDF-1/CXCL12 Induced CD34 + Hematopoietic Progenitor Cell Cycling Through β-Arrestin 2-Dependent Akt Activation

The Tetraspanin CD9 Is Involved in Primary Myelofibrosis Dysmegakaryopoiesis Through c-Myb Regulation and Stroma Interactions,

Abnormal Expression and Function of the Lnk Adaptor Protein in Myeloproliferative Neoplasms (MPN).

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American Society of Hematology

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American Society of Hematology

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