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Journal Articles

p38 MAPK Controls Sensitivity Towards BH3 Mimetics By Regulating Mcl-1 Expression of Chronic Lymphocytic Leukemia in Hypoxia and Acquired Resistance

Malte F Huelsemann, Michaela Patz, PhD, Laura Beckmann, Kerstin Brinkmann, Teresa Otto, Joachim Fandrey, MD, Hans Jiro Becker, Sebastian Theurich, MD, Michael S. von Bergwelt-Baildon, MD PhD, Christian P. Pallasch, MD, Réne P. Zahedi, Hamid Kashkar, PhD, Christian Reinhardt, MD, Michael Hallek, MD, Clemens-Martin Wendtner, MD, Lukas P. Frenzel, MD

Blood (2014) 124 (21): 1947.

https://doi.org/10.1182/blood.V124.21.1947.1947

Published: 2014

Journal Articles

Mirs-138 and -424 Control Palmitoylation-Dependent CD95-Mediated Cell Death By Targeting Acyl Protein Thioesterases 1 and 2 in Chronic Lymphocytic Leukemia

Valeska Berg, Marion Rusch, PhD, Nachiket Vartak, PhD, Christian Juengst, Astrid Schauss, Herbert Waldmann, PhD, Christian Hedberg, PhD, Christian P. Pallasch, MD, Philippe Bastiaens, PhD, Michael Hallek, MD, Clemens-Martin Wendtner, MD, Lukas P. Frenzel, MD

Blood (2014) 124 (21): 1953.

https://doi.org/10.1182/blood.V124.21.1953.1953

Published: 2014

Journal Articles

Phagocytic Function of Macrophages Is Impaired By Chronic Lymphocytic Leukemia and high–grade Lymphoma Progression and Can be Highly Effectively Restored for Chemo-Immunotherapy

Janine Schwamb, MD, Nina Reinart, Daniela Vorholt, Thomas Ulas, PhD, Vangica Ristovska, MD, Christian J Braun, MD, Michael T Hemann, PhD, Joachim Schultze, MD, Michael Hallek, MD, Christian P. Pallasch, MD

Blood (2014) 124 (21): 2727.

https://doi.org/10.1182/blood.V124.21.2727.2727

Published: 2014

Journal Articles

A Complex Molecular Network Controls Palmitoylation-Dependant CD95 Sensitivity Of CLL Cells

Valeska Berg, Nachiket Vartak, PhD, Rainer Claus, MD, Julia Claasen, Marion Rusch, PhD, Christian P. Pallasch, MD, Herbert Waldmann, PhD, Christopher Plass, PhD, Philippe Bastiaens, PhD, Michael Hallek, MD, Christian Hedberg, PhD, Clemens Wendtner, MD, Lukas P. Frenzel, MD

Blood (2013) 122 (21): 4148.

https://doi.org/10.1182/blood.V122.21.4148.4148

Published: 2013

Journal Articles

Drug-Induced Cytokine Release Sensitizes Protective Tumor Microenvironments to Antibody- Mediated Therapy

Christian P. Pallasch, MD, Leskov Ilya, MD, PhD, Yadira M Soto, Christian J. Braun, MD, Nadine Kutsch, MD, Adam Drake, PhD, Lukas P. Frenzel, MD, Bettina Iliopoulou, PhD, Nico van Rooijen, PhD, Clemens Wendtner, MD, Michael Hallek, MD, Jianzhu Chen, PhD, Michael T Hemann, PhD

Blood (2012) 120 (21): 1335.

https://doi.org/10.1182/blood.V120.21.1335.1335

Published: 2012

Journal Articles

Impact of Hypoxia As Novel Microenvironmental Factor On Drug Susceptibility of Primary CLL Cells

Malte Huelsemann, Lukas P. Frenzel, MD, Dunja Baatout, M.Sc., Julia Claasen, Sebastian Theurich, MD, Laurent Kintzelé, Hans Jiro Becker, Michaela Patz, PhD, Christian P. Pallasch, MD, Michael S. von Bergwelt-Baildon, MD, PhD, Michael Hallek, MD, Clemens-Martin Wendtner, MD

Blood (2012) 120 (21): 3918.

https://doi.org/10.1182/blood.V120.21.3918.3918

Published: 2012

Journal Articles

TOSO Deficiency Exerts Impact On BAFF-R Expression, Thereby Causing Impaired B Cell Development in Vivo

Alexandra Schulz, PhD, Yoon Jung Park, Ph.D., Rainer Claus, MD, Hamid Kashkar, PhD, Jens Seeger, PhD, Julia Claasen, Christian P. Pallasch, MD, Christoph Plass, PhD, Michael Hallek, MD, Clemens Wendtner, Lukas P. Frenzel, MD

Blood (2012) 120 (21): 3898.

https://doi.org/10.1182/blood.V120.21.3898.3898

Published: 2012

Journal Articles

Novel Tyrosine Kinase Inhibitors Trigger Drug Sensitivity of Primary CLL Cells by Controlling Glucosylation of Ceramides

Janine Schwamb, MD, Valeska Feldhaus, M.Sc., Michael Baumann, MD, Michaela Patz, PhD, Susanne Brodesser, PhD, Reinhild Brinker, Julia Claasen, Christian P. Pallasch, MD, Michael Hallek, MD, Clemens-Martin Wendtner, MD, Lukas P. Frenzel, MD

Blood (2012) 120 (21): 3905.

https://doi.org/10.1182/blood.V120.21.3905.3905

Published: 2012

Journal Articles

TOSO-Deficient B Cells Show An Impaired NF-κB and Migration Signaling In Vivo

Alexandra Schulz, Christian P. Pallasch, MD, Michael Hallek, MD, Lukas P. Frenzel, MD, Clemens Wendtner, MD

Blood (2011) 118 (21): 1779.

https://doi.org/10.1182/blood.V118.21.1779.1779

Published: 2011

Journal Articles

B-Cell Receptor-Mediated Glucosylceramide Synthesis Protects Primary CLL Cells From Ceramide-Dependent Apoptosis

Janine Schwamb, MD, Valeska Feldhaus, Susanne Brodesser, PhD, Reinhild Brinker, Julia Claasen, Christian P. Pallasch, MD, Michael Hallek, MD, Clemens Martin Wendtner, MD, Lukas P. Frenzel, MD

Blood (2011) 118 (21): 1766.

https://doi.org/10.1182/blood.V118.21.1766.1766

Published: 2011

Journal Articles

Primed for Death: Hypoxia Sensitizes Primary CLL Cells towards Compounds Targeting Mitochondrial Integrity

Lukas P. Frenzel, MD, Malte Huelsemann, Julia Claasen, Reinhild Brinker, Sebastian Theurich, MD, Hans Jiro Becker, Michael S. von Bergwelt-Baildon, MD, PhD, Christian P. Pallasch, MD, Michael Hallek, MD, Clemens Wendtner, MD

Blood (2011) 118 (21): 1767.

https://doi.org/10.1182/blood.V118.21.1767.1767

Published: 2011

Journal Articles

Palmitoylation Controls Death Receptor Function in Chronic Lymphocytic Leukemia

Lukas P. Frenzel, MD, Valeska Feldhaus, Marion Rusch, Reinhild Brinker, Julia Claasen, Christian P. Pallasch, MD, Herbert Waldmann, PhD, Michael Hallek, MD, Christian Hedberg, PhD, Clemens-Martin Wendtner, MD

Blood (2011) 118 (21): 2829.

https://doi.org/10.1182/blood.V118.21.2829.2829

Published: 2011

Journal Articles

B Cell Receptor Stimulation of CLL Cells Leads to Upregulation of IRF4 Proteinexpression Influenced by SNP Expression,

Michaela Patz, PhD, Nina-Felizitas Linde, Lukas P. Frenzel, MD, Christian P. Pallasch, MD, Reinhild Brinker, Julia Claasen, Michael Hallek, MD, Clemens Wendtner, MD

Blood (2011) 118 (21): 3886.

https://doi.org/10.1182/blood.V118.21.3886.3886

Published: 2011

Journal Articles

Microenvironment Influences Expression of TOSO – a Novel NF-Kappa B Target Gene In Chronic Lymphocytic Leukemia

Lukas P. Frenzel, MD, Alexandra Schulz, Christian P. Pallasch, MD, Rainer Claus, MD, Sabine Ponader, PhD, Jan A. Burger, MD, PhD, Michael Hallek, MD, Christoph Plass, PhD, Clemens-Martin Wendtner, MD

Blood (2010) 116 (21): 695.

https://doi.org/10.1182/blood.V116.21.695.695

Published: 2010

Journal Articles

Novel X-Linked Inhibitor of Apoptosis (XIAP) Inhibiting Compound as Sensitizer for TRAIL-Mediated Apoptosis In Chronic Lymphocytic Leukemia with Poor Prognosis

Lukas P. Frenzel, MD, Michaela Patz, PhD, Christian P. Pallasch, MD, Reinhild Brinker, Julia Claasen, Alexandra Schulz, Michael Hallek, MD, Hamid Kashkar, PhD, Clemens-Martin Wendtner, MD

Blood (2010) 116 (21): 1375.

https://doi.org/10.1182/blood.V116.21.1375.1375

Published: 2010

Journal Articles

Sustained NF-Kappa B Activity In Chronic Lymphocytic Leukemia Is Independent of Genetic and Epigenetic Modifications of the Tumor Suppressor Genes CYLD and A20

Lukas P. Frenzel, MD, Janine Schwamb, MD, Rainer Claus, MD, Julia Claasen, Reinhild Brinker, Christian P. Pallasch, MD, Christoph Plass, PhD, Clemens-Martin Wendtner, MD

Blood (2010) 116 (21): 3597.

https://doi.org/10.1182/blood.V116.21.3597.3597

Published: 2010

Journal Articles

Deregulation of miRNAs by Epigenetic Silencing Disrupts Suppression of the Oncogene PLAG1 in Chronic Lymphocytic Leukemia.

Christian P Pallasch, MD, Michaela Patz, PhD, Yoon Jung Park, PhD, Susanne Hagist, MD, Daniela Eggle, PhD, Rainer Claus, MD, Svenja Debey-Pascher, PhD, Alexandra Schulz, Lukas P Frenzel, MD, Julia Claasen, Nadine Kutsch, Günter Krause, PhD, Christine Mayr, MD, Andreas Rosenwald, MD, Christoph Plass, PhD, Joachim L Schultze, MD, Michael Hallek, MD, Clemens-Martin Wendtner, MD

Blood (2009) 114 (22): 3463.

https://doi.org/10.1182/blood.V114.22.3463.3463

Published: 2009

Journal Articles

Overexpression of TOSO in CLL Is Triggered by B-Cell Receptor Signaling and Associated with Progressive Disease.

Christian P Pallasch, MD, Alexandra Schulz, Nadine Kutsch, Janine Schwamb, Susanne Hagist, MD, Claudia Wickenhauser, MD, Alfred Ultsch, PhD, Hamid Kashkar, PhD, Michael Hallek, MD, Clemens-Martin Wendtner, MD

Blood (2008) 112 (11): 2070.

https://doi.org/10.1182/blood.V112.11.2070.2070

Published: 2008

Journal Articles

Disruption of T Cell Suppression in Chronic Lymphocytic Leukemia by CD200 Blockade.

Christian P Pallasch, MD, Susanne Ulbrich, MD, Reinhild Brinker, Robert A Uger, PhD, Michael Hallek, MD, Clemens- Martin Wendtner, MD

Blood (2008) 112 (11): 2072.

https://doi.org/10.1182/blood.V112.11.2072.2072

Published: 2008

Journal Articles

Deregulation of Micrornas Results in Overexpression of Oncogenic Transcription Factors Involved in Pathogenesis of CLL.

Christian P Pallasch, MD, Susanne Hagist, MD, Michaela Patz, Alexandra Schulz, Svenja Debey, Daniela Eggle, Joachim L Schultze, MD, Michael Hallek, MD, Clemens-Martin Wendtner, MD

Blood (2008) 112 (11): 2075.

https://doi.org/10.1182/blood.V112.11.2075.2075

Published: 2008

NARROW

p38 MAPK Controls Sensitivity Towards BH3 Mimetics By Regulating Mcl-1 Expression of Chronic Lymphocytic Leukemia in Hypoxia and Acquired Resistance

Mirs-138 and -424 Control Palmitoylation-Dependent CD95-Mediated Cell Death By Targeting Acyl Protein Thioesterases 1 and 2 in Chronic Lymphocytic Leukemia

Phagocytic Function of Macrophages Is Impaired By Chronic Lymphocytic Leukemia and high–grade Lymphoma Progression and Can be Highly Effectively Restored for Chemo-Immunotherapy

A Complex Molecular Network Controls Palmitoylation-Dependant CD95 Sensitivity Of CLL Cells

Drug-Induced Cytokine Release Sensitizes Protective Tumor Microenvironments to Antibody- Mediated Therapy

Impact of Hypoxia As Novel Microenvironmental Factor On Drug Susceptibility of Primary CLL Cells

TOSO Deficiency Exerts Impact On BAFF-R Expression, Thereby Causing Impaired B Cell Development in Vivo

Novel Tyrosine Kinase Inhibitors Trigger Drug Sensitivity of Primary CLL Cells by Controlling Glucosylation of Ceramides

TOSO-Deficient B Cells Show An Impaired NF-κB and Migration Signaling In Vivo

B-Cell Receptor-Mediated Glucosylceramide Synthesis Protects Primary CLL Cells From Ceramide-Dependent Apoptosis

Primed for Death: Hypoxia Sensitizes Primary CLL Cells towards Compounds Targeting Mitochondrial Integrity

Palmitoylation Controls Death Receptor Function in Chronic Lymphocytic Leukemia

B Cell Receptor Stimulation of CLL Cells Leads to Upregulation of IRF4 Proteinexpression Influenced by SNP Expression,

Microenvironment Influences Expression of TOSO – a Novel NF-Kappa B Target Gene In Chronic Lymphocytic Leukemia

Novel X-Linked Inhibitor of Apoptosis (XIAP) Inhibiting Compound as Sensitizer for TRAIL-Mediated Apoptosis In Chronic Lymphocytic Leukemia with Poor Prognosis

Sustained NF-Kappa B Activity In Chronic Lymphocytic Leukemia Is Independent of Genetic and Epigenetic Modifications of the Tumor Suppressor Genes CYLD and A20

Deregulation of miRNAs by Epigenetic Silencing Disrupts Suppression of the Oncogene PLAG1 in Chronic Lymphocytic Leukemia.

Overexpression of TOSO in CLL Is Triggered by B-Cell Receptor Signaling and Associated with Progressive Disease.

Disruption of T Cell Suppression in Chronic Lymphocytic Leukemia by CD200 Blockade.

Deregulation of Micrornas Results in Overexpression of Oncogenic Transcription Factors Involved in Pathogenesis of CLL.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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