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Journal Articles

Targeting mTOR Signaling Is An Effective Treatment Strategy for IKAROS and JAK Kinase Mutated Acute Lymphoblastic Leukemia

David T. Teachey, MD, TIffaney Vincent, Cheryl L. Willman, MD, Mignon L. Loh, M.D., Charles Mullighan, MBBS, MD, FRACP, FRCPA, MSc, Stephen Hunger, MD, Stephan A. Grupp, MD, PhD

Blood (2010) 116 (21): 3251.

https://doi.org/10.1182/blood.V116.21.3251.3251

Published: 2010

Journal Articles

The Role of Dominant-Negative IKAROS Mutations In the Pathogenesis and Treatment Responsiveness of BCR-ABL1 positive Acute Lymphoblastic Leukemia

J. Racquel Collins-Underwood, PhD, Nidal Boulos, PhD, Debbie Payne-Turner, Shann-Ching Chen, Ph.D., Richard Williams, MD, PhD, Charles Mullighan, MBBS, MD, FRACP, FRCPA, MSc

Blood (2010) 116 (21): 540.

https://doi.org/10.1182/blood.V116.21.540.540

Published: 2010

Journal Articles

Integrated Genetic and Epigenetic Analysis of Childhood Acute Lymphoblastic Leukemia Reveals a Synergistic Role for Structural and Epigenetic Lesions In Determining Disease Phenotype

Maria E. Figueroa, MD, Shann-Ching Chen, Ph.D., Anna K. Andersson, PhD, Wei Liu, Ph.D., Cheng Cheng, Ph.D., Letha A Phillips, Yushan Li, James R. Downing, MD, Ari M. Melnick, Charles Mullighan, MBBS, MD, FRACP, FRCPA, MSc

Blood (2010) 116 (21): 537.

https://doi.org/10.1182/blood.V116.21.537.537

Published: 2010

Journal Articles

Genome-Wide Analysis Reveals Frequent Inactivating Mutations of Acetyltransferase Genes In B-Cell Lymphoma

Laura Pasqualucci, MD, David Dominguez-Sola, MD, PhD, Annalisa Chiarenza, MD, Giulia Fabbri, MD, Adina Grunn, Vladimir Trifonov, PhD, Lawryn H. Kasper, PhD, Stephanie Lerach, PhD, Ma Jing, PhD, Davide Rossi, MD, Charles Mullighan, MBBS, MD, FRACP, FRCPA, MSc, Gianluca Gaidano, MD, Raul Rabadan, PhD, Paul K. Brindle, PhD, Riccardo Dalla-Favera, MD

Blood (2010) 116 (21): 474.

https://doi.org/10.1182/blood.V116.21.474.474

Published: 2010

Journal Articles

CREBBP Mutations In Relapsed Acute Lymphoblastic Leukemia

Charles Mullighan, MBBS, MD, FRACP, FRCPA, MSc, Jinghui Zhang, Ph.D., Lawryn H. Kasper, Ph.D., Stephanie Lerach, Ph.D., Debbie Payne-Turner, Letha A Phillips, J. Racquel Collins-Underwood, Ph.D., Susan L. Heatley, Ph.D., Jing Ma, Ph.D., Kenneth Buetow, Ph.D., Ching-Hon Pui, MD, Paul K. Brindle, Ph.D., James R. Downing, MD

Blood (2010) 116 (21): 413.

https://doi.org/10.1182/blood.V116.21.413.413

Published: 2010

Journal Articles

Genome-Wide Analysis of Genetic Alterations In Hypodiploid Acute Lymphoblastic Leukemia Identifies a High Frequency of Mutations Targeting the IKAROS Gene Family and Ras Signaling

Linda Holmfeldt, PhD, Jinghui Zhang, Ph.D., Jing Ma, Ph.D., Meenakshi Devidas, PhD, Andrew J. Carroll, PhD, Nyla A. Heerema, Ph.D., Julie M. Gastier-Foster, PhD, Susana C. Raimondi, PhD, Mignon L. Loh, M.D., Stephen Hunger, MD, Charles Mullighan, MBBS, MD, FRACP, FRCPA, MSc

Blood (2010) 116 (21): 411.

https://doi.org/10.1182/blood.V116.21.411.411

Published: 2010

Journal Articles

Lack of Somatic Sequence Mutations In Protein Tyrosine Kinase Genes Other Than the JAK Kinase Family In High Risk B-Precursor Childhood Acute Lymphoblastic Leukemia (ALL): A Report From the Children's Oncology Group (COG) High-Risk (HR) ALL TARGET Project

Jinghui Zhang, Ph.D., Charles Mullighan, MBBS, MD, FRACP, FRCPA, MSc, Richard Harvey, PhD, William L. Carroll, MD, I-Ming L. Chen, DVM, MS, Meenakshi Devidas, PhD, Eric Larsen, Michael Edmonson, Ph.D., Ken Buetow, Ph.D., Daniela S Gerhard, Ph.D., Mignon L. Loh, M.D., Gregory H. Reaman, MD, Mary V. Relling, PharmD, Malcolm A Smith, M.D., Ph.D., James R. Downing, MD, Cheryl L. Willman, MD, Stephen Hunger, MD

Blood (2010) 116 (21): 2752.

https://doi.org/10.1182/blood.V116.21.2752.2752

Published: 2010

Journal Articles

T-Cell Receptor Gene Deletions Are Associated with High Risk Features and Worse Outcome In Childhood Precursor B-Cell Acute Lymphoblastic Leukemia (ALL)

Jonathan Downie, BS, Phillip Barnette, MD, Vladimir Rodic, BS, J. Kimble Frazer, MD, PhD, Nikolaus Trede, MD, PhD, Meenakshi Devidas, PhD, Charles Mullighan, MBBS, MD, FRACP, FRCPA, MSc, Stephen Hunger, MD, Rodney R. Miles, MD, PhD, Joshua D. Schiffman, MD

Blood (2010) 116 (21): 275.

https://doi.org/10.1182/blood.V116.21.275.275

Published: 2010

Journal Articles

Evolution of Human BCR-ABL1 lymphoblastic Leukaemia-Initiating Cells.

Faiyaz Notta, PhD, Charles Mullighan, MBBS, MD, FRACP, FRCPA, MSc, Jean Wang, MD, PhD, Armando G Poeppl, Sergei Doulatov, Letha A Phillips, Jing Ma, Ph.D., Mark D. Minden, MD, PhD, James R. Downing, MD, John E. Dick, PhD

Blood (2010) 116 (21): 1023.

https://doi.org/10.1182/blood.V116.21.1023.1023

Published: 2010

Journal Articles

Cross-Species Comparison of Acquired Genetic Changes In T Cell Malignancy.

Lynnie A. Rudner, AB, Kim H. Brown, PhD, Kimberly P. Dobrinski, PhD, Diana F. Bradley, BS, Jonathan Downie, BS, Nathan D. Meeker, MD, Alexandra Smith, BA, Martha Iveth Garcia, Alejandro Gutierrez, MD, Charles Mullighan, MBBS, MD, FRACP, FRCPA, MSc, A. Thomas Look, MD, James R. Downing, MD, Joshua D. Schiffman, MD, Charles Lee, PhD, Nikolaus Trede, MD, PhD, J. Kimble Frazer, MD, PhD

Blood (2010) 116 (21): 1192.

https://doi.org/10.1182/blood.V116.21.1192.1192

Published: 2010

NARROW

Targeting mTOR Signaling Is An Effective Treatment Strategy for IKAROS and JAK Kinase Mutated Acute Lymphoblastic Leukemia

The Role of Dominant-Negative IKAROS Mutations In the Pathogenesis and Treatment Responsiveness of BCR-ABL1 positive Acute Lymphoblastic Leukemia

Integrated Genetic and Epigenetic Analysis of Childhood Acute Lymphoblastic Leukemia Reveals a Synergistic Role for Structural and Epigenetic Lesions In Determining Disease Phenotype

Genome-Wide Analysis Reveals Frequent Inactivating Mutations of Acetyltransferase Genes In B-Cell Lymphoma

CREBBP Mutations In Relapsed Acute Lymphoblastic Leukemia

Genome-Wide Analysis of Genetic Alterations In Hypodiploid Acute Lymphoblastic Leukemia Identifies a High Frequency of Mutations Targeting the IKAROS Gene Family and Ras Signaling

Lack of Somatic Sequence Mutations In Protein Tyrosine Kinase Genes Other Than the JAK Kinase Family In High Risk B-Precursor Childhood Acute Lymphoblastic Leukemia (ALL): A Report From the Children's Oncology Group (COG) High-Risk (HR) ALL TARGET Project

T-Cell Receptor Gene Deletions Are Associated with High Risk Features and Worse Outcome In Childhood Precursor B-Cell Acute Lymphoblastic Leukemia (ALL)

Evolution of Human BCR-ABL1 lymphoblastic Leukaemia-Initiating Cells.

Cross-Species Comparison of Acquired Genetic Changes In T Cell Malignancy.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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