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Journal Articles

A Phase 1/2 Study of Quizartinib (Q) in Combination with Re-Induction Chemotherapy and As Single-Agent Continuation Therapy in Pediatric and Young Adult Patients with Relapsed/Refractory (R/R) FLT3 -ITD Acute Myeloid Leukemia (AML)

C. Michel Zwaan, MD PhD, Edward Anders Kolb, MD, Derek E. Mires, PharmD, Michele Vigliotti, PharmD, Jingdong Xie, PhD, Pamela Downs, BS, Arthur P DeCillis, MD MS, Cara A Rabik, MD PhD, Todd M Cooper, DO

Blood (2019) 134 (Supplement_1): 3937.

https://doi.org/10.1182/blood-2019-121736

Published: 2019

Journal Articles

Distinct Co-Occurring Mutational Profiles in Acute Myeloid Leukemia Confers Prognostic Significance in Children and Young Adults with FLT3 /ITD Mutations

Katherine Tarlock, MD, Todd A Alonzo, PhD, Robert B Gerbing, MA, Rhonda E. Ries, MA, Brenda Gibson, MD PhD, Naghmeh Niktoreh, Sanne Noort, MD MSc, Marry M. Van den Heuvel-Eibrink, MD, C. Michel Zwaan, MD PhD, Soheil Meshinchi, MD PhD

Blood (2018) 132 (Supplement 1): 443.

https://doi.org/10.1182/blood-2018-99-113676

Published: 2018

Journal Articles

Gemtuzumab in Children with Relapsed and Refractory Acute Myeloid Leukemia Treated on Compassionate-Use Basis: A Report of the AML-BFM Study Group

Mareike Rasche, MD, Beate Lerius, Ursula Creutzig, MD PhD, Martin Zimmermann, PhD, C. Michel Zwaan, MD PhD, Dirk Reinhardt, MD PhD

Blood (2016) 128 (22): 1637.

https://doi.org/10.1182/blood.V128.22.1637.1637

Published: 2016

Journal Articles

JAK2 Aberrations in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia

Elisabeth M.P. Steeghs, MSc, Isabel S. Jerchel, MSc, Willemieke de Goffau-Nobel, MSc, Alex Q. Hoogkamer, BSc, Judith M. Boer, PhD, Aurélie Boeree, BSc, Cesca van de Ven, PhD, Marco J. Koudijs, PhD, Nicolle J.M. Besselink, BSc, Hester A. de Groot-Kruseman, PhD, C. Michel Zwaan, MD PhD, Martin A. Horstmann, MD, Rob Pieters, MD PhD, Monique L. Den Boer, PhD

Blood (2016) 128 (22): 583.

https://doi.org/10.1182/blood.V128.22.583.583

Published: 2016

Journal Articles

Genomic Landscape of Pediatric Mixed Phenotype Acute Leukemia

Thomas B. Alexander, MD MPH, Zhaohui Gu, PhD, John K Choi, MD, Mignon L. Loh, MD, John Horan, MD MPH, Barbara Buldini, MD, Giuseppe Basso, Sarah Elitzur, MD, C. Michel Zwaan, MD PhD, Valerie de Haas, MD PhD, Allen Eng Juh Yeoh, MD, Dirk Reinhardt, MD PhD, Daisuke Tomizawa, MD, PhD, Tim Lammens, Barbara De Moerloose, MD, Li Zhou, PhD, Hiroki Hori, MD PhD, Anthony V. Moorman, PhD, Andrew S. Moore, MBBS FRACP PhD, Ondrej Hrusak, MD PhD, Soheil Meshinchi, MD PhD, Etan Orgel, MD MS, Meenakshi Devidas, PhD, Stephen P. Hunger, MD, Jamie M Guidry Auvil, Malcolm A. Smith, MD PhD, Tanja M. Davidsen, PhD, Leandro C. Hermida, Patee Gesuwan, Marco A. Marra, PhD, Yussanne Ma, PhD, Andrew J. Mungall, Richard Moore, PhD, Daniela S. Gerhard, PhD, Xueyuan Cao, Lei Shi, PhD, Stanley Pounds, PhD, Hiroto Inaba, MD PhD, Charles Mullighan, MBBS, MSc, MD

Blood (2016) 128 (22): 454.

https://doi.org/10.1182/blood.V128.22.454.454

Published: 2016

Journal Articles

RAS Pathway Mutations As Predictive Biomarker for Treatment Adaptation in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Isabel S. Jerchel, MSc, Alex Q. Hoogkamer, BSc, Ingrid M. Ariës, PhD, Elisabeth M.P. Steeghs, MSc, Judith M. Boer, PhD, Nicolle J.M. Besselink, BSc, Aurélie Boeree, BSc, Cesca van de Ven, PhD, Hester A. de Groot-Kruseman, PhD, Valerie De Haas, MD PhD, Martin A. Horstmann, MD, Gabriele Escherich, MD, Ronald W. Stam, PhD, C. Michel Zwaan, MD PhD, Edwin Cuppen, PhD, Marco J. Koudijs, PhD, Rob Pieters, MD PhD, Monique L. Den Boer, MSc, PhD

Blood (2016) 128 (22): 4087.

https://doi.org/10.1182/blood.V128.22.4087.4087

Published: 2016

Journal Articles

Next Generation Sequencing Identifies a Novel Subset of Non-Down Syndrome Acute Megakaryoblastic Leukemia Characterized By Chimeric Transcripts Involving HOX Cluster Genes

Blood (2015) 126 (23): 171.

https://doi.org/10.1182/blood.V126.23.171.171

Published: 2015

Journal Articles

The Integrated Immunological Signature of Refractory Cytopenia of Childhood (RCC)

Demi de Winter, Marry M van den Heuvel-Eibrink, MD PhD, Vincent H.J. van der Velden, PhD, Anton W. Langerak, Jacques J.M. Dongen, Michael Dworzak, MD, Barbara De Moerloose, MD PhD, Jan Starý, MD, Charlotte M Niemeyer, MD PhD, Franco Locatelli, MD, Henrik Hasle, MD, Markus Schmugge, MD, C. Michel Zwaan, MD PhD, Rob Pieters, MD PhD

Blood (2015) 126 (23): 1657.

https://doi.org/10.1182/blood.V126.23.1657.1657

Published: 2015

Journal Articles

A Phase 1/2, Open-Label, Dose-Escalation Study of Midostaurin in Pediatric Patients (Pts) with Relapsed or Refractory (R/R) Acute Leukemia: Final Results of Study ITCC-024 (CPKC412A2114)

C. Michel Zwaan, MD PhD, Stefan Söderhäll, MD PhD, Benoit Brethon, MD, Matteo Luciani, MD, Carmelo Rizzari, MD, David Sternberg, MD PhD, Emmanuelle Besse, Catherine Dutreix, MD, Franca Fagioli, MD, Phoenix Ho, MD, Carlo Dufour, MD, Rob Pieters, MD PhD

Blood (2015) 126 (23): 2564.

https://doi.org/10.1182/blood.V126.23.2564.2564

Published: 2015

Journal Articles

Glucocorticoid-Induced Proliferation and Lack of Differentation in Untreated Pediatric Acute Myeloid Leukemic Blasts

Kim Klein, MD MSc, Eric Haarman, MD PhD, Valerie De Haas, MD PhD, C. Michel Zwaan, MD PhD, Ursula Creutzig, MD, Gertjan JL Kaspers, MD PhD

Blood (2015) 126 (23): 4843.

https://doi.org/10.1182/blood.V126.23.4843.4843

Published: 2015

Journal Articles

Phase II Study on Bortezomib (BTZ) in Multiple Relapsed or Refractory Pediatric Acute Lymphoblastic Leukemia (rALL): High Response Rate with a Modestly Intensive Regimen Including BTZ, Not Related to Pharmacokinetics

Blood (2015) 126 (23): 2501.

https://doi.org/10.1182/blood.V126.23.2501.2501

Published: 2015

Journal Articles

Results of a Feasibility and Phase II Study on Bortezomib (BTZ) in Pediatric Multiply Relapsed or Refractory Acute Lymphoblastic Leukemia: Complete Hematological Responses with a Modestly Intensive Regimen Including BTZ

Gertjan Kaspers, MD PhD, Denise Niewerth, MSc, Satianand Ramnarain, MSc, Andishe Attarbaschi, MD, André Baruchel, MD, Evelina S De Bont, MDPhD, Franca Fagioli, MD, Barbara De Moerloose, MD PhD, Karsten Nysom, MD, Giuseppe Palumbo, MD, Dirk Reinhardt, MD PhD, Pierre-Simon Rohrlich, MDPhD, Pauline Simon, MD, Arend von Stackelberg, MD, C. Michel Zwaan, MD PhD

Blood (2014) 124 (21): 2290.

https://doi.org/10.1182/blood.V124.21.2290.2290

Published: 2014

Journal Articles

ETV6 Aberrations Are a Recurrent Event in Pediatric Acute Myeloid Leukemia with Poor Clinical Outcome

Jasmijn de Rooij, MD, Eva Beuling, PhD, Maarten Fornerod, PhD, Askar Obulkasim, André Baruchel, MD, Jan Trka, MD, PhD, Prof., Dirk Reinhardt, MD PhD, Edwin Sonneveld, PhD, Martin Zimmermann, Rob Pieters, MD PhD, Marry van den Heuvel-Eibrink, MD PhD, C. Michel Zwaan, MD PhD

Blood (2014) 124 (21): 1012.

https://doi.org/10.1182/blood.V124.21.1012.1012

Published: 2014

Journal Articles

Microrna-106b~25 Cluster Is Involved in Relapsed MLL -Rearranged Pediatric AML

Lonneke Verboon, Maarten Fornerod, PhD, Askar Obulkasim, Edwin Sonneveld, PhD, André Baruchel, MD, Jan Trka, MD PhD, Dirk Reinhardt, MD PhD, Rob Pieters, MD PhD, Jacqueline Cloos, PhD, Gertjan JL Kaspers, MD PhD, Jan-Henning Klusmann, MD, C. Michel Zwaan, MD PhD, Marry van den Heuvel-Eibrink, MD PhD

Blood (2014) 124 (21): 1038.

https://doi.org/10.1182/blood.V124.21.1038.1038

Published: 2014

Journal Articles

BCOR and BCORL1 Mutations In Pediatric Acute Myeloid Leukemia

Malou C.H. Hermkens, Marry M. van den Heuvel-Eibrink, MD, PhD, Susan T.J.C.M. Arentsen-Peters, Maarten W.J. Fornerod, PhD, Andre Baruchel, MD, PhD, Jan Stary, Dirk Reinhardt, MD, PhD, Valerie de Haas, MD, PhD, Rob Pieters, C. Michel Zwaan, MD, PhD

Blood (2013) 122 (21): 3815.

https://doi.org/10.1182/blood.V122.21.3815.3815

Published: 2013

Journal Articles

NADH Dehydrogenase Subunit 4 ( ND4 ) Mutations in Pediatric Acute Myeloid Leukemia

Michael A Morgan, PhD, Birgit Markus, MD, Malou Hermkens, Frederik Damm, MD, Katarina Reinhardt, PhD, Martin Zimmermann, PhD, Iris H.I.M. Hollink, MD, PhD, MM van den Heuvel-Eibrink, MD, PhD, C. Michel Zwaan, MD, PhD, Felicitas Thol, MD, Tania Bunke, Dessislava Bogoeva, Christoph WM Reuter, MD, PhD, Arnold Ganser, Dirk Reinhardt, MD

Blood (2012) 120 (21): 1380.

https://doi.org/10.1182/blood.V120.21.1380.1380

Published: 2012

Journal Articles

Frequency and Prognostic Impact of NUP98/NSD1 Translocations in Adult AML and MDS Patients

Felicitas Thol, MD, Britta Kölking, Iris H.I.M. Hollink, MD, PhD, Frederik Damm, MD, Marry M. van den Heuvel-Eibrink, C. Michel Zwaan, MD, PhD, Gesine Bug, Oliver G. Ottmann, MD, Katharina Wagner, MD, Michael A Morgan, PhD, Wolf-Karsten Hofmann, Gudrun Göhring, MD, Brigitte Schlegelberger, Jürgen Krauter, Prof. Dr. med., Arnold Ganser, Michael Heuser, MD

Blood (2012) 120 (21): 1402.

https://doi.org/10.1182/blood.V120.21.1402.1402

Published: 2012

Journal Articles

Frequency and Prognostic Relevance of Gene Mutations in Pediatric AML Patients At First Relapse.

Costa Bachas, MSc, Gerrit Jan Schuurhuis, PhD, Dirk Reinhardt, MD, Ursula Creutzig, MD, PhD, Zinia J. Kwidama, BSc, C. Michel Zwaan, MD, PhD, Marry M. van den Heuvel-Eibrink, Evelina S De Bont, MD, PhD, Sara Elitzur, MD, Carmelo Rizzari, MD, PhD, Valérie de Haas, MD, PhD, Martin Zimmermann, Jacqueline Cloos, PhD, Gertjan J.L. Kaspers, MD, PhD

Blood (2012) 120 (21): 2480.

https://doi.org/10.1182/blood.V120.21.2480.2480

Published: 2012

Journal Articles

Harnessing Gene Expression Profiles for the Identification of Drug Resistance Genes in Pediatric AML

Costa Bachas, MSc, Gerrit Jan Schuurhuis, PhD, C. Michel Zwaan, MD, PhD, Marry M. van den Heuvel-Eibrink, Monique L. Den Boer, PhD, Zinia J. Kwidama, BSc, Evelina S. De Bont, MD, PhD, Dirk Reinhardt, MD, Ursula Creutzig, MD, PhD, Valérie de Haas, MD, PhD, Yehuda Assaraf, PhD, Gertjan J.L. Kaspers, MD, PhD, Jacqueline Cloos, PhD

Blood (2012) 120 (21): 283.

https://doi.org/10.1182/blood.V120.21.283.283

Published: 2012

Journal Articles

High Frequency of GATA1 Mutations in Childhood Non-Down Syndrome Acute Megakaryoblastic Leukemia

Katarina Reinhardt, PhD, C. Michel Zwaan, MD, PhD, Michael Dworzak, Jasmijn D.E. de Rooij, MD, Gertjan Kaspers, MD, PhD, Thomas Lehrnbecher, Henrik Hasle, Toralf Bernig, Jean-Michel Cavuela, Alexandra Kolenova, MD, PhD, Jochen Harbott, Jean-Pierre Bourquin, MD, PhD, Jan Stary, Ursula Creutzig, Dirk Reinhardt, MD

Blood (2012) 120 (21): 888.

https://doi.org/10.1182/blood.V120.21.888.888

Published: 2012

NARROW

A Phase 1/2 Study of Quizartinib (Q) in Combination with Re-Induction Chemotherapy and As Single-Agent Continuation Therapy in Pediatric and Young Adult Patients with Relapsed/Refractory (R/R) FLT3 -ITD Acute Myeloid Leukemia (AML)

Distinct Co-Occurring Mutational Profiles in Acute Myeloid Leukemia Confers Prognostic Significance in Children and Young Adults with FLT3 /ITD Mutations

Gemtuzumab in Children with Relapsed and Refractory Acute Myeloid Leukemia Treated on Compassionate-Use Basis: A Report of the AML-BFM Study Group

JAK2 Aberrations in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia

Genomic Landscape of Pediatric Mixed Phenotype Acute Leukemia

RAS Pathway Mutations As Predictive Biomarker for Treatment Adaptation in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Next Generation Sequencing Identifies a Novel Subset of Non-Down Syndrome Acute Megakaryoblastic Leukemia Characterized By Chimeric Transcripts Involving HOX Cluster Genes

The Integrated Immunological Signature of Refractory Cytopenia of Childhood (RCC)

A Phase 1/2, Open-Label, Dose-Escalation Study of Midostaurin in Pediatric Patients (Pts) with Relapsed or Refractory (R/R) Acute Leukemia: Final Results of Study ITCC-024 (CPKC412A2114)

Glucocorticoid-Induced Proliferation and Lack of Differentation in Untreated Pediatric Acute Myeloid Leukemic Blasts

Phase II Study on Bortezomib (BTZ) in Multiple Relapsed or Refractory Pediatric Acute Lymphoblastic Leukemia (rALL): High Response Rate with a Modestly Intensive Regimen Including BTZ, Not Related to Pharmacokinetics

Results of a Feasibility and Phase II Study on Bortezomib (BTZ) in Pediatric Multiply Relapsed or Refractory Acute Lymphoblastic Leukemia: Complete Hematological Responses with a Modestly Intensive Regimen Including BTZ

ETV6 Aberrations Are a Recurrent Event in Pediatric Acute Myeloid Leukemia with Poor Clinical Outcome

Microrna-106b~25 Cluster Is Involved in Relapsed MLL -Rearranged Pediatric AML

BCOR and BCORL1 Mutations In Pediatric Acute Myeloid Leukemia

NADH Dehydrogenase Subunit 4 ( ND4 ) Mutations in Pediatric Acute Myeloid Leukemia

Frequency and Prognostic Impact of NUP98/NSD1 Translocations in Adult AML and MDS Patients

Frequency and Prognostic Relevance of Gene Mutations in Pediatric AML Patients At First Relapse.

Harnessing Gene Expression Profiles for the Identification of Drug Resistance Genes in Pediatric AML

High Frequency of GATA1 Mutations in Childhood Non-Down Syndrome Acute Megakaryoblastic Leukemia

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American Society of Hematology

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American Society of Hematology

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