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Journal Articles

Unveiling a Critical Role of Thrombin in Enhanced CD8+ T Cell Response to Cancer

Rachel Cantrell, BS, Leah A. Rosenfeldt, BS, Duaa Mureb, BS, Balkrishan Sharma, PhD, Alexey Revenko, PhD, Brett P Monia, PhD, Joseph S. Palumbo, MD

Blood (2019) 134 (Supplement_1): 4918.

https://doi.org/10.1182/blood-2019-128739

Published: 2019

Journal Articles

Rationale and Design of a Phase 3 Study to Evaluate the Efficacy and Safety of ION-682884 in Patients with Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)

Rodney H Falk, MD, Morie A Gertz, MD, Merrill D Benson, MD, Gustavo Buchele, MD PhD, Michela Brambatti, MD MS, Sotirios Tsimikas, MD, Nicholas J Viney, Bsc, Li-Jung Tai, MD PhD, Cecilia Monteiro, MD PhD, Qingqing Yang, MS, Louis St L O'Dea, MB B.Ch. BAO, FRCP, Ewa Karwatowska-Prokopczuk, MD PhD, Eugene Schneider, MD, Richard S Geary, PhD, Brett P Monia, PhD

Blood (2019) 134 (Supplement_1): 5764.

https://doi.org/10.1182/blood-2019-129269

Published: 2019

Journal Articles

Antisense Oligonucleotide Targeting of Thrombopoietin Synthesis Reduces Platelet Count within the Hemostatic Range and Slows Progression of De Novo Mammary Carcinogenesis in the Mmtv-Pymt Mouse

Toshiaki Shirai, PhD, Alexey Revenko, PhD, Justin Tibbits, MS, Lisa M Coussens, PhD, Owen JT McCarty, PhD, Brett P. Monia, PhD, Andras Gruber, MD

Blood (2018) 132 (Supplement 1): 989.

https://doi.org/10.1182/blood-2018-99-114157

Published: 2018

Journal Articles

Transmembrane Protease, Serine 6 (TMPRSS6) Antisense Oligonucleotide (IONIS-TMPRSS6-L RX ) Reduces Plasma Iron Levels of Healthy Volunteers in a Phase 1 Clinical Study

Michael McCaleb, PhD, Jason Lickliter, MBBS, PhD, Andrew Dibble, PhD, Eugene Schneider, MD, Mariam Aghajan, Shuling Guo, Steve Hughes, MD MBA, Richard S Geary, PhD, Brett P. Monia, PhD

Blood (2018) 132 (Supplement 1): 3634.

https://doi.org/10.1182/blood-2018-99-115339

Published: 2018

Journal Articles

Differential Role of Plasma and Platelet-Derived Factor V In Vivo

Lacramioara Ivanciu, PhD, Jeffrey Crosby, PhD, Alexey Revenko, PhD, A. Robert MacLeod, PhD, Brett P. Monia, PhD, Robert J. Davidson, BS, Rodney M Camire, PhD

Blood (2017) 130 (Supplement 1): 364.

https://doi.org/10.1182/blood.V130.Suppl_1.364.364

Published: 2017

Journal Articles

Developing a Galnac-Conjugated TMPRSS6 Antisense Therapy for the Treatment of β-Thalassemia

Mariam Aghajan, PhD, Carla Casu, PhD, Vania lo Presti, Sheri Booten, Brett P. Monia, PhD, Stefano Rivella, PhD, Shuling Guo, PhD

Blood (2016) 128 (22): 1013.

https://doi.org/10.1182/blood.V128.22.1013.1013

Published: 2016

Journal Articles

Platelet-Localized FXI Promotes a Glycoprotein Ib Alpha Dependent Feedback Loop in Arterial Hypertension and Vascular Inflammation

Blood (2015) 126 (23): 2192.

https://doi.org/10.1182/blood.V126.23.2192.2192

Published: 2015

Journal Articles

Thrombin and Factor XII Drive Prostate Tumor Growth In Vivo

Gregory Adams, PhD, Leah Rosenfeldt, BS, Malinda Frederick, BS, Keith Kombrinck, MS, Brett P. Monia, PhD, Alexey Revenko, PhD, Joseph S. Palumbo, MD

Blood (2015) 126 (23): 424.

https://doi.org/10.1182/blood.V126.23.424.424

Published: 2015

Journal Articles

Targeting TMPRSS6 Using Antisense Technology for the Treatment of Beta-Thalassemia

Shuling Guo, PhD, Mariam Aghajan, PhD, Carla Casu, PhD, Sara Gardenghi, PhD, Sheri Booten, Stefano Rivella, PhD, Brett P. Monia, PhD

Blood (2015) 126 (23): 753.

https://doi.org/10.1182/blood.V126.23.753.753

Published: 2015

Journal Articles

Combination of Tmprss6 -ASO and the Iron Chelator Deferiprone Improves Erythropoiesis and Reduces Iron Overload in a Mouse Model of Beta-Thalassemia

Carla Casu, PhD, Mariam Aghajan, PhD, Rea Oikonomidau, MD, Shuling Guo, PhD, Brett P. Monia, PhD, Stefano Rivella, PhD

Blood (2014) 124 (21): 4024.

https://doi.org/10.1182/blood.V124.21.4024.4024

Published: 2014

Journal Articles

Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis

Harry Roger Buller, MD PhD, Claudette Bethune, PhD, Sanjay Bhanot, MDPhD, David Gailani, MD, Brett P. Monia, PhD, Gary E. Raskob, PhD, Annelise Segers, Peter Verhamme, MD PhD, Jeffrey I. Weitz, MDFRCPC

Blood (2014) 124 (21): LBA-1.

https://doi.org/10.1182/blood.V124.21.LBA-1.LBA-1

Published: 2014

Journal Articles

Thrombin Drives Colorectal Cancer Pathogenesis at the Level of Primary Tumor Growth, Tumor Invasion and Metastasis

Gregory N Adams, PhD, Dusty Waltz, Leah Rosenfeldt, Malinda Frederick, Whitney Miller, Alexey S Revenko, PhD, Brett P. Monia, PhD, Joseph S. Palumbo, MD

Blood (2014) 124 (21): 2812.

https://doi.org/10.1182/blood.V124.21.2812.2812

Published: 2014

Journal Articles

Lack of Substantial Antithrombotic Effect of Low Circulating Coagulation Factor VII Levels in a Baboon Model of Acute Vascular Graft Thrombosis

Michael Wallisch, PhD, Greisel Jennifer, BS, Erik I Tucker, PhD, Owen J.T. McCarty, PhD, Monica T Hinds, PhD, Sue Murray, Jeff Crosby, PhD, Brett P. Monia, PhD, Andras Gruber, MD

Blood (2014) 124 (21): 1485.

https://doi.org/10.1182/blood.V124.21.1485.1485

Published: 2014

Journal Articles

Regulation Of Hematopoietic Stem Cell Trafficking By The Coagulation Pathway

Shiri Gur Cohen, MSc, Tomer Itkin, PhD, Orit Kollet, PhD, Sagarika Chakrabarty, PhD, Aya Ludin, DMD, PhD, Karin Golan, MSc, Alexander Kalinkovich, MD, PhD, Xin-Jiang Lu, PhD, Jeff R. Crosby, PhD, Brett P. Monia, PhD, Charles T Esmon, PhD, Wolfram Ruf, MD, Tsvee Lapidot, PhD

Blood (2013) 122 (21): 456.

https://doi.org/10.1182/blood.V122.21.456.456

Published: 2013

Journal Articles

Target TMPRSS6 Using Antisense Technology for the Treatment of Hereditary Hemochromatosis and β-Thalassemia

Shuling Guo, PhD, Carla Casu, Sara Gardenghi, PhD, Sheri Booten, Andy Watt, Susan Freier, Ph.D, Stefano Rivella, PhD, Brett P. Monia, PhD

Blood (2012) 120 (21): 481.

https://doi.org/10.1182/blood.V120.21.481.481

Published: 2012

Journal Articles

Antisense Oligonucleotide Mediated Depletion of Factor XI Prevents Vascular Occlusion in An Experimental Thrombosis Model in Primates

Jeff R. Crosby, PhD, Ulla M Marzec, MS, Chenguang Zhao, Dacao Gao, Alexey S Revenko, PhD, Anton Matafonov, MD, David Gailani, MD, Robert MacLeod, Ph.D., Andras Gruber, MD, Stephen Hanson, PhD, Brett P. Monia, PhD

Blood (2011) 118 (21): 2250.

https://doi.org/10.1182/blood.V118.21.2250.2250

Published: 2011

Journal Articles

ISIS-FXI Rx , a Potent Antisense Inhibitor of Factor XI, Suppresses FXI Activity and Elevates Aptt without Increased Risk of Bleeding in Cynomolgus Monkeys Following 13 Weeks of Treatment

Husam Younis, Jeff R. Crosby, PhD, Chenguang Zhao, Robert MacLeod, Ph.D., Brett P. Monia, PhD, Scott Henry

Blood (2011) 118 (21): 2255.

https://doi.org/10.1182/blood.V118.21.2255.2255

Published: 2011

Journal Articles

ISIS-FXI Rx , A Novel and Specific Antisense Inhibitor of Factor XI, Caused Significant Reduction in FXI Antigen and Activity and Increased aPTT without Causing Bleeding in Healthy Volunteers

Que Liu, MD PhD, Claudette Bethune, PhD, Esmat Dessouki, MD, John Grundy, PhD, Brett P. Monia, PhD, Sanjay Bhanot, MD PhD

Blood (2011) 118 (21): 209.

https://doi.org/10.1182/blood.V118.21.209.209

Published: 2011

Journal Articles

Thrombin Supports Colitis and Colitis-Associated Cancer Pathogenesis

Brian K. Turpin, DO, Whitney M Miller, Eric S. Mullins, MD, Jay L. Degen, PhD, Matthew J. Flick, PhD, Brett P. Monia, PhD, Robert MacLeod, Ph.D., Alexey S Revenko, PhD, Joseph S. Palumbo, MD

Blood (2011) 118 (21): 2237.

https://doi.org/10.1182/blood.V118.21.2237.2237

Published: 2011

Journal Articles

Target TMPRSS6 for the Treatment of Hereditary Hemochromatosis

Sheri Booten, Daniel Knox, Luis Alvarado, Shuling Guo, PhD, Brett P. Monia, PhD

Blood (2011) 118 (21): 1047.

https://doi.org/10.1182/blood.V118.21.1047.1047

Published: 2011

NARROW

Unveiling a Critical Role of Thrombin in Enhanced CD8+ T Cell Response to Cancer

Rationale and Design of a Phase 3 Study to Evaluate the Efficacy and Safety of ION-682884 in Patients with Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)

Antisense Oligonucleotide Targeting of Thrombopoietin Synthesis Reduces Platelet Count within the Hemostatic Range and Slows Progression of De Novo Mammary Carcinogenesis in the Mmtv-Pymt Mouse

Transmembrane Protease, Serine 6 (TMPRSS6) Antisense Oligonucleotide (IONIS-TMPRSS6-L RX ) Reduces Plasma Iron Levels of Healthy Volunteers in a Phase 1 Clinical Study

Differential Role of Plasma and Platelet-Derived Factor V In Vivo

Developing a Galnac-Conjugated TMPRSS6 Antisense Therapy for the Treatment of β-Thalassemia

Platelet-Localized FXI Promotes a Glycoprotein Ib Alpha Dependent Feedback Loop in Arterial Hypertension and Vascular Inflammation

Thrombin and Factor XII Drive Prostate Tumor Growth In Vivo

Targeting TMPRSS6 Using Antisense Technology for the Treatment of Beta-Thalassemia

Combination of Tmprss6 -ASO and the Iron Chelator Deferiprone Improves Erythropoiesis and Reduces Iron Overload in a Mouse Model of Beta-Thalassemia

Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis

Thrombin Drives Colorectal Cancer Pathogenesis at the Level of Primary Tumor Growth, Tumor Invasion and Metastasis

Lack of Substantial Antithrombotic Effect of Low Circulating Coagulation Factor VII Levels in a Baboon Model of Acute Vascular Graft Thrombosis

Regulation Of Hematopoietic Stem Cell Trafficking By The Coagulation Pathway

Target TMPRSS6 Using Antisense Technology for the Treatment of Hereditary Hemochromatosis and β-Thalassemia

Antisense Oligonucleotide Mediated Depletion of Factor XI Prevents Vascular Occlusion in An Experimental Thrombosis Model in Primates

ISIS-FXI Rx , a Potent Antisense Inhibitor of Factor XI, Suppresses FXI Activity and Elevates Aptt without Increased Risk of Bleeding in Cynomolgus Monkeys Following 13 Weeks of Treatment

ISIS-FXI Rx , A Novel and Specific Antisense Inhibitor of Factor XI, Caused Significant Reduction in FXI Antigen and Activity and Increased aPTT without Causing Bleeding in Healthy Volunteers

Thrombin Supports Colitis and Colitis-Associated Cancer Pathogenesis

Target TMPRSS6 for the Treatment of Hereditary Hemochromatosis

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American Society of Hematology

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ASH Publications

American Society of Hematology

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