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Bradley R. Pearse, PhD
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Journal Articles

Single Agent CD45-Targeted Antibody Drug Conjugate Enables Full Mismatch Allogeneic Hematopoietic Stem Cell Transplantation in a Murine HSCT Model

Sharon L. Hyzy, MS, Jennifer L Proctor, BS, Geoff O Gillard, PhD, Katelyn J. Hammond, BS, Ganapathy N. Sarma, PhD, Asim Saha, PhD, Nicholas Clark, PhD, Anjali Bhat, MS, Tahirih L Lamothe, BS, Rahul Palchaudhuri, PhD, Bradley R Pearse, PhD, Charlotte F McDonagh, PhD, Hans-Peter Kiem, MDPhD, John E Wagner, MD, Bruce R. Blazar, MD, Anthony E Boitano, PhD, Michael P Cooke, PhD, John C. Davis, Jr., MD MPH, MS
Journal: Blood
Blood (2020) 136 (Supplement 1): 31.
https://doi.org/10.1182/blood-2020-140489
Published: 2020
Journal Articles

A Single Dose of a Novel Anti-Human CD117-Amanitin Antibody Drug Conjugate (ADC) Engineered for a Short Half-Life Provides Dual Conditioning and Anti-Leukemic Activity and Extends Survival Compared to Standard of Care in Multiple Preclinical Models of Acute Myeloid Leukemia (AML)

Leanne Lanieri, Tahirih L Lamothe, BS, Oliver Miske, Sean M McDonough, Ganapathy N Sarma, Prashant Bhattarai, Kellie Latimer, Junia Dushime, Nidhi Jain, Rahul Palchaudhuri, PhD, Ryan Knihtila, Bradley R Pearse, PhD, Jennifer L Proctor, BS, Anthony E Boitano, PhD, Michael P Cooke, PhD, John C. Davis, Jr., MD MPH, MS
Journal: Blood
Blood (2020) 136 (Supplement 1): 47–48.
https://doi.org/10.1182/blood-2020-140422
Published: 2020
Journal Articles

A Single Dose of CD117 Antibody Drug Conjugate Enables Autologous Gene-Modified Hematopoietic Stem Cell Transplant (Gene Therapy) in Nonhuman Primates

John F. Tisdale, MD, Robert E. Donahue, VMD, Naoya Uchida, MD, Bradley R Pearse, PhD, Sean M McDonough, MS, Jennifer L Proctor, BS, Allen Krouse, Nathaniel S. Linde, Aylin C. Bonifacino, Rajiv Panwar, PhD, Ganapathy N. Sarma, PhD, Lena Kien, BS, Kellie Latimer, Junia Dushime, BS, Sharon L. Hyzy, MS, Melissa L. Brooks, BS, Rahul Palchaudhuri, PhD, Qing Li, PhD, Pranoti Sawant, MS, Charlotte F McDonagh, PhD, Anthony E. Boitano, PhD, Michael P. Cooke, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 610.
https://doi.org/10.1182/blood-2019-125968
Published: 2019
Journal Articles

A Novel Targeted Approach to Achieve Immune System Reset: CD45-Targeted Antibody Drug Conjugates Enable Autologous HSCT, Ameliorate Disease in Autoimmune Models, Potently Kill Human Immune Cells from Normal Donors and MS Patients, and Achieve Immune Depletion in Non-Human Primates (NHP)

Geoff O Gillard, Jennifer L Proctor, BS, Melissa L. Brooks, BS, Tahirih L Lamothe, BS, Sharon L. Hyzy, MS, Oliver Mikse, Sean McDonough, Rahul Palchaudhuri, PhD, Anjali Bhat, MS, Ganapathy N. Sarma, PhD, Prashant Bhattarai, Pranoti Sawant, MS, Bradley R Pearse, PhD, Charlotte F. Mcdonough, PhD, Anthony E. Boitano, PhD, Michael P. Cooke, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3208.
https://doi.org/10.1182/blood-2019-130752
Published: 2019
Journal Articles

CD117-Amanitin Antibody Drug Conjugates Effectively Deplete Human and Non-Human Primate HSCs: Proof of Concept As a Targeted Strategy for Conditioning Patients for Bone Marrow Transplant

Bradley R Pearse, PhD, Sean M McDonough, MS, Jennifer L Proctor, BS, Rajiv Panwar, PhD, Ganapathy Sarma, PhD, Molly A McShea, MS, Lena Kien, BS, Junia Dushime, BS, Hillary L Adams, MS, Sharon L. Hyzy, MS, Melissa L. Brooks, BS, Rahul Palchaudhuri, PhD, Qing Li, PhD, Nathan M Kallen, BA, Pranoti Sawant, MS, Charlotte F McDonagh, PhD, Anthony E. Boitano, PhD, Michael P. Cooke, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3314.
https://doi.org/10.1182/blood-2018-99-114881
Published: 2018
Journal Articles

Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models

Jennifer L Proctor, BS, Sharon L. Hyzy, MS, Hillary L Adams, MS, Melissa L. Brooks, BS, Andrew D Gabros, Sean M McDonough, MS, Lena Kien, BS, Sharon Aslanian, MS, Bradley R Pearse, PhD, Rahul Palchaudhuri, PhD, Qing Li, PhD, Nathan M Kallen, BA, Ganapathy Sarma, PhD, Molly A McShea, MS, Danielle Ladwig, MS, Junia Dushime, BS, Rajiv Panwar, PhD, Charlotte F McDonagh, PhD, Anthony E. Boitano, PhD, Michael P. Cooke, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3316.
https://doi.org/10.1182/blood-2018-99-112726
Published: 2018
Journal Articles

Targeting CD45 with an Amanitin Antibody-Drug Conjugate Effectively Depletes Human HSCs and Immune Cells for Transplant Conditioning

Rahul Palchaudhuri, PhD, Bradley R Pearse, PhD, Jennifer L Proctor, BS, Sharon L. Hyzy, MS, Sharon Aslanian, MS, Sean M McDonough, MS, Ganapathy Sarma, PhD, Melissa L. Brooks, BS, Anjali Bhat, MS, Danielle Ladwig, MS, Molly A McShea, MS, Nathan M Kallen, BA, Qing Li, PhD, Rajiv Panwar, PhD, Junia Dushime, BS, Pranoti Sawant, MS, Hillary L Adams, MS, Patrick C. Falahee, PhD, Tahirih L Lamothe, Andrew D Gabros, Lena Kien, BS, Geoff Gillard, PhD, Charlotte F McDonagh, PhD, Anthony E. Boitano, PhD, Michael P. Cooke, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4526.
https://doi.org/10.1182/blood-2018-99-117167
Published: 2018
Journal Articles

Antibody Drug Conjugates Targeted to CD45 or CD117 Enable Allogeneic Hematopoietic Stem Cell Transplantation in Animal Models

Rahul Palchaudhuri, PhD, Sharon L. Hyzy, MS, Jennifer L Proctor, BS, Hillary L Adams, MS, Bradley R Pearse, PhD, Ganapathy Sarma, PhD, Sharon Aslanian, MS, Geoff Gillard, PhD, Tahirih L Lamothe, Olga Burenkova, BS, Melissa L. Brooks, BS, Andrew D Gabros, Charlotte F McDonagh, PhD, Anthony E. Boitano, PhD, Michael P. Cooke, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3324.
https://doi.org/10.1182/blood-2018-99-119432
Published: 2018
Journal Articles

Non-Genotoxic Conditioning for Hematopoietic Stem Cell Transplant Using a Human Antibody Drug Conjugate Targeting C-KIT

Adam J. Hartigan, PhD, Bradley R. Pearse, PhD, Sean M. McDonough, Jennifer L. Proctor, BS, Hillary L. Adams, MS, Molly A. McShea, Megan D. Hoban, Rajiv Panwar, PhD, Sharon L. Hyzy, MS, Kevin A. Goncalves, PhD, Rahul Palchaudhuri, PhD BA, Anthony E. Boitano, PhD, Michael P. Cooke, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1894.
https://doi.org/10.1182/blood.V130.Suppl_1.1894.1894
Published: 2017