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Journal Articles

Simultaneous Kinase Inhibition with Ibrutinib and BCL2 Inhibition with Venetoclax As a Therapeutic Strategy for Acute Lymphoblastic Leukemia

Christopher A. Eide, Stephen E Kurtz, PhD, Andy Kaempf, MS, Nicola Long, Jessica Leonard, MD, Bill H. Chang, MD PhD, Motomi Mori, PhD, Brian J. Druker, Jeffrey W. Tyner

Blood (2019) 134 (Supplement_1): 3950.

https://doi.org/10.1182/blood-2019-131288

Published: 2019

Journal Articles

Significant In Vivo Sensitivity to Aurora Kinase Inhibition in TCF3-Hlf rearranged Acute Lymphoblastic Leukemia

Bill H. Chang, MD PhD, Jessica Leonard, MD, Joelle Wolf, Michelle Degnin, BS, Kyle Lenz, MD, Beth Wilmot, PhD, Charles G. Mullighan, MBBS, MD, Mignon L. Loh, MD, Stephen P. Hunger, MD, Jeffrey W. Tyner, PhD, Brian J. Druker, MD

Blood (2018) 132 (Supplement 1): 4026.

https://doi.org/10.1182/blood-2018-99-115706

Published: 2018

Journal Articles

T-Cell Suppression By Src/ABL Kinase Inhibitors When Combined with Blinatumomab in Ph+ Acute Lymphoblastic Leukemia

Jessica Leonard, MD, Yoko Kosaka, PhD, Pavani Malla, MS, Brandon Hayes-Lattin, MD, Adam J. Lamble, MD, Brian J. Druker, MD, Jeffrey W. Tyner, PhD, Bill H. Chang, MD PhD, Evan F. Lind, PhD

Blood (2018) 132 (Supplement 1): 2694.

https://doi.org/10.1182/blood-2018-99-119301

Published: 2018

Journal Articles

Altered T Cell Subsets and Function in Patients with Acute Lymphoblastic Leukemia

Jessica Leonard, MD, Yoko Kosaka, PhD, Matthew T Newman, BS, Adam J. Lamble, MD, Pavani Malla, MS, Brian J. Druker, MD, Jeffrey W. Tyner, PhD, Bill H. Chang, MD PhD, Evan F. Lind, PhD

Blood (2018) 132 (Supplement 1): 1547.

https://doi.org/10.1182/blood-2018-99-119409

Published: 2018

Journal Articles

Targeting of Glutamine Pathways Restores Sensitivity in Venetoclax Resistant Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

Jessica T Leonard, MD, Bill H. Chang, MD PhD, Jeffrey W. Tyner, PhD, Brian J. Druker, MD, Marc Loriaux, MD PhD, Pavani Malla, MS

Blood (2017) 130 (Supplement 1): 1264.

https://doi.org/10.1182/blood.V130.Suppl_1.1264.1264

Published: 2017

Journal Articles

Venetoclax Resistant Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Cells Are Also Resistant to ABL Inhibitors, Which Can be Overcome By Targeting the PI3K/AKT/ mTOR Pathway

Jessica T Leonard, MD, Jeffrey W. Tyner, PhD, Joelle Rowley, Marc M. Loriaux, Brian J. Druker, Bill H. Chang, MD PhD

Blood (2016) 128 (22): 1583.

https://doi.org/10.1182/blood.V128.22.1583.1583

Published: 2016

Journal Articles

PTPN11 Mutations in JMML Confer Dasatinib Sensitivity in a TNK2-Dependent Manner

Chelsea Jenkins, B.S., Samuel B Luty, BS, Julia E. Maxson, PhD, Christopher A. Eide, Bill H. Chang, MD PhD, Jeffrey W. Tyner

Blood (2016) 128 (22): 3154.

https://doi.org/10.1182/blood.V128.22.3154.3154

Published: 2016

Journal Articles

Selective Targeting Cyclin-Dependent Kinase-9 (CDK9) Downmodulates c-MYC and Induces Apoptosis in Diffuse Large B-Cell Lymphoma (DLBCL) Cells

Taylor Rowland, Cody Paiva, BS, Joelle Rowley, Andy Chen, MD PhD, Lisa Drew, PhD, Peter Hurlin, Bill H. Chang, MD PhD, Alexey V Danilov, MD PhD

Blood (2016) 128 (22): 289.

https://doi.org/10.1182/blood.V128.22.289.289

Published: 2016

Journal Articles

Novel Targets Identified By in Vitro Screening of Patient Samples with Adult Acute Lymphoblastic Leukemia

Jessica T Leonard, MD, Bill H. Chang, MD PhD, Jeffrey W. Tyner, PhD, Brandon Hayes-Lattin, MD, Marc M. Loriaux, Brian J. Druker, Uma Borate, MD

Blood (2016) 128 (22): 2811.

https://doi.org/10.1182/blood.V128.22.2811.2811

Published: 2016

Journal Articles

Chimeric T Cells for Therapy of CD30+ Hodgkin and Non-Hodgkin Lymphomas

Carlos A. Ramos, MD, Brandon Ballard, BS, Enli Liu, MD MS, Olga Dakhova, PhD, Zhuyong Mei, MD, Hao Liu, PhD, Bambi Grilley, RPh, Cliona M. Rooney, PhD, Adrian P. Gee, PhD, Bill H. Chang, MD PhD, Catherine M. Bollard, MD, Malcolm K. Brenner, MD PhD, Gianpietro Dotti, MD, Helen E. Heslop, MD, Barbara Savoldo, MD PhD

Blood (2015) 126 (23): 185.

https://doi.org/10.1182/blood.V126.23.185.185

Published: 2015

Journal Articles

Dual Targeting of Ph+ ALL with Dasatinib and ABT-199 (Venetoclax)

Jessica Leonard, MD, Joelle Rowley, Brandon Hayes-Lattin, MD, Jeffrey W. Tyner, PhD, Marc Loriaux, MD PhD, Brian J. Druker, MD, Bill H Chang, MD PhD

Blood (2015) 126 (23): 1329.

https://doi.org/10.1182/blood.V126.23.1329.1329

Published: 2015

Journal Articles

ROR1 Protein Expression Is Regulated By UHRF1 in t(1;19) Pre B-Cell ALL

Marilynn Chow, MS,BS, Jason D. MacManiman, Vincent T. Bicocca, PhD, Lina Gao, PhD, Joshi A. Alumkal, MD, Bill H. Chang, MD PhD, Jeffrey W. Tyner, PhD

Blood (2015) 126 (23): 3648.

https://doi.org/10.1182/blood.V126.23.3648.3648

Published: 2015

Journal Articles

Self-Enforcing Feedback Activation Between BCL6 and Tonic Pre-B Cell Receptor Signaling in Acute Lymphoblastic Leukemia

Blood (2014) 124 (21): 284.

https://doi.org/10.1182/blood.V124.21.284.284

Published: 2014

Journal Articles

Invasive Candida Infections in Pediatric Patients Treated on the Pilot Study of Decitabine and Vorinostat with Chemotherapy for Relapsed ALL: A Report from the Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Consortium

Michael J. Burke, MD, Patrick Brown, MD, Lia Gore, MD, Richard Sposto, PhD, Deepa Bhojwani, Bill H Chang, MD PhD, Steven G. Dubois, MD, Paul S Gaynon, MD, Julia Glade-Bender, MD, Kenneth Matthew Heym, MD, Maria Luisa Sulis, MD, Jessica A. Pollard, MD, Anupam Verma, MD, Van Huynh, MD

Blood (2014) 124 (21): 3650.

https://doi.org/10.1182/blood.V124.21.3650.3650

Published: 2014

Journal Articles

Coordinate Regulation of Residual Bone Marrow Function in Acute Myeloid Leukemia By Exosomal Microrna

Noah I Hornick, BS, Jianya Huan, PhD, Natalya A. Goloviznina, B.S., Lulu Cambronne, PhD, Rongkun Shen, PhD, Bill H Chang, MD PhD, Peter Kurre, MD

Blood (2014) 124 (21): 1592.

https://doi.org/10.1182/blood.V124.21.1592.1592

Published: 2014

Journal Articles

Dasatinib Shows Therapeutic Potential in the Murine Xenograft Model for TCF3 rearranged Acute Lymphoblastic Leukemia

Kyle Lenz, Sarah Thompson, Natalya A. Goloviznina, B.S., Jianya Huan, PhD, Dorian H LaTocha, BS, Brian J. Druker, Jeffrey W. Tyner, Peter Kurre, MD, Bill H Chang, MD PhD

Blood (2014) 124 (21): 3718.

https://doi.org/10.1182/blood.V124.21.3718.3718

Published: 2014

Journal Articles

Sorafenib Treatment Following Hematopoietic Stem Cell Transplant In Pediatric FLT3/ITD+ AML

Jessica Pollard, MD, Bill H Chang, MD, PhD, Todd Michael Cooper, Thomas Gross, MD, PhD, Sumit Gupta, MD, Phoenix A. Ho, MD, Suzanne M. McGoldrick, MD, Tanya C. Watt, MD, MSc, India Sisler, MD, Blythe Thomson, MD, Ann E Woolfrey, MD, Soheil Meshinchi, MD, PhD

Blood (2013) 122 (21): 3969.

https://doi.org/10.1182/blood.V122.21.3969.3969

Published: 2013

Journal Articles

The CSF3R T618I Mutation Found In Chronic Neutrophilic Leukemia Removes An O-Linked Glycosylation Site and Increases Receptor Dimerization

Blood (2013) 122 (21): 270.

https://doi.org/10.1182/blood.V122.21.270.270

Published: 2013

Journal Articles

Replication Timing and Pediatric Leukemia

David M Gilbert, PhD, Dana Battaglia, MS, Bill H Chang, MD, PhD, Quinton Buckley, BS, Benjamin D Pope, BS, Brian J. Druker, Tyrone Ryba, PhD

Blood (2012) 120 (21): 4609.

https://doi.org/10.1182/blood.V120.21.4609.4609

Published: 2012

Journal Articles

TYK2-STAT1 Pathway Positively Regulates BCL2 Gene Expression in T-Cell Acute Lymphoblastic Leukemia

Blood (2012) 120 (21): 1470.

https://doi.org/10.1182/blood.V120.21.1470.1470

Published: 2012

NARROW

Simultaneous Kinase Inhibition with Ibrutinib and BCL2 Inhibition with Venetoclax As a Therapeutic Strategy for Acute Lymphoblastic Leukemia

Significant In Vivo Sensitivity to Aurora Kinase Inhibition in TCF3-Hlf rearranged Acute Lymphoblastic Leukemia

T-Cell Suppression By Src/ABL Kinase Inhibitors When Combined with Blinatumomab in Ph+ Acute Lymphoblastic Leukemia

Altered T Cell Subsets and Function in Patients with Acute Lymphoblastic Leukemia

Targeting of Glutamine Pathways Restores Sensitivity in Venetoclax Resistant Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

Venetoclax Resistant Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Cells Are Also Resistant to ABL Inhibitors, Which Can be Overcome By Targeting the PI3K/AKT/ mTOR Pathway

PTPN11 Mutations in JMML Confer Dasatinib Sensitivity in a TNK2-Dependent Manner

Selective Targeting Cyclin-Dependent Kinase-9 (CDK9) Downmodulates c-MYC and Induces Apoptosis in Diffuse Large B-Cell Lymphoma (DLBCL) Cells

Novel Targets Identified By in Vitro Screening of Patient Samples with Adult Acute Lymphoblastic Leukemia

Chimeric T Cells for Therapy of CD30+ Hodgkin and Non-Hodgkin Lymphomas

Dual Targeting of Ph+ ALL with Dasatinib and ABT-199 (Venetoclax)

ROR1 Protein Expression Is Regulated By UHRF1 in t(1;19) Pre B-Cell ALL

Self-Enforcing Feedback Activation Between BCL6 and Tonic Pre-B Cell Receptor Signaling in Acute Lymphoblastic Leukemia

Invasive Candida Infections in Pediatric Patients Treated on the Pilot Study of Decitabine and Vorinostat with Chemotherapy for Relapsed ALL: A Report from the Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Consortium

Coordinate Regulation of Residual Bone Marrow Function in Acute Myeloid Leukemia By Exosomal Microrna

Dasatinib Shows Therapeutic Potential in the Murine Xenograft Model for TCF3 rearranged Acute Lymphoblastic Leukemia

Sorafenib Treatment Following Hematopoietic Stem Cell Transplant In Pediatric FLT3/ITD+ AML

The CSF3R T618I Mutation Found In Chronic Neutrophilic Leukemia Removes An O-Linked Glycosylation Site and Increases Receptor Dimerization

Replication Timing and Pediatric Leukemia

TYK2-STAT1 Pathway Positively Regulates BCL2 Gene Expression in T-Cell Acute Lymphoblastic Leukemia

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American Society of Hematology

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American Society of Hematology

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