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Journal Articles

Efficacy of Tubulin Polymerization Inhibitor in Myelodysplastic Syndrome

Cheng Zhong, Kensuke Kayamori, MD PhD, Shuhei Koide, Daisuke Shinoda, MD, Motohiko Oshima, PhD, Yaeko Nakajima-Takagi, PhD, Yurie Nagai, MD, Naoya Mimura, MD PhD, William Lennox, Josephine Sheedy, BS, MSc, Marla Weetall, PhD, Atsushi Iwama, MD PhD

Blood (2020) 136 (Supplement 1): 35.

https://doi.org/10.1182/blood-2020-134754

Published: 2020

Journal Articles

Immunoglobulin Superfamily Member 8 Is Indispensable for Myeloid Leukemia Via Wnt/β-Catenin Signaling Pathway

Koji Jimbo, MD, Takaaki Konuma, MD PhD, Takahiro Ito, PhD, Yaeko Nakajima-Takagi, PhD, Atsushi Iwama, MD PhD, Arinobu Tojo, MD PhD

Blood (2020) 136 (Supplement 1): 23–24.

https://doi.org/10.1182/blood-2020-136045

Published: 2020

Journal Articles

The Preclinical Activities of PTC596, a Novel Tubulin Binding Agent That Down-Regulates BMI1, Alone and in Combination with Bortezomib in Multiple Myeloma

Blood (2019) 134 (Supplement_1): 4414.

https://doi.org/10.1182/blood-2019-122350

Published: 2019

Journal Articles

Synergistic Effect of DHODH Inhibitor PTC299 with DNA Demethylating Agent Decitabine in Myelodysplastic Syndromes

Kensuke Kayamori, Cheng Zhong, Daisuke Shinoda, MD, Shuhei Koide, PhD, Motohiko Oshima, PhD, Yaeko Nakajima-Takagi, PhD, Naoya Mimura, MD PhD, Ryoji Ito, Kaoru Tohyama, MD PhD, William Lennox, Marla Weetall, PhD, Josephine Sheedy, BS, MSc, Emiko Sakaida, MD PhD, Koutaro Yokote, MD PhD, Atsushi Iwama, MD PhD

Blood (2019) 134 (Supplement_1): 5407.

https://doi.org/10.1182/blood-2019-125200

Published: 2019

Journal Articles

Akt Inhibition Differently Controls PRC2 Components and Synergizes with Dual EZH2/1 Inhibitor in the Treatment of Multiple Myeloma

Mohamed Rizk, BSc, MSc, Ola Rizq, MD PhD, Motohiko Oshima, PhD, Yaeko Nakajima-Takagi, PhD, Shuhei Koide, PhD, Atsunori Saraya, Yusuke Isshiki, MD PhD, Tetsuhiro Chiba, MD PhD, Satoshi Yamazaki, PhD, Anqi Ma, PhD, Jian Jin, PhD, Atsushi Iwama, MD PhD, Naoya Mimura, MD PhD

Blood (2019) 134 (Supplement_1): 4400.

https://doi.org/10.1182/blood-2019-122157

Published: 2019

Journal Articles

Variant Pcgf-PRC1 Regulates Susceptibility of PRC2 Mediated H3K27me3 to Safeguard B Cell Fate of Hematopoietic Stem/Progenitor Cells

Junichiro Takano, MD, Yaeko Nakajima-Takagi, PhD, Shinsuke Ito, PhD, Haruhiko Koseki, MD PhD, Atsushi Iwama, MD PhD, Tomokatsu Ikawa, PhD

Blood (2019) 134 (Supplement_1): 3717.

https://doi.org/10.1182/blood-2019-129518

Published: 2019

Journal Articles

Hmga2 Functions As an Oncogene upon the Deletion of Tet2 and Promotes the Pathogenesis of Myelodysplastic Syndrome

Jie Bai, Sho Kubota, PhD, Takako Yokomizo, PhD, Akinori Kanai, PhD, Yuqi Sun, MD, Mihoko Iimori, CLS, Hironori Harada, MD PhD, Naomi Nakagata, PhD, Atsushi Iwama, MD PhD, Goro Sashida, MD PhD

Blood (2019) 134 (Supplement_1): 3782.

https://doi.org/10.1182/blood-2019-127583

Published: 2019

Journal Articles

New Insights into PLZF/Rara Mechanism during APL Onset: EZH2 on the Road

Mathilde Poplineau, Nadine Platet, PhD, Lia N'Guyen, Shuhei Koide, PhD, Julien Vernerey, PhD, Yaeko Nakajima-Takagi, PhD, Motohiko Oshima, PhD, Atsushi Iwama, MD PhD, Estelle Duprez, PhD

Blood (2019) 134 (Supplement_1): 3761.

https://doi.org/10.1182/blood-2019-125509

Published: 2019

Journal Articles

Anagrelide Inhibits Proliferation and Platelet Generation in Immortalized Megakaryocyte Progenitor Cell Lines Established from Human Induced Pluripotent Stem Cells

Blood (2018) 132 (Supplement 1): 1789.

https://doi.org/10.1182/blood-2018-99-111683

Published: 2018

Journal Articles

Regulation of Mitophagy By O -Linked N -Acetylglucosamine Transferase Is Essential for Hematopoietic Stem Cell Maintenance

Blood (2018) 132 (Supplement 1): 171.

https://doi.org/10.1182/blood-2018-171

Published: 2018

Journal Articles

Lineage-Specific RUNX2 Super-Enhancer Activates MYC Via Translocation (6;8) to Promote the Development of Blastic Plasmacytoid Dendritic Cell Neoplasm

Sho Kubota, PhD, Kenji Tokunaga, MD, Tomohiro Umezu, PhD, Takako Yokomizo, PhD, Motohiko Oshima, PhD, Eisaku Iwanaga, MD PhD, Norio Asou, MDPhD, Atsushi Iwama, MD PhD, Kazuma Ohyashiki, MD PhD, Motomi Osato, MD, PhD, Goro Sashida, MD PhD

Blood (2018) 132 (Supplement 1): 761.

https://doi.org/10.1182/blood-2018-99-110333

Published: 2018

Journal Articles

Role of KDM2B and Non-Canonical PRC1.1 As a Tumor Suppressor in T-ALL

Yusuke Isshiki, MD, Yaeko Nakajima-Takagi, PhD, Motohiko Oshima, PhD, Kazumasa Aoyama, PhD, Atsunori Saraya, Emiko Sakaida, MD PhD, Chiaki Nakaseko, MD PhD, Koutaro Yokote, MD PhD, Haruhiko Koseki, PhD, Atsushi Iwama, MD PhD

Blood (2018) 132 (Supplement 1): 2597.

https://doi.org/10.1182/blood-2018-99-117831

Published: 2018

Journal Articles

Utx Insufficiency Cooperates with Braf V600E in the Induction of Myeloma in Mice

Ola Rizq, MD PhD, Naoya Mimura, MD PhD, Motohiko Oshima, PhD, Shuji Momose, MD PhD, Yaeko Nakajima-Takagi, PhD, Kazumasa Aoyama, PhD, Atsunori Saraya, Tohru Iseki, MD PhD, Emiko Sakaida, MD PhD, Chiaki Nakaseko, MDPhD, Yutaka Okuno, MD, PhD, Hiroaki Honda, MD PhD, Jun-ichi Tamaru, MDPhD, Atsushi Iwama, MD PhD

Blood (2018) 132 (Supplement 1): 1005.

https://doi.org/10.1182/blood-2018-99-114053

Published: 2018

Journal Articles

Residual Wild-Type Tet2/Tet3 Allele Is the Savior Preventing Mouse Hematopoietic Progenitor Cells from Leukemia Development

Raksha Shrestha, MD, DiMM, Maie Koichiro, MD PhD, Mamiko Sakata-Yanagimoto, MD PhD, Olivier Bernard, Hirotaka Matsui, MD PhD, Yaeko Nakajima-Takagi, PhD, Takayasu Kato, MD PhD, Haruhiko Koseki, PhD, Atsushi Iwama, MD PhD, Shigeru Chiba, MD PhD

Blood (2018) 132 (Supplement 1): 1330.

https://doi.org/10.1182/blood-2018-99-112352

Published: 2018

Journal Articles

Insufficiency of Non-Canonical PRC1 Complex Cooperates with an Activating JAK2 Mutation in the Pathogenesis of Myelofibrosis

Daisuke Shinoda, MD, Yaeko Nakajima-Takagi, PhD, Motohiko Oshima, PhD, Atsunori Saraya, Hironori Harada, MD PhD, Haruhiko Koseki, PhD, Kazuya Shimoda, MD PhD, Goro Sashida, MD PhD, Atsushi Iwama, MD PhD

Blood (2018) 132 (Supplement 1): 100.

https://doi.org/10.1182/blood-2018-99-117741

Published: 2018

Journal Articles

RUNX3 Promotes the Development of MDS/MPN Overlap Syndrome Via Enhancing Expression of Myc in the Absence of Tet2

Takako Yokomizo, PhD, Daiki Tanaka, Sho Kubota, PhD, Motohiko Oshima, PhD, Yuka Harada, MD PhD, Akinori Kanai, PhD, Atsushi Iwama, MD PhD, Hironori Harada, Motomi Osato, MD PhD, Goro Sashida, MD PhD

Blood (2017) 130 (Supplement 1): 2494.

https://doi.org/10.1182/blood.V130.Suppl_1.2494.2494

Published: 2017

Journal Articles

Molecular Mechanism behind the Synergistic Activity of Proteasome Inhibition and PRC2 Inhibition in the Treatment of Multiple Myeloma

Ola Rizq, MD, Naoya Mimura, MD PhD, Motohiko Oshima, PhD, Atsunori Saraya, Shuhei Koide, PhD, Yuko Kato, PhD, Kazumasa Aoyama, PhD, Yaeko Nakajima-Takagi, PhD, Changshan Wang, PhD, Anqi Ma, Jian Jin, PhD, Tohru Iseki, MD PhD, Chiaki Nakaseko, MD, PhD, Atsushi Iwama, MD PhD

Blood (2016) 128 (22): 312.

https://doi.org/10.1182/blood.V128.22.312.312

Published: 2016

Journal Articles

Role of the Polycomb Methyltransferase Ezh1 in Myelodysplastic Syndrome Induced By Ezh2 Insufficiency

Kazumasa Aoyama, PhD, Makiko Mochizuki-Kashio, PhD, Motohiko Oshima, PhD, Shuhei Koide, PhD, Yaeko Nakajima-Takagi, PhD, Mitsutaka Maeda, Goro Sashida, MD PhD, Atsushi Iwama, MD PhD

Blood (2016) 128 (22): 1968.

https://doi.org/10.1182/blood.V128.22.1968.1968

Published: 2016

Journal Articles

HMGA2 Orchestrates the Tumorgenesis of Myeloproliferative Neoplasms (MPN) in Corporation with JAK2 V617F

Koki Ueda, MD PhD, Kazuhiko Ikeda, MD PhD, Takayuki Ikezoe, MD PhD, Kazuei Ogawa, MD PhD, Yuko Hashimoto, MD PhD, Kayo Harada-Shirado, Hiroshi Ohkawara, MD PhD, Norio Komatsu, MD PhD, Kotaro Shide, MD PhD, Kazuya Shimoda, MD, PhD, Shuhei Koide, PhD, Motohiko Oshima, PhD, Atsushi Iwama, MD PhD, Yasuchika Takeishi, MD PhD

Blood (2016) 128 (22): 796.

https://doi.org/10.1182/blood.V128.22.796.796

Published: 2016

Journal Articles

Distinctive Genetic Features of Plasma Cells in POEMS Syndrome

Blood (2016) 128 (22): 4404.

https://doi.org/10.1182/blood.V128.22.4404.4404

Published: 2016

NARROW

Efficacy of Tubulin Polymerization Inhibitor in Myelodysplastic Syndrome

Immunoglobulin Superfamily Member 8 Is Indispensable for Myeloid Leukemia Via Wnt/β-Catenin Signaling Pathway

The Preclinical Activities of PTC596, a Novel Tubulin Binding Agent That Down-Regulates BMI1, Alone and in Combination with Bortezomib in Multiple Myeloma

Synergistic Effect of DHODH Inhibitor PTC299 with DNA Demethylating Agent Decitabine in Myelodysplastic Syndromes

Akt Inhibition Differently Controls PRC2 Components and Synergizes with Dual EZH2/1 Inhibitor in the Treatment of Multiple Myeloma

Variant Pcgf-PRC1 Regulates Susceptibility of PRC2 Mediated H3K27me3 to Safeguard B Cell Fate of Hematopoietic Stem/Progenitor Cells

Hmga2 Functions As an Oncogene upon the Deletion of Tet2 and Promotes the Pathogenesis of Myelodysplastic Syndrome

New Insights into PLZF/Rara Mechanism during APL Onset: EZH2 on the Road

Anagrelide Inhibits Proliferation and Platelet Generation in Immortalized Megakaryocyte Progenitor Cell Lines Established from Human Induced Pluripotent Stem Cells

Regulation of Mitophagy By O -Linked N -Acetylglucosamine Transferase Is Essential for Hematopoietic Stem Cell Maintenance

Lineage-Specific RUNX2 Super-Enhancer Activates MYC Via Translocation (6;8) to Promote the Development of Blastic Plasmacytoid Dendritic Cell Neoplasm

Role of KDM2B and Non-Canonical PRC1.1 As a Tumor Suppressor in T-ALL

Utx Insufficiency Cooperates with Braf V600E in the Induction of Myeloma in Mice

Residual Wild-Type Tet2/Tet3 Allele Is the Savior Preventing Mouse Hematopoietic Progenitor Cells from Leukemia Development

Insufficiency of Non-Canonical PRC1 Complex Cooperates with an Activating JAK2 Mutation in the Pathogenesis of Myelofibrosis

RUNX3 Promotes the Development of MDS/MPN Overlap Syndrome Via Enhancing Expression of Myc in the Absence of Tet2

Molecular Mechanism behind the Synergistic Activity of Proteasome Inhibition and PRC2 Inhibition in the Treatment of Multiple Myeloma

Role of the Polycomb Methyltransferase Ezh1 in Myelodysplastic Syndrome Induced By Ezh2 Insufficiency

HMGA2 Orchestrates the Tumorgenesis of Myeloproliferative Neoplasms (MPN) in Corporation with JAK2 V617F

Distinctive Genetic Features of Plasma Cells in POEMS Syndrome

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American Society of Hematology

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ASH Publications

American Society of Hematology

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