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Journal Articles

Β-Catenin and Axl Receptor Tyrosine Kinase Modulation in CLL B-Cells with Co-Culture on Marrow Stromal Cells: Implications for Drug Resistance

Sutapa Sinha, PhD, Charla R Secreto, Justin C. Boysen, Steven L. Warner, PhD, David J. Bearss, PhD, Asish K Ghosh, PhD, Neil E. Kay, MD

Blood (2019) 134 (Supplement_1): 1739.

https://doi.org/10.1182/blood-2019-121772

Published: 2019

Journal Articles

Enhanced Expression of Beta-Catenin and Axl Receptor Tyrosine Kinase (RTK) in Chronic Lymphocytic Leukemia (CLL) B-Cells with Co-Culture on Marrow Stromal Cells: Implications for Leukemic Cell Drug Resistance

Sutapa Sinha, PhD, Charla R Secreto, Justin C. Boysen, Steven L. Warner, PhD, David J. Bearss, PhD, Asish K Ghosh, PhD, Neil E. Kay, MD

Blood (2018) 132 (Supplement 1): 3125.

https://doi.org/10.1182/blood-2018-99-110981

Published: 2018

Journal Articles

Sensitivity of Ibrutinib Exposed Chronic Lymphocytic Leukemia B-Cells to Inhibition of Axl Receptor Tyrosine Kinase

Sutapa Sinha, PhD, Justin C Boysen, Kari G. Chaffee, MS, Brian F Kabat, Susan L. Slager, PhD, Sameer A. Parikh, MD, Charla R Secreto, Tait D. Shanafelt, MD, Jose F. Leis, MD PhD, Steven L. Warner, PhD, David J. Bearss, PhD, Asish K Ghosh, PhD, Neil E. Kay, MD

Blood (2016) 128 (22): 2020.

https://doi.org/10.1182/blood.V128.22.2020.2020

Published: 2016

Journal Articles

Epigenetic Silencing of Catalase Induces Accumulation of Reactive Oxygen Species in Chronic Lymphocytic Leukemia B Cells Leading to Activation of Axl: An Escape Strategy?

Guru P Maiti, PhD MSc, Sutapa Sinha, PhD, Justin C Boysen, Neil E. Kay, MD, Asish K Ghosh, PhD

Blood (2016) 128 (22): 4363.

https://doi.org/10.1182/blood.V128.22.4363.4363

Published: 2016

Journal Articles

Axl Regulates Fibroblast Growth Factor Receptor Signaling in B-Cell Chronic Lymphocytic Leukemia: Dual Targeting in CLL Therapy

Sutapa Sinha, PhD, Justin Boysen, Charla Secreto, Steven L. Warner, PhD, Neil E. Kay, MD, Asish K Ghosh, PhD

Blood (2014) 124 (21): 831.

https://doi.org/10.1182/blood.V124.21.831.831

Published: 2014

Journal Articles

Targeted Inhibition of Axl Primes Chronic Lymphocytic Leukemia B-Cells for Apoptosis: Synergistic/Additive Effects in Combination with Bruton Tyrosine Kinase Inhibitors

Sutapa Sinha, PhD, Justin Boysen, Michael Nelson, Charla Secreto, Steven L. Warner, PhD, David J. Bearss, PhD, Connie Lesnick, M.Sc, Tait D. Shanafelt, MD, Neil E. Kay, MD, Asish K Ghosh, PhD

Blood (2014) 124 (21): 1946.

https://doi.org/10.1182/blood.V124.21.1946.1946

Published: 2014

Journal Articles

Activated Chronic Lymphocytic Leukemia B-Cells Preferentially Shed CD52 + Microvesicles, but Not CD19 + , and May Predict Therapeutic Outcome

Sutapa Sinha, PhD, Justin Boysen, Michael Nelson, Connie Lesnick, M.Sc, Tait D. Shanafelt, MD, Neil E. Kay, MD, Asish K Ghosh, PhD

Blood (2014) 124 (21): 1961.

https://doi.org/10.1182/blood.V124.21.1961.1961

Published: 2014

Journal Articles

Novel Pharmacological Agents Differentially Modulate Cytokine Release On CLL B-Cell-Stromal Cell Co-Culture: Implications for Stromal Rescue of CLL B-Cells From Chemotherapy

Connie Lesnick, M.Sc, Asish K Ghosh, PhD, Betsy R. LaPlant, Wei Ding, MD, PhD, Neil E. Kay, MD, Tait D. Shanafelt, MD

Blood (2012) 120 (21): 3927.

https://doi.org/10.1182/blood.V120.21.3927.3927

Published: 2012

Journal Articles

Axl Receptor Tyrosine Kinase Signaling Pathway and the p53 Tumor Suppressor Protein Exist In A Novel Regulatory Loop In B-Cell Chronic Lymphocytic Leukemia Cells

Asish K Ghosh, PhD, Justin Boysen, Tammy Price-troska, Charla Secreto, Clive S. Zent, MD, Neil Kay, MD

Blood (2011) 118 (21): 799.

https://doi.org/10.1182/blood.V118.21.799.799

Published: 2011

Journal Articles

Epigallocatechin-3-Gallate (EGCG) Modulates Cytokine Production When Leukemic CLL B-Cells and Marrow Stromal Cells Are Co-Cultured: Correlations with Clinical Activity in a Phase II Trial,

Connie Lesnick, Neil Kay, MD, Betsy R. LaPlant, Asish K Ghosh, PhD, Tait D. Shanafelt, MD

Blood (2011) 118 (21): 3882.

https://doi.org/10.1182/blood.V118.21.3882.3882

Published: 2011

Journal Articles

TRIS (DIBENZYLIDENEACETONE) Dipalladium a Small-Molecule Palladium Complex Is Effective in the Induction of Apoptosis for B-Chronic Lymphocytic Leukemia B-Cells

Neil Kay, MD, Traci Sassoon, Charla Secreto, Asish K Ghosh, PhD, Jack L Arbiser

Blood (2011) 118 (21): 2851.

https://doi.org/10.1182/blood.V118.21.2851.2851

Published: 2011

Journal Articles

A Novel Receptor Tyrosine Kinase Axl is Constitutively Active in B-Cell Chronic Lymphocytic Leukemia and Acts as a Docking Site of Non-Receptor Kinases: Implications for Therapy

Asish K Ghosh, PhD, Charla Secreto, Justin Boysen, Traci Sassoon, Sacha Holland, Tait Shanafelt, MD, Debabrata Mukhopadhyay, Neil E. Kay

Blood (2010) 116 (21): 54.

https://doi.org/10.1182/blood.V116.21.54.54

Published: 2010

Journal Articles

Bosutinib, a Src/Abl Kinase Inhibitor Induces Apoptosis in CLL B Cells by Targeting Multiple Tyrosine Kinases and Overcomes Stroma Protection.

Asish K Ghosh, PhD, Debabrata Mukhopadhyay, Neil E. Kay, MD

Blood (2009) 114 (22): 2368.

https://doi.org/10.1182/blood.V114.22.2368.2368

Published: 2009

Journal Articles

Role of Platelet-Derived Growth Factor On Vascular Endothelial Growth Factor Synthesis by Mesenchymal Stem Cells in Chronic Lymphocytic Leukemia: Implications for Clinical Progression.

Wei Ding, MD, PhD, Traci Knox, Susan Schwager, Charla Secreto, Asish K Ghosh, PhD, Wenting Wu, Neil E. Kay, MD

Blood (2009) 114 (22): 804.

https://doi.org/10.1182/blood.V114.22.804.804

Published: 2009

Journal Articles

Aberrant Regulation of pVHL Levels by Microrna May Explain Autocrine Secretion of VEGF in CLL B Cells.

Asish K Ghosh, PhD, Tait Shanafelt, MD, George A Calin, MD, PhD, Carlo M. Croce, MD, Linda Wellik, Debabrata Mukhopadhyay, Neil Kay

Blood (2008) 112 (11): 1064.

https://doi.org/10.1182/blood.V112.11.1064.1064

Published: 2008

Journal Articles

Dietary Products Induce Apoptosis in CLL B Cells and Reveal Potential as a Therapeutic Combination That Can Overcome Stromal Cell Mediated Protection.

Asish K. Ghosh, PhD, Tait D. Shanafelt, MD, Charla Secreto, Neil E. Kay, MD

Blood (2007) 110 (11): 3130.

https://doi.org/10.1182/blood.V110.11.3130.3130

Published: 2007

Journal Articles

Crosstalk between Chronic Lymphocytic Leukemia (CLL) B-Cells and Marrow Stromal Cells: Implication for CLL B-Cell Activation and Survival.

Wei Ding, MD, Grzegorz S. Nowakowski, MD, Jennifer L. Abrahamzon, Linda E. Wellik, Asish K. Ghosh, PhD, Charla R. Secreto, Kay L. Medina, PhD, Tait D. Shanafelt, MD, Clive S. Zent, MD, Neil E. Kay, MD

Blood (2007) 110 (11): 337.

https://doi.org/10.1182/blood.V110.11.337.337

Published: 2007

Journal Articles

Characterization of Microvesicles in B-Cell Chronic Lymphocytic Leukemia (CLL): A Potential Mediator in CLL B Cell Disease Progression?.

Asish K. Ghosh, PhD, Neil E. Kay, MD

Blood (2007) 110 (11): 747.

https://doi.org/10.1182/blood.V110.11.747.747

Published: 2007

NARROW

Β-Catenin and Axl Receptor Tyrosine Kinase Modulation in CLL B-Cells with Co-Culture on Marrow Stromal Cells: Implications for Drug Resistance

Enhanced Expression of Beta-Catenin and Axl Receptor Tyrosine Kinase (RTK) in Chronic Lymphocytic Leukemia (CLL) B-Cells with Co-Culture on Marrow Stromal Cells: Implications for Leukemic Cell Drug Resistance

Sensitivity of Ibrutinib Exposed Chronic Lymphocytic Leukemia B-Cells to Inhibition of Axl Receptor Tyrosine Kinase

Epigenetic Silencing of Catalase Induces Accumulation of Reactive Oxygen Species in Chronic Lymphocytic Leukemia B Cells Leading to Activation of Axl: An Escape Strategy?

Axl Regulates Fibroblast Growth Factor Receptor Signaling in B-Cell Chronic Lymphocytic Leukemia: Dual Targeting in CLL Therapy

Targeted Inhibition of Axl Primes Chronic Lymphocytic Leukemia B-Cells for Apoptosis: Synergistic/Additive Effects in Combination with Bruton Tyrosine Kinase Inhibitors

Activated Chronic Lymphocytic Leukemia B-Cells Preferentially Shed CD52 + Microvesicles, but Not CD19 + , and May Predict Therapeutic Outcome

Novel Pharmacological Agents Differentially Modulate Cytokine Release On CLL B-Cell-Stromal Cell Co-Culture: Implications for Stromal Rescue of CLL B-Cells From Chemotherapy

Axl Receptor Tyrosine Kinase Signaling Pathway and the p53 Tumor Suppressor Protein Exist In A Novel Regulatory Loop In B-Cell Chronic Lymphocytic Leukemia Cells

Epigallocatechin-3-Gallate (EGCG) Modulates Cytokine Production When Leukemic CLL B-Cells and Marrow Stromal Cells Are Co-Cultured: Correlations with Clinical Activity in a Phase II Trial,

TRIS (DIBENZYLIDENEACETONE) Dipalladium a Small-Molecule Palladium Complex Is Effective in the Induction of Apoptosis for B-Chronic Lymphocytic Leukemia B-Cells

A Novel Receptor Tyrosine Kinase Axl is Constitutively Active in B-Cell Chronic Lymphocytic Leukemia and Acts as a Docking Site of Non-Receptor Kinases: Implications for Therapy

Bosutinib, a Src/Abl Kinase Inhibitor Induces Apoptosis in CLL B Cells by Targeting Multiple Tyrosine Kinases and Overcomes Stroma Protection.

Role of Platelet-Derived Growth Factor On Vascular Endothelial Growth Factor Synthesis by Mesenchymal Stem Cells in Chronic Lymphocytic Leukemia: Implications for Clinical Progression.

Aberrant Regulation of pVHL Levels by Microrna May Explain Autocrine Secretion of VEGF in CLL B Cells.

Dietary Products Induce Apoptosis in CLL B Cells and Reveal Potential as a Therapeutic Combination That Can Overcome Stromal Cell Mediated Protection.

Crosstalk between Chronic Lymphocytic Leukemia (CLL) B-Cells and Marrow Stromal Cells: Implication for CLL B-Cell Activation and Survival.

Characterization of Microvesicles in B-Cell Chronic Lymphocytic Leukemia (CLL): A Potential Mediator in CLL B Cell Disease Progression?.

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American Society of Hematology

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American Society of Hematology

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