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Journal Articles

Metformin Upregulates Mir-26a to Improve Erythropoiesis in Preclinical Models of Diamond Blackfan Anemia through Suppression of Nlk Expression

Mark C Wilkes, PhD, Kavitha Siva, PhD, Jacqueline D Mercado, Ethan Patrick Wentworth, Mallika Saxena, Jun Chen, MD PhD, Anupama Narla, MD, Bertil Glader, MD PhD, Shuo Lin, PhD, Manuel Serrano, PhD, Johan Flygare, MD PhD, Kathleen M. Sakamoto, MD PhD

Blood (2020) 136 (Supplement 1): 7.

https://doi.org/10.1182/blood-2020-137170

Published: 2020

Journal Articles

SATB1 Regulates GATA1 Protein Expression in Early Hematopoiesis and Is Deregulated in Diamond Blackfan Anemia

Mark C Wilkes, PhD, Hee-Don Chae, PhD, Ethan Patrick Wentworth, Toshinobu Nishimura, PhD, Anupama Narla, MD, Bertil Glader, MD PhD, Hiromitsu Nakauchi, Joanna Wysocka, Kathleen M. Sakamoto, MD PhD

Blood (2020) 136 (Supplement 1): 3.

https://doi.org/10.1182/blood-2020-140437

Published: 2020

Journal Articles

Targeting of Calbindin 1 (CALB1) Rescues Erythropoiesis in a Human Model of Diamond Blackfan Anemia: Implications for Novel Therapies

Nan of Wang, PhD, Corinne Marie Lavasseur, BA, Hongxia Yan, MS, Scott Younger, PhD, Bertil Glader, MD PhD, Kathleen M. Sakamoto, MD PhD, Lionel Blanc, PhD, Anupama Narla, MD

Blood (2020) 136 (Supplement 1): 4.

https://doi.org/10.1182/blood-2020-139823

Published: 2020

Journal Articles

Enasidenib Drives Maturation of Human Erythroid Precursors Independently of IDH2

Ritika Dutta, BS, Tian Y Zhang, MD PhD, Thomas Koehnke, MD, Daniel Thomas, MD PhD, Eric Gars, MD, Melissa Stafford, Yusuke Nakauchi, MD PhD, Satinder Kaur, BS, Raymond Yin, Anupama Narla, MD, Ravindra Majeti, MD PhD

Blood (2019) 134 (Supplement_1): 540.

https://doi.org/10.1182/blood-2019-124551

Published: 2019

Journal Articles

Pharmacological Inhibition of Nemo-like Kinase Rescues mTOR-Mediated Translation and Primes Progenitors for Leucine-Stimulated Erythroid Expansion in Pre-Clinical Models of Diamond Blackfan Anemia

Mark C Wilkes, PhD, Jacqueline D Mercado, Mallika Saxena, Jun Chen, MD PhD, Kavitha Siva, PhD, Hee-Don Chae, PhD, Minyoung Youn, PhD, Ethan Patrick Wentworth, Kevin Jung, Ryan Sathianathen, Hiral Patel, Bertil Glader, MD PhD, Anupama Narla, MD, Claire E Repellin, PhD, Hanna T Gazda, MD PhD, Manuel Serrano, PhD, Johan Flygare, MD PhD, Kathleen M. Sakamoto, MD PhD

Blood (2019) 134 (Supplement_1): 455.

https://doi.org/10.1182/blood-2019-129570

Published: 2019

Journal Articles

Glucocorticoids Induce the Maintenance and Expansion of an Immature CFU-E Erythroid Progenitor Population in Humans

Ryan Ashley, BS, MS, Hongxia Yan, MS, Nan Wang, PhD, John Hale, PhD, Brian M Dulmovits, MS, Julien Papoin, MS, Meagan Olive, Namrata Udeshi, PhD, Steven Carr, PhD, Adrianna Vlachos, MD, Jeffrey Michael M Lipton, MD PhD, Lydie M. Da Costa, MD PhD, Christopher D. Hillyer, MD, Sandrina Kinet, PhD, Naomi Taylor, MD PhD, Mohandas Narla, DSc, Anupama Narla, MD, Lionel Blanc, PhD

Blood (2019) 134 (Supplement_1): 943.

https://doi.org/10.1182/blood-2019-130710

Published: 2019

Journal Articles

Chromatin Organization By SATB1 Regulates HSP70 Induction in Early Erythropoiesis and Lost in Diamond Blackfan Anemia

Mark C Wilkes, Kaoru Takasaki, MD, Minyoung Youn, PhD, Hee-Don Chae, PhD, Anupama Narla, MD, Kathleen M. Sakamoto, MD PhD

Blood (2018) 132 (Supplement 1): 2591.

https://doi.org/10.1182/blood-2018-99-119729

Published: 2018

Journal Articles

Dexamethasone Accelerates the Transition of Human BFU-E to CFU-E and Enhances CFU-E Proliferation through Cell Cycle Regulation

Ryan Ashley, BS, MS, Hongxia Yan, MS, Brian Dulmovits, BA, MS, Nan Wang, PhD, Julien Papoin, MS, Jeffrey M Lipton, MD PhD, Mohandas Narla, DSc, Anupama Narla, MD, Lionel Blanc, PhD

Blood (2018) 132 (Supplement 1): 3620.

https://doi.org/10.1182/blood-2018-99-116596

Published: 2018

Journal Articles

Pharmacological Inhibition of Nlk (Nemo-like Kinase) Rescues Erythropoietic Defects in Pre-Clinical Models of Diamond Blackfan Anemia

Mark C Wilkes, Jun Chen, MD PhD, Kavitha Siva, PhD, Gianluca Veretti, PhD, Daniel P. Dever, PhD, Minyoung Youn, PhD, Hee-Don Chae, PhD, Jacqueline D Mercado, Mallika Saxena, Anupama Narla, MD, Bertil Glader, MD, Matthew Porteus, MD PhD, Claire E Repellin, PhD, Hanna T Gazda, MD PhD, Manuel Serrano, PhD, Johan Flygare, MD PhD, Kathleen M. Sakamoto, MD PhD

Blood (2018) 132 (Supplement 1): 754.

https://doi.org/10.1182/blood-2018-99-119954

Published: 2018

Journal Articles

Leucine for the Treatment of Transfusion Dependence in Patients with Diamond Blackfan Anemia

Adrianna Vlachos, MD, Evangelia Atsidaftos, MA, MPH, Ellen Muir, RN, MSN, Zora R. Rogers, MD, Mohammad Lufti Lababidi, MD, Waseem Alhushki, MD, Jason E. Farrar, MD, Bertil Glader, MD, Barbara Gruner, MD, Helge Hartung, MD, Christine M. Knoll, MD, Grzegorz Nalepa, MDPhD, Anupama Narla, MD, Arun Ranjan Panigrahi, MD, Colin A. Sieff, MB, BCh, Kelly J. Walkovich, MD, Jeffrey M Lipton, MD PhD

Blood (2018) 132 (Supplement 1): 755.

https://doi.org/10.1182/blood-2018-99-113570

Published: 2018

Journal Articles

MMP9 Inhibition Rescues the Erythroid Defect in RPS14-Deficient Del(5q) MDS Models

Minyoung Youn, PhD, Haigen Huang, PhD, Cheng Chen, Sharon Kam, BS, Mark C Wilkes, Hee-Don Chae, PhD, Anupama Narla, MD, Shuo Lin, PhD, Kathleen M. Sakamoto, MD PhD

Blood (2018) 132 (Supplement 1): 756.

https://doi.org/10.1182/blood-2018-99-117508

Published: 2018

Journal Articles

Nemo-like Kinase Hyper-Activated in Erythroid Progenitors in Models of Diamond Blackfan Anemia

Mark C Wilkes, Jae Wook Lee, Sriya Kudaravalli, Anupama Narla, MD, Bertil Glader, MD, Kathleen M. Sakamoto, MD PhD

Blood (2017) 130 (Supplement 1): 78.

https://doi.org/10.1182/blood.V130.Suppl_1.78.78

Published: 2017

Journal Articles

High Mobility Group Box 1 Protein (HMGB1) Mediates Anemia of Inflammation through Lineage Skewing and Direct Inhibition of EPO Signaling

Brian M Dulmovits, MS, Julien Papoin, MS, Jian Hua Li, MS, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Yousef Al-Abed, MD, Luanne L. Peters, PhD, Betty Diamond, MD, Anupama Narla, MD, Jeffrey M Lipton, MDPhD, Mohandas Narla, DSc, Kevin Tracey, MD, Lionel Blanc, PhD

Blood (2017) 130 (Supplement 1): 2196.

https://doi.org/10.1182/blood.V130.Suppl_1.2196.2196

Published: 2017

Journal Articles

A Pharmacologic Approach Using Pomalidomide and Dexamethasone to Study Stage-Specific Regulation of Erythroid Progenitors

Brian M Dulmovits, MS, Nan Wang, PhD, Hongxia Yan, MS, Julien Papoin, MS, Ryan Ashley, BS, MS, John Hale, Jeffrey M Lipton, MDPhD, Mohandas Narla, DSc, Anupama Narla, MD, Lionel Blanc, PhD

Blood (2017) 130 (Supplement 1): 12.

https://doi.org/10.1182/blood.V130.Suppl_1.12.12

Published: 2017

Journal Articles

Erythrocyte Adenosine Deaminase Levels Are Elevated in Classic Diamond Blackfan Anemia but Not in the 5q- Syndrome

Anupama Narla, MD, Natalie Louise Davis, MD, Corinne LaVasseur, BA, Carolyn Wong, Bertil Glader, MD PhD

Blood (2016) 128 (22): 1501.

https://doi.org/10.1182/blood.V128.22.1501.1501

Published: 2016

Journal Articles

Role of Mir-34 Upregulation in Disruption of c-Myc, c-Myb and NOTCH Signaling in Diamond-Blackfan Anemia

Mark Wilkes, PhD, Elena Bibikova, PhD, Minyoung Youn, PhD, Alex Gia Lee, PhD, Ascia Eskin, M.S., Stanley Nelson, MD, Bertil Glader, MD PhD, Anupama Narla, MD, Kathleen M. Sakamoto, MD PhD

Blood (2016) 128 (22): 3895.

https://doi.org/10.1182/blood.V128.22.3895.3895

Published: 2016

Journal Articles

Pomalidomide and Dexamethasone Regulate Human Erythroid Progenitor Signaling through Two Distinct Pathways

Brian M. Dulmovits, MS, Nan Wang, PhD, Corinne LaVasseur, BA, Julien Papoin, MS, Hongxia Yan, MS, Xiuli An, MD PhD, Jeffrey M Lipton, MD PhD, Narla Mohandas, Anupama Narla, MD, Lionel Blanc, PhD

Blood (2016) 128 (22): 2423.

https://doi.org/10.1182/blood.V128.22.2423.2423

Published: 2016

Journal Articles

Loss of FoxM1 Promotes Erythroid Differentiation through Increased Proliferation of Erythroid Progenitors

Minyoung Youn, PhD, Elena Bibikova, PhD, Corinne LaVasseur, BA, Bertil Glader, MD PhD, Kathleen Sakamoto, MD PhD, Anupama Narla, MD

Blood (2015) 126 (23): 933.

https://doi.org/10.1182/blood.V126.23.933.933

Published: 2015

Journal Articles

RPS19 Deficiency Leads to GATA1 Downregulation through TNF-Mediated p38 MAPK Activation

Minyoung Youn, Elena Bibikova, Nadia Danilova, Yukako Ono-Uruga, Yoan Konto-Ghiorghi, Rachel Ochoa, Anupama Narla, MD, Bertil Glader, Shuo Lin, Kathleen Sakamoto, MD PhD

Blood (2014) 124 (21): 2934.

https://doi.org/10.1182/blood.V124.21.2934.2934

Published: 2014

Journal Articles

Understanding the Role of Erythrocyte Adenosine Deaminase in the Ribosomopathies

Anupama Narla, MD, Bertil Glader, Carolyn Wong

Blood (2014) 124 (21): 5152.

https://doi.org/10.1182/blood.V124.21.5152.5152

Published: 2014

NARROW

Metformin Upregulates Mir-26a to Improve Erythropoiesis in Preclinical Models of Diamond Blackfan Anemia through Suppression of Nlk Expression

SATB1 Regulates GATA1 Protein Expression in Early Hematopoiesis and Is Deregulated in Diamond Blackfan Anemia

Targeting of Calbindin 1 (CALB1) Rescues Erythropoiesis in a Human Model of Diamond Blackfan Anemia: Implications for Novel Therapies

Enasidenib Drives Maturation of Human Erythroid Precursors Independently of IDH2

Pharmacological Inhibition of Nemo-like Kinase Rescues mTOR-Mediated Translation and Primes Progenitors for Leucine-Stimulated Erythroid Expansion in Pre-Clinical Models of Diamond Blackfan Anemia

Glucocorticoids Induce the Maintenance and Expansion of an Immature CFU-E Erythroid Progenitor Population in Humans

Chromatin Organization By SATB1 Regulates HSP70 Induction in Early Erythropoiesis and Lost in Diamond Blackfan Anemia

Dexamethasone Accelerates the Transition of Human BFU-E to CFU-E and Enhances CFU-E Proliferation through Cell Cycle Regulation

Pharmacological Inhibition of Nlk (Nemo-like Kinase) Rescues Erythropoietic Defects in Pre-Clinical Models of Diamond Blackfan Anemia

Leucine for the Treatment of Transfusion Dependence in Patients with Diamond Blackfan Anemia

MMP9 Inhibition Rescues the Erythroid Defect in RPS14-Deficient Del(5q) MDS Models

Nemo-like Kinase Hyper-Activated in Erythroid Progenitors in Models of Diamond Blackfan Anemia

High Mobility Group Box 1 Protein (HMGB1) Mediates Anemia of Inflammation through Lineage Skewing and Direct Inhibition of EPO Signaling

A Pharmacologic Approach Using Pomalidomide and Dexamethasone to Study Stage-Specific Regulation of Erythroid Progenitors

Erythrocyte Adenosine Deaminase Levels Are Elevated in Classic Diamond Blackfan Anemia but Not in the 5q- Syndrome

Role of Mir-34 Upregulation in Disruption of c-Myc, c-Myb and NOTCH Signaling in Diamond-Blackfan Anemia

Pomalidomide and Dexamethasone Regulate Human Erythroid Progenitor Signaling through Two Distinct Pathways

Loss of FoxM1 Promotes Erythroid Differentiation through Increased Proliferation of Erythroid Progenitors

RPS19 Deficiency Leads to GATA1 Downregulation through TNF-Mediated p38 MAPK Activation

Understanding the Role of Erythrocyte Adenosine Deaminase in the Ribosomopathies

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American Society of Hematology

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American Society of Hematology

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