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Journal Articles

Regulatory T Cell Adoptive Immunotherapy Promotes B Cell Immunity after Haploidentical Transplantation

Sara Piccinelli, Antonella Mancusi, PhD, Eni Hoxha, Loredana Ruggeri, MD, Franca Falzetti, MD, Alessandra Carotti, MD, Adelmo Terenzi, MD, Samanta Bonato, MD, Matteo Paradiso, MD, Tiziana Zei, Roberta Iacucci Ostini, Barbara Bigerna, Brunangelo Falini, MD PhD, Mauro Di Ianni, MD PhD, Massimo Fabrizio Martelli, MD, Andrea Velardi, MD, Antonio Pierini, MD PhD

Blood (2019) 134 (Supplement_1): 1917.

https://doi.org/10.1182/blood-2019-125715

Published: 2019

Journal Articles

Adoptive Immunotherapy with Regulatory and Conventional T Cells in Haploidentical Transplantation Primes Dendritic Cells to Promote T Cell Alloreactivity in the Bone Marrow and Tolerance in the Periphery

Mauro Di Ianni, MD PhD, Raffaella Giancola, Stefano Baldoni, Francesca Ulbar, Beatrice Del Papa, Stella Santarone, Annalisa Natale, Paola Olioso, Paolo Di Bartolomeo, Tiziana Bonfini, Patrizia Accorsi, Paolo Sportoletti, Alessandra Carotti, MD, Antonio Pierini, MD PhD, Loredana Ruggeri, MD, Franca Falzetti, MD, Massimo Fabrizio Martelli, MD, Andrea Velardi, MD

Blood (2019) 134 (Supplement_1): 3224.

https://doi.org/10.1182/blood-2019-126061

Published: 2019

Journal Articles

Activation of Regulatory T Cells with IL-2 and TNF-α to Promote Homing to the Gut and to Improve Acute GvHD Prevention

Antonella Mancusi, PhD, Samanta Bonato, MD, Rachele Del Sordo, MD, Sara Piccinelli, Eni Hoxha, Tiziana Zei, Roberta Iacucci Ostini, Franca Falzetti, MD, Alessandra Carotti, MD, Loredana Ruggeri, MD, Michele Giansanti, MD, Robert S. Negrin, MD, Massimo Fabrizio Martelli, MD, Andrea Velardi, MD, Antonio Pierini, MD PhD

Blood (2019) 134 (Supplement_1): 4447.

https://doi.org/10.1182/blood-2019-123202

Published: 2019

Journal Articles

Low-Toxicity/High-Efficacy HLA Haploidentical Transplantation for Elderly/Unfit Patients with Acute Leukemia

Andrea Velardi, MD, Alessandra Carotti, MD, Franca Falzetti, MD, Adelmo Terenzi, MD, Loredana Ruggeri, MD PhD, Antonio Pierini, MD PhD, Sara Piccinelli, MD, Sara Tricarico, MD, Amico Lucia, MD, Genni Casarola, MD, Valentina Lancillotta, MD, Simonetta Saldi, MD, Mauro Di Ianni, MD PhD, Cynthia Aristei, MD PhD, Massimo Fabrizio Martelli, MD PhD

Blood (2017) 130 (Supplement 1): 4601.

https://doi.org/10.1182/blood.V130.Suppl_1.4601.4601

Published: 2017

Journal Articles

The Use of Monoclonal Antibody Directed Chimeric Antigen Receptors to Facilitate Conventional T Cell and Treg Control of GvHD and Tissue Tolerance in Murine Models

Antonio Pierini, MD, Bettina Iliopoulou, PhD, Heshan Peiris, PhD, Magdiel Perez Cruz, PhD, Jeanette Baker, PhD, Katie Hsu, PhD, William Strober, Ping-Ping Zheng, PhD, Tom Erkers, PhD, Aaron Ring, MD PhD, Andrea Velardi, Robert S. Negrin, MD, Seung Kim, MD PhD, Everett Meyer, MD PhD

Blood (2016) 128 (22): 3355.

https://doi.org/10.1182/blood.V128.22.3355.3355

Published: 2016

Journal Articles

Chemotherapy-Based HLA Haploidentical Transplantation with Treg/Tcon Immunotherapy in Unfit/Elderly Leukemia Patients: Powerful Gvl Effect and Insights from Animal Models

Loredana Ruggeri, Alessandra Carotti, Franca Falzetti, MD, Mauro Diianni, Antonio Pierini, MD, Maria Speranza Massei, Lucia Amico, Sara Piccinelli, Elena Urbani, Massimo Fabrizio Martelli, Andrea Velardi

Blood (2016) 128 (22): 3483.

https://doi.org/10.1182/blood.V128.22.3483.3483

Published: 2016

Journal Articles

DR3 Signaling Modulates the Function of Foxp3 + regulatory T Cells and the Severity of Acute Graft and Host Disease

Hidekazu Nishikii, MD PhD, Kim Byung-Su, Yan Chen, MD, Jeanette Baker, PhD, Antonio Pierini, MD, Maite Alvarez, PhD, Melissa Mavers, MD, Kristina Maas-Bauer, MD, Robert S. Negrin, MD

Blood (2016) 128 (22): 2148.

https://doi.org/10.1182/blood.V128.22.2148.2148

Published: 2016

Journal Articles

Foxp3 + regulatory T Cells Maintain Bone Marrow Microenvironment for B Cell Differentiation from Hematopoietic Stem Cells

Hidekazu Nishikii, MD PhD, Antonio Pierini, MD, Yasuhisa Yokoyama, MD,PhD, Takaharu Kimura, MD PhD, Hye-Sook Kwon, PhD, Maite Alvarez, PhD, Jeanette Baker, PhD, Judith Shizuru, MD PhD, Joy Wu, MD PhD, Shigeru Chiba, MD, PhD, Robert S. Negrin, MD

Blood (2016) 128 (22): 431.

https://doi.org/10.1182/blood.V128.22.431.431

Published: 2016

Journal Articles

Expanded CD4+Foxp3+ Regulatory T Cells through DR3 Signaling Have a Distinct Immunophenotype and Abrogate the Lethal Acute-Graft and Host Disease after Allogeneic Transplantation

Hidekazu Nishikii, MD, PhD, Byung-Su Kim, MD, Yasuhisa Yokoyama, MD,PhD, Jeanette Baker, PhD, Antonio Pierini, MD, Maite Alvarez, PhD, Yuqiong Pan, MD, PhD, Yan Chen, MD, Dominik Schneidawind, MD, Shigeru Chiba, MD, PhD, Robert Negrin, MD

Blood (2015) 126 (23): 1876.

https://doi.org/10.1182/blood.V126.23.1876.1876

Published: 2015

Journal Articles

TNF-Alpha Priming Enhances CD4 + FoxP3 + Regulatory T Cell Suppressive Function in GvHD Prevention and Treatment

Antonio Pierini, MD, Caitlin Moffett, Dominik Schneidawind, MD, Jeanette Baker, PhD, Hidekazu Nishikii, MD PhD, Yuqiong Pan, MD, PhD, Maite Alvarez, PhD, Everett Meyer, MD PhD, Robert Negrin, MD

Blood (2015) 126 (23): 1885.

https://doi.org/10.1182/blood.V126.23.1885.1885

Published: 2015

Journal Articles

CD4+FoxP3+ Regulatory T Cells Regulate B Cell Differentiation and Induce Tolerance to Bone Marrow Grafts

Antonio Pierini, MD, Hidekazu Nishikii, MD PhD, Yuqiong Pan, MD, Jeanette Baker, PhD, Dennis B Leveson-Gower, PhD, Mareike Florek, MD, Robert Negrin, MD

Blood (2014) 124 (21): 4322.

https://doi.org/10.1182/blood.V124.21.4322.4322

Published: 2014

Journal Articles

Loss of CD62L Expression in CD4+FoxP3+ Regulatory T Cells Following Freeze-and-Thaw Prevents Protection Against GVHD in Murine Models

Mareike Florek, MD, Dominik Schneidawind, MD, Jeanette Baker, PhD, Antonio Pierini, MD, Dennis B Leveson-Gower, PhD, Yuqiong Pan, MD, Robert S. Negrin, MD, Everett H. Meyer, MD PhD

Blood (2014) 124 (21): 2427.

https://doi.org/10.1182/blood.V124.21.2427.2427

Published: 2014

Journal Articles

Activation of DR3 Signaling Expands Recipient Derived Regulatory T Cells and Enhances Donor Immune Reconstitution Derived from Allogeneic Hematopoietic Stem Cells

Hidekazu Nishikii, MD PhD, Byung Su Kim, MD, Antonio Pierini, MD, Jeanette Baker, PhD, Dominik Schneidawind, MD, Yuqiong Pan, MD, Maite Alvarez, PhD, Robert S. Negrin, MD

Blood (2014) 124 (21): 1087.

https://doi.org/10.1182/blood.V124.21.1087.1087

Published: 2014

Journal Articles

Donor Requirements For CD4+CD25+FoxP3+ Regulatory T Cells Capable Of Suppressing CD4+ and CD8+ Conventional T Cell Proliferation and Graft Versus Host Disease

Antonio Pierini, MD, Lucrezia Colonna, PhD, Maite Alvarez, PhD, Dominik Schneidawind, MD, Byung-Su Kim, MD, Jeanette Baker, PhD, Robert Negrin, MD

Blood (2013) 122 (21): 4484.

https://doi.org/10.1182/blood.V122.21.4484.4484

Published: 2013

Journal Articles

Adoptive Transfer Of Ex Vivo “Educated” CD4+CD25+FoxP3+ Regulatory T Cells Effectively Treats Acute Graft Versus Host Disease Preserving Graft Versus Tumor Effect

Antonio Pierini, MD, Dominik Schneidawind, MD, Mareike Florek, MD, Maite Alvarez, PhD, Yuqiong Pan, MD, Jeanette Baker, PhD, Everett Meyer, MD, PhD, Robert Negrin, MD

Blood (2013) 122 (21): 4485.

https://doi.org/10.1182/blood.V122.21.4485.4485

Published: 2013

Journal Articles

Host CD4+CD25+FoxP3+ Regulatory T Cells Facilitate Donor Engraftment Without Impacting Graft Versus Host Disease Onset After Major-Mismatched Hematopoietic Stem Cell Transplantation

Antonio Pierini, MD, Hidekazu Nishikii, MD, PhD, Mareike Florek, MD, Dennis B Leveson-Gower, PhD, Yuqiong Pan, MD, Byung-Su Kim, MD, Jeanette Baker, PhD, Robert Negrin, MD

Blood (2013) 122 (21): 1996.

https://doi.org/10.1182/blood.V122.21.1996.1996

Published: 2013

Journal Articles

Agonistic Anti-DR3 Antibody Expands Treg and Reduces Experimental Acute Graft-Versus-Host Disease

Byung-Su Kim, MD, Antonio Pierini, MD, Dominik Schneidawind, MD, Jeanette Baker, PhD, Hidekazu Nishikii, MD, PhD, Yuqiong Pan, MD, Maite Alvarez, PhD, Robert Negrin, MD

Blood (2013) 122 (21): 135.

https://doi.org/10.1182/blood.V122.21.135.135

Published: 2013

Journal Articles

CD4+ Invariant Natural Killer T Cells Require NKG2D To Protect From Lethal Acute Graft-Versus-Host Disease

Dominik Schneidawind, MD, Antonio Pierini, MD, Maite Alvarez, PhD, Yuqiong Pan, MD, Jeanette Baker, PhD, Everett Meyer, MD, PhD, Robert Negrin, MD

Blood (2013) 122 (21): 898.

https://doi.org/10.1182/blood.V122.21.898.898

Published: 2013

NARROW

Regulatory T Cell Adoptive Immunotherapy Promotes B Cell Immunity after Haploidentical Transplantation

Adoptive Immunotherapy with Regulatory and Conventional T Cells in Haploidentical Transplantation Primes Dendritic Cells to Promote T Cell Alloreactivity in the Bone Marrow and Tolerance in the Periphery

Activation of Regulatory T Cells with IL-2 and TNF-α to Promote Homing to the Gut and to Improve Acute GvHD Prevention

Low-Toxicity/High-Efficacy HLA Haploidentical Transplantation for Elderly/Unfit Patients with Acute Leukemia

The Use of Monoclonal Antibody Directed Chimeric Antigen Receptors to Facilitate Conventional T Cell and Treg Control of GvHD and Tissue Tolerance in Murine Models

Chemotherapy-Based HLA Haploidentical Transplantation with Treg/Tcon Immunotherapy in Unfit/Elderly Leukemia Patients: Powerful Gvl Effect and Insights from Animal Models

DR3 Signaling Modulates the Function of Foxp3 + regulatory T Cells and the Severity of Acute Graft and Host Disease

Foxp3 + regulatory T Cells Maintain Bone Marrow Microenvironment for B Cell Differentiation from Hematopoietic Stem Cells

Expanded CD4+Foxp3+ Regulatory T Cells through DR3 Signaling Have a Distinct Immunophenotype and Abrogate the Lethal Acute-Graft and Host Disease after Allogeneic Transplantation

TNF-Alpha Priming Enhances CD4 + FoxP3 + Regulatory T Cell Suppressive Function in GvHD Prevention and Treatment

CD4+FoxP3+ Regulatory T Cells Regulate B Cell Differentiation and Induce Tolerance to Bone Marrow Grafts

Loss of CD62L Expression in CD4+FoxP3+ Regulatory T Cells Following Freeze-and-Thaw Prevents Protection Against GVHD in Murine Models

Activation of DR3 Signaling Expands Recipient Derived Regulatory T Cells and Enhances Donor Immune Reconstitution Derived from Allogeneic Hematopoietic Stem Cells

Donor Requirements For CD4+CD25+FoxP3+ Regulatory T Cells Capable Of Suppressing CD4+ and CD8+ Conventional T Cell Proliferation and Graft Versus Host Disease

Adoptive Transfer Of Ex Vivo “Educated” CD4+CD25+FoxP3+ Regulatory T Cells Effectively Treats Acute Graft Versus Host Disease Preserving Graft Versus Tumor Effect

Host CD4+CD25+FoxP3+ Regulatory T Cells Facilitate Donor Engraftment Without Impacting Graft Versus Host Disease Onset After Major-Mismatched Hematopoietic Stem Cell Transplantation

Agonistic Anti-DR3 Antibody Expands Treg and Reduces Experimental Acute Graft-Versus-Host Disease

CD4+ Invariant Natural Killer T Cells Require NKG2D To Protect From Lethal Acute Graft-Versus-Host Disease

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American Society of Hematology

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ASH Publications

American Society of Hematology

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