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Journal Articles

Daratumumab, a Novel Therapeutic Human CD38 Monoclonal Antibody, Induces Killing of Refractory Patient-Derived Multiple Myeloma Cells, Growing in a Novel Humanized Mouse MM Model

Willy A Noort, PhD, Richard W.J. Groen, PhD, Reinier Raymakers, MD, PhD, Linda Aalders, Frans M Hofhuis, Berris Van Kessel, Jeroen F Van Velzen, Joost de Bruijn, PhD, Huipin Yuan, PhD, Jeroen Lammerts van Bueren, PhD, Andries C Bloem, PhD, Paul W.H.I. Parren, PhD, Henk Lokhorst, MD, Tuna Mutis, MD PhD, Anton C.M. Martens, PhD

Blood (2012) 120 (21): 940.

https://doi.org/10.1182/blood.V120.21.940.940

Published: 2012

Journal Articles

Phagocytosis Is A Mechanism of Action for Daratumumab

Marije B. Overdijk, PhD student, Sandra Verploegen, PhD, Bögels Marijn, PhD student, Marjolein van Egmond, Prof., Richard W.J. Groen, PhD, Anton C.M. Martens, PhD, Jeroen Lammerts van Bueren, PhD, Wim Bleeker, PhD, Paul W.H.I. Parren, PhD

Blood (2012) 120 (21): 4054.

https://doi.org/10.1182/blood.V120.21.4054.4054

Published: 2012

Journal Articles

Daratumumab, a Novel Human CD38 Monoclonal Antibody for Treatment of Multiple Myeloma, Prevents Intra-Medullary Spreading of Patient Derived Multiple Myeloma Cells Growing in a Humanized Mouse Model

Willy A Noort, PhD, Richard W.J. Groen, PhD, Reinier Raymakers, MD, PhD, Linda Aalders, Joost de Bruijn, PhD, Huipin Yuan, PhD, Jeroen Lammerts van Bueren, PhD, Paul W.H.I. Parren, PhD, Henk Lokhorst, MD, Tuna Mutis, MD PhD, Anton C.M. Martens, PhD

Blood (2012) 120 (21): 1834.

https://doi.org/10.1182/blood.V120.21.1834.1834

Published: 2012

Journal Articles

Targeting EXT-1 Reveals a Crucial Role of Heparan Sulfate in the Growth of Multiple Myeloma.

Rogier M Reijmers, Richard W.J. Groen, Henk Rozemuller, Annemieke Kuil, Anneke de Haan - Kramer, Tamas Csikos, Anton C.M. Martens, Marcel Spaargaren, Steven T Pals

Blood (2009) 114 (22): 1830.

https://doi.org/10.1182/blood.V114.22.1830.1830

Published: 2009

Journal Articles

The Humanized Multiple Myeloma Mouse Model: Opportunities for Studying the Pathogenesis of MM in Its Natural Environment.

Richard W.J. Groen, Frans M. Hofhuis, Henk-Jan Prins, Henk Rozemuller, PhD, Berris van Kessel, Michel de Weers, PhD, Henk Lokhorst, MD, PhD, Anton C.M. Martens, PhD

Blood (2009) 114 (22): 1847.

https://doi.org/10.1182/blood.V114.22.1847.1847

Published: 2009

Journal Articles

Development of an Effective Safety Switch for Selective Elimination of Human T Cells In Vivo after Adoptive Transfer.

Tom van Meerten, BSc, Henk Rozemuller, PhD, Wendy J.M. Mackus, PhD, Paul W.H.I. Parren, PhD, Jan G.J. van de Winkel, PhD, Marie-Jose Claessen, MSc, Rozemarijn S. van Rijn, MD, Anton Hagenbeek, MD PhD, Anton C.M. Martens, PhD, Saskia B. Ebeling, PhD

Blood (2006) 108 (11): 5488.

https://doi.org/10.1182/blood.V108.11.5488.5488

Published: 2006

Journal Articles

Induction of Xenogeneic Graft-Versus-Host Disease through Administration of HuPBMC to Immune Deficient RAG2 −/− γc −/− Mice: A Model for B Cell-Involvement in Chronic Graft-Versus-Host Disease.

Marijke C. Canninga-van Dijk, MD, PhD, Rozemarijn S. van Rijn, MD, Elles R. Simonetti, BSc, Marieke C. Hogenes, MD, Saskia Smulders, BSc, Roel A. de Weger, PhD, Anton Hagenbeek, MD, PhD, Jan G. van de Tweel, MD, PhD, Leo F. Verdonck, MD, PhD, Anton C.M. Martens, PhD, Saskia B. Ebeling, PhD

Blood (2005) 106 (11): 3099.

https://doi.org/10.1182/blood.V106.11.3099.3099

Published: 2005

Journal Articles

Quantitative Assessment of the Impact of Ex Vivo Manipulation on the In Vivo Functionality of Human T Cells in RAG2 −/− γ c −/− mice.

Rozemarijn S. van Rijn, MD, Elles R. Simonetti, Gert Storm, PhD, Mark Bonyhadi, PhD, Anton Hagenbeek, MD, PhD, Anton C.M. Martens, PhD, Saskia B. Ebeling, PhD

Blood (2004) 104 (11): 450.

https://doi.org/10.1182/blood.V104.11.450.450

Published: 2004

Journal Articles

Diphtheria Toxin Fused to Granulocyte-Macrophage Colony-Stimulating Factor Eliminates Acute Myeloid Leukemia Cells With the Potential to Initiate Leukemia in Immunodeficient Mice, But Spares Normal Hemopoietic Stem Cells

Wim Terpstra, Henk Rozemuller, Dimitri A. Breems, Elwin J.C. Rombouts, Arie Prins, David J.P. FitzGerald, Robert J. Kreitman, Jenne J. Wielenga, Rob E. Ploemacher, Bob Löwenberg, Anton Hagenbeek, Anton C.M. Martens

Blood (1997) 90 (9): 3735–3742.

https://doi.org/10.1182/blood.V90.9.3735

Published: 1997

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Daratumumab, a Novel Therapeutic Human CD38 Monoclonal Antibody, Induces Killing of Refractory Patient-Derived Multiple Myeloma Cells, Growing in a Novel Humanized Mouse MM Model

Phagocytosis Is A Mechanism of Action for Daratumumab

Daratumumab, a Novel Human CD38 Monoclonal Antibody for Treatment of Multiple Myeloma, Prevents Intra-Medullary Spreading of Patient Derived Multiple Myeloma Cells Growing in a Humanized Mouse Model

Targeting EXT-1 Reveals a Crucial Role of Heparan Sulfate in the Growth of Multiple Myeloma.

The Humanized Multiple Myeloma Mouse Model: Opportunities for Studying the Pathogenesis of MM in Its Natural Environment.

Development of an Effective Safety Switch for Selective Elimination of Human T Cells In Vivo after Adoptive Transfer.

Induction of Xenogeneic Graft-Versus-Host Disease through Administration of HuPBMC to Immune Deficient RAG2 −/− γc −/− Mice: A Model for B Cell-Involvement in Chronic Graft-Versus-Host Disease.

Quantitative Assessment of the Impact of Ex Vivo Manipulation on the In Vivo Functionality of Human T Cells in RAG2 −/− γ c −/− mice.

Diphtheria Toxin Fused to Granulocyte-Macrophage Colony-Stimulating Factor Eliminates Acute Myeloid Leukemia Cells With the Potential to Initiate Leukemia in Immunodeficient Mice, But Spares Normal Hemopoietic Stem Cells

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