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Angelo Agathanggelou, PhD
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Journal Articles

BCR Unresponsiveness and 13q14 Duplication Underpin Spontaneous Disease Regression in Chronic Lymphocytic Leukemia

Marwan Kwok, MBBS,MRCP, Andy Rawstron, PhD, Angelo Agathanggelou, PhD, Anshita Goel, PhD, Ceri Oldreive, PhD, Rhiannon E Jones, PhD, Samantha Drennan, PhD, Archana Sharma-Oates, PhD, Paul Evans, PhD, Edward Smith, MSc, Jingwen Mao, Jamie Beaumont, Jusveen Rai, Mayumi Hamada, MB ChB, Surita Dalal, PhD, Naheema Gordon, MSc, Nicholas Davies, PhD, Helen Parry, MB ChB, MRCP, PhD, Andrew Beggs, MBBS, PhD FRCS, Talha Munir, Paul Moreton, MD MRCP, FRCPath, Shankara Paneesha, MD MRCP, FRCPath, Guy Pratt, MD FRCP, FRCPath, Malcolm Taylor, PhD, Francesco Forconi, MD DM, PhD FRCPath, Duncan M Baird, PhD, Jean-Baptiste Cazier, PhD, Paul Moss, MBBS, PhD FRCP, Peter Hillmen, MBChB, PhD, Tatjana Stankovic, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3004.
https://doi.org/10.1182/blood.V130.Suppl_1.3004.3004
Published: 2017
Journal Articles

A New Murine Model for B Cell Malignancies on ATM-Deficient Background Reveals Involvement of Multiple Pathogenic Mechanisms

Tegan A Francis, PhD, Nicholas J Davies, PhD, Michael John Griffiths, BSc, Angelo Agathanggelou, PhD, Maha Ibrahim, Paul G. Murray, PhD, Zbigniew Rudzki, Tatjana Stankovic, MD PhD, Alexander M R Taylor, PhD
Journal: Blood
Blood (2016) 128 (22): 4093.
https://doi.org/10.1182/blood.V128.22.4093.4093
Published: 2016
Journal Articles

UCHL1 Is a New Therapeutic Target in Lymphoid Malignancies, Independent of ATM and TP53 status

Edward Smith, MSc, Angelo Agathanggelou, PhD, Guy Pratt, MDPhD, Paul Moss, Wenbin Wei, PhD, Leanine Harrigan, Xavier Jacq, PhD, Tatjana Stankovic
Journal: Blood
Blood (2015) 126 (23): 1746.
https://doi.org/10.1182/blood.V126.23.1746.1746
Published: 2015
Journal Articles

CLL Progression Is Associated with Increased Clonal Diversity and Replication Stress

Angelo Agathanggelou, PhD, Anna Skowronska, PhD, Nick Davies, PhD, Marwan Kwok, MB ChB, MRCP, Samuel Clockie, Mike Griffiths, Alexander Taylor, Tatjana Stankovic, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1977.
https://doi.org/10.1182/blood.V124.21.1977.1977
Published: 2014
Journal Articles

Primary CLL Xenograft: A Model System to Study the Role of T-Cells in CLL Biology and Therapeutic Response

Ceri E Oldreive, PhD, Anna Skowronska, PhD, Angelo Agathanggelou, PhD, Helen M Parry, Sergey Krysov, Graham K Packham, PhD, Rudzki Zbgniew, Guy Pratt, A. Malcolm R Taylor, PhD, Paul Moss, MDPhD, Tatjana Stankovic, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3284.
https://doi.org/10.1182/blood.V124.21.3284.3284
Published: 2014
Journal Articles

ATR Inhibition Exacerbates Replication Stress in TP53 or ATM Deficient CLL Cells and Enhances Sensitivity to Chemotherapy and Targeted Therapy

Marwan Kwok, MB ChB, MRCP, Nicholas Davies, PhD, Angelo Agathanggelou, PhD, Edward Smith, BSc, Eva Petermann, PhD, Eliot Yates, BMedSc, Jeffrey Brown, PhD, Alan Lau, PhD, Tatjana Stankovic, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3340.
https://doi.org/10.1182/blood.V124.21.3340.3340
Published: 2014
Journal Articles

Inhibition of BRD4 Bromodomains Is a Potent Novel Strategy to Target Apoptosis Resistance in Paediatric ALL

David Da Costa, Victoria J Weston, PhD, Wenbin Wei, PhD, Angelo Agathanggelou, PhD, Eva Petermann, PhD, Stefan Knapp, PhD, Pamela R Kearns, BSc, MBBCh, MRCP, PhD, Tatjana Stankovic, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 77.
https://doi.org/10.1182/blood.V118.21.77.77
Published: 2011
Journal Articles

New Therapeutic Strategy for Sensitisation of CLL Cells with Inactivation of the DNA Damage Response by Targeting the Deubiquitylating Enzyme USP7-Dependent Pathways,

Angelo Agathanggelou, PhD, Anastasia Zlatanou, PhD, Ahmed Gulshanara, MSc, Grant Stewart, PhD, Pamela R Kearns, BSc, MBBCh, MRCP, PhD, Guy Pratt, MD, Paul AH Moss, MD PhD, A. Malcolm R Taylor, PhD, Frederic Colland, PhD, Tatjana Stankovic, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 3865.
https://doi.org/10.1182/blood.V118.21.3865.3865
Published: 2011
Journal Articles

ATM Mutant Lymphoid Tumour Cells Exhibit Impaired Activation of the Redox-Sensitive Nrf2-ARE Detoxification Pathway and Are Differentially Sensitive to Nrf2-Activating Compounds

Victoria J Weston, PhD, Angelo Agathanggelou, PhD, Paul AH Moss, MD, PhD, Pamela R. Kearns, BSc, MBBCh, MRCP, PhD, A. Malcolm R Taylor, PhD, Tatjana Stankovic, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 49.
https://doi.org/10.1182/blood.V116.21.49.49
Published: 2010
Journal Articles

The Epigenetic Therapies Azacitidine and Sodium Valproate Augment Immune Responses to the MAGE Cancer Testis Antigen in Acute Myeloid Leukemia and Myeloma.

Oliver Charles Goodyear, PhD, Angelo Agathanggelou, PhD, Gordon Ryan, Igor Novitsky-Basso, Tatjana Stankovic, MD., PhD, Paul Moss, MBBS, PhD, FRCP, Charles F. Craddock, BM, MRCP, MRCPath
Journal: Blood
Blood (2009) 114 (22): 2086.
https://doi.org/10.1182/blood.V114.22.2086.2086
Published: 2009