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Journal Articles

RNA Sequencing in Childhood B-Lymphoblastic Leukemia Improves Molecular and Risk Assignment

Allen Eng Juh Yeoh, MD, Zhenhua Li, PhD, Shawn Lee, MD, Winnie Hui Ni Chin, Nan Jiang, PhD, Yi Lu, PhD, Shirley Kow Yin Kham, BSc, Ah Moy Tan, MD, Hai_peng Lin, Thuan Chong Quah, Hany Ariffin, Jun J. Yang, PhD

Blood (2019) 134 (Supplement_1): 651.

https://doi.org/10.1182/blood-2019-131653

Published: 2019

Journal Articles

RNA-Seq Can Help Identify IGH Disease Clones for MRD Monitoring in Childhood B-Lymphoblastic Leukemia

Zhenhua Li, PhD, Nan Jiang, PhD, Evelyn Huizi Lim, Winnie Hui Ni Chin, Shirley Kow Yin Kham, BSc, Wentao Yang, Thuan Chong Quah, Hai_peng Lin, Ah Moy Tan, MD, Hany Ariffin, Jun J. Yang, PhD, Allen Eng Juh Yeoh, MD

Blood (2019) 134 (Supplement_1): 1471.

https://doi.org/10.1182/blood-2019-131548

Published: 2019

Journal Articles

Successful Toxicity Reduction in Ma-Spore ALL 2010 in Standard/Intermediate Risk Childhood ALL: Replacing Cytarabine/Doxorubicin with More Vincristine and L-Asparaginase during Consolidation and Delayed Intensification

Bernice Oh, MBBS, MRCP, Shawn Lee, MD, Zelia Seeto, Germaine Liew, Bsc, Edwynn Chiew, MBBS, Zhi Wei Chen, Bsc, Yiong Huak Chan, PhD, Jing Jia Eng, Bsc, Koon Mian Foo, Bsc, Ching Mei Joyce Lam, MD, Ah Moy Tan, MD, Allen Eng Juh Yeoh, MD

Blood (2019) 134 (Supplement_1): 1307.

https://doi.org/10.1182/blood-2019-122098

Published: 2019

Journal Articles

Tolerable Dose of 6-Mercaptopurine and Prognostic Impact of NUDT15-Deficient Genotype in Childhood Acute Lymphoblastic Leukemia

Yoichi Tanaka, PhD, Motohiro Kato, MD PhD, Takaya Moriyama, MD PhD, Yuki Arakawa, MD, Daisuke Hasegawa, MD PhD, Junya Fujimura, MD PhD, Dai Keino, MD PhD, Atsushi Sato, MD, Takahiro Ueda, MD PhD, Yuichi Taneyama, MD, Masatoshi Takagi, MD PhD, Masaki Yamamoto, MD, Masaki Matsuoka, MD, Moeko Hino, MD, Hiroki Hori, MD PhD, Katsuyoshi Koh, MD, Allen Eng Juh Yeoh, MD, Jun J. Yang, PhD, Atsushi Manabe, MD PhD

Blood (2018) 132 (Supplement 1): 4032.

https://doi.org/10.1182/blood-2018-99-114290

Published: 2018

Journal Articles

Pediatric-Inspired Protocol Improved Overall Survival in Young Adult Aged 18-30 Years Old with Philadelphia-Negative Acute Lymphoblastic Leukemia Compared to the Standard Adult Hypercvad Protocol

Victor Ling Wei Teik, MD MRCP, Elaine Seah, BSc, Michelle Poon, Melissa Ooi, Allen Eng Juh Yeoh, MD, Chin Hin Ng, MD MRCP

Blood (2017) 130 (Supplement 1): 5043.

https://doi.org/10.1182/blood.V130.Suppl_1.5043.5043

Published: 2017

Journal Articles

Intensifying Treatment in Childhood B-Lymphoblastic Leukemia with IKZF1 Deletions Negates Its Adverse Outcome: Results of Ma-Spore ALL 2003 and 2010 Studies

Yi Lu, PhD, Winnie Hui Ni Chin, Evelyn Huizi Lim, Shirley Kow Yin Kham, BSc, Ah Moy Tan, MD, Hany Ariffin, MD PhD, Allen Eng Juh Yeoh, MD

Blood (2017) 130 (Supplement 1): 478.

https://doi.org/10.1182/blood.V130.Suppl_1.478.478

Published: 2017

Journal Articles

Paediatric-Inspired Acute Lymphoblastic Leukemia Protocols, Are They Too Toxic for Young Adults?

Melissa G. Ooi, MDMRCP FRCPath PhD, Wee J Chng, MD MRCP, FRCPATH, PhD, Chin-Hin Ng, MD MRCP, FRCPATH, Yi Ching Yuen, MClinPharm, BCOP, BCPS, CGP, Allen Eng Juh Yeoh, MD, Chiew Kean Hui, Elaine Seah, BSc

Blood (2016) 128 (22): 5162.

https://doi.org/10.1182/blood.V128.22.5162.5162

Published: 2016

Journal Articles

Whole Transcriptome Sequencing Identified a Distinct Subtype of Acute Lymphoblastic Leukemia with Abnormalities of CREBBP and EP300

Blood (2016) 128 (22): 3912.

https://doi.org/10.1182/blood.V128.22.3912.3912

Published: 2016

Journal Articles

Genomic Landscape of Pediatric Mixed Phenotype Acute Leukemia

Thomas B. Alexander, MD MPH, Zhaohui Gu, PhD, John K Choi, MD, Mignon L. Loh, MD, John Horan, MD MPH, Barbara Buldini, MD, Giuseppe Basso, Sarah Elitzur, MD, C. Michel Zwaan, MD PhD, Valerie de Haas, MD PhD, Allen Eng Juh Yeoh, MD, Dirk Reinhardt, MD PhD, Daisuke Tomizawa, MD, PhD, Tim Lammens, Barbara De Moerloose, MD, Li Zhou, PhD, Hiroki Hori, MD PhD, Anthony V. Moorman, PhD, Andrew S. Moore, MBBS FRACP PhD, Ondrej Hrusak, MD PhD, Soheil Meshinchi, MD PhD, Etan Orgel, MD MS, Meenakshi Devidas, PhD, Stephen P. Hunger, MD, Jamie M Guidry Auvil, Malcolm A. Smith, MD PhD, Tanja M. Davidsen, PhD, Leandro C. Hermida, Patee Gesuwan, Marco A. Marra, PhD, Yussanne Ma, PhD, Andrew J. Mungall, Richard Moore, PhD, Daniela S. Gerhard, PhD, Xueyuan Cao, Lei Shi, PhD, Stanley Pounds, PhD, Hiroto Inaba, MD PhD, Charles Mullighan, MBBS, MSc, MD

Blood (2016) 128 (22): 454.

https://doi.org/10.1182/blood.V128.22.454.454

Published: 2016

Journal Articles

Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia

Blood (2016) 128 (22): 452.

https://doi.org/10.1182/blood.V128.22.452.452

Published: 2016

Journal Articles

Next Generation Sequencing Identifies a Novel Subset of Non-Down Syndrome Acute Megakaryoblastic Leukemia Characterized By Chimeric Transcripts Involving HOX Cluster Genes

Blood (2015) 126 (23): 171.

https://doi.org/10.1182/blood.V126.23.171.171

Published: 2015

Journal Articles

Effective Response Metric (ERM-D8) Using Time-Series Gene Expression Profiling at Diagnosis and Day 8 of Remission-Induction Therapy Is a Novel Early Prognostic Marker to Predict Relapse in Childhood Acute Lymphoblastic Leukemia (ALL) — a Malaysia-Singapore ALL Study

Allen Eng Juh Yeoh, MD, Zhenhua Li, PhD, Difeng Dong, PhD, Yi Lu, PhD, Jan Trka, MD, PhD, Prof., Shirley Kow Yin Kham, B.Sc., Ah Moy Tan, MD, Hany Ariffin, MD, Limsoon Wong, PhD

Blood (2014) 124 (21): 2393.

https://doi.org/10.1182/blood.V124.21.2393.2393

Published: 2014

Journal Articles

Genomic Profiling of Pharmacogenetic Variants Establishes a SNP-Based Predictor for Poor Outcome in Asian Children with Acute Lymphoblastic Leukemia (ALL): A Report from Malaysia-Singapore ALL Study Group

Yi Lu, PhD, Marc Hai Liang Wong, M.B.,B.S., Zhenhua Li, PhD, Shirley Kow Yin Kham, B.Sc., Ah Moy Tan, MD, Hany Ariffin, MD, Allen Eng Juh Yeoh, MD

Blood (2014) 124 (21): 1069.

https://doi.org/10.1182/blood.V124.21.1069.1069

Published: 2014

Journal Articles

Vincristine and Prednisolone Combination Reduces MDR1 and Microenvironment-Mediated Treatment Resistance In Acute Lymphoblastic Leukemia

Nan Jiang, Ph.D., Zhenhua Li, Ph.D., Grace Shimin Koh, B.Sc., Yi Lu, Ph.D., Shirley K.Y. Kham, Allen Eng Juh Yeoh, MD

Blood (2013) 122 (21): 2529.

https://doi.org/10.1182/blood.V122.21.2529.2529

Published: 2013

Journal Articles

BIM Regulates Prednisolone-Induced Apoptosis in B-Lineage ALL: A Potential Biomarker.

Nan Jiang, PhD, Grace Shi Min Koh, BSc, Shirley Kow Yin Kham, BSc, Yi Lu, PhD, Fook Tim Chew, PhD, Allen Eng Juh Yeoh, MD

Blood (2008) 112 (11): 1505.

https://doi.org/10.1182/blood.V112.11.1505.1505

Published: 2008

Journal Articles

Single IGH/TCR MRD Marker Is More Informative and Cost-Effective in Risk-Stratified Therapy for Childhood ALL: Prospective Treatment Trial Results from the Malaysia-Singapore (Ma-Spore) ALL 2003 Study

Allen Eng Juh Yeoh, MD, Hany Ariffin, MD, Ah Moy Tan, MD, Thi Thu Ha Truong, BSc, Hai Peng Lin, MD, Yiong Huak Chan, PhD, Shirley Kow Yin Kham, BSc, Thuan Chong Quah, MD

Blood (2008) 112 (11): 2551.

https://doi.org/10.1182/blood.V112.11.2551.2551

Published: 2008

Journal Articles

MDR1 C3435T Polymorphism Is Highly Correlated with Early Response to Therapy and Outcome in Childhood Acute Lymphoblastic Leukaemia: Malaysia-Singapore 2003 ALL Study.

Shirley Kow Yin Kham, BSc, Hany Ariffin, MD, Yiong Huak Chan, PhD, Thuan Chong Quah, MD, Allen Eng Juh Yeoh, MD

Blood (2007) 110 (11): 226.

https://doi.org/10.1182/blood.V110.11.226.226

Published: 2007

Journal Articles

Genetic Polymorphisms in the Folate Pathway and Risk of Childhood Acute Lymphoblastic Leukemia (ALL): MTHFR, MTHFD1, RFC1 and TS.

Allen Eng-Juh Yeoh, MD, Shirley Kow-Yin Kham, BSc, Yi Lu, PhD, Toon-Chai Foo, BSc, Hany Ariffin, MD, Thuan-Chong Quah, MD

Blood (2006) 108 (11): 2274.

https://doi.org/10.1182/blood.V108.11.2274.2274

Published: 2006

Journal Articles

Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism Decreases Risk of Childhood Acute Lymphoblastic Leukemia (ALL): A Study of the Chinese and Malay Population.

Shirley Kow Yin Kham, BSc, Toon Chai Foo, Ariffin Hany, MD, Yiong Huak Chan, PhD, Hai Peng Lin, MD, Thuan Chong Quah, MD, Allen Eng Juh Yeoh, MD

Blood (2005) 106 (11): 1459.

https://doi.org/10.1182/blood.V106.11.1459.1459

Published: 2005

NARROW

RNA Sequencing in Childhood B-Lymphoblastic Leukemia Improves Molecular and Risk Assignment

RNA-Seq Can Help Identify IGH Disease Clones for MRD Monitoring in Childhood B-Lymphoblastic Leukemia

Successful Toxicity Reduction in Ma-Spore ALL 2010 in Standard/Intermediate Risk Childhood ALL: Replacing Cytarabine/Doxorubicin with More Vincristine and L-Asparaginase during Consolidation and Delayed Intensification

Tolerable Dose of 6-Mercaptopurine and Prognostic Impact of NUDT15-Deficient Genotype in Childhood Acute Lymphoblastic Leukemia

Pediatric-Inspired Protocol Improved Overall Survival in Young Adult Aged 18-30 Years Old with Philadelphia-Negative Acute Lymphoblastic Leukemia Compared to the Standard Adult Hypercvad Protocol

Intensifying Treatment in Childhood B-Lymphoblastic Leukemia with IKZF1 Deletions Negates Its Adverse Outcome: Results of Ma-Spore ALL 2003 and 2010 Studies

Paediatric-Inspired Acute Lymphoblastic Leukemia Protocols, Are They Too Toxic for Young Adults?

Whole Transcriptome Sequencing Identified a Distinct Subtype of Acute Lymphoblastic Leukemia with Abnormalities of CREBBP and EP300

Genomic Landscape of Pediatric Mixed Phenotype Acute Leukemia

Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia

Next Generation Sequencing Identifies a Novel Subset of Non-Down Syndrome Acute Megakaryoblastic Leukemia Characterized By Chimeric Transcripts Involving HOX Cluster Genes

Effective Response Metric (ERM-D8) Using Time-Series Gene Expression Profiling at Diagnosis and Day 8 of Remission-Induction Therapy Is a Novel Early Prognostic Marker to Predict Relapse in Childhood Acute Lymphoblastic Leukemia (ALL) — a Malaysia-Singapore ALL Study

Genomic Profiling of Pharmacogenetic Variants Establishes a SNP-Based Predictor for Poor Outcome in Asian Children with Acute Lymphoblastic Leukemia (ALL): A Report from Malaysia-Singapore ALL Study Group

Vincristine and Prednisolone Combination Reduces MDR1 and Microenvironment-Mediated Treatment Resistance In Acute Lymphoblastic Leukemia

BIM Regulates Prednisolone-Induced Apoptosis in B-Lineage ALL: A Potential Biomarker.

Single IGH/TCR MRD Marker Is More Informative and Cost-Effective in Risk-Stratified Therapy for Childhood ALL: Prospective Treatment Trial Results from the Malaysia-Singapore (Ma-Spore) ALL 2003 Study

MDR1 C3435T Polymorphism Is Highly Correlated with Early Response to Therapy and Outcome in Childhood Acute Lymphoblastic Leukaemia: Malaysia-Singapore 2003 ALL Study.

Genetic Polymorphisms in the Folate Pathway and Risk of Childhood Acute Lymphoblastic Leukemia (ALL): MTHFR, MTHFD1, RFC1 and TS.

Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism Decreases Risk of Childhood Acute Lymphoblastic Leukemia (ALL): A Study of the Chinese and Malay Population.

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American Society of Hematology

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American Society of Hematology

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