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Journal Articles

Inducible Phase Separation of GSK3α As a Mechanism for Asparaginase Resistance in Acute Leukemias

Laura Hinze, Sabine Schreek, Andre Zeug, PhD, Evgeni Ponimaskin, PhD, Roxane Labrosse, MD FRCPC, James Degar, Gabriela Chiosis, PhD, Sung-Yun Pai, MD, Kristen E. Stevenson, MS, Donna S Neuberg, ScD, Beat Bornhauser, PhD, Jean-Pierre Bourquin, MD PhD, Martin Stanulla, MD, Alejandro Gutierrez, MD

Blood (2019) 134 (Supplement_1): 169.

https://doi.org/10.1182/blood-2019-126633

Published: 2019

Journal Articles

PRC2 Inactivation Induces Resistance to Chemotherapy-Induced Apoptosis By Upregulating the TRAP1 Mitochondrial Chaperone in T-ALL

Blood (2018) 132 (Supplement 1): 889.

https://doi.org/10.1182/blood-2018-99-113518

Published: 2018

Journal Articles

Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias

Laura Hinze, Maren Pfirrmann, Salmaan Karim, James Degar, Connor McGuckin, Divya Vinjamur, PhD, Sacher Joshua, Kristen E. Stevenson, MS, Donna S Neuberg, ScD, Daniel E. Bauer, MD PhD, Florence Wagner, PhD, Kimberly Stegmaier, MD, Alejandro Gutierrez, MD

Blood (2018) 132 (Supplement 1): 891.

https://doi.org/10.1182/blood-2018-99-113794

Published: 2018

Journal Articles

An Off-the-Shelf™ Fratricide-Resistant CAR-T for the Treatment of T Cell Hematologic Malignancies

Blood (2017) 130 (Supplement 1): 844.

https://doi.org/10.1182/blood.V130.Suppl_1.844.844

Published: 2017

Journal Articles

The Fanconi Pathway in Pediatric T-Cell Acute Lymphoblastic Leukemia

Blood (2017) 130 (Supplement 1): 2722.

https://doi.org/10.1182/blood.V130.Suppl_1.2722.2722

Published: 2017

Journal Articles

Hedgehog Pathway Mutations Drive Oncogenic Transformation in High-Risk T-Cell Acute Lymphoblastic Leukemia

Melissa A. Burns, MD, Zi Wei Liao, Gayle P. Pouliot, MD PhD, Kristen E. Stevenson, MS, Donna S. Neuberg, ScD, Aaron R. Thorner, PhD, Matthew D. Ducar, MS, Emily A. Silverman, Stephen P. Hunger, MD, Mignon L. Loh, MD, Stuart S. Winter, MD, Kimberly P. Dunsmore, MD, Brent Wood, MDPhD, Meenakshi Devidas, PhD, Marian H. Harris, MD PhD, Lewis B. Silverman, MD, Stephen E. Sallan, MD, Alejandro Gutierrez, MD

Blood (2017) 130 (Supplement 1): 367.

https://doi.org/10.1182/blood.V130.Suppl_1.367.367

Published: 2017

Journal Articles

PRC2 Mutations Induce Resistance to Conventional Chemotherapy By Inhibiting Mitochondrial Apoptosis in T-Cell Acute Lymphoblastic Leukemia

Blood (2016) 128 (22): 604.

https://doi.org/10.1182/blood.V128.22.604.604

Published: 2016

Journal Articles

Proxe: A Public Repository of Xenografts to Facilitate Studies of Biology and Expedite Preclinical Drug Development in Leukemia and Lymphoma

Mark A. Murakami, MD MA, Alexandra N. Christodoulou, M.S., Amanda L Christie, B.S., Tiffany DeSouza, B.S., Abner Louissaint, Jr., MD PhD, Una Vojinovic, B.S., Raphael Koch, MD, Loretta S. Li, MD, Scott P. Kallgren, PhD, Prakash Rao, PhD, Johannes Köster, PhD, Raga Vadhi, M.S., Eilene Duberow, B.S., Elizabeth A. Morgan, MD, Hongjun Wang, Samia S. Ahmed, Katharine L. Majewski, Marina Konopleva, MD PhD, Jerome Tamburini, MD, PhD, Alejandro Gutierrez, MD, Michelle Kelliher, PhD, Julia Etchin, PhD, Irmela Jeremias, MD, Andrew P. Weng, MD PhD, Andrew L Kung, MD PhD, Andrew A Lane, MD PhD, Francine Garnache-Ottou, PhD, Shai Izraeli, MD Prof, Eric Jacobsen, MD, Ilene Galinsky, ANP, Richard M. Stone, MD, Marian H. Harris, MD PhD, David M. Dorfman, MD PhD, Jon C Aster, MDPhD, Henry Long, PhD, Lewis B. Silverman, MD, David M Weinstock, MD

Blood (2015) 126 (23): 3252.

https://doi.org/10.1182/blood.V126.23.3252.3252

Published: 2015

Journal Articles

Phenothiazines Induce Apoptosis in T-Cell Acute Lymphoblastic Leukemia by Activating the Phosphatase Activity of the PP2A Tumor Suppressor

Blood (2012) 120 (21): 3558.

https://doi.org/10.1182/blood.V120.21.3558.3558

Published: 2012

Journal Articles

TYK2-STAT1 Pathway Positively Regulates BCL2 Gene Expression in T-Cell Acute Lymphoblastic Leukemia

Blood (2012) 120 (21): 1470.

https://doi.org/10.1182/blood.V120.21.1470.1470

Published: 2012

Journal Articles

Mutationally Activated TYK2 From T-ALL Specimens Exhibits Tranformative Capacity in Cell Lines and Primary Cell Models and T-Lineage Expansion in Mice

Angela G. Fleischman, MD, PhD, Takaomi Sanda, MD, PhD, Alejandro Gutierrez, MD, Samuel B Luty, Stephanie G Willis, A. Thomas Look, M.D., Brian J. Druker, Jeffrey W Tyner, PhD

Blood (2011) 118 (21): 74.

https://doi.org/10.1182/blood.V118.21.74.74

Published: 2011

Journal Articles

A Notch Mutational Hierarchy Among Human T-ALL Leukemia Stem Cells.

Wenxue Ma, MD, PhD, Alejandro Gutierrez, MD, Daniel Goff, BS, Angela Court-Recart, MS, Alice Shih, BS, Qingfei Jiang, Ph.D., Anil Sadarangani, Ph.D., Christina Wu, Ph.D., Christina Jamieson, Ph.D., Mitchell Diccianni, PhD, Ping Wei, Ph.D., Todd Van Arsdale, PhD, Thomas Look, MD, Catriona Jamieson, MD, PhD

Blood (2010) 116 (21): 1034.

https://doi.org/10.1182/blood.V116.21.1034.1034

Published: 2010

Journal Articles

Pathway Dependence on the Tyrosine Kinase TYK2 and Its Mediator STAT1 In T-Cell Acute Lymphoblastic Leukemia

Takaomi Sanda, MD, PhD, Jeffrey W Tyner, PhD, Alejandro Gutierrez, MD, Vu N Ngo, PhD, Richard Moriggl, Yebin Ahn, Jason M Glover, MD, Bill H Chang, MD, PhD, Stephanie G Willis, Louis M. Staudt, MD, PhD, Brian J Druker, MD, A. Thomas Look, MD

Blood (2010) 116 (21): 3155.

https://doi.org/10.1182/blood.V116.21.3155.3155

Published: 2010

Journal Articles

The BCL11B Tumor Suppressor Is Mutated In Human T-Cell Acute Lymphoblastic Leukemia

Alejandro Gutierrez, MD, Alex Kentsis, MD, PhD, Takaomi Sanda, MD, PhD, Julia Etchin, PhD, Alexei Protopopov, PhD, Jianhua Zhang, PhD, Lynda Chin, MD, Lewis B. Silverman, MD, Stuart Winter, MD, Stephen Hunger, MD, Stephen E. Sallan, MD, Shan Zha, PhD, Frederick Alt, PhD, A. Thomas Look, MD

Blood (2010) 116 (21): 4177.

https://doi.org/10.1182/blood.V116.21.4177.4177

Published: 2010

Journal Articles

RNAi Screen Reveals TYK2 as a Novel Therapeutic Gene Target In T-Cell Acute Lymphoblastic Leukemia

Jeffrey W Tyner, PhD, Takaomi Sanda, MD, PhD, Alejandro Gutierrez, MD, Jason M Glover, MD, Bill H Chang, MD, PhD, Stephanie G Willis, Yebin Ahn, A. Thomas Look, MD, Brian J Druker, MD

Blood (2010) 116 (21): 1001.

https://doi.org/10.1182/blood.V116.21.1001.1001

Published: 2010

Journal Articles

Cross-Species Comparison of Acquired Genetic Changes In T Cell Malignancy.

Lynnie A. Rudner, AB, Kim H. Brown, PhD, Kimberly P. Dobrinski, PhD, Diana F. Bradley, BS, Jonathan Downie, BS, Nathan D. Meeker, MD, Alexandra Smith, BA, Martha Iveth Garcia, Alejandro Gutierrez, MD, Charles Mullighan, MBBS, MD, FRACP, FRCPA, MSc, A. Thomas Look, MD, James R. Downing, MD, Joshua D. Schiffman, MD, Charles Lee, PhD, Nikolaus Trede, MD, PhD, J. Kimble Frazer, MD, PhD

Blood (2010) 116 (21): 1192.

https://doi.org/10.1182/blood.V116.21.1192.1192

Published: 2010

Journal Articles

LEF1 Is a Tumor Suppressor in T Cell Acute Lymphoblastic Leukemia

Alejandro Gutierrez, MD, Takaomi Sanda, MD, PhD, Stuart Winter, MD, Richard S. Larson, MD, PhD, Lewis B. Silverman, MD, Stephen P. Hunger, MD, Stephen E. Sallan, MD, A. Thomas Look, MD

Blood (2008) 112 (11): 3802.

https://doi.org/10.1182/blood.V112.11.3802.3802

Published: 2008

Journal Articles

A Tamoxifen-Dependent Conditional Model of MYC- Induced T Cell Acute Lymphoblastic Leukemia in the Zebrafish.

Alejandro Gutierrez, MD, Hui Feng, PhD, Prochownik Edward, MD, PhD, John Kanki, PhD, A. Thomas Look, MD

Blood (2007) 110 (11): 2808.

https://doi.org/10.1182/blood.V110.11.2808.2808

Published: 2007

Journal Articles

Large Scale Copy Number Variation Upregulates the Expression of MYB in Human T-ALL.

Jennifer O’Neil, PhD, Joelle Tchinda, PhD, Alejandro Gutierrez, MD, Lisa Moreau, Keith McKenna, Richard Maser, PhD, Kwok-Kin Wong, MD, Wen-shu Wu, PhD, Ronald DePinho, MD, Lynda Chin, MD, Charles Lee, PhD, A. Thomas Look, MD

Blood (2006) 108 (11): 1408.

https://doi.org/10.1182/blood.V108.11.1408.1408

Published: 2006

Journal Articles

Emi1 Is Required for Normal Cell Cycle Progression in Zebrafish Myelopoiesis and Likely Functions as a Haploinsufficient Tumor Suppressor on Chromosome 6q in Human Leukmias.

Jennifer Rhodes, PhD, Adam Amsterdam, PhD, Karen Ho, Stefan Heinrichs, PhD, John P. Kanki, PhD, Jennifer E. O’Neil, PhD, Alejandro Gutierrez, MD, Keith McKenna, Hui Feng, PhD, Mark Fleming, MD, Donna Neuberg, ScD, Ilene Galinsky, RN, Richard M. Stone, MD, Nancy Hopkins, PhD, A. Thomas Look, MD

Blood (2006) 108 (11): 1405.

https://doi.org/10.1182/blood.V108.11.1405.1405

Published: 2006

NARROW

Inducible Phase Separation of GSK3α As a Mechanism for Asparaginase Resistance in Acute Leukemias

PRC2 Inactivation Induces Resistance to Chemotherapy-Induced Apoptosis By Upregulating the TRAP1 Mitochondrial Chaperone in T-ALL

Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias

An Off-the-Shelf™ Fratricide-Resistant CAR-T for the Treatment of T Cell Hematologic Malignancies

The Fanconi Pathway in Pediatric T-Cell Acute Lymphoblastic Leukemia

Hedgehog Pathway Mutations Drive Oncogenic Transformation in High-Risk T-Cell Acute Lymphoblastic Leukemia

PRC2 Mutations Induce Resistance to Conventional Chemotherapy By Inhibiting Mitochondrial Apoptosis in T-Cell Acute Lymphoblastic Leukemia

Proxe: A Public Repository of Xenografts to Facilitate Studies of Biology and Expedite Preclinical Drug Development in Leukemia and Lymphoma

Phenothiazines Induce Apoptosis in T-Cell Acute Lymphoblastic Leukemia by Activating the Phosphatase Activity of the PP2A Tumor Suppressor

TYK2-STAT1 Pathway Positively Regulates BCL2 Gene Expression in T-Cell Acute Lymphoblastic Leukemia

Mutationally Activated TYK2 From T-ALL Specimens Exhibits Tranformative Capacity in Cell Lines and Primary Cell Models and T-Lineage Expansion in Mice

A Notch Mutational Hierarchy Among Human T-ALL Leukemia Stem Cells.

Pathway Dependence on the Tyrosine Kinase TYK2 and Its Mediator STAT1 In T-Cell Acute Lymphoblastic Leukemia

The BCL11B Tumor Suppressor Is Mutated In Human T-Cell Acute Lymphoblastic Leukemia

RNAi Screen Reveals TYK2 as a Novel Therapeutic Gene Target In T-Cell Acute Lymphoblastic Leukemia

Cross-Species Comparison of Acquired Genetic Changes In T Cell Malignancy.

LEF1 Is a Tumor Suppressor in T Cell Acute Lymphoblastic Leukemia

A Tamoxifen-Dependent Conditional Model of MYC- Induced T Cell Acute Lymphoblastic Leukemia in the Zebrafish.

Large Scale Copy Number Variation Upregulates the Expression of MYB in Human T-ALL.

Emi1 Is Required for Normal Cell Cycle Progression in Zebrafish Myelopoiesis and Likely Functions as a Haploinsufficient Tumor Suppressor on Chromosome 6q in Human Leukmias.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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