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Journal Articles

Subtractive Interaction Proteomics Reveal a Network of Signaling Pathways Activated By an Oncogenic Transcription Factor in High Risk AML

Claudia Chiriches, PhD, Nathalie Guillen, PhD, Michal Rokicki, Carol Guy, Afsar Mian, PhD, Oliver G. Ottmann, MD, Martin Ruthardt
Journal: Blood
Blood (2018) 132 (Supplement 1): 3917.
https://doi.org/10.1182/blood-2018-99-116631
Published: 2018
Journal Articles

A Network of Activated Cancer Signaling Pathways in a High Risk Subgroup of Acute Myeloid Leukemia Targetable By SRC-Kinase Inhibitors

Claudia Chiriches, PhD, Dilawar Khan, PhD, Nathalie Guillen, PhD, Michal Rokicki, Carol Guy, Afsar Mian, PhD, Oliver G. Ottmann, MD, Martin Ruthardt, MD
Journal: Blood
Blood (2016) 128 (22): 2746.
https://doi.org/10.1182/blood.V128.22.2746.2746
Published: 2016
Journal Articles

The Functional Interplay Between the t(9;22)-Associated Fusion Proteins BCR/ABL and ABL/BCR in Philadelphia Chromosome Positive Acute Lymphatic Leukemia

Afsar Mian, PhD, Anahita Rafiei, Claudia Oancea, PhD, Oliver G. Ottmann, MD, Martin Ruthardt, MD
Journal: Blood
Blood (2014) 124 (21): 2402.
https://doi.org/10.1182/blood.V124.21.2402.2402
Published: 2014
Journal Articles

Transphosphorylation of Endogenous BCR Mediates the Effect of T315I on the Transformation Potential of BCR/ABL

Afsar Mian, PhD, Isabella Haberbosch, Oliver G. Ottmann, MD, Martin Ruthardt, MD
Journal: Blood
Blood (2014) 124 (21): 4523.
https://doi.org/10.1182/blood.V124.21.4523.4523
Published: 2014
Journal Articles

PF-114, a Novel Selective Pan BCR/ABL Inhibitor Targets The T315I and Suppress Models Of Advanced Ph+ ALL

Afsar Mian, PhD, Anahita Rafiei, Anna Metodieva, Isabella Haberbosch, Alexey Zeifman, Ilya Titov, Victor Stroylov, Oleg Stroganov, Fedor Novikov, Oliver G. Ottmann, MD, Ghermes Chilov, Martin Ruthardt, MD
Journal: Blood
Blood (2013) 122 (21): 3907.
https://doi.org/10.1182/blood.V122.21.3907.3907
Published: 2013
Journal Articles

Prominin-1/CD133 Is Involved in the Lineage Decision As Well As a in the Sensitivity to Molecular Therapy in Ph+ Acute Lymphatic Leukemia.

Anna T. Metodieva, Heike Pfeifer, MD, Afsar Mian, PhD, Anja Vogel, Hubert Serve, Prof. Dr. med., Oliver G. Ottmann, MD, Martin Ruthardt, MD
Journal: Blood
Blood (2012) 120 (21): 2579.
https://doi.org/10.1182/blood.V120.21.2579.2579
Published: 2012
Journal Articles

The Reciprocal t(9;22) p96 ABL/BCR fusion Protein Eenhances the Transformation Potential of BCR/ABL and Increases Therapy Resistance in Models of Ph+ Acute Lymphatic Leukemia

Anahita Rafiei, Afsar Mian, PhD, Anna Metodieva, Claudia Oancea, Hubert Serve, MD, Heike Pfeifer, MD, Oliver G. Ottmann, MD, Martin Ruthardt, MD
Journal: Blood
Blood (2012) 120 (21): 3539.
https://doi.org/10.1182/blood.V120.21.3539.3539
Published: 2012
Journal Articles

The Degree of Response of Philadelphia Chromosome Positive Acute Lymphatic Leukemia to Allosteric Inhibition by GNF-2 Depends on the Presence of Either p185-BCR/ABL or p210-BCR/ABL

Afsar Mian, Anna Metodieva, Yousef Najajreh, Hubert Serve, Oliver Ottmann, Jamal Mahajna, Martin Ruthardt
Journal: Blood
Blood (2010) 116 (21): 598.
https://doi.org/10.1182/blood.V116.21.598.598
Published: 2010