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Aaron Schimmer, PhD, MD
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Journal Articles

DNA Demethylation Activity Over Time and Safety Of 3 Different Dose-Escalation Regimens Of SGI-110, a Novel Subcutaneous (SQ) Hypomethylating Agent (HMA), In The Treatment Of Relapsed/Refractory Patients With MDS and AML

Gail J. Roboz, MD, Jean-Pierre Issa, MD, David Rizzieri, MD, Wendy Stock, MD, Casey O'Connell, MD, Karen Yee, MD, Raoul Tibes, MD, Elizabeth A. Griffiths, MD, Katherine Walsh, MD, Eric J. Feldman, MD, Ellen Ritchie, MD, Arati V. Rao, MD, Richard A. Larson, MD, Guillermo Garcia-Manero, MD, Farhad Ravandi, MD, Elias Jabbour, MD, Jorge E. Cortes, MD, Aaron Schimmer, PhD, MD, Ruben A. Mesa, MD, William Blum, MD, Woonbok Chung, PhD, Sue Naim, Pietro Taverna, PhD, Yong Hao, PhD, Gavin Choy, PharmD, Mohammad Azab, MD, Hagop M. Kantarjian, MD
Journal: Blood
Blood (2013) 122 (21): 1548.
https://doi.org/10.1182/blood.V122.21.1548.1548
Published: 2013
Journal Articles

Targeting The Mitochondrial ClpP As a Novel Therapeutic Strategy For Acute Myeloid Leukemia

Alicia Cole, PhD, Zezhou Wang, PhD, Rachel Mattson, Etienne Coyaud, PhD, Rose Hurren, Marcela Gronda, MSc, Fengshu Lin, PhD, Neil Maclean, BSc, Elisa Leung, BSc, Yihua Qiu, MD, Nianxiang Zhang, PhD, Kevin R. Coombes, PhD, Mark D. Minden, MD PhD, Walid A. Houry, PhD, Zenyaho Hao, PhD, Steven M. Kornblau, MD, Brian Raught, PhD, Aaron Schimmer, PhD, MD
Journal: Blood
Blood (2013) 122 (21): 3937.
https://doi.org/10.1182/blood.V122.21.3937.3937
Published: 2013
Journal Articles

FV-162 Is a Novel Orally Bioavailable Proteasome Inhibitor With Improved Pharmacokinetics That Displays Preclinical Efficacy In Vitro and In Vivo

Zezhou Wang, PhD, Peter Dove, Xiaoming Wang, Carolyn A. Goard, PhD, Zhihua Li, Alex Nachman, Yoonsun Jenny Oh, Rose Hurren, Amy Ruschak, PhD, Shane Climie, PhD, David O'Neill, PhD, Barry Press, PhD, Carly Griffin, PhD, Elijus Undzys, Ahmed Aman, PhD, Rima Al-awar, PhD, Lewis Kay, PhD, Suzanne Trudel, MD, MSC, FRCPC, Malik Slassi, PhD, Aaron Schimmer, PhD, MD
Journal: Blood
Blood (2013) 122 (21): 1988.
https://doi.org/10.1182/blood.V122.21.1988.1988
Published: 2013
Journal Articles

Mutations In UBA3 Confer Resistance To The NEDD8-Activating Enzyme Inhibitor MLN4924 In Human Leukemic Cells

G. Wei Xu, MD, PhD, Julia I. Toth, PhD, Sara R. da Silva, BSc, Stacey-Lynn Paiva, BSc, Julie L. Lukkarila, PhD, Rose Hurren, Neil Maclean, BSc, Mahadeo A. Sukhai, PhD, Rabindra N. Bhattacharjee, PhD, Carolyn A. Goard, PhD, Bruno C Medeiros, MD, Patrick T. Gunning, PhD, Sirano Dhe-Paganon, PhD, Matthew D. Petroski, PhD, Aaron Schimmer, PhD, MD
Journal: Blood
Blood (2013) 122 (21): 2527.
https://doi.org/10.1182/blood.V122.21.2527.2527
Published: 2013
Journal Articles

ODE-Adefovir As Potential Therapeutic Agent In AML

Haytham Khoury, MD, Hu Ruijuan, Aaron Schimmer, PhD, MD, Karl Hostetler, MD, Mark D Minden, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 3970.
https://doi.org/10.1182/blood.V122.21.3970.3970
Published: 2013
Journal Articles

Unraveling The Molecular and Metabolic Basis For Glutamine Addiction In Leukemias

Polina Matre, PhD, Ismael Samudio, PhD, Rodrigo Jacamo, PhD, Ying Wang, Jing Wang, R Eric Davis, Xiaohua Su, Sonja Schindela, Rachel Newman, Jianhua Hu, Torsten Haferlach, MD, Michael Andreeff, MD, PhD, Elsa R. Flores, Aaron Schimmer, PhD, MD, Marina Konopleva, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 606.
https://doi.org/10.1182/blood.V122.21.606.606
Published: 2013
Journal Articles

A Phase I Study Of Nilotinib As a c-Kit Inhibitor Combined With Re-Induction Chemotherapy For Relapsed and Refractory c-Kit Positive Acute Myeloid Leukemia

Joseph M. Brandwein, MD, David Hedley, MD, Sue Chow, Karen Yee, MD, Andre C Schuh, MD, Vikas Gupta, MD, FRCP, FRCPath, Aaron Schimmer, PhD, MD, Mark D. Minden, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 3961.
https://doi.org/10.1182/blood.V122.21.3961.3961
Published: 2013