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Journal Articles

ADG153, an Anti-CD47 Monoclonal Antibody Prodrug, Has Strong In Vivo Anti-Tumor Activity, Minimal RBC-Related and Antigen Sink Liabilities, and Extended Half Life in Comparison with Benchmark Clinical Antibodies of the Same IgG Subclass

Bin Cai, Aaron N Nguyen, Songmao Zheng, Jianfeng Shi, Guizhong Liu, Yan Li, Felix Du, Peter Luo, Jiangchun Xu
Journal: Blood
Blood (2021) 138 (Supplement 1): 3342.
https://doi.org/10.1182/blood-2021-152130
Published: 2021
Journal Articles

ADG152, a Novel CD20xCD3 T Cell Engager Prodrug with Enhanced Therapeutic Index, Demonstrates Strong Anti-Tumor Activity with Improved Safety

Bin Cai, Aaron N Nguyen, Songmao Zheng, Jianfeng Shi, Guizhong Liu, Yan Li, Felix Du, Stanley Frankel, Peter Luo, Jiangchun Xu
Journal: Blood
Blood (2021) 138 (Supplement 1): 1204.
https://doi.org/10.1182/blood-2021-147573
Published: 2021
Journal Articles

Inhibition of the TGF-β receptor I kinase promotes hematopoiesis in MDS

Li Zhou, Aaron N. Nguyen, Davendra Sohal, Jing Ying Ma, Perry Pahanish, Krishna Gundabolu, Josh Hayman, Adam Chubak, Yongkai Mo, Tushar D. Bhagat, Bhaskar Das, Ann M. Kapoun, Tony A. Navas, Simrit Parmar, Suman Kambhampati, Andrea Pellagatti, Ira Braunchweig, Ying Zhang, Amittha Wickrema, Satyanarayana Medicherla, Jacqueline Boultwood, Leonidas C. Platanias, Linda S. Higgins, Alan F. List, Markus Bitzer, Amit Verma
Journal: Blood
Blood (2008) 112 (8): 3434–3443.
https://doi.org/10.1182/blood-2008-02-139824
Published: 2008
Includes: Supplemental data
Journal Articles

Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors

Tony A. Navas, Mani Mohindru, Myka Estes, Jing Ying Ma, Lubomir Sokol, Perry Pahanish, Simrit Parmar, Edwin Haghnazari, Li Zhou, Robert Collins, Irene Kerr, Aaron N. Nguyen, Yin Xu, Leonidas C. Platanias, Alan A. List, Linda S. Higgins, Amit Verma
Journal: Blood
Blood (2006) 108 (13): 4170–4177.
https://doi.org/10.1182/blood-2006-05-023093
Published: 2006
Journal Articles

SD-208, a Novel Transforming Growth Factor Beta Receptor I Kinase Inhibitor, Can Stimulate Hematopoiesis in Myelodysplastic Syndrome Progenitors.

Amit Verma, Tony A. Navas, Jing Ying, Ma, Aaron N. Nguyen, Perry Pahanish, Mahesh Seetharam, Irene Kerr, Robert Collins, Mimi Kim, Mani Mohindru, Linda S. Higgins
Journal: Blood
Blood (2005) 106 (11): 3448.
https://doi.org/10.1182/blood.V106.11.3448.3448
Published: 2005
Journal Articles

SCIO-469, a Potent and Selective Inhibitor of the p38a MAPK, Inhibits TNFa-Induced Adhesion of Multiple Myeloma Cells to Bone Marrow Stromal Cells Via Downregulation of Chemokines CXCL10/IP-10 and CCL8.

Aaron N. Nguyen, PhD, Gilbert O’ Young, Diana Quon, Debby Damm, Ann M. Kapoun, PhD, Linda S. Higgins, PhD, Tony A. Navas, PhD
Journal: Blood
Blood (2005) 106 (11): 1569.
https://doi.org/10.1182/blood.V106.11.1569.1569
Published: 2005
Journal Articles

SCIO-469, a Potent and Selective Inhibitor of p38a MAPK, Normalizes the Bone Marrow Microenvironment and Inhibits Multiple Myeloma Cell Proliferation in In Vitro and In Vivo Models.

Aaron N. Nguyen, PhD, Mamatha Reddy, MS, Margaret Henson, MS, Elizabeth G. Stebbins, PhD, Gilbert O’Young, BS, Jing Y. Ma, MD, Edwin Haghnazari, PhD, Ann M. Kapoun, PhD, Satya Medicherla, PhD, Andy Protter, PhD, Tony A. Navas, PhD, Linda S. Higgins, PhD
Journal: Blood
Blood (2004) 104 (11): 1501.
https://doi.org/10.1182/blood.V104.11.1501.1501
Published: 2004
Journal Articles

Inhibition of p38 MAPK by SCIO-469 Suppresses TNF Generation and Promotes CD34+ Cell Survival in an In Vitro MDS Cell Culture Model.

Tony A. Navas, Ph.D., Aaron N. Nguyen, Ph.D., Jing Y. Ma, M.D., Elizabeth G. Stebbins, Ph.D., Edwin Haghnazari, Ph.D., Ruth Heaton, Alan F. List, M.D., Linda S. Higgins, Ph.D.
Journal: Blood
Blood (2004) 104 (11): 3424.
https://doi.org/10.1182/blood.V104.11.3424.3424
Published: 2004