From signaling mediators in stem cells to markers of differentiation and lineage commitment to facilitators for the entry of viruses, such as HIV-1, cell surface heparan sulfate (HS) glycans with distinct modification patterns play important roles in hematopoietic biology. In this review, we provide an overview of the importance of HS and the proteoglycans (HSPGs) to which they are attached within the major cellular subtypes of the hematopoietic system. We summarize the roles of HSPGs, HS, and HS modifications within each main hematopoietic cell lineage of both myeloid and lymphoid arms. Lastly, we discuss the biological advances in the detection of HS modifications and their potential to further discriminate cell types within hematopoietic tissue.
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REVIEW ARTICLE|
June 20, 2024
Heparan sulfates and heparan sulfate proteoglycans in hematopoiesis
Richard T. Piszczatowski,
Richard T. Piszczatowski
1Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY
2Department of Pediatrics, Weill Cornell Medicine, New York Presbyterian Hospital, New York, NY
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Hannes E. Bülow,
Hannes E. Bülow
3Department of Genetics, Albert Einstein College of Medicine, Bronx, NY
4Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY
5Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine-Montefiore Health System, Bronx, NY
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Ulrich Steidl
Ulrich Steidl
1Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY
5Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine-Montefiore Health System, Bronx, NY
6Departments of Oncology, Albert Einstein College of Medicine-Montefiore Health System, Bronx, NY
7Blood Cancer Institute, Albert Einstein College of Medicine, Bronx, NY
8Ruth L. and David S. Gottesman Institute for Stem Cell Research and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, NY
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Blood (2024) 143 (25): 2571–2587.
Article history
Submitted:
October 4, 2023
Accepted:
March 14, 2024
First Edition:
March 25, 2024
Citation
Richard T. Piszczatowski, Hannes E. Bülow, Ulrich Steidl; Heparan sulfates and heparan sulfate proteoglycans in hematopoiesis. Blood 2024; 143 (25): 2571–2587. doi: https://doi.org/10.1182/blood.2023022736
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June 20 2024
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