Methods: CBC, performed by an automated hematology analyzer, included hemoglobin
hematocrit, erythrocytes, MCV, MCH, MCHC, platelets, and white blood cell counts and
differentials (neutrophils, lymphocytes, monocytes, eosinophils, and basophils), as well as red
blood cell distribution width (RDW) and mean platelet volume (MPV). Other indicators were
indirectly calculated (by dividing the numerator by the denominator) based on the values of CBC
and included neutrophils to lymphocyte rate (NLR), monocytes to lymphocyte rate (MLR)
platelets to leukocyte rate (PLR), leukocytes to eosinophil rate (LER), and leukocytes to basophil
rate (LBR). Among them, NLR, MLR, and PLR have been linked to various inflammatory
conditions, but their role in SA diagnosis is unknown. CBC values obtained at diagnosis from a
set of 128 Vietnamese patients with SA (mean age 43, 67% female) treated at Hanoi Medical
University Hospital were compared with those derived from 596 age-matched healthy controls.
Results: Among the values directly obtained from CBC, only neutrophil counts and MPV were
statistically significant between the two groups, with higher neutrophil counts (4,200 vs. 3,700, p
= 0.02) and lower MPV (7.41 vs. 8.35, p = 0.0002) observed in SA patients compared with
controls. The analysis of other indicators showed significantly higher NLR (2.3 vs. 1.8, p = 0.04)
and EBR (4.42 vs. 5.64; p = 0.03) in SA patients compared with controls. No differences in MLR
and PLR were observed between SA patients and controls. In multivariate analysis, a higher
NLR (p = 0.05), lower MPV (p = 0.001), and higher EBR (p = 0.02) remained associated with
the diagnosis of SA.
Conclusions: This study substantiates the relevance of a decreased MPV as well as an increased
NLR and EBR in patients with SA. CBC is a rapid and low-cost test, and NLR and EBR are
easily calculated; thus, these indexes could help clinicians in the diagnosis of SA.
Disclosures
No relevant conflicts of interest to declare.
