Reconceptualizing High ED Use in Patients With SCD
According to a study published in the New England Journal of Medicine, measurable residual disease (MRD)-guided therapy with the BTK inhibitor ibrutinib plus venetoclax ...
Small Activating RNA-Mediated Induction of HBG Gene Via In Vivo Delivery Shows Potential in SCD
In preclinical models of sickle cell disease (SCD), in vivo delivery of small activating RNA (RNAa) oligonucleotides via MT011391, a drug candidate also known as MTL-HBG ...
Pneumococcal Meningitis Mortality Remains High in Children in France With SCD
For children in France with sickle cell disease (SCD), the rate of death caused by pneumococcal meningitis remains high despite pneumococcal conjugate immunization ...
PDMPs May Negatively Affect ED Uptake by People With Sickle Cell Disease
According to a retrospective longitudinal cohort study published in Blood Advances, prescription drug monitoring programs (PDMPs) may impact emergency department ...
SACRED Trial Shows Utility of Hydroxyurea for Stroke Prevention in Hispanic Children with SCA
The Hispanic Caribbean island of the Dominican Republic (DR) has a high overall prevalence of sickle cell anemia (SCA), four times that of the U.S. Study results from the Stroke ...
Altered T-Cell Subsets, Lower Lymphocyte Counts Found in Carriers of Sickle Cell Trait
A study published in Blood and Genomics Discovery has found that individuals carrying sickle cell trait (SCT) have fewer total lymphocytes and certain types of mature T-cell lymphocyte ...
Telemedicine Approach Helps Improve IC-Based SCD Pain Management
An approach that uses telemedicine for triage has helped patients with sickle cell disease (SCD) get infusion center (IC)-based treatment without having to go through the emergency department ...
Study Confirms Safety, Efficacy of Mitapivat to Improve Anemia, Decrease Pain Crises in Sickle Cell Disease
Sickle cell disease (SCD) affects millions of people worldwide and causes reduced quality of life (QoL), negative clinical outcomes, unpredictable pain, anemia, and shortened lifespan ...
Danicopan Plus Ravulizumab, Eculizumab Shows Long-Term Efficacy in PNH With Clinically Significant EVH
In patients with paroxysmal nocturnal hemoglobinuria (PNH) and clinically significant extravascular hemolysis (cs-EVH), treatment with the oral factor D inhibitor danicopan plus C5 inhibitors (C5i) ravulizumab and ...
Patient Motivators Key for Participation in SCD Clinical Trials
During a poster session at the 66th American Society of Hematology (ASH) Annual Meeting and Exposition, Biree Andemariam, MD, a hematologist and founding director of the New England Sickle Cell Institute ...
