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Red Blood Cell and Iron Disorders

December 20, 2021

A collection of features and news articles published in ASH Clinical News related to red blood cell and iron disorders.

Roxadustat Increases Hemoglobin in Patients With Anemia Receiving Myelosuppressive Chemotherapy

In patients with chemotherapy-induced anemia, roxadustat increased hemoglobin regardless of tumor type or chemotherapy regimen, according to data presented at the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting....

Rituximab, Bortezomib, and Dexamethasone Combo Effective in Patients With Warm Autoimmune Hemolytic Anemia

Low-dose rituximab combined with bortezomib and dexamethasone was effective and had an acceptable safety profile in patients with warm autoimmune hemolytic anemia (wAIHA), according to a study published in Medicine (Baltimore)....

Ad Astra: Hemolysis, Anemia Increased During Long-Term Space Flight

Space-related anemia is a hemolytic condition, according to study results published in Nature Medicine. The pattern of hemolysis in the three phases of the study (on Earth, in space, and back on Earth) confirmed that increased hemolysis ...

AML After Lovo-Cel in SCD Likely Independent of Insertional Oncogenesis

A woman with sickle cell disease (SCD) developed acute myeloid leukemia (AML) approximately 5.5 years after being treated with lovotibeglogene autotemcel (lovo-cel) as part of a clinical trial...

Patients With SCD Exhibit Steady Decrease in Lung Function Akin to Declines Seen in Cystic Fibrosis

“Our study helps bring to the forefront that [SCD] should be considered a clinically significant lung disease,” said lead author Shaina Willen, MD, of UC Davis Children’s Hospital in Sacramento, California.

Mortality Trends in Patients With Beta Thalassemia and Pulmonary Arterial Hypertension

Results of a study published in Blood offer greater insight into mortality rates of patients with beta thalassemia and confirmed pulmonary arterial hypertension (PAH). ...

You Make the Call: Would You Consider Oral Iron Chelation in a Patient With Beta Thalassemia Minor and Elevated Serum Ferritin Levels?

A 60-year-old male patient presented with beta thalassemia minor and a hemoglobin level of 12.5 g/dL. He was noted to have persistently elevated serum ferritin levels by his primary care physician with the most recent being 999 mcg/L.

HIF-1 Alpha Inhibitor Roxadustat Holds Promise for MDS-Related Anemia

The first-in-class hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor roxadustat may be a potential new treatment option for lower-risk myelodysplastic syndromes (MDS) ...

You Make the Call: When would you use next-generation sequencing data in the management of anemia?

A 76-year-old woman was referred for anemia. Her hemoglobin level was 8.5 g/dL, her mean corpuscular volume was 88 fL, and she had normal white blood cell and platelet counts. There was no evidence of hemolysis, ...

Researchers Report Positive Early Data for Etavopivat in Sickle Cell Disease

Treatment with etavopivat, a small molecule activator of erythrocyte pyruvate kinase (PKR), improved anemia and decreased intravascular hemolysis in patients with sickle cell disease (SCD) treated for up to 12 weeks....

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