Current Issue

April 2025

Now Enrolling: Vulnerable Populations

Updates to the Declaration of Helsinki encourage researchers to include people who previously were excluded from clinical trials.

Viewpoints

Editor’s Corner

Fax Machines, Hockey Sticks, and AI: How Health Care Can Evolve with Technology

Education

You Make the Call

You Make the Call: How would you treat an older patient presenting with cardiomyopathy, refractory AF, and findings suggestive of cardiac amyloidosis?

You Make the Call Readers' Response

How would you treat an older patient presenting with cardiomyopathy, refractory AF, and findings suggestive of cardiac amyloidosis?

Spotlight

Feature Articles

Now Enrolling: Vulnerable Populations

Drawing First Blood

Should Patients Be Tested for Thrombophilia?

The Search for Research

A Study Evaluating Safety and Efficacy of Venetoclax in Combination With Azacitidine Versus Standard of Care After Allogeneic Stem Cell Transplantation (SCT) in Participants With Acute Myeloid Leukemia (AML) (VIALE-T, NCT04161885)
A Study to Evaluate the Safety and Efficacy of Axatilimab in Combination With Ruxolitinib in Participants With Newly Diagnosed Chronic Graft-Versus-Host Disease (NCT06388564)

News

On Location

IL-15 Agonist Boosts Response in Phase II LBCL CAR-T Trial
Predicting Response to Obe-Cel in Patients With R/R B-ALL
Cilta-Cel Treatment in Lenalidomide-Refractory MM Results in High Rates of MRD Negativity
Study Highlights Characteristics of Post-CAR-T Treatment–Related Myeloid Neoplasms
CAR-T Shows Acceptable Efficacy, Safety in Phase II R/R T-ALL/LBL Study
Multimodal Machine Learning Boosts CAR-T Outcome Prediction in LBCL
Physical Function Can Help Gauge ICANS Risk, Study Finds

In a Different Vein: News from the Blood Journals

Responses to BCMA CAR T Cells Not Durable in Patients with MM with CNS Involvement
Front-Line Brentuximab Vedotin, Nivolumab Plus Chemotherapy Shows Durable Response, Acceptable Safety in Advanced cHL
New Tool Aims to Improve Capture of Patient Outcomes in cGVHD-Associated Sclerosis
SACRED Trial Shows Utility of Hydroxyurea for Stroke Prevention in Hispanic Children with SCA

Literature Scan

Talquetamab Plus Teclistamab Effective for Relapsed or Refractory Multiple Myeloma
Post-Transplant Mutation Clearance Important Indicator of Prognosis for Myelofibrosis
miRNA Identified as Potential ITP Diagnostic Biomarker
Altered T-Cell Subsets, Lower Lymphocyte Counts Found in Carriers of Sickle Cell Trait

ASH Directions

Updated ASH Position Statement Affirms Sickle Cell Trait Is Not a Primary Cause of Sudden Death

Data Stream

April 2025 Data Stream

Online Exclusives

On Location

Non-Viral, Allogeneic BCMA-Directed CAR-T Therapy Eliminates Bridging in R/R MM
Clonal Hematopoiesis Associated With Cytopenias After CAR-T Therapy for MM
Extramedullary Disease Helps Predict Immune Effector Cell Toxicities After CAR-T in MM
Study of LBCL Confirms Prognostic Value of ctDNA in Second-Line Liso-Cel Versus Standard of Care
Teclistamab Safe for Treating Patients with R/R MM with Renal Impairment

In a Different Vein: News from the Blood Journals

BCMA CAR T Cells Effective, Safe for Older Adults and Frail Patients with R/R Multiple Myeloma

Literature Scan

Non-Transplant Salvage Therapy Safe for Pediatric, Adolescent Patients with R/R cHL
Study Suggests Disparities in MM Outcomes Persist on a Global Scale