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Bleeding Disorders

December 20, 2021

A collection of features and news articles published in ASH Clinical News related to bleeding disorders.

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Thromboelastography: Measuring Blood Coagulation in Real Time

The development of thromboelastography (TEG) in 1948 is credited to Dr. Helmut Hartert, who was working at the University of Heidelberg in Germany at the time. Also called a “viscoelastic assay,” this non-invasive test ...

Prophylactic TXA Does Not Prevent Bleeding in Thrombocytopenia From Hematologic Malignancy Treatment

Prophylactic tranexamic acid (TXA) did not decrease World Health Organization (WHO) grade ≥2 bleeding incidence or rates of platelet or red blood cell (RBC) transfusions in patients with thrombocytopenia ...

Switching to Nonacog Beta Pegol Reduces Bleeding Rates in Patients With Hemophilia B

Patients with hemophilia B who switched from recombinant factor IX-Fc-fusion protein (rFIXFc) or standard half-life (SHL) recombinant factor IX (rFIX) to nonacog beta pegol (N9-GP) experienced lower annualized rates of bleeding and reduced factor consumption ...

Long-Term Bleeding Prophylaxis Found Cost-Effective for VWD

Recent guidelines from ASH and other groups conditionally recommend long-term prophylaxis to prevent excess bleeding for patients with von Willebrand disease (VWD), specifically in those with a history of severe and frequent bleeds....

Study Results Further Characterize Genotypes and Therapeutic Response in VWD

Research findings published in Blood Advances offer insights into the genotype characterization of variants of type 2 von Willebrand disease (VWD) and describe the association between VWD genotype and response to desmopressin....

Valoctocogene Roxaparvovec Reduces Bleeding and Use of Factor VIII Concentrate in Severe Hemophilia A

Treatment with valoctocogene roxaparvovec led to endogenous factor VIII production and was associated with significant reductions in bleeding and factor VIII concentrate use compared with factor VIII prophylaxis in patients with severe hemophilia A...

Study Identifies Factors Associated With Bleeding Risk After Total Hip or Knee Arthroplasty

Although there is a high risk of bleeding after total hip arthroplasty (THA) and total knee arthroplasty (TKA) procedures in patients with hemophilia, antifibrinolytic medications may decrease this risk, a new study suggests. ...

Modified Caplacizumab Dosing for iTTP Offers Cost Savings, More Individualized Therapy

The extension of caplacizumab application intervals from daily to alternate-day dosing may be safely considered after three to four weeks of daily treatment in selected patients with immune-mediated thrombotic thrombocytopenic purpura (iTTP)...

You Make the Call: How would you treat a pregnant woman with low VWF, elevated aPTT, and a history of heavy menses?

I have a challenging case of low von Willebrand factor (VWF) levels and a mildly elevated activated partial thromboplastin time (aPTT) in 38-year-old female who is currently six weeks pregnant. She has a history of heavy menses...

Adolescents With Heavy Menstrual Bleeding and Low VWF Exhibit Bleeding-Related Genetic Variants

Heavy menstrual bleeding in adolescents with low levels of von Willebrand factor (VWF) is associated with genetic variations related to anemia and bleeding disorders, according to a study in Blood Advances. ...

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