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Journal Articles

Single cell multiomics reveal divergent effects of DNMT3A and TET2 mutant clonal hematopoiesis in inflammatory response

Wazim Mohammed Ismail, Jenna Fernandez, Moritz Binder, Terra L Lasho, Minsuk Kim, Susan Geyer, Amelia Mazzone, Christy M. Finke, Abhishek A Mangaonkar, Jeong-Heon Lee, Liguo Wang, Kwan Hyun Kim, Vernadette A. Simon, Fariborz Rakhshan Rohakthar, Amik Munankarmy, Seul Kee Byeon, Susan M. Schwager, Jonathan J. Harington, Melissa R. Snyder, Keith D. Robertson, Akhilesh Pandey, Eric D. Wieben, Nicholas Chia, Alexandre Gaspar-Maia, Mrinal M. Patnaik
Journal: Blood Advances
Blood Adv bloodadvances.2024014467.
https://doi.org/10.1182/bloodadvances.2024014467
Published: 2024
Includes: Supplemental data
Journal Articles

Myeloid clonal hematopoiesis of indeterminate potential in patients with chronic lymphocytic leukemia

Clinical Trials & Observations
Abi Vijenthira, Virginia O. Volpe, Aswin Sekar, Roberta Santos Azevedo, Mariia Mikhaleva, Christopher J. Gibson, Stephen P. Martindale, Rayan Fardoun, Svitlana Tyekucheva, Yue Ren, Stacey M. Fernandes, Binyamin A. Knisbacher, Cynthia K. Hahn, Gad Getz, Catherine J. Wu, Matthew S. Davids, Jennifer R. Brown
Journal: Blood Advances
Blood Adv (2024) 8 (23): 5949–5956.
https://doi.org/10.1182/bloodadvances.2024013414
Published: 2024
Includes: Supplemental data
Journal Articles

Development of iPSC-derived human bone marrow organoid for autonomous hematopoiesis and patient-derived HSPC engraftment

Kehan Ren, Ermin Li, Inci Aydemir, Yijie Liu, Xu Han, Honghao Bi, Pan Wang, Kara Tao, Amy Ji, Yi-Hua Chen, Jing Yang, Madina Sukhanova, Peng Ji
Journal: Blood Advances
Blood Adv bloodadvances.2024013361.
https://doi.org/10.1182/bloodadvances.2024013361
Published: 2024
Includes: Supplemental data
Journal Articles

NFAT5 counters long-term IFN-1 responses in hematopoietic stem cells to preserve reconstitution potential

Laia Traveset, Víctor Cerdán Porqueras, Hector Huerga Encabo, Silvia Avalle, Anna Esteve-Codina, Oscar Fornas, Jose Aramburu, Cristina Lopez-Rodriguez
Journal: Blood Advances
Blood Adv (2024) 8 (21): 5510–5526.
https://doi.org/10.1182/bloodadvances.2023011306
Published: 2024
Includes: Supplemental data
Journal Articles

Targeting CDC42 reduces skeletal degeneration after hematopoietic stem cell transplantation

Theresa Landspersky, Merle Stein, Mehmet Saçma, Johanna Geuder, Krischan Braitsch, Jennifer Rivière, Franziska Hettler, Sandra Romero Marquez, Baiba Vilne, Erik Hameister, Daniel Richter, Emely Schönhals, Jan Tuckermann, Mareike Verbeek, Peter Herhaus, Judith S. Hecker, Florian Bassermann, Katharina S. Götze, Wolfgang Enard, Hartmut Geiger, Robert A. J. Oostendorp, Christina Schreck
Journal: Blood Advances
Blood Adv (2024) 8 (20): 5400–5414.
https://doi.org/10.1182/bloodadvances.2024012879
Published: 2024
Includes: Supplemental data
Journal Articles

Impact of cancer therapy on clonal hematopoiesis mutations and subsequent clinical outcomes

Clinical Trials & Observations
Kevin T. Nead, Taebeom Kim, LiJin Joo, Tina L. McDowell, Justin W. Wong, Irenaeus C. C. Chan, Elizabeth Brock, Jing Zhao, Ting Xu, Chad Tang, Chang-Lung Lee, Jun-ichi Abe, Kelly L. Bolton, Zhongxing Liao, Paul A. Scheet, Steven H. Lin
Journal: Blood Advances
Blood Adv (2024) 8 (19): 5215–5224.
https://doi.org/10.1182/bloodadvances.2024012929
Published: 2024
Includes: Supplemental data
Journal Articles

Impact of hydroxyurea on follicle density in patients with sickle cell disease

Tamara Diesch-Furlanetto, Carlos Sanchez, Andrew Atkinson, Corinne Pondarré, Nathalie Dhedin, Bénédicte Neven, Cécile Arnaud, Annie Kamdem, France Pirenne, Gilles Lenaour, Isabelle Brocheriou, Benoit Terris, Françoise Bernaudin, Jean-Hugues Dalle, Catherine Poirot
Journal: Blood Advances
Blood Adv (2024) 8 (19): 5227–5235.
https://doi.org/10.1182/bloodadvances.2023011536
Published: 2024
Includes: Supplemental data
Journal Articles

Hydroxyurea and follicle density in sickle cell

Susan Creary, Chelsea Kebodeaux, Leena Nahata
Journal: Blood Advances
Blood Adv (2024) 8 (19): 5225–5226.
https://doi.org/10.1182/bloodadvances.2024013815
Published: 2024
Journal Articles

CHIP shot: aiming at therapy-induced clonal hematopoiesis

Clinical Trials & Observations
Leo Y. Luo, Alexander G. Bick
Journal: Blood Advances
Blood Adv (2024) 8 (19): 5213–5214.
https://doi.org/10.1182/bloodadvances.2024013724
Published: 2024
Journal Articles

Maintenance of hematopoietic stem cells by tyrosine-unphosphorylated STAT5 and JAK inhibition

Matthew J Williams, Xiaonan Wang, Hugo P Bastos, Gabriela Grondys-Kotarba, Qin Wu, Shucheng Jin, Carys S Johnson, Nicole Mende, Emily Francesca Calderbank, Michelle Wantoch, Hyun Jung Park, Giovanna Mantica, Rebecca Louise Hannah, Nicola K Wilson, Dean C Pask, Tina L Hamilton, Sarah J Kinston, Ryan Asby, Rachel Sneade, E. Joanna Baxter, Peter J Campbell, George S Vassiliou, Elisa Laurenti, PhD, Juan Li, Berthold Gottgens, Anthony R Green
Journal: Blood Advances
Blood Adv bloodadvances.2024014046.
https://doi.org/10.1182/bloodadvances.2024014046
Published: 2024
Includes: Supplemental data
Journal Articles

Association of busulfan exposure and outcomes after HCT for patients with an inborn error of immunity

Tim Bognàr, Moises Garcia-Rosa, Arief Lalmohamed, Tayfun Güngör, Mathias Hauri-Hohl, Susan Prockop, Layne Oram, Sung-Yun Pai, Jordan Brooks, Rada M. Savic, Christopher C. Dvorak, Janel R. Long-Boyle, Maja Krajinovic, Henrique Bittencourt, Anne-Charlotte Teyssier, Yves Théorêt, Cary Martinez, Toine C. G. Egberts, Erin Morales, Mary Slatter, Geoffrey D. E. Cuvelier, Robert Chiesa, Robert F. Wynn, Mary Coussons, Maria P. Cicalese, Marc Ansari, Susan E. Long, Christen L. Ebens, Hannah Lust, Sonali Chaudhury, Christa E. Nath, Peter J. Shaw, Steven J. Keogh, M. Y. Eileen C. van der Stoep, Robbert Bredius, Caroline A. Lindemans, Jaap-Jan Boelens, Imke H. Bartelink
Journal: Blood Advances
Blood Adv (2024) 8 (19): 5137–5145.
https://doi.org/10.1182/bloodadvances.2024013275
Published: 2024
Includes: Supplemental data
Journal Articles

Utilizing epigenetic regulators to improve HSC-based lentiviral gene therapy

Parisa Tajer, Emin Onur Karakaslar, Kirsten Canté-Barrett, Brigitta A. E. Naber, Sandra A. Vloemans, Marja C. J. A. van Eggermond, Marie-Louise van der Hoorn, Erik van den Akker, Karin Pike-Overzet, Frank J. T. Staal
Journal: Blood Advances
Blood Adv (2024) 8 (18): 4936–4947.
https://doi.org/10.1182/bloodadvances.2024013047
Published: 2024
Includes: Supplemental data
Journal Articles

Permissible HLA mismatches in 9/10 unrelated donor pediatric stem cell transplants using HLA-EMMA: an EBMT Inborn Errors Working Party study

Erik G. J. von Asmuth, Fleur Hiensch, Sebastiaan Heidt, Alexander B. Mohseny, Dave L. Roelen, Cynthia S. M. Kramer, Frans H. J. Claas, Michael H. Albert, Bénédicte Neven, Arjan C. Lankester, Adriaan A. van Beek
Journal: Blood Advances
Blood Adv (2024) 8 (18): 4767–4777.
https://doi.org/10.1182/bloodadvances.2024012945
Published: 2024
Includes: Supplemental data
Journal Articles

Genetic deletion of JAM-C in preleukemic cells rewires leukemic stem cell gene expression program in AML

Julien M. P. Grenier, Céline Testut, Matthieu Bal, Florence Bardin, Maria De Grandis, Véronique Gelsi-Boyer, Julien Vernerey, Marjorie Delahaye, Samuel Granjeaud, Christophe Zemmour, Jean-François Spinella, Triantafyllos Chavakis, Stéphane J. C. Mancini, Jean-Marie Boher, Josée Hébert, Guy Sauvageau, Norbert Vey, Jürg Schwaller, Marie-Anne Hospital, Cyril Fauriat, Michel Aurrand-Lions
Journal: Blood Advances
Blood Adv (2024) 8 (17): 4662–4678.
https://doi.org/10.1182/bloodadvances.2023011747
Published: 2024
Includes: Supplemental data
Journal Articles

In utero hematopoietic stem cell transplantation for Fanconi anemia

Leah Swartzrock, Carla Dib, Morgane Denis, Hana Willner, Katie Ho, Ethan Haslett, Jian Han, Wenjing Pan, Miranda Byrne-Steele, Brittany Brown, Mark R. Krampf, Anna Girsen, Yair J. Blumenfeld, Yasser Y. El-Sayed, Maria G. Roncarolo, Tippi C. MacKenzie, Agnieszka D. Czechowicz
Journal: Blood Advances
Blood Adv (2024) 8 (17): 4554–4558.
https://doi.org/10.1182/bloodadvances.2023011894
Published: 2024
Includes: Supplemental data
Journal Articles

Long-term outcomes of peripheral blood stem cell unrelated donors mobilized with filgrastim

Clinical Trials & Observations
Heather E. Stefanski, Michelle Kuxhausen, Stephanie Bo-Subait, Hati Kobusingye, Deborah Mattila, Jennifer Schenfeld, Darcie Sandschafer, Cisio De Oliveira Brandao, Linda J. Burns, Bronwen E. Shaw, Michael A. Pulsipher, John P. Miller, Steven M. Devine
Journal: Blood Advances
Blood Adv (2024) 8 (15): 4196–4206.
https://doi.org/10.1182/bloodadvances.2024012646
Published: 2024
Includes: Supplemental data
Journal Articles

Donor safety confirmed

Jeff Szer
Journal: Blood Advances
Blood Adv (2024) 8 (15): 4194–4195.
https://doi.org/10.1182/bloodadvances.2024013477
Published: 2024
Journal Articles

Chronic TNF in the aging microenvironment exacerbates Tet2 loss-of-function myeloid expansion

Candice Quin, Erica N. DeJong, Amy J. M. McNaughton, Marco M. Buttigieg, Salman Basrai, Sagi Abelson, Maggie J. Larché, Michael J. Rauh, Dawn M. E. Bowdish
Journal: Blood Advances
Blood Adv (2024) 8 (15): 4169–4180.
https://doi.org/10.1182/bloodadvances.2023011833
Published: 2024
Includes: Supplemental data
Journal Articles

Neurobeachin regulates hematopoietic progenitor differentiation and survival by modulating Notch activity

Miguel Ganuza, Antonio Morales-Hernández, Alanna Van Huizen, Ashley Chabot, Trent Hall, Claire Caprio, David Finkelstein, Manfred W. Kilimann, Shannon McKinney-Freeman
Journal: Blood Advances
Blood Adv (2024) 8 (15): 4129–4143.
https://doi.org/10.1182/bloodadvances.2023012426
Published: 2024
Includes: Supplemental data
Journal Articles

A simplified G-CSF–free procedure allows for in vivo HSC gene therapy of sickle cell disease in a mouse model

Chang Li, Anna K. Anderson, Peter Ruminski, Michael Rettig, Darja Karpova, Hans-Peter Kiem, John F. DiPersio, André Lieber
Journal: Blood Advances
Blood Adv (2024) 8 (15): 4089–4101.
https://doi.org/10.1182/bloodadvances.2024012757
Published: 2024
Includes: Supplemental data