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Issue Archive

Volume 3, Issue 15
August 13 2019
Issue Cover

Table of Contents

EXCEPTIONAL CASE REPORT

Clonal expansion of CAR T cells harboring lentivector integration in the CBL gene following anti-CD22 CAR T-cell therapy
Clinical Trials & Observations
Nirali N. Shah,Haiying Qin,Bonnie Yates,Ling Su,Haneen Shalabi,Mark Raffeld,Mark A. Ahlman,Maryalice Stetler-Stevenson,Constance Yuan,Shuang Guo,Siyuan Liu,Stephen H. Hughes,Terry J. Fry,Xiaolin Wu
View Articletitled, Clonal expansion of CAR T cells harboring lentivector integration in the CBL gene following anti-CD22 CAR T-cell therapy

STIMULUS REPORTS

Impact of preleukemic mutations and their persistence on hematologic recovery after induction chemotherapy for AML
Tracy Murphy,Jinfeng Zou,Georgina S. Daher-Reyes,Andrea Arruda,Vikas Gupta,Caroline J. McNamara,Mark D. Minden,Aaron D. Schimmer,Hassan Sibai,Karen W. L. Yee,Mariam Korulla,Tracy Stockley,Suzanne Kamel-Reid,Dawn Maze,Anne Tierens,Scott V. Bratman,Andre C. Schuh,Steven M. Chan
View Articletitled, Impact of preleukemic mutations and their persistence on hematologic recovery after induction chemotherapy for AML
Supplemental data
Ponatinib treatment promotes arterial thrombosis and hyperactive platelets
Alona Merkulova,Steven C. Mitchell,Evi X. Stavrou,Gabriel L. Forbes,Alvin H. Schmaier
View Articletitled, Ponatinib treatment promotes arterial thrombosis and hyperactive platelets
Supplemental data
High mitochondrial mass is associated with reconstitution capacity and quiescence of hematopoietic stem cells
Yuji Takihara,Ayako Nakamura-Ishizu,Darren Qiancheng Tan,Masahiro Fukuda,Takayoshi Matsumura,Mitsuhiro Endoh,Yuichiro Arima,Desmond Wai Loon Chin,Terumasa Umemoto,Michihiro Hashimoto,Hidenobu Mizuno,Toshio Suda
View Articletitled, High mitochondrial mass is associated with reconstitution capacity and quiescence of hematopoietic stem cells
Supplemental data

REVIEW ARTICLES

Pathophysiology and management of monoclonal gammopathy of renal significance
Clinical Trials & Observations
Ankur Jain,Richard Haynes,Jaimal Kothari,Akhil Khera,Maria Soares,Karthik Ramasamy
View Articletitled, Pathophysiology and management of monoclonal gammopathy of renal significance
Supplemental data
Allogeneic reactivity–mediated endothelial cell complications after HSCT: a plea for consensual definitions
Simona Pagliuca,David Michonneau,Flore Sicre de Fontbrune,Aurélien Sutra del Galy,Aliénor Xhaard,Marie Robin,Régis Peffault de Latour,Gérard Socie
View Articletitled, Allogeneic reactivity–mediated endothelial cell complications after HSCT: a plea for consensual definitions

SYSTEMATIC REVIEW

Systematic review and meta-analysis of the efficacy and safety of apixaban compared to rivaroxaban in acute VTE in the real world
Madan Raj Aryal,Rohit Gosain,Anthony Donato,Han Yu,Anjan Katel,Yashoda Bhandari,Rashmi Dhital,Peter A. Kouides
View Articletitled, Systematic review and meta-analysis of the efficacy and safety of apixaban compared to rivaroxaban in acute VTE in the real world
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

A phase 2 study of brentuximab vedotin in patients with CD30-positive advanced systemic mastocytosis
Clinical Trials & Observations
Jason Gotlib,John H. Baird,Tracy I. George,Cheryl Langford,Isabel Reyes,Justin Abuel,Cecelia Perkins,Kurt Schroeder,Prithviraj Bose,Srdan Verstovsek
View Articletitled, A phase 2 study of brentuximab vedotin in patients with CD30-positive advanced systemic mastocytosis
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Phf6-null hematopoietic stem cells have enhanced self-renewal capacity and oncogenic potentials
Yueh-Chwen Hsu,Tsung-Chih Chen,Chien-Chin Lin,Chang-Tsu Yuan,Chia-Lang Hsu,Hsin-An Hou,Chein-Jun Kao,Po-Han Chuang,Yu-Ren Chen,Wen-Chien Chou,Hwei-Fang Tien
View Articletitled, Phf6-null hematopoietic stem cells have enhanced self-renewal capacity and oncogenic potentials
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Interplay between HGAL and Grb2 proteins regulates B-cell receptor signaling
Xiaoyu Jiang,Xiaoqing Lu,Yu Zhang,Leda Lacaria,Brett J. Schuchardt,David C. Mikles,Marco Magistri,Idoia García-Ramírez,Isidro Sanchez-Garcia,Amjad Farooq,Ramiro E. Verdun,Midhat H. Abdulreda,Vincent T. Moy,Izidore S. Lossos
View Articletitled, Interplay between HGAL and Grb2 proteins regulates B-cell receptor signaling
Supplemental data
A pilot study of pembrolizumab in smoldering myeloma: report of the clinical, immune, and genomic analysis
Elisabet E. Manasanch,Guangchun Han,Rohit Mathur,Yun Qing,Zheng Zhang,Hans Lee,Donna M. Weber,Behrang Amini,Zuzana Berkova,Karina Eterovic,Shaojun Zhang,Jianhua Zhang,Xingzhi Song,Xizeng Mao,Margaret Morgan,Lei Feng,Veera Baladandayuthapani,Andrew Futreal,Linghua Wang,Sattva S. Neelapu,Robert Z. Orlowski
View Articletitled, A pilot study of pembrolizumab in smoldering myeloma: report of the clinical, immune, and genomic analysis
Supplemental data

MYELOID NEOPLASIA

The efficiency of murine MLL-ENL–driven leukemia initiation changes with age and peaks during neonatal development
Theresa Okeyo-Owuor,Yanan Li,Riddhi M. Patel,Wei Yang,Emily B. Casey,Andrew S. Cluster,Shaina N. Porter,David Bryder,Jeffrey A. Magee
View Articletitled, The efficiency of murine MLL-ENL–driven leukemia initiation changes with age and peaks during neonatal development
Supplemental data

PLATELETS AND THROMBOPOIESIS

Nix-mediated mitophagy regulates platelet activation and life span
Weilin Zhang,Qi Ma,Sami Siraj,Paul A. Ney,Junling Liu,Xudong Liao,Yefeng Yuan,Wei Li,Lei Liu,Quan Chen
View Articletitled, Nix-mediated mitophagy regulates platelet activation and life span
Supplemental data
Combined deficiency of RAB32 and RAB38 in the mouse mimics Hermansky-Pudlak syndrome and critically impairs thrombosis
Alicia Aguilar,Josiane Weber,Julie Boscher,Monique Freund,Catherine Ziessel,Anita Eckly,Stéphanie Magnenat,Catherine Bourdon,Béatrice Hechler,Pierre H. Mangin,Christian Gachet,François Lanza,Catherine Léon
View Articletitled, Combined deficiency of RAB32 and RAB38 in the mouse mimics Hermansky-Pudlak syndrome and critically impairs thrombosis
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Clinical meaning of PROMIS pain domains for children with sickle cell disease
Clinical Trials & Observations
Ashima Singh,Julie A. Panepinto
View Articletitled, Clinical meaning of PROMIS pain domains for children with sickle cell disease
Insights into determinants of spleen injury in sickle cell anemia
Clinical Trials & Observations
Sara El Hoss,Sylvie Cochet,Mickaël Marin,Claudine Lapouméroulie,Michael Dussiot,Naïm Bouazza,Caroline Elie,Mariane de Montalembert,Cécile Arnaud,Corinne Guitton,Béatrice Pellegrino,Marie Hélène Odièvre,Frédérique Moati,Caroline Le Van Kim,Yves Colin Aronovicz,Wassim El Nemer,Valentine Brousse
View Articletitled, Insights into determinants of spleen injury in sickle cell anemia
Supplemental data

TRANSFUSION MEDICINE

Differences in Steap3 expression are a mechanism of genetic variation of RBC storage and oxidative damage in mice
Heather L. Howie,Ariel M. Hay,Karen de Wolski,Hayley Waterman,Jenna Lebedev,Xiaoyun Fu,Rachel Culp-Hill,Angelo D’Alessandro,James D. Gorham,Matthew S. Ranson,John D. Roback,Peter C. Thomson,James C. Zimring
View Articletitled, Differences in Steap3 expression are a mechanism of genetic variation of RBC storage and oxidative damage in mice
Supplemental data
Incidence and risk factors of transfusion reactions in postpartum blood transfusions
Lars Thurn,Agneta Wikman,Magnus Westgren,Pelle G. Lindqvist
View Articletitled, Incidence and risk factors of transfusion reactions in postpartum blood transfusions

TRANSPLANTATION

Kinetics of immune cell reconstitution predict survival in allogeneic bone marrow and G-CSF–mobilized stem cell transplantation
Clinical Trials & Observations
Edmund K. Waller,Brent R. Logan,Mingwei Fei,Stephanie J. Lee,Dennis Confer,Alan Howard,Shanmuganathan Chandrakasan,Claudio Anasetti,Shanelle M. Fernando,Cynthia R. Giver
View Articletitled, Kinetics of immune cell reconstitution predict survival in allogeneic bone marrow and G-CSF–mobilized stem cell transplantation
Supplemental data

COMMENTARY

Validation of genetic associations with acute GVHD and nonrelapse mortality in DISCOVeRY-BMT
Hancong Tang,Theresa Hahn,Ezgi Karaesmen,Abbas A. Rizvi,Junke Wang,Sophie Paczesny,Tao Wang,Leah Preus,Qianqian Zhu,Yiwen Wang,Christopher A. Haiman,Daniel Stram,Loreall Pooler,Xin Sheng,David Van Den Berg,Guy Brock,Amy Webb,Marcelo C. Pasquini,Philip L. McCarthy,Stephen R. Spellman,Lara E. Sucheston-Campbell
View Articletitled, Validation of genetic associations with acute GVHD and nonrelapse mortality in DISCOVeRY-BMT
  • Cover Image

    Cover Image

    issue cover

    COVER FIGURE
    Features of light chain proximal tubulopathy. Immunohistochemistry stained strongly positive for κ light chain in proximal tubules; λ, not shown, was negative (original magnification ×400; DAB + Harris’s hematoxylin stain). See the article by Jain et al.

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Subsequent malignant neoplasms in patients previously treated with anti-CD19 CAR T-cell therapy
Phillips NS, Mulrooney DA, Williams AM, et al. Neurocognitive impairment associated with chronic morbidity in long-term survivors of Hodgkin Lymphoma. Blood Adv. 2023;7(23):7270-7278.
Unleashed monocytic engagement in Sézary syndrome during the combination of anti-CCR4 antibody with type I interferon
A multicenter study of venetoclax-based treatment for patients with Richter transformation of chronic lymphocytic leukemia
Race and ethnicity reporting and representation in hemophilia clinical trials

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