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Issue Archive

Volume 1, Issue 21
September 26 2017
Issue Cover

Table of Contents

STIMULUS REPORT

TG02 inhibits proteasome inhibitor–induced HSF1 serine 326 phosphorylation and heat shock response in multiple myeloma
Shardule P. Shah,Ajay K. Nooka,Sagar Lonial,Lawrence H. Boise
View Articletitled, TG02 inhibits proteasome inhibitor–induced HSF1 serine 326 phosphorylation and heat shock response in multiple myeloma
Supplemental data

REVIEW ARTICLE

Emerging role of BCR signaling inhibitors in immunomodulation of chronic lymphocytic leukemia
Kamira Maharaj,Eva Sahakian,Javier Pinilla-Ibarz
View Articletitled, Emerging role of BCR signaling inhibitors in immunomodulation of chronic lymphocytic leukemia

HEMATOPOIESIS AND STEM CELLS

TLR5 signaling in murine bone marrow induces hematopoietic progenitor cell proliferation and aids survival from radiation
Benyue Zhang,Damilola Oyewole-Said,Jun Zou,Ifor R. Willliams,Andrew T. Gewirtz
View Articletitled, TLR5 signaling in murine bone marrow induces hematopoietic progenitor cell proliferation and aids survival from radiation
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

CD4 T cells specific for factor VIII are present at high frequency in healthy donors and comprise naïve and memory cells
Sylvain Meunier,Catherine Menier,Elodie Marcon,Sébastien Lacroix-Desmazes,Bernard Maillère
View Articletitled, CD4 T cells specific for factor VIII are present at high frequency in healthy donors and comprise naïve and memory cells
Supplemental data

MYELOID NEOPLASIA

Clinical impact of BAALC expression in high-risk acute promyelocytic leukemia
Clinical Trials & Observations
Antonio R. Lucena-Araujo,Diego A. Pereira-Martins,Luisa C. Koury,Pedro L. Franca-Neto,Juan L. Coelho-Silva,Virginia M. de Deus Wagatsuma,Raul A. M. Melo,Rosane Bittencourt,Katia Pagnano,Ricardo Pasquini,Carlos S. Chiattone,Evandro M. Fagundes,Maria de Lourdes Chauffaille,Stanley L. Schrier,Martin S. Tallman,Raul C. Ribeiro,David Grimwade,Arnold Ganser,Bob Löwenberg,Francesco Lo-Coco,Miguel A. Sanz,Nancy Berliner,Eduardo M. Rego
View Articletitled, Clinical impact of <em>BAALC</em> expression in high-risk acute promyelocytic leukemia
Supplemental data

PLATELETS AND THROMBOPOIESIS

Gene editing rescue of a novel MPL mutant associated with congenital amegakaryocytic thrombocytopenia
Cédric Cleyrat,Romain Girard,Eun H. Choi,Éric Jeziorski,Thierry Lavabre-Bertrand,Sylvie Hermouet,Serge Carillo,Bridget S. Wilson
View Articletitled, Gene editing rescue of a novel <em>MPL</em> mutant associated with congenital amegakaryocytic thrombocytopenia
Supplemental data
A unique microenvironment in the developing liver supports the expansion of megakaryocyte progenitors
Nathalie Brouard,Camille Jost,Nadine Matthias,Camille Albrecht,Sébastien Egard,Poojabahen Gandhi,Catherine Strassel,Tomoko Inoue,Daisuke Sugiyama,Paul J. Simmons,Christian Gachet,Francois Lanza
View Articletitled, A unique microenvironment in the developing liver supports the expansion of megakaryocyte progenitors
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Disease severity and slower psychomotor speed in adults with sickle cell disease
Clinical Trials & Observations
Dana R. Jorgensen,Andrea Metti,Meryl A. Butters,Joseph M. Mettenburg,Caterina Rosano,Enrico M. Novelli
View Articletitled, Disease severity and slower psychomotor speed in adults with sickle cell disease
Supplemental data

THROMBOSIS AND HEMOSTASIS

Safety, pharmacokinetics, and reversal of apixaban anticoagulation with andexanet alfa
Deborah Siegal,Genmin Lu,Janet M. Leeds,Mark Karbarz,Janice Castillo,Vandana Mathur,Athiwat Hutchaleelaha,Uma Sinha,Michael Kitt,Matt McClure,Stanley J. Hollenbach,John T. Curnutte,Pamela B. Conley,Mark Crowther
View Articletitled, Safety, pharmacokinetics, and reversal of apixaban anticoagulation with andexanet alfa
Supplemental data

COMMENTARIES

Systematic STAT3 sequencing in patients with unexplained cytopenias identifies unsuspected large granular lymphocytic leukemia
Elizabeth A. Morgan,Mark N. Lee,Daniel J. DeAngelo,David P. Steensma,Richard M. Stone,Frank C. Kuo,Jon C. Aster,Christopher J. Gibson,R. Coleman Lindsley
View Articletitled, Systematic <em>STAT3</em> sequencing in patients with unexplained cytopenias identifies unsuspected large granular lymphocytic leukemia
Supplemental data
Treatment and relative survival in very elderly patients with DLBCL in The Netherlands: a population-based study, 1989 to 2015
Clinical Trials & Observations
Avinash G. Dinmohamed,Djamila E. Issa,Marjolein W. M. van der Poel,Harry C. Schouten,Pieternella J. Lugtenburg,Martine E. D. Chamuleau,Sonja Zweegman,Otto Visser
View Articletitled, Treatment and relative survival in very elderly patients with DLBCL in The Netherlands: a population-based study, 1989 to 2015
Supplemental data
  • Cover Image

    Cover Image

    issue cover

    COVER FIGURE
    Descriptive illustration highlighting the complex interaction of immune cells within the microenvironment of chronic lymphocytic leukemia (CLL). Abnormal function of immune compartments, especially T cells, contributes to the malignant progression of CLL B cells and may be targeted by B-cell receptor signaling inhibitors. See the article by Maharaj et al.

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