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Journal Articles

Expression Profiling of mRNA By Next Generation Sequencing and the Development of Algorithm for Predicting Response in Acute Myeloid Leukemia

Maher Albitar, MD, Marina Y Konopleva, MD PhD, Hong Zhang, PhD, Ivan De Dios, BS, Wanlong Ma, Spiraggelos Antzoulatos, Steven M. Kornblau, MD, Antonio Cavazos, Sanam Loghavi, MD, Koichi Takahashi, MD, Hagop M. Kantarjian, MD, Courtney D. DiNardo, MDMSc

Blood (2019) 134 (Supplement_1): 1314.

https://doi.org/10.1182/blood-2019-127449

Published: 2019

Journal Articles

SOX17 Is Essential for Integration of Arterial and HOXA Programs in Hemogenic Endothelium

Ho Sun Jung, Gene I. Uenishi, PhD, Mi Ae Park, PhD, Peng Liu, PhD, Matthew Raymond, James Thomson, Irene Ong, Igor Slukvin, MD PhD

Blood (2019) 134 (Supplement_1): 2476.

https://doi.org/10.1182/blood-2019-130789

Published: 2019

Journal Articles

Chromoplexy and Chromothripsis Are Important Prognostically in Myeloma and Deregulate Gene Function By a Range of Mechanisms

Cody Ashby, PhD, Eileen M Boyle, MD MSc, Brian A Walker, PhD, Michael A Bauer, PhD, Katie Rose Ryan, PhD, Judith Dent, Anjan Thakurta, Erin Flynt, Faith E. Davies, MD, Gareth Morgan, MD PhD

Blood (2019) 134 (Supplement_1): 3767.

https://doi.org/10.1182/blood-2019-130335

Published: 2019

Journal Articles

GLI3 repressor determines Hedgehog pathway activation and is required for response to SMO antagonist glasdegib in AML

Parvesh Chaudhry, Mohan Singh, Timothy J. Triche, Monica Guzman, Akil A. Merchant

Blood (2017) 129 (26): 3465–3475.

https://doi.org/10.1182/blood-2016-05-718585

Published: 2017

Includes: Supplemental data

Journal Articles

The GLI-Code As a Potential Therapeutic Target in Myeloid Neoplasms

Sayer Alharbi, PhD, Alek d Nielsen, B.S., Metis Hasipek, PhD, Bartlomiej P Przychodzen, MSc, James G Phillips, PhD, Jaroslaw P Maciejewski, MD PhD FACP, Babal Jha, PhD

Blood (2016) 128 (22): 1655.

https://doi.org/10.1182/blood.V128.22.1655.1655

Published: 2016

Journal Articles

Genomic Profiling Identifies Novel Mutations and Fusion Genes in Newly Diagnosed and Relapsed Pediatric FLT3-ITD-Positive AML

Daelynn R Buelow, PhD, Stanley Pounds, PhD, Yong-Dong Wang, Lei Shi, PhD, Yongjin Li, PhD, David Finkelstein, Sheila A Shurtleff, PhD, Geoffrey A. Neale, PhD, Hiroto Inaba, MD PhD, Raul C. Ribeiro, MD, Dominique Garrison, Shelley Orwick, BS, James S. Blachly, MD, John C. Byrd, MD, Karl Kroll, Tanja A. Gruber, MD PhD, Jeffrey E Rubnitz, MD PhD, Sharyn D Baker, PharmD, PhD

Blood (2016) 128 (22): 2838.

https://doi.org/10.1182/blood.V128.22.2838.2838

Published: 2016

Journal Articles

The Alternate Activation of Hedgehog Pathway, Either in CD138+ or in CD138-CD19+ Multiple Myeloma Primary Cells, Impacts on Disease Outcome

Marina Martello, PhD, Daniel Remondini, PhD, Enrica Borsi, PhD, Mauro Procacci, Barbara Santacroce, Annalisa Pezzi, PhD, Angela Flores Dico, Elena Zamagni, Paola Tacchetti, MD, Lucia Pantani, MD, Giulia Marzocchi, PhD, Giovanni Martinelli, MD PhD, Michele Cavo, Carolina Terragna, PhD

Blood (2015) 126 (23): 2961.

https://doi.org/10.1182/blood.V126.23.2961.2961

Published: 2015

Journal Articles

The Hedgehog Regulated Transcription Factor and Tumor Suppressor, Gli3, Regulates Hematopoietic Stem Cell Number, Self-Renewal and Differentiation

Parvesh Chaudhry, PhD, Mohan Singh, PhD, Amy R McManus, Aparna Jorapur, Stephen James Capone, BS, Giridharan Ramsingh, MD, Akil Merchant, MD

Blood (2015) 126 (23): 2381.

https://doi.org/10.1182/blood.V126.23.2381.2381

Published: 2015

Journal Articles

Presence of Primary Cilia in Human Hematopoietic System

Mohan Singh, PhD, Parvesh Chaudhry, PhD, Giridharan Ramsingh, MD, Akil Merchant, MD

Blood (2015) 126 (23): 4762.

https://doi.org/10.1182/blood.V126.23.4762.4762

Published: 2015

Journal Articles

The Hedgehog Pathway As Targetable Vulnerability with 5-Azacitidine in MDS and AML

Raoul Tibes, MD PhD, Devora Delman, B.S., Nanna Hansen, M.S., Krisstina L. Gowin, DO, Ruben Mesa, MD, James M Bogenberger, PhD

Blood (2014) 124 (21): 4612.

https://doi.org/10.1182/blood.V124.21.4612.4612

Published: 2014

Journal Articles

GLI1 Inhibitor GANT61 Deregulates stat3 Phosphorylation In Chronic Lymphocytic Leukemia Cells

Cheng Wang, Kang Lu MM, Xin Wang

Blood (2013) 122 (21): 4935.

https://doi.org/10.1182/blood.V122.21.4935.4935

Published: 2013

Journal Articles

Transcriptional Regulation Of GLI1 , Potential New Therapeutic Target For Diffuse Large B-Cell Lymphoma

Nitin K Agarwal, PhD, Kranthi Kunkalla, MS, David H Hawke, PhD, Yadong Liu, MD, Changju Qu, MD PhD, Francisco Vega, MD, PhD

Blood (2013) 122 (21): 2513.

https://doi.org/10.1182/blood.V122.21.2513.2513

Published: 2013

Journal Articles

High-Resolution Genomic Methylation Analysis Using Next Generation Sequencing Identifies Loci Associated With Differential Prognosis In Mantle Cell Lymphoma Patients Treated With Bortezomib + DA-EPOCH-R

Violetta V. Leshchenko, PhD, Pei-Yu Kuo, MS, Deepak Perumal, PhD, Melissa J Fazzari, PhD, Francine E. Garrett-Bakelman, MD, PhD, Nakhle S Saba, MD, Delong Liu, PhD, Weijia Zhang, PhD, Joshua Brody, MD, Ari M. Melnick, MD, Kieron Dunleavy, MD, Wyndham H Wilson, MD, PhD, Adrian Wiestner, MD, PhD, Samir Parekh, MD

Blood (2013) 122 (21): 3760.

https://doi.org/10.1182/blood.V122.21.3760.3760

Published: 2013

Journal Articles

The Transcription Factor GLI3 Is a Novel Candidate Effector Of Toll-Like Receptor 4 (TLR4) Signaling In Monocytes

Shannon K. Boi, BS, Martin E. Fernandez-Zapico, MD, Sherine F. Elsawa, PhD

Blood (2013) 122 (21): 2269.

https://doi.org/10.1182/blood.V122.21.2269.2269

Published: 2013

Journal Articles

Expression Of Hedgehog Pathway Mediator Gli2 Represents a Clinically Negative Prognostic Marker In Acute Myeloid Leukemia and Its Inhibitor GANT61 Exerts Anti-Leukemic Effects In Vitro

Jasmin Wellbrock, Ph.D., Julian M Koehler, Katharina Wagner, MD, Emily Latuske, M.Sc., Hauke Stamm, M.Sc., Eik Vettorazzi, M.Sc., Gabi Vohwinkel, M.Sc., Marianne Klokow, Roswitha Kuhling-Thees, Sonja Loges, MD, Ph.D, Michael Amling, MD, Carsten Bokemeyer, MD, Michael Heuser, MD, Juergen Krauter, MD, Walter Fiedler, MD

Blood (2013) 122 (21): 53.

https://doi.org/10.1182/blood.V122.21.53.53

Published: 2013

Journal Articles

Gli3-mediated hedgehog inhibition in human pluripotent stem cells initiates and augments developmental programming of adult hematopoiesis

Brendan A. S. McIntyre, Veronica Ramos-Mejia, Shravanti Rampalli, Rami Mechael, Jong-Hee Lee, Cantas Alev, Guojun Sheng, Mickie Bhatia

Blood (2013) 121 (9): 1543–1552.

https://doi.org/10.1182/blood-2012-09-457747

Published: 2013

Includes: Supplemental data

Journal Articles

Analysis of Wnt and Hedgehog Pathways Regulating Protein Kinases CK1 and CK2 in Acute Myeloid Leukemia Cells and Stem Cells: Correlation with the Expression of Wnt and Hedgehog Targets and Biological and Clinical Features.

Alessandra Brancalion, Laura Quotti Tubi, Sabrina Manni, Anna Cabrelle, Fortunato Zaffino, Carmela Gurrieri, Gianpietro Semenzato, Francesco Piazza

Blood (2012) 120 (21): 2501.

https://doi.org/10.1182/blood.V120.21.2501.2501

Published: 2012

Journal Articles

Cycling Toward Leukemia Stem Cell Elimination Wtih a Selective Sonic Hedgehog Antagonist,

Blood (2011) 118 (21): 3776.

https://doi.org/10.1182/blood.V118.21.3776.3776

Published: 2011

Journal Articles

Expression of Gli2, a Downstream Mediator of the Activated Hedgehog Pathway, Represents a Negative Prognostic Marker in AML,

Walter Fiedler, M.D., Gabi Vohwinkel, MSc, Juergen Krauter, MD, Eik Vettorazzi, MSc, Sonja Loges, M.D., Ph.D., Livia Fuhrmann, Patrizia Seyfert, Carsten Bokemeyer, M.D., Jasmin Wellbrock, PhD

Blood (2011) 118 (21): 3535.

https://doi.org/10.1182/blood.V118.21.3535.3535

Published: 2011

Journal Articles

Whole-Transcriptome Sequencing In Chronic Myeloid Leukemia Reveals Novel Gene Mutations That May Be Associated with Disease Pathogenesis and Progression

Simona Soverini, Angela Poerio, Alberto Ferrarini, Ilaria Iacobucci, Marco Sazzini, Joannah Score, PhD, Enrico Giacomelli, Luciano Xumerle, Sabrina Colarossi, Alessandra Gnani, Fausto Castagnetti, Francesca Palandri, Gabriele Gugliotta, Marilina Amabile, Gianantonio Rosti, Michele Baccarani, Nicholas C. P. Cross, MD, Massimo Delledonne, Giovanni Martinelli

Blood (2010) 116 (21): 885.

https://doi.org/10.1182/blood.V116.21.885.885

Published: 2010

NARROW

Expression Profiling of mRNA By Next Generation Sequencing and the Development of Algorithm for Predicting Response in Acute Myeloid Leukemia

SOX17 Is Essential for Integration of Arterial and HOXA Programs in Hemogenic Endothelium

Chromoplexy and Chromothripsis Are Important Prognostically in Myeloma and Deregulate Gene Function By a Range of Mechanisms

GLI3 repressor determines Hedgehog pathway activation and is required for response to SMO antagonist glasdegib in AML

The GLI-Code As a Potential Therapeutic Target in Myeloid Neoplasms

Genomic Profiling Identifies Novel Mutations and Fusion Genes in Newly Diagnosed and Relapsed Pediatric FLT3-ITD-Positive AML

The Alternate Activation of Hedgehog Pathway, Either in CD138+ or in CD138-CD19+ Multiple Myeloma Primary Cells, Impacts on Disease Outcome

The Hedgehog Regulated Transcription Factor and Tumor Suppressor, Gli3, Regulates Hematopoietic Stem Cell Number, Self-Renewal and Differentiation

Presence of Primary Cilia in Human Hematopoietic System

The Hedgehog Pathway As Targetable Vulnerability with 5-Azacitidine in MDS and AML

GLI1 Inhibitor GANT61 Deregulates stat3 Phosphorylation In Chronic Lymphocytic Leukemia Cells

Transcriptional Regulation Of GLI1 , Potential New Therapeutic Target For Diffuse Large B-Cell Lymphoma

High-Resolution Genomic Methylation Analysis Using Next Generation Sequencing Identifies Loci Associated With Differential Prognosis In Mantle Cell Lymphoma Patients Treated With Bortezomib + DA-EPOCH-R

The Transcription Factor GLI3 Is a Novel Candidate Effector Of Toll-Like Receptor 4 (TLR4) Signaling In Monocytes

Expression Of Hedgehog Pathway Mediator Gli2 Represents a Clinically Negative Prognostic Marker In Acute Myeloid Leukemia and Its Inhibitor GANT61 Exerts Anti-Leukemic Effects In Vitro

Gli3-mediated hedgehog inhibition in human pluripotent stem cells initiates and augments developmental programming of adult hematopoiesis

Analysis of Wnt and Hedgehog Pathways Regulating Protein Kinases CK1 and CK2 in Acute Myeloid Leukemia Cells and Stem Cells: Correlation with the Expression of Wnt and Hedgehog Targets and Biological and Clinical Features.

Cycling Toward Leukemia Stem Cell Elimination Wtih a Selective Sonic Hedgehog Antagonist,

Expression of Gli2, a Downstream Mediator of the Activated Hedgehog Pathway, Represents a Negative Prognostic Marker in AML,

Whole-Transcriptome Sequencing In Chronic Myeloid Leukemia Reveals Novel Gene Mutations That May Be Associated with Disease Pathogenesis and Progression

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American Society of Hematology

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ASH Publications

American Society of Hematology

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