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Journal Articles

Mebendazole Mediates Its Anti-Leukemic Effects By Proteasomal Degradation of GLI Transcription Factors Via Inhibition of HSP70/90-Chaperone Activity in Acute Myeloid Leukemia in a Preclinical and Clinical Setting

Fabian Freisleben, Hauke Stamm, PhD, Jana Muschhammer, Vanessa Thaden, Franziska Modemann, MD, Alexander Krispien, Franziska Brauneck, Jasmin Wellbrock, PhD, Walter Fiedler, MD

Blood (2019) 134 (Supplement_1): 5050.

https://doi.org/10.1182/blood-2019-129973

Published: 2019

Journal Articles

Novel Role of Raft-Associated Smoothened (SMO) in AKT Signal Regulation in Diffuse Large B Cell Lymphoma

Nitin Agarwal, PhD, Kranthi Kunkalla, Daniel Bilbao, PhD, Ralf Landgraf, PhD, Francisco Vega, MD PhD

Blood (2019) 134 (Supplement_1): 3972.

https://doi.org/10.1182/blood-2019-121847

Published: 2019

Journal Articles

Mebendazole Exerts Potent Anti-Leukemic Effects By Downregulating Protein Levels of Hedgehog Transcription Factors GLI1 and GLI2

Fabian Freisleben, Hauke Stamm, PhD, Jana Muschhammer, Alexander Krispien, Vanessa Thaden, Jasmin Wellbrock, PhD, Walter Fiedler, MD

Blood (2018) 132 (Supplement 1): 5145.

https://doi.org/10.1182/blood-2018-99-118189

Published: 2018

Journal Articles

Predicting Drug Response and Novel Therapeutic Candidates Using Signatures of Molecular Alterations in Hematologic Malignancies

Guillaume Labilloy, MS, Eric O'Brien, BSc, Brett VanCauwenbergh, BSc, Luke Byerly, BSc, Mitali Basu, MSc, William Seibel, PhD, Erin H. Breese, MD PhD, John Peter Perentesis, MD, Mayur Sarangdhar, PhD

Blood (2018) 132 (Supplement 1): 2219.

https://doi.org/10.1182/blood-2018-99-119933

Published: 2018

Journal Articles

Therapeutic Targeting of GLI1 in Acute Myeloid Leukemia

Metis Hasipek, PhD, Sayer Al-Harbi, PhD, James G Phillips, PhD, Bartlomiej P. Przychodzen, MSc, Alek Nielsen, BS, Yihong Guan, PhD, Dale Grabowski, BS, Phillip J Maciejewski, Aziz Nazha, MD, Hetty E. Carraway, MD MBA, Jaroslaw P. Maciejewski, PhD MD FACP, Babal K Jha, PhD

Blood (2017) 130 (Supplement 1): 2654.

https://doi.org/10.1182/blood.V130.Suppl_1.2654.2654

Published: 2017

Journal Articles

Drug-Insensitive CML Stem/Progenitor Cells Highly Express Key Regulators of the Hedgehog Pathway and Inhibition of the Hedgehog Pathway Enhances Their Response to TKI Treatment

Kelly A. Turner, BSc, Katharina Rothe, PhD, Adrian Woolfson, MD PhD, Xiaoyan Jiang, MD PhD

Blood (2016) 128 (22): 4236.

https://doi.org/10.1182/blood.V128.22.4236.4236

Published: 2016

Journal Articles

The GLI-Code As a Potential Therapeutic Target in Myeloid Neoplasms

Sayer Alharbi, PhD, Alek d Nielsen, B.S., Metis Hasipek, PhD, Bartlomiej P Przychodzen, MSc, James G Phillips, PhD, Jaroslaw P Maciejewski, MD PhD FACP, Babal Jha, PhD

Blood (2016) 128 (22): 1655.

https://doi.org/10.1182/blood.V128.22.1655.1655

Published: 2016

Journal Articles

Biomarker and Gene Profiling Analyses in Acute Myeloid Leukemia during Treatment with Hedgehog Signaling Inhibitor

Seiji Kakiuchi, MD, Yosuke Minami, MD PhD, Nobuaki Fukushima, MD, Hiroshi Matsuoka, MD PhD, Tomoki Naoe, MD PhD, Hironobu Minami, MD D.MDSci.

Blood (2015) 126 (23): 1263.

https://doi.org/10.1182/blood.V126.23.1263.1263

Published: 2015

Journal Articles

The Hedgehog Regulated Transcription Factor and Tumor Suppressor, Gli3, Regulates Hematopoietic Stem Cell Number, Self-Renewal and Differentiation

Parvesh Chaudhry, PhD, Mohan Singh, PhD, Amy R McManus, Aparna Jorapur, Stephen James Capone, BS, Giridharan Ramsingh, MD, Akil Merchant, MD

Blood (2015) 126 (23): 2381.

https://doi.org/10.1182/blood.V126.23.2381.2381

Published: 2015

Journal Articles

The Alternate Activation of Hedgehog Pathway, Either in CD138+ or in CD138-CD19+ Multiple Myeloma Primary Cells, Impacts on Disease Outcome

Marina Martello, PhD, Daniel Remondini, PhD, Enrica Borsi, PhD, Mauro Procacci, Barbara Santacroce, Annalisa Pezzi, PhD, Angela Flores Dico, Elena Zamagni, Paola Tacchetti, MD, Lucia Pantani, MD, Giulia Marzocchi, PhD, Giovanni Martinelli, MD PhD, Michele Cavo, Carolina Terragna, PhD

Blood (2015) 126 (23): 2961.

https://doi.org/10.1182/blood.V126.23.2961.2961

Published: 2015

Journal Articles

A Novel Mechanism of GLI2 Mediated Regulation of IgM Secretion in Waldenström Macroglobulinemia

David A. Jackson, Timothy D. Smith, MS, Nansalmaa Amarsaikhan, PhD, Ann Vrabel, Ezequiel Tolosa, PhD, Luciana L. Almada, PhD, Martin E. Fernandez-Zapico, MD, Sherine F. Elsawa, PhD

Blood (2014) 124 (21): 3006.

https://doi.org/10.1182/blood.V124.21.3006.3006

Published: 2014

Journal Articles

Aberrant Hedgehog Pathway Activity Marks Clinical MDS Progression and Accelerates Leukemic Transformation in Vivo

Lukasz P Gondek, MD PhD, Yiting Lim, PhD, Hideki Makishima, MD PhD, Qiuju Wang, MA, Jaroslaw P. Maciejewski, MD PhD FACP, Peter D Aplan, MD, Amy E. DeZern, MD MHS, William Matsui, MD

Blood (2014) 124 (21): 528.

https://doi.org/10.1182/blood.V124.21.528.528

Published: 2014

Journal Articles

Steap3 Is a Novel Candidate Gene for Regulating the RBC Blood Storage Lesion By Mitigating Peroxidation of Membrane Lipids in a Mouse Model

Karen S deWolski, Hayley R Waterman, Peter C Thomson, PhD, James D Gorham, MD PhD, Matthew S Ranson, Heather L Howie, PhD, Adam Munday, PhD, Jill M Johnsen, MD, James C. Zimring, MD PhD

Blood (2014) 124 (21): 760.

https://doi.org/10.1182/blood.V124.21.760.760

Published: 2014

Journal Articles

GLI2 Transcription Factor Modulates CD40 Ligand Expression In Bone Marrow Stromal Cells

Matthew S. Neil, BS, Joel R. Dennison, Martin E. Fernandez-Zapico, MD, Sherine F. Elsawa, PhD

Blood (2013) 122 (21): 4271.

https://doi.org/10.1182/blood.V122.21.4271.4271

Published: 2013

Journal Articles

GLI1 Inhibitor GANT61 Deregulates stat3 Phosphorylation In Chronic Lymphocytic Leukemia Cells

Cheng Wang, Kang Lu MM, Xin Wang

Blood (2013) 122 (21): 4935.

https://doi.org/10.1182/blood.V122.21.4935.4935

Published: 2013

Journal Articles

Transcriptional Regulation Of GLI1 , Potential New Therapeutic Target For Diffuse Large B-Cell Lymphoma

Nitin K Agarwal, PhD, Kranthi Kunkalla, MS, David H Hawke, PhD, Yadong Liu, MD, Changju Qu, MD PhD, Francisco Vega, MD, PhD

Blood (2013) 122 (21): 2513.

https://doi.org/10.1182/blood.V122.21.2513.2513

Published: 2013

Journal Articles

GLI Transcription Factors Modulate IgM Secretion In Waldenström Macroglobulinemia

Nansalmaa Amarsaikhan, PhD, Joel R. Dennison, Shannon K. Boi, BS, Matthew S. Neil, BS, Sherine F. Elsawa, PhD

Blood (2013) 122 (21): 1771.

https://doi.org/10.1182/blood.V122.21.1771.1771

Published: 2013

Journal Articles

Expression Of Hedgehog Pathway Mediator Gli2 Represents a Clinically Negative Prognostic Marker In Acute Myeloid Leukemia and Its Inhibitor GANT61 Exerts Anti-Leukemic Effects In Vitro

Jasmin Wellbrock, Ph.D., Julian M Koehler, Katharina Wagner, MD, Emily Latuske, M.Sc., Hauke Stamm, M.Sc., Eik Vettorazzi, M.Sc., Gabi Vohwinkel, M.Sc., Marianne Klokow, Roswitha Kuhling-Thees, Sonja Loges, MD, Ph.D, Michael Amling, MD, Carsten Bokemeyer, MD, Michael Heuser, MD, Juergen Krauter, MD, Walter Fiedler, MD

Blood (2013) 122 (21): 53.

https://doi.org/10.1182/blood.V122.21.53.53

Published: 2013

Journal Articles

Analysis of Wnt and Hedgehog Pathways Regulating Protein Kinases CK1 and CK2 in Acute Myeloid Leukemia Cells and Stem Cells: Correlation with the Expression of Wnt and Hedgehog Targets and Biological and Clinical Features.

Alessandra Brancalion, Laura Quotti Tubi, Sabrina Manni, Anna Cabrelle, Fortunato Zaffino, Carmela Gurrieri, Gianpietro Semenzato, Francesco Piazza

Blood (2012) 120 (21): 2501.

https://doi.org/10.1182/blood.V120.21.2501.2501

Published: 2012

Journal Articles

Cycling Toward Leukemia Stem Cell Elimination Wtih a Selective Sonic Hedgehog Antagonist,

Blood (2011) 118 (21): 3776.

https://doi.org/10.1182/blood.V118.21.3776.3776

Published: 2011

NARROW

Mebendazole Mediates Its Anti-Leukemic Effects By Proteasomal Degradation of GLI Transcription Factors Via Inhibition of HSP70/90-Chaperone Activity in Acute Myeloid Leukemia in a Preclinical and Clinical Setting

Novel Role of Raft-Associated Smoothened (SMO) in AKT Signal Regulation in Diffuse Large B Cell Lymphoma

Mebendazole Exerts Potent Anti-Leukemic Effects By Downregulating Protein Levels of Hedgehog Transcription Factors GLI1 and GLI2

Predicting Drug Response and Novel Therapeutic Candidates Using Signatures of Molecular Alterations in Hematologic Malignancies

Therapeutic Targeting of GLI1 in Acute Myeloid Leukemia

Drug-Insensitive CML Stem/Progenitor Cells Highly Express Key Regulators of the Hedgehog Pathway and Inhibition of the Hedgehog Pathway Enhances Their Response to TKI Treatment

The GLI-Code As a Potential Therapeutic Target in Myeloid Neoplasms

Biomarker and Gene Profiling Analyses in Acute Myeloid Leukemia during Treatment with Hedgehog Signaling Inhibitor

The Hedgehog Regulated Transcription Factor and Tumor Suppressor, Gli3, Regulates Hematopoietic Stem Cell Number, Self-Renewal and Differentiation

The Alternate Activation of Hedgehog Pathway, Either in CD138+ or in CD138-CD19+ Multiple Myeloma Primary Cells, Impacts on Disease Outcome

A Novel Mechanism of GLI2 Mediated Regulation of IgM Secretion in Waldenström Macroglobulinemia

Aberrant Hedgehog Pathway Activity Marks Clinical MDS Progression and Accelerates Leukemic Transformation in Vivo

Steap3 Is a Novel Candidate Gene for Regulating the RBC Blood Storage Lesion By Mitigating Peroxidation of Membrane Lipids in a Mouse Model

GLI2 Transcription Factor Modulates CD40 Ligand Expression In Bone Marrow Stromal Cells

GLI1 Inhibitor GANT61 Deregulates stat3 Phosphorylation In Chronic Lymphocytic Leukemia Cells

Transcriptional Regulation Of GLI1 , Potential New Therapeutic Target For Diffuse Large B-Cell Lymphoma

GLI Transcription Factors Modulate IgM Secretion In Waldenström Macroglobulinemia

Expression Of Hedgehog Pathway Mediator Gli2 Represents a Clinically Negative Prognostic Marker In Acute Myeloid Leukemia and Its Inhibitor GANT61 Exerts Anti-Leukemic Effects In Vitro

Analysis of Wnt and Hedgehog Pathways Regulating Protein Kinases CK1 and CK2 in Acute Myeloid Leukemia Cells and Stem Cells: Correlation with the Expression of Wnt and Hedgehog Targets and Biological and Clinical Features.

Cycling Toward Leukemia Stem Cell Elimination Wtih a Selective Sonic Hedgehog Antagonist,

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American Society of Hematology

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ASH Publications

American Society of Hematology

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