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Journal Articles

Venetoclax Dosing in Combination with Antifungal Agents: Real World Experience in Patients with Acute Myeloid Leukemia

Caitlin R. Rausch, PharmD, Courtney D. DiNardo, MDMSc, Abhishek Maiti, MBBS, Nadya Jammal, PharmD, Tapan M. Kadia, MD, Kayleigh Marx, PharmD, Gautam M. Borthakur, MD, J Michael Savoy, PharmD, Naveen Pemmaraju, MD, Adam Dipippo, PharmD, Naval G. Daver, MD, Serena Chew, PharmD, Koji Sasaki, MD, Ghayas C. Issa, MD, Kiran Naqvi, MDMPH, Farhad Ravandi, MD, Hagop M. Kantarjian, MD, Marina Y Konopleva, MD PhD

Blood (2019) 134 (Supplement_1): 2640.

https://doi.org/10.1182/blood-2019-131988

Published: 2019

Journal Articles

Isavuconazole (ISAV) As Primary Anti-Fungal Prophylaxis in Acute Myeloid Leukemia or Myelodysplastic Syndrome: An Open-Label, Prospective Study

Blood (2018) 132 (Supplement 1): 2674.

https://doi.org/10.1182/blood-2018-99-111727

Published: 2018

Journal Articles

In Vivo Evaluation of Novel Geranylgeranyl Diphosphate Synthase Inhibitors

Staci L. Haney, PhD, Yashpal S. Chhonker, PhD, Michelle L. Varney, MS, Geoffrey A. Talmon, MD, Daryl J. Murry, PharmD, Sarah A. Holstein, MD PhD

Blood (2018) 132 (Supplement 1): 215.

https://doi.org/10.1182/blood-2018-99-113007

Published: 2018

Journal Articles

Isoprenoid Amide Bisphosphonates As a Novel Class of Geranylgeranyl Diphosphate Synthase Inhibitors

Michelle L. Varney, MS, Daniel B. Goetz, BA, David F. Wiemer, PhD, Sarah A. Holstein, MD PhD

Blood (2018) 132 (Supplement 1): 4679.

https://doi.org/10.1182/blood-2018-99-112965

Published: 2018

Journal Articles

Incidence of Breakthrough Invasive Fungal Infections after Posaconazole Prophylaxis in Allogeneic Stem Cell Transplant Patients

Rayaz Ahmed, MD DM, Sanghmitra Thakur, MSc, Jyotsna Kapoor, MSc, Narendra Agrawal, MD DM, Pallavi Mehta, MD DM, Shinto Francis Thekuddan, MD DM, Ambar Garg, MD, Dinesh Bhurani, MD DM, FRCPA

Blood (2018) 132 (Supplement 1): 5695.

https://doi.org/10.1182/blood-2018-99-118157

Published: 2018

Journal Articles

Preclinical Investigation of a Potent Geranylgeranyl Diphosphate Synthase Inhibitor

Staci L. Haney, PhD, Yashpal S. Chhonker, PhD, Michelle L. Varney, MS, Geoffrey A. Talmon, MD, Daryl J. Murry, PharmD, Sarah A. Holstein, MD PhD

Blood (2017) 130 (Supplement 1): 4625.

https://doi.org/10.1182/blood.V130.Suppl_1.4625.4625

Published: 2017

Journal Articles

Anti-Fungal Prophylaxis Using Intermediate Dose Ambisome Is Associated with Delayed Methotrexate Clearance in Pediatric Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Liora M. Schultz, MD, Karan Kumar, MD, Suzette Stone, Elizabeth Callard, Jessica Witkowski, MD, Leigh Shinn, Lisa Pinner, Shizuka Franklin, Julianna Kula, Namrata Patel, Prianka Kumar, Kenneth I. Weinberg, MD, Matthew Porteus, MD PhD, Rajni Agarwal, MD, Ami Shah, MD, Sandhya Kharbanda, MD

Blood (2016) 128 (22): 5762.

https://doi.org/10.1182/blood.V128.22.5762.5762

Published: 2016

Journal Articles

Synergistic Inhibition of Geranylgeranyl Diphosphate Synthase By a Mixture of Olefin Stereoisomers

Cheryl Allen, BS, Joseph I. Metzger, BA, Veronica S. Wills, PhD, Huaxiang Tong, PhD, Sandhya Kortagere, PhD, David F. Wiemer, PhD, Sarah A. Holstein, MD PhD

Blood (2016) 128 (22): 2320.

https://doi.org/10.1182/blood.V128.22.2320.2320

Published: 2016

Journal Articles

Pharmacokinetic Analysis during Antifungal Prophylaxis with Posaconazole Suspension in Pediatric and Adolescent Patients after Allogeneic Hematopoietic Stem Cell Transplantation

Michaela Döring, MD, Karin Melanie Cabanillas Stanchi, Manon Queudeville, MD, Judith Feucht, MD, Patrick Schlegel, MD, Tobias Feuchtinger, MD, Peter Lang, MD, Rupert Handgretinger, Prof. MD, Werner J. Heinz, MD

Blood (2015) 126 (23): 4338.

https://doi.org/10.1182/blood.V126.23.4338.4338

Published: 2015

Journal Articles

Whole Genome Sequencing of Azole-Resistant Aspergillus Fumigatus Strains from Hematopoietic Stem Cell Recipients Identifies Candidate Molecular Targets Potentially Implicated in Novel Resistance Mediating Mechanisms - First Results

Maximilian Mossner, Birgit Spiess, PhD, Johann-Christoph Jann, Verena Nowak, Julia Obländer, Oliver Bader, Wolf-Karsten Hofmann, MD, Daniel Nowak, MD, Dieter Buchheidt, MD, Tobias Boch, MD

Blood (2015) 126 (23): 4325.

https://doi.org/10.1182/blood.V126.23.4325.4325

Published: 2015

Journal Articles

Antifungal Prophylaxis with Posaconazole in Allogeneic Hematopoietic Stem Cell Transplantation Using Sirolimus for Prevention of Graft-Versus-Host Disease

Raffaella Greco, MD, Maria Chiara Barbanti, MD, Alessandra Forcina, MD, Maria Teresa Lupo Stanghellini, MD, Fabio Giglio, MD, Mara Morelli, MD, Luca Vago, MD PhD, Simona Piemontese, MD, Carlo Messina, MD, Elisa Sala, MD, Francesca Pavesi, MD, Sarah Marktel, MD, Matteo G Carrabba, MD, Andrea Assanelli, MD, Massimo Bernardi, MD, Jacopo Peccatori, MD, Consuelo Corti, MD, Fabio Ciceri, MD

Blood (2015) 126 (23): 4335.

https://doi.org/10.1182/blood.V126.23.4335.4335

Published: 2015

Journal Articles

A Novel Class of Geranylgeranyl Diphosphate Synthase Inhibitors: Structure-Activity Relationships of Homoisoprenoid Triazoles in Myeloma Cells

Veronica S. Wills, B.S., Cheryl Allen, BS, Ella J. Born, B.A., Xiang Zhou, B.S., David F. Wiemer, PhD, Sarah A Holstein, MD PhD

Blood (2014) 124 (21): 2156.

https://doi.org/10.1182/blood.V124.21.2156.2156

Published: 2014

Journal Articles

Primary Treatment of Invasive Mucormycosis (IM) with Isavuconazole (VITAL Study) or Amphotericin Formulations (FungiScope™): Case Matched Analysis

Maria J.G.T. Vehreschild, MD, J. Janne Vehreschild, MD, Francisco M Marty, MD, John R Perfect, MD, Luis Ostrosky-Zeichner, MD, Galia Rahav, MD, Bernhardt Zeiher, MD, Misun Lee, PhD, Rochelle Maher, MD, Clint Lovell, MS, Marc Engelhardt, MD, Oliver A Cornely, MD

Blood (2014) 124 (21): 1151.

https://doi.org/10.1182/blood.V124.21.1151.1151

Published: 2014

Journal Articles

A Phase III, Randomized, Double-Blind Trial to Evaluate Efficacy and Safety of Isavuconazole Versus Voriconazole in Patients with Invasive Mold Disease (SECURE): Outcomes in Hematopoietic Stem Cell Transplant Patients with Invasive Aspergillosis

Werner J Heinz, MD, Oliver A Cornely, MD, Billy Franks, PhD, Fei Shi, PhD, Nkechi Azie, MD, Johan Maertens, MD

Blood (2014) 124 (21): 1133.

https://doi.org/10.1182/blood.V124.21.1133.1133

Published: 2014

Journal Articles

A New Form Of Therapeutic Resistance: Drug Glucuronidation Regulated By The Sonic Hedgehog Factor Gli1

Hiba A Zahreddine, Biljana Culjkovic-Kraljacic, PhD, Sarit Assouline, MD, Abdellatif Amri, Patrick Gendron, M.Sc., Andrea A. Romeo, PhD, Stephen Morris, PhD, James Jaquith, PhD, Gregory Cormack, Eftihia Cocolakis, PhD, Julie Bergeron, MD, Leandro Cerchietti, MD, Brian Leber, MD, Wilson H. Miller, Jr., MD, PhD, Katherine LB. Borden, PhD

Blood (2013) 122 (21): 821.

https://doi.org/10.1182/blood.V122.21.821.821

Published: 2013

Journal Articles

Synthesis and Structure-Function Relationship Of Novel Triazole Phosphonates As Inhibitors Of Rab Geranylgeranyl Transferase

Sarah D. Ferree, Xiang Zhou, B.S., Veronica S. Wills, B.S., Ella J. Born, B.A., Huaxiang Tong, PhD, David F. Wiemer, PhD, Sarah A Holstein, MD, PhD

Blood (2013) 122 (21): 4223.

https://doi.org/10.1182/blood.V122.21.4223.4223

Published: 2013

Journal Articles

Posaconazole Prophylaxis in Patients Undergoing Chemotherapy for Acute Myeloid Leukemia: A Single Center Experience of Therapeutic Drug Monitoring.

Laura Pavan, Arianna Loregian, Angela Maria Quinto, Speranza Antonia Di Maggio, Silvana Pagni, Marco Gazzola, Elena De March, Giorgio Palù, Gianpietro Semenzato, Livio Trentin, Fabrizio Vianello, Renato Zambello

Blood (2012) 120 (21): 2595.

https://doi.org/10.1182/blood.V120.21.2595.2595

Published: 2012

Journal Articles

Updated Results of a Phase I/II, Randomized Study of Clofarabine Combined with Idarubicin and Cytarabine (CIA) or Fludarabine Combined with Idarubicin and Cytarabine (FIA) for the Treatment of Patients (pts) with Newly Diagnosed or Relapsed/Refractory (RR) Acute Myeloid Leukemia (AML)

Michael S Mathisen, PharmD, Hagop M. Kantarjian, MD, Farhad Ravandi, MD, Naveen Pemmaraju, M.D., Guillermo Garcia-Manero, MD, Jorge E. Cortes, MD, Susan O'Brien, M.D., Alfonso Quintas-Cardama, MD, Hady Ghanem, MD, Naval G. Daver, MD, Sherry A. Pierce, RN, BS, Cynthia Lira, RN, Stefan Faderl, MD, Elias Jabbour, MD

Blood (2012) 120 (21): 3610.

https://doi.org/10.1182/blood.V120.21.3610.3610

Published: 2012

Journal Articles

A Multicenter, Open-Label Study of Posaconazole Oral Suspension in Treatment of Patients with Invasive Fungal Infection Refractory to or Intolerant of First-Line Therapy,

Xiaojun Huang, Fengrong Wang, Yuhong Chen, MD, PhD, Ting Liu, MD, Jianxiang Wang, MD, Jianda Hu, PhD, Jie Jin, MD, Fangping Chen, Shujie Wang, MD, PhD, Zhixiang Shen, MD, PhD, Li Yu, Kang Yu, Yingmin Liang

Blood (2011) 118 (21): 3241.

https://doi.org/10.1182/blood.V118.21.3241.3241

Published: 2011

Journal Articles

Safety and Efficacy of Posaconazole for the Treatment of Invasive Fungal Infections After Failure of One Prior Line of Therapy

Shariq Haider, MD FRCPC FACP CCST(UK), Laverdiere Michel, MD, Maryse M. Power, MD, FRCPath, Coleman Rotstein, MD, FRCPC, FACP, Shahid Husain, MD, MS, Jeffrey H. Lipton, MD, PhD, Karen Doucette, FRCPC, MSc, Peter Phillips, MD FRCPC, Andre Galarneau, Jean-Francois Pouliot, PhD

Blood (2011) 118 (21): 4479.

https://doi.org/10.1182/blood.V118.21.4479.4479

Published: 2011

NARROW

Venetoclax Dosing in Combination with Antifungal Agents: Real World Experience in Patients with Acute Myeloid Leukemia

Isavuconazole (ISAV) As Primary Anti-Fungal Prophylaxis in Acute Myeloid Leukemia or Myelodysplastic Syndrome: An Open-Label, Prospective Study

In Vivo Evaluation of Novel Geranylgeranyl Diphosphate Synthase Inhibitors

Isoprenoid Amide Bisphosphonates As a Novel Class of Geranylgeranyl Diphosphate Synthase Inhibitors

Incidence of Breakthrough Invasive Fungal Infections after Posaconazole Prophylaxis in Allogeneic Stem Cell Transplant Patients

Preclinical Investigation of a Potent Geranylgeranyl Diphosphate Synthase Inhibitor

Anti-Fungal Prophylaxis Using Intermediate Dose Ambisome Is Associated with Delayed Methotrexate Clearance in Pediatric Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Synergistic Inhibition of Geranylgeranyl Diphosphate Synthase By a Mixture of Olefin Stereoisomers

Pharmacokinetic Analysis during Antifungal Prophylaxis with Posaconazole Suspension in Pediatric and Adolescent Patients after Allogeneic Hematopoietic Stem Cell Transplantation

Whole Genome Sequencing of Azole-Resistant Aspergillus Fumigatus Strains from Hematopoietic Stem Cell Recipients Identifies Candidate Molecular Targets Potentially Implicated in Novel Resistance Mediating Mechanisms - First Results

Antifungal Prophylaxis with Posaconazole in Allogeneic Hematopoietic Stem Cell Transplantation Using Sirolimus for Prevention of Graft-Versus-Host Disease

A Novel Class of Geranylgeranyl Diphosphate Synthase Inhibitors: Structure-Activity Relationships of Homoisoprenoid Triazoles in Myeloma Cells

Primary Treatment of Invasive Mucormycosis (IM) with Isavuconazole (VITAL Study) or Amphotericin Formulations (FungiScope™): Case Matched Analysis

A Phase III, Randomized, Double-Blind Trial to Evaluate Efficacy and Safety of Isavuconazole Versus Voriconazole in Patients with Invasive Mold Disease (SECURE): Outcomes in Hematopoietic Stem Cell Transplant Patients with Invasive Aspergillosis

A New Form Of Therapeutic Resistance: Drug Glucuronidation Regulated By The Sonic Hedgehog Factor Gli1

Synthesis and Structure-Function Relationship Of Novel Triazole Phosphonates As Inhibitors Of Rab Geranylgeranyl Transferase

Posaconazole Prophylaxis in Patients Undergoing Chemotherapy for Acute Myeloid Leukemia: A Single Center Experience of Therapeutic Drug Monitoring.

Updated Results of a Phase I/II, Randomized Study of Clofarabine Combined with Idarubicin and Cytarabine (CIA) or Fludarabine Combined with Idarubicin and Cytarabine (FIA) for the Treatment of Patients (pts) with Newly Diagnosed or Relapsed/Refractory (RR) Acute Myeloid Leukemia (AML)

A Multicenter, Open-Label Study of Posaconazole Oral Suspension in Treatment of Patients with Invasive Fungal Infection Refractory to or Intolerant of First-Line Therapy,

Safety and Efficacy of Posaconazole for the Treatment of Invasive Fungal Infections After Failure of One Prior Line of Therapy

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American Society of Hematology

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American Society of Hematology

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