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Journal Articles

Platelet Response to Lusutrombopag, a Thrombopoietin Receptor Agonist, in Patients with Chronic Liver Disease and Thrombocytopenia Undergoing Non-Emergency Invasive Procedures: Results from a Phase 3 Randomized, Double-Blind, Placebo-Controlled Study

Nezam Afdhal, MD, Ajay Duggal, MD, Toshimitsu Ochiai, Tomoko Motomiya, Takeshi Kano, MSc, Tsutae Nagata, MD, Markus Peck-Radosavljevic, MD

Blood (2017) 130 (Supplement 1): 291.

https://doi.org/10.1182/blood.V130.Suppl_1.291.291

Published: 2017

Journal Articles

Inverse PAR1 Activity of Hematopoietic Stem Cells and BM Stromal Cells Mediates G-CSF-Induced Mobilization By Regulation of Nitric Oxide Generation

Neta Nevo, MD, Shiri Gur-Cohen, PhD, Orit Kollet, PhD, Francesca Avemaria, PhD, Seymen Avci, MSc, Tomer Itkin, PhD, Sagarika Chakrabarty, PhD, Tzila Zuckerman, MD, Benjamin Brenner, MD, Yona Nadir, MD, Irina Zaidman, MD, Myriam Ben Arush, MD, Charles Esmon, PhD, Wolfram Ruf, MD, Tsvee Lapidot, PhD

Blood (2016) 128 (22): 3370.

https://doi.org/10.1182/blood.V128.22.3370.3370

Published: 2016

Journal Articles

Daily Light and Darkness Signals Regulate Bone Marrow Stem Cell Development and Leukocyte Production Via Tnfα and an Interplay Between Norepinephrine and Melatonin

Karin Golan, PhD, Anju Kumari, PhD, Eman Khatib-Massalha, Msc, Sylwia Rzeszotek, PhD, Shiri Gur-Cohen, PhD, Zulma S. Ferreira, PhD, Tomer Itkin, PhD, Orit Kollet, PhD, Mariusz Z Ratajczak, MD PhD, Regina P. Markus, PhD, Tsvee Lapidot, PhD

Blood (2016) 128 (22): 721.

https://doi.org/10.1182/blood.V128.22.721.721

Published: 2016

Journal Articles

EPCR/PAR1 Signaling Navigates Long-Term Repopulating Hematopoietic Stem Cell Bone Marrow Homing to Thrombomodulin-Enriched Blood Vessels

Shiri Gur Cohen, PhD, Tomer Itkin, PhD, Sagarika Chakrabarty, PhD, Claudine Graf, MD, Orit Kollet, PhD, Karin Golan, PhD, Alexander Kalinkovich, MDPhD, Charles T. Esmon, PhD, Wolfram Ruf, MD, Irit Sagi, PhD, Ayelet Erez, PhD, Tsvee Lapidot, PhD

Blood (2015) 126 (23): 33.

https://doi.org/10.1182/blood.V126.23.33.33

Published: 2015

Journal Articles

Increased TACE (Tumor necrosis factor-alpha±-converting enzyme; ADAM17) Activity Associates with Decreased CD62L Expression, Increased Soluble CD62L Plasma Levels and Predicts Molecular Response to Nilotinib Therapy in Patients with Early Chronic Phase Chronic Myelogenous Leukemia (CML-CP): Results from an ENEST1st Substudy

Sieghart Sopper, PhD, Satu Mustjoki, MD PhD, Angelica Loskog, PhD, Bjorn T. Gjertsen, MD PhD, Guenther A. Gastl, MD, Frank Giles, MDMB, Andreas Hochhaus, MD, Gert J. Ossenkoppele, MD PhD, Kimmo Porkka, MD PhD, Dominik Wolf, MD

Blood (2015) 126 (23): 4033.

https://doi.org/10.1182/blood.V126.23.4033.4033

Published: 2015

Journal Articles

Romiplostim in Management of the Thrombocytopenic Surgical Patient

Ariela L. Marshall, MD, Katayoon Goodarzi, MD, David J. Kuter, MD DPhil

Blood (2014) 124 (21): 1459.

https://doi.org/10.1182/blood.V124.21.1459.1459

Published: 2014

Journal Articles

Reduced Expression of CD62L Is Associated with Increased ADAM17 Activity and Predicts Molecular Response to Nilotinib Therapy in Patients with Early Chronic Phase Chronic Myelogenous Leukemia (CML-CP)

Sieghart Sopper, PhD, Satu Mustjoki, MD PhD, Angelica Loskog, PhD, Bjorn T. Gjertsen, MD PhD, Ute Mark, Jens Haenig, Nidas Jurjonas, Gunther Gastl, Prof., Dr., Frank Giles, MDMB, Andreas Hochhaus, MD, Gert J Ossenkoppele, MD PhD, Kimmo Porkka, MD PhD, Dominik Wolf, MD

Blood (2014) 124 (21): 4522.

https://doi.org/10.1182/blood.V124.21.4522.4522

Published: 2014

Journal Articles

Identiﬁcation Of a Novel Small-Molecule TNFα Inhibitor With Activity Against Inflammation In a Hepatitis Mouse Model

Li Ma, PhD, Haiyan Gong, PhD, Haiyan Zhu, PhD, Pei Su, PhD, Shannan Cao, PhD, Peng Liu, PhD, Jianfeng Yao, PhD, Ming-Zhe Han, MD, Hongbo R. Luo, PhD, Fei Wang, PhD, Jiaxi Zhou, PhD, Yuanfu Xu, PhD

Blood (2013) 122 (21): 4229.

https://doi.org/10.1182/blood.V122.21.4229.4229

Published: 2013

Journal Articles

EPCR Limits Nitric Oxide Levels, Mediating Human and Murine Stem Cell Adhesion and Retention In The Bone Marrow, By Conjugating PAR1 and CXCR4 Signaling

Shiri Gur Cohen, MSc, Tomer Itkin, PhD, Aya Ludin, DMD, PhD, Sagarika Chakrabarty, PhD, Orit Kollet, PhD, Karin Golan, MSc, Alexander Kalinkovich, MD, PhD, Eitan Wong, PhD, Ayelet Erez, MD PhD, Irit Sagi, PhD, Charles T Esmon, PhD, Wolfram Ruf, MD, Tsvee Lapidot, PhD

Blood (2013) 122 (21): 795.

https://doi.org/10.1182/blood.V122.21.795.795

Published: 2013

Journal Articles

Tetraspanin CD9 Inhibits ADAM17-Mediated LR11 Shedding In Leukemia Cells

Shokichi Tsukamoto, MD, Masahiro Takeuchi, MD, PhD, Takeharu Kawaguchi, MD, PhD, Emi Togasaki, MD, Atsuko Yamazaki, MD, Yasumasa Sugita, MD, Tomoya Muto, MD, PhD, Shio Sakai, MD, PhD, Yusuke Takeda, MD, PhD, Chikako Ohwada, MD, PhD, Naomi Shimizu, MD, PhD, Emiko Sakaida, MD, PhD, Keigo Nishii, Meizi Jiang, MD, PhD, Tohru Iseki, MD, PhD, Koutaro Yokote, MD, PhD, Hideaki Bujo, MD, PhD, Chiaki Nakaseko, M.D., Ph.D.

Blood (2013) 122 (21): 1035.

https://doi.org/10.1182/blood.V122.21.1035.1035

Published: 2013

Journal Articles

Angiopoietin-Like Proteins Stimulate HSC Development Through Direct Interaction With Notch

Michelle I Lin, PhD, Emily Price, Sonja Boatman, Eirini Trompouki, PhD, Sruthi Satishchandran, Charles W Carspecken, MD, Audrey Uong, Anthony DiBiase, Jon C. Aster, MD, PhD, Richard M. White, MD, PhD, Leonard I. Zon, M.D.

Blood (2013) 122 (21): 463.

https://doi.org/10.1182/blood.V122.21.463.463

Published: 2013

Journal Articles

ADAM17, a Novel Metalloproteinase, Mediates CD16 and CD62L Shedding in Human NK Cells and Modulates IFNγ Responses

Rizwan Romee, MD, Todd Lenvik, Yue Wang, Bruce Walcheck, Michael R Verneris, MD, Jeffrey S. Miller, MD

Blood (2011) 118 (21): 2184.

https://doi.org/10.1182/blood.V118.21.2184.2184

Published: 2011

Journal Articles

Analysis of the Mechanisms of Increased Platelet Count Induced by Dietary α-Linolenic Acid Indicates Reduced Cleavage of GPIb and Reduced p38 Phosphorylation

Simona Stivala, Ph.D., Christine Lohmann, Eric Holy, M.D., Christian Matter, M.D., Thomas F. Luscher, MD, Juerg H. Beer, MD

Blood (2011) 118 (21): 2198.

https://doi.org/10.1182/blood.V118.21.2198.2198

Published: 2011

Journal Articles

p38 mitogen-activated protein kinase activation during platelet storage: consequences for platelet recovery and hemostatic function in vivo

Matthias Canault, Daniel Duerschmied, Alexander Brill, Lucia Stefanini, Daphne Schatzberg, Stephen M. Cifuni, Wolfgang Bergmeier, Denisa D. Wagner

Blood (2010) 115 (9): 1835–1842.

https://doi.org/10.1182/blood-2009-03-211706

Published: 2010

Includes: Supplemental data

Journal Articles

Peculiar Hepatocellular Carcinoma Clinical Findings in patients with Thalassemia Syndromes.

Gaetano Restivo, Franco Valenza, Fabio D'Amato, Angela Vitrano, Paolo Rigano, Disma Renda, Filippo Cassarà, Aurelio Maggio, MD

Blood (2009) 114 (22): 5108.

https://doi.org/10.1182/blood.V114.22.5108.5108

Published: 2009

Journal Articles

GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-α converting enzyme (TACE)

Masahiro Hiasa, Masahiro Abe, Ayako Nakano, Asuka Oda, Hiroe Amou, Shinsuke Kido, Kyoko Takeuchi, Kumiko Kagawa, Kenichiro Yata, Toshihiro Hashimoto, Shuji Ozaki, Kenzo Asaoka, Eiji Tanaka, Keiji Moriyama, Toshio Matsumoto

Blood (2009) 114 (20): 4517–4526.

https://doi.org/10.1182/blood-2009-04-215020

Published: 2009

Includes: Supplemental data

Journal Articles

The Histone Deacetylase-8 (HDAC8) Selective Inhibitor PCI-34051 Decreases Interleukin-1 Beta Secretion in Vitro and Reduces Inflammation in Vivo

Sriram Balasubramanian, PhD, Susanne Steggerda, Ph.D., Mint Sirisawad, M.S., Marshall Schreeder, Luke Doiron, Joseph J Buggy, Ph.D.

Blood (2008) 112 (11): 2581.

https://doi.org/10.1182/blood.V112.11.2581.2581

Published: 2008

Journal Articles

p38 MAPK Inhibition Prevents TACE-Mediated Receptor Shedding and Improves the Hemostatic Function of Stored Platelets.

Matthias Canault, PhD, Daniel Duerschmied, MD, Alexander Brill, PhD, Ian Sean Patten, Wolfgang Bergmeier, PhD, Denisa D. Wagner, PhD

Blood (2008) 112 (11): 990.

https://doi.org/10.1182/blood.V112.11.990.990

Published: 2008

Journal Articles

Inhibition of TACE Activity Enhances the Susceptibility of Myeloma Cells to TRAIL.

Kumiko Kagawa, MD, Masahiro Abe, MD, Shiro Fujii, MD, Osamu Tanaka, MD, Ai Mihara, MD, Shingen Nakamura, MD, Kazuhiro Miki, MD, Jin Asano, MD, Kyoko Takeuchi, MD, Kenichiro Yata, MD, Toshihiro Hashimoto, MD, Shuji Ozaki, MD, Masahiro Hiasa, DDS, Toshio Matsumoto, MD

Blood (2007) 110 (11): 244.

https://doi.org/10.1182/blood.V110.11.244.244

Published: 2007

Journal Articles

Absence of donor T-cell–derived soluble TNF decreases graft-versus-host disease without impairing graft-versus-tumor activity

Chiara Borsotti, Anna R. K. Franklin, Sydney X. Lu, Theo D. Kim, Odette M. Smith, David Suh, Chris G. King, Andrew Chow, Chen Liu, Onder Alpdogan, Marcel R. M. van den Brink

Blood (2007) 110 (2): 783–786.

https://doi.org/10.1182/blood-2006-10-054510

Published: 2007

Includes: Supplemental data

NARROW

Platelet Response to Lusutrombopag, a Thrombopoietin Receptor Agonist, in Patients with Chronic Liver Disease and Thrombocytopenia Undergoing Non-Emergency Invasive Procedures: Results from a Phase 3 Randomized, Double-Blind, Placebo-Controlled Study

Inverse PAR1 Activity of Hematopoietic Stem Cells and BM Stromal Cells Mediates G-CSF-Induced Mobilization By Regulation of Nitric Oxide Generation

Daily Light and Darkness Signals Regulate Bone Marrow Stem Cell Development and Leukocyte Production Via Tnfα and an Interplay Between Norepinephrine and Melatonin

EPCR/PAR1 Signaling Navigates Long-Term Repopulating Hematopoietic Stem Cell Bone Marrow Homing to Thrombomodulin-Enriched Blood Vessels

Romiplostim in Management of the Thrombocytopenic Surgical Patient

Reduced Expression of CD62L Is Associated with Increased ADAM17 Activity and Predicts Molecular Response to Nilotinib Therapy in Patients with Early Chronic Phase Chronic Myelogenous Leukemia (CML-CP)

Identiﬁcation Of a Novel Small-Molecule TNFα Inhibitor With Activity Against Inflammation In a Hepatitis Mouse Model

EPCR Limits Nitric Oxide Levels, Mediating Human and Murine Stem Cell Adhesion and Retention In The Bone Marrow, By Conjugating PAR1 and CXCR4 Signaling

Tetraspanin CD9 Inhibits ADAM17-Mediated LR11 Shedding In Leukemia Cells

Angiopoietin-Like Proteins Stimulate HSC Development Through Direct Interaction With Notch

ADAM17, a Novel Metalloproteinase, Mediates CD16 and CD62L Shedding in Human NK Cells and Modulates IFNγ Responses

Analysis of the Mechanisms of Increased Platelet Count Induced by Dietary α-Linolenic Acid Indicates Reduced Cleavage of GPIb and Reduced p38 Phosphorylation

p38 mitogen-activated protein kinase activation during platelet storage: consequences for platelet recovery and hemostatic function in vivo

Peculiar Hepatocellular Carcinoma Clinical Findings in patients with Thalassemia Syndromes.

GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-α converting enzyme (TACE)

The Histone Deacetylase-8 (HDAC8) Selective Inhibitor PCI-34051 Decreases Interleukin-1 Beta Secretion in Vitro and Reduces Inflammation in Vivo

p38 MAPK Inhibition Prevents TACE-Mediated Receptor Shedding and Improves the Hemostatic Function of Stored Platelets.

Inhibition of TACE Activity Enhances the Susceptibility of Myeloma Cells to TRAIL.

Absence of donor T-cell–derived soluble TNF decreases graft-versus-host disease without impairing graft-versus-tumor activity

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American Society of Hematology

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American Society of Hematology

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