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Journal Articles

Parthenolide and DMAPT Induce Cell Death in Chronic Myeloid Leukemia Cells Via Generation of Reactive Oxygen Species

Gabriela Flores-López, PhD Candidate, Hector Mayani, PhD, María Antonieta Chávez-Gonzalez, PhD

Blood (2016) 128 (22): 4242.

https://doi.org/10.1182/blood.V128.22.4242.4242

Published: 2016

Journal Articles

Combining BCL-2 Inhibitors with Parthenolide to Treat Childhood Acute Lymphoblastic Leukaemia

Paraskevi Diamanti, BSc, PhD, William J Barendt, BSc, Benjamin C Ede, BSc, Charlotte V. Cox, BSc, Allison Blair, PhD BSc

Blood (2015) 126 (23): 2531.

https://doi.org/10.1182/blood.V126.23.2531.2531

Published: 2015

Journal Articles

Selectively Targeting Mutated NOTCH1 with a Folate-Thapsigargin Derivative

Giovanni Roti, MD, Jun Qi, PhD, Angela Su, B.S., Antony Varca, B.S., Jon C Aster, MD PhD, James E. Bradner, Kimberly Stegmaier, MD

Blood (2014) 124 (21): 2158.

https://doi.org/10.1182/blood.V124.21.2158.2158

Published: 2014

Journal Articles

ALDH Genes and Reactive Aldehydes Play Important Roles in HSCs and Leukemia and May Be Exploited to Treat AML

Maura Gasparetto, MD, Craig T. Jordan, PhD, Mohammad Minhajuddin, Daniel A Pollyea, MD, MS, Vasilis Vasilou, Philip Reigan, PhD, R. Keith Humphries, MD, PhD, Clayton A. Smith, MD, FRCPC

Blood (2013) 122 (21): 2893.

https://doi.org/10.1182/blood.V122.21.2893.2893

Published: 2013

Journal Articles

The Sesquiterpene Oil α-Bisabolol Induces Apoptosis of B-Chronic Lymphocytic Leukemia Primary Cells

Massimiliano Bonifacio, Antonella Rigo, Angela Bonalumi, Emanuele Guardalben, Ilaria Nichele, Cinzia Sissa, Elisabetta Cavalieri, Christian Bergamini, Giovanni Pizzolo, Hisanori Suzuki, Fabrizio Vinante

Blood (2011) 118 (21): 1319.

https://doi.org/10.1182/blood.V118.21.1319.1319

Published: 2011

Journal Articles

Small Compound 6- O -Angeloylplenolin Induces Mitotic Arrest and Exhibits Therapeutic Potential In Multiple Myeloma

Ying Liu, Xiaoqin Chen, Yongxian Cheng, Guangbiao Zhou, MD, PhD

Blood (2010) 116 (21): 5043.

https://doi.org/10.1182/blood.V116.21.5043.5043

Published: 2010

Journal Articles

Investigating Drug Resistance In Leukemia Initiating Cell Populations.

Paraskevi Diamanti, BSc, PhD, Charlotte Victoria Cox, BSc, Allison Blair, PhD, BSc

Blood (2010) 116 (21): 1570.

https://doi.org/10.1182/blood.V116.21.1570.1570

Published: 2010

Journal Articles

Mitochondrial-Mediated Apoptosis by the Sesquiterpene Oil α-Bisabolol and Its Synergism with Imatinib and Nilotinib In BCR-ABL + Cells

Massimiliano Bonifacio, Antonella Rigo, Elisabetta Cavalieri, Emanuele Guardalben, Christian Bergamini, Giovanni Pizzolo, Hisanori Suzuki, Fabrizio Vinante

Blood (2010) 116 (21): 4456.

https://doi.org/10.1182/blood.V116.21.4456.4456

Published: 2010

Journal Articles

Modulation of Cell Surface Protein Free Thiols; A Potential Novel Mechanism of Action of the Sesquiterpene Lactone Parthenolide in Non-Hodgkin's Lymphoma.

Jolanta Skalska, PhD, Paul S Brookes, PhD, S. M Nadtochy, Shannon Hilchey, PhD, Craig T. Jordan, PhD, Monica L. Guzman, PhD, Sanjay Maggirwar, PhD, Margaret M Briehl, PhD, Steven H. Bernstein, MD

Blood (2009) 114 (22): 3774.

https://doi.org/10.1182/blood.V114.22.3774.3774

Published: 2009

Journal Articles

The Plant-Derived Agent α-Bisabolol Induces Apoptosis of Leukemic Blasts Ex Vivo.

Massimiliano Bonifacio, Elisabetta Cavalieri, Antonella Rigo, Alessandra Carcereri de Prati, Giovanni Pizzolo, Fabrizio Vinante, Hisanori Suzuki

Blood (2009) 114 (22): 4800.

https://doi.org/10.1182/blood.V114.22.4800.4800

Published: 2009

Journal Articles

Induction of Noxa Via Generation of Reactive Oxygen Species Plays a Key Role in Induction of CLL Cell Apoptosis by Two Novel p53-Independent Cytotoxic Agents.

Andrew Steele, BSc, MSc, PhD, Archibald G Prentice, MBChB, FRCP, FRCPath, Anastasios Chanalaris, A. Victor Hoffbrand, DM, FRCP, FRCPath, DSc, Kate Cwynarski, Ranmohan Wickremasinghe

Blood (2009) 114 (22): 2752.

https://doi.org/10.1182/blood.V114.22.2752.2752

Published: 2009

Journal Articles

Stem Cells in Paediatric Leukaemia Are Resistant to Parthenolide.

Charlotte Victoria Cox, BSc, Paraskevi Diamanti, BSc, PhD, Allison Blair, PhD

Blood (2009) 114 (22): 1429.

https://doi.org/10.1182/blood.V114.22.1429.1429

Published: 2009

Journal Articles

Level of Myeloperoxidase Expression as a Crucial Determinant of Sensitivity of Myeloid Leukemia Cells to Parthenolide-Induced Apoptosis

Soo Jeong Kim, M.D., Ju In Eom, Hye Won Lee, M.D., Hoi Kyung Jeung, Jin Seok Kim, M.D., Ph.D., Yoo-Hong Min, M.D., Ph.D.

Blood (2008) 112 (11): 2945.

https://doi.org/10.1182/blood.V112.11.2945.2945

Published: 2008

Journal Articles

Effect of Parthenolide on Stem Cells in Childhood Acute Lymphoblastic Leukaemia.

Paraskevi Diamanti, PhD, BSc, Charlotte V Cox, BSc, Allison Blair, PhD, BSc

Blood (2008) 112 (11): 1341.

https://doi.org/10.1182/blood.V112.11.1341.1341

Published: 2008

Journal Articles

Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data

Duane C. Hassane, Monica L. Guzman, Cheryl Corbett, Xiaojie Li, Ramzi Abboud, Fay Young, Jane L. Liesveld, Martin Carroll, Craig T. Jordan

Blood (2008) 111 (12): 5654–5662.

https://doi.org/10.1182/blood-2007-11-126003

Published: 2008

Includes: Supplemental data

Journal Articles

A Search of Public Gene Expression Microarray Data Identifies Novel Agents That Selectively Eradicate AML Stem Cells.

Duane C. Hassane, PhD, Monica L. Guzman, PhD, Cheryl Corbett, Xiaojie Li, MD, Jane L. Liesveld, MD, Fay Young, MD, Martin Carroll, MD, Craig T. Jordan, PhD

Blood (2007) 110 (11): 776.

https://doi.org/10.1182/blood.V110.11.776.776

Published: 2007

Journal Articles

The Sesquiterpene Lactone Parthenolide Induces Apoptosis and Overcomes the Protective Effect of the Bone Marrow Microenvironment in Human Multiple Myeloma Cells.

Attaya Suvannasankha, MD, Colin D. Crean, Rajasubramaniam Shanmugam, PhD, Rafat Abonour, MD, H. Scott Boswell, MD, Harikrishna Nakshatri, PhD

Blood (2006) 108 (11): 5058.

https://doi.org/10.1182/blood.V108.11.5058.5058

Published: 2006

Journal Articles

Mechanisms Controlling Selective Death of Leukemia Stem Cells in Response to Parthenolide.

Monica L. Guzman, PhD, Xiaojie Li, Cheryl Corbett, Duane C. Hassane, PhD, Craig T. Jordan, PhD

Blood (2005) 106 (11): 467.

https://doi.org/10.1182/blood.V106.11.467.467

Published: 2005

Journal Articles

The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells

Monica L. Guzman, Randall M. Rossi, Lilliana Karnischky, Xiaojie Li, Derick R. Peterson, Dianna S. Howard, Craig T. Jordan

Blood (2005) 105 (11): 4163–4169.

https://doi.org/10.1182/blood-2004-10-4135

Published: 2005

Journal Articles

The Sesquiterpene Lactone Parthenolide Rapidly and Selectively Induces Apoptosis of B-Chronic Lymphocytic Leukemia Cells.

Andrew J. Steele, PhD, Anouska A. Casanova, BSc, A. Victor Hoffbrand, DSc, Atul B. Mehta, MD, Kanagasabai Ganeshaguru, PhD, Dylan T. Jones, PhD, R. Gitendra Wickremasinghe, PhD

Blood (2004) 104 (11): 3483.

https://doi.org/10.1182/blood.V104.11.3483.3483

Published: 2004

NARROW

Parthenolide and DMAPT Induce Cell Death in Chronic Myeloid Leukemia Cells Via Generation of Reactive Oxygen Species

Combining BCL-2 Inhibitors with Parthenolide to Treat Childhood Acute Lymphoblastic Leukaemia

Selectively Targeting Mutated NOTCH1 with a Folate-Thapsigargin Derivative

ALDH Genes and Reactive Aldehydes Play Important Roles in HSCs and Leukemia and May Be Exploited to Treat AML

The Sesquiterpene Oil α-Bisabolol Induces Apoptosis of B-Chronic Lymphocytic Leukemia Primary Cells

Small Compound 6- O -Angeloylplenolin Induces Mitotic Arrest and Exhibits Therapeutic Potential In Multiple Myeloma

Investigating Drug Resistance In Leukemia Initiating Cell Populations.

Mitochondrial-Mediated Apoptosis by the Sesquiterpene Oil α-Bisabolol and Its Synergism with Imatinib and Nilotinib In BCR-ABL + Cells

Modulation of Cell Surface Protein Free Thiols; A Potential Novel Mechanism of Action of the Sesquiterpene Lactone Parthenolide in Non-Hodgkin's Lymphoma.

The Plant-Derived Agent α-Bisabolol Induces Apoptosis of Leukemic Blasts Ex Vivo.

Induction of Noxa Via Generation of Reactive Oxygen Species Plays a Key Role in Induction of CLL Cell Apoptosis by Two Novel p53-Independent Cytotoxic Agents.

Stem Cells in Paediatric Leukaemia Are Resistant to Parthenolide.

Level of Myeloperoxidase Expression as a Crucial Determinant of Sensitivity of Myeloid Leukemia Cells to Parthenolide-Induced Apoptosis

Effect of Parthenolide on Stem Cells in Childhood Acute Lymphoblastic Leukaemia.

Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data

A Search of Public Gene Expression Microarray Data Identifies Novel Agents That Selectively Eradicate AML Stem Cells.

The Sesquiterpene Lactone Parthenolide Induces Apoptosis and Overcomes the Protective Effect of the Bone Marrow Microenvironment in Human Multiple Myeloma Cells.

Mechanisms Controlling Selective Death of Leukemia Stem Cells in Response to Parthenolide.

The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells

The Sesquiterpene Lactone Parthenolide Rapidly and Selectively Induces Apoptosis of B-Chronic Lymphocytic Leukemia Cells.

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American Society of Hematology

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American Society of Hematology

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