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Journal Articles

Gfi1 Upregulates c-Myc Expression and Promotes c-Myc-Driven Cell Proliferation

Yangyang Zhang, MD, Fan Dong, MD PhD

Blood (2019) 134 (Supplement_1): 3769.

https://doi.org/10.1182/blood-2019-124833

Published: 2019

Journal Articles

C-Myc-Driven and PRMT5-Dependent Regulation of Multiple Myeloma Cell Proliferation through TNRC6B Gene

Peipei Xu, Guo Dan, Bing Chen, PhD, Quan Zhao, Rong-Fu Zhou, Prof., Jian Ouyang

Blood (2019) 134 (Supplement_1): 5520.

https://doi.org/10.1182/blood-2019-125027

Published: 2019

Journal Articles

Dual Inhibition of MDM2 and XPO1 Synergizes to Induce Apoptosis in Acute Myeloid Leukemia Progenitor Cells with Wild-Type TP53 through Nuclear Accumulation of p53 and Suppression of c-Myc

Yuki Nishida, MD PhD, Jo Ishizawa, MD PhD, Vivian Ruvolo, MS, Kensuke Kojima, MD PhD, Rafael Heinz Montoya, Naval G. Daver, MD, Arnaud Lesegretain, Sharon Shacham, PhD MBA, Michael Andreeff, MD PhD

Blood (2019) 134 (Supplement_1): 2556.

https://doi.org/10.1182/blood-2019-126950

Published: 2019

Journal Articles

PP2A Activators Enhance Efficacy of FLT3 Inhibitors in FLT3-ITD Acute Myeloid Leukemia Cells through AKT Inactivation-Dependent Pim-1 and c-Myc Proteasomal Degradation

Mario Scarpa, PhD, Prerna Singh, MS, Shivani Kapoor, MS, Jonelle K. Lee, MS, Sandrine Niyongere, MD, Goutham Narla, MD PhD, Danilo Perrotti, MD PhD, Maria R. Baer, MD

Blood (2019) 134 (Supplement_1): 1276.

https://doi.org/10.1182/blood-2019-129011

Published: 2019

Journal Articles

GFI1-Dependent SGPP1 Repression Promotes Growth and Survival of Myeloma Cells

Daniela Nicoleta Petrusca, PhD, Evgeny Berdyshev, PhD, Colin D. Crean, BS, Judith L Anderson, BS, G. David Roodman, MD PhD

Blood (2019) 134 (Supplement_1): 4387.

https://doi.org/10.1182/blood-2019-131106

Published: 2019

Journal Articles

Combined Targeting of Distinct c-Myc and JunB Transcriptional Programs for Multiple Myelioma Therapy

Judith Lind, PhD, Felix Czernilofsky, Sonia Vallet, MD, Fengjuan Fan, PhD, Martin Sattler, PhD, Latifa Bakiri, Erwin F Wagner, PhD, Martin Percherstorfer, MD, Klaus Podar, MD PhD

Blood (2019) 134 (Supplement_1): 4415.

https://doi.org/10.1182/blood-2019-125202

Published: 2019

Journal Articles

The Novel Berbamine Derivative, Cbbm, Downregulates c-Myc to Block Diffuse Large B-Cell Lymphoma Cell Maintenance

Lei Zhang, MD, Rongzhen Xu, PhD, Ling Li, PhD, Xiaoying Zhao, MD, Jinwen Huang, MD

Blood (2018) 132 (Supplement 1): 212.

https://doi.org/10.1182/blood-2018-99-112006

Published: 2018

Journal Articles

Concurrent FLT3 Inhibitor and PP2A Activating Drug Treatment Induces Synergistic Cytotoxicity in Acute Myeloid Leukemia Cells with FLT3 Internal Tandem Duplication through Proteasomal Degradation of Pim-1 and c-Myc

Mario Scarpa, PhD, Shivani Kapoor, MS, Danilo Perrotti, MD PhD, Maria R. Baer, MD

Blood (2018) 132 (Supplement 1): 3951.

https://doi.org/10.1182/blood-2018-99-117609

Published: 2018

Journal Articles

Lncrna RP1-68D18.2 Promotes K562 Cell Line Resistance to Imatinib through CD44 and Its Downstream Signal Molecules

Tianyou Yan, Yuping Gong, MD

Blood (2018) 132 (Supplement 1): 5149.

https://doi.org/10.1182/blood-2018-99-115865

Published: 2018

Journal Articles

Mutations in the RNA Splicing Factor SF3B1 Promote Transformation through MYC Stabilization

Akihide Yoshimi, MD, Zhaoqi Liu, PhD, Wang Jiguang, Hana Cho, MSc, Stanley C Lee, PhD, Michelle Ki, BSc, Lillian E Bitner, BSc, Timothy Chu, Anthony R Mato, MD, Peter P. Ruvolo, PhD, Giulia Fabbri, Laura Pasqualucci, MD, Raul Rabadan, PhD, Omar I Abdel-Wahab, MD

Blood (2018) 132 (Supplement 1): 882.

https://doi.org/10.1182/blood-2018-99-110328

Published: 2018

Journal Articles

The Gfi1-SphK1 Axis Regulates the Growth and Survival of Myeloma Cells

Daniela Nicoleta Petrusca, PhD, Evgeny Berdyshev, PhD, Patrick Mulcrone, PhD, Colin D. Crean, BS, Judith L Anderson, BS, Quanhong Sun, PhD, Deborah Lynn Galson, PhD, G. David Roodman, MD PhD

Blood (2018) 132 (Supplement 1): 5615.

https://doi.org/10.1182/blood-2018-99-119507

Published: 2018

Journal Articles

Combination of BR101801 and Venetoclax Demonstrates Synergistic Activity in DLBCL Cell Lines Harboring Double Hit and Double Expressor Alterations

Hahn-Sun Jung, PhD, Nam Hoon Kim, Jinsang Wang, Mi Kwon Son, PhD, Baek-Kyung Kim, PhD, Byeongwook Jeon, MS, Yeonseo Choi, Jayhyuk Myung, PhD, Dal-Hyun Kim, PhD VMD

Blood (2017) 130 (Supplement 1): 4114.

https://doi.org/10.1182/blood.V130.Suppl_1.4114.4114

Published: 2017

Journal Articles

Leflunomide Inhibits c-Myc Signaling and Impairs Myeloma Cell Growth

Ralf Buettner, PhD, Corey James Morales, BA, BS, Enrico Caserta, PhD, Domenico Viola, BS, Joycelynne M. Palmer, PhD, Xiwei Wu, PhD, Nagarajan Vaidehi, PhD, Hongzhi Li, PhD, Tim Synold, PhD, Amrita Krishnan, MD, Flavia Pichiorri, PhD, Michael Rosenzweig, MD, Steven T. Rosen, MD

Blood (2017) 130 (Supplement 1): 4426.

https://doi.org/10.1182/blood.V130.Suppl_1.4426.4426

Published: 2017

Journal Articles

Vitamin K3 (menadione) Induces Cytotoxicity in Chronic Myeloid Leukemia Stem Cells By Upregulating DYRK2 through the Inhibition of SIAH2 Ubiquitin Ligase

Chun Shik Park, PhD, Ye Shen, PhD, Andrew H Lewis, BS, Koramit Suppipat, MD, Monica Puppi, Julie Tomolonis, Taylor J Chen, Paul Pang, Toni-Ann Mistretta, Leyuan Ma, Michael R Green, PhD, Rachel E. Rau, MD, H. Daniel Lacorazza, PhD

Blood (2017) 130 (Supplement 1): 4171.

https://doi.org/10.1182/blood.V130.Suppl_1.4171.4171

Published: 2017

Journal Articles

Small Molecule Activators of Protein Phosphatase 2A (SMAPs) Cause c-Myc Degradation and Tumor Growth Suppression in Preclinical Models of Lymphoid Malignancies

Molly M Gallogly, MDPhD, Eric Yuan, MPhil, Sahar Mazhar, BA, Caroline Farrington, BA, Goutham Narla, MD PhD

Blood (2017) 130 (Supplement 1): 2819.

https://doi.org/10.1182/blood.V130.Suppl_1.2819.2819

Published: 2017

Journal Articles

Combination Therapy with Bortezomib or Carfilzomib and Selinexor Induces Nuclear Localization of Ikbα and Overcomes Acquired Proteasome Inhibitor Resistance in Human Multiple Myeloma

Joel G Turner, PhD, Trinayan Kashyap, MS, Jana L Dawson, BS, Juan A Gomez, BS, Alexis Bauer, BS, Steven Grant, MD, Yun Dai, PhD, Kenneth H. Shain, MD PhD, Mark B Meads, PhD, Yosef Landesman, PhD, Daniel M Sullivan, MD

Blood (2016) 128 (22): 3299.

https://doi.org/10.1182/blood.V128.22.3299.3299

Published: 2016

Journal Articles

DYRK2 Inhibits the Self-Renewal of Leukemic Stem Cells in Chronic Myeloid Leukemia By Inducing Degradation of c-Myc Downstream of the Reprogramming Factor KLF4

Chun Shik Park, PhD, Ye Shen, BS, Koramit Suppipat, MD, Andrew Lewis, B.S., Julie Tomolonis, B.S., Monica Puppi, M.Sc., toni-Ann Mistretta, PhD, Leyuan Ma, Michael R Green, MD PhD, Daniel Lacorazza, PhD

Blood (2016) 128 (22): 1879.

https://doi.org/10.1182/blood.V128.22.1879.1879

Published: 2016

Journal Articles

Global and MYC-Specific Translation Is Enhanced in Activated Chronic Lymphocytic Leukemia Cells Carrying NOTCH1 C.7541_7542delct Mutations

Annalisa D'Avola, MSc, Alison Yeomans, PhD, Samantha Drennan, PhD, Matthew Rose-Zerilli, PhD, Jonathan C. Strefford, Freda K Stevenson, DPhil, Andrew J Steele, PhD, Graham Packham, PhD, Francesco Forconi, MD DM, PhD FRCPath

Blood (2016) 128 (22): 970.

https://doi.org/10.1182/blood.V128.22.970.970

Published: 2016

Journal Articles

Acute Myeloid Leukemia Cells Export c-Myc in Extracellular Vesicles Driving a Proliferation of Immune-Suppressive Myeloid-Derived Suppressor Cells

Athalia Rachel Pyzer, MD, Dina Stroopinsky, PhD, Hasan Rajabi, PhD, Abigail J. Washington, BA, Leandra Cole, BA, Salvia Jain, MD, Ashujit Tagde, PhD BPharm, Arie Apel, MD, Malgorzata McMasters, MD, James D. Levine, MD, Robin Joyce, MD, Jon Arnason, MD, Poorvi Somaiya, Rebecca Karp Leaf, MD, Myrna R. Nahas, MD, Donald Küfe, MD, Jacalyn Rosenblatt, MD, David E. Avigan, MD

Blood (2016) 128 (22): 703.

https://doi.org/10.1182/blood.V128.22.703.703

Published: 2016

Journal Articles

Transition out of HSC Dormancy By a Continuous Upregulation of Metabolism Is Controlled Via Dietary Vitamin A/ Retinoic Acid Signaling

Blood (2016) 128 (22): LBA-4.

https://doi.org/10.1182/blood.V128.22.LBA-4.LBA-4

Published: 2016

NARROW

Gfi1 Upregulates c-Myc Expression and Promotes c-Myc-Driven Cell Proliferation

C-Myc-Driven and PRMT5-Dependent Regulation of Multiple Myeloma Cell Proliferation through TNRC6B Gene

Dual Inhibition of MDM2 and XPO1 Synergizes to Induce Apoptosis in Acute Myeloid Leukemia Progenitor Cells with Wild-Type TP53 through Nuclear Accumulation of p53 and Suppression of c-Myc

PP2A Activators Enhance Efficacy of FLT3 Inhibitors in FLT3-ITD Acute Myeloid Leukemia Cells through AKT Inactivation-Dependent Pim-1 and c-Myc Proteasomal Degradation

GFI1-Dependent SGPP1 Repression Promotes Growth and Survival of Myeloma Cells

Combined Targeting of Distinct c-Myc and JunB Transcriptional Programs for Multiple Myelioma Therapy

The Novel Berbamine Derivative, Cbbm, Downregulates c-Myc to Block Diffuse Large B-Cell Lymphoma Cell Maintenance

Concurrent FLT3 Inhibitor and PP2A Activating Drug Treatment Induces Synergistic Cytotoxicity in Acute Myeloid Leukemia Cells with FLT3 Internal Tandem Duplication through Proteasomal Degradation of Pim-1 and c-Myc

Lncrna RP1-68D18.2 Promotes K562 Cell Line Resistance to Imatinib through CD44 and Its Downstream Signal Molecules

Mutations in the RNA Splicing Factor SF3B1 Promote Transformation through MYC Stabilization

The Gfi1-SphK1 Axis Regulates the Growth and Survival of Myeloma Cells

Combination of BR101801 and Venetoclax Demonstrates Synergistic Activity in DLBCL Cell Lines Harboring Double Hit and Double Expressor Alterations

Leflunomide Inhibits c-Myc Signaling and Impairs Myeloma Cell Growth

Vitamin K3 (menadione) Induces Cytotoxicity in Chronic Myeloid Leukemia Stem Cells By Upregulating DYRK2 through the Inhibition of SIAH2 Ubiquitin Ligase

Small Molecule Activators of Protein Phosphatase 2A (SMAPs) Cause c-Myc Degradation and Tumor Growth Suppression in Preclinical Models of Lymphoid Malignancies

Combination Therapy with Bortezomib or Carfilzomib and Selinexor Induces Nuclear Localization of Ikbα and Overcomes Acquired Proteasome Inhibitor Resistance in Human Multiple Myeloma

DYRK2 Inhibits the Self-Renewal of Leukemic Stem Cells in Chronic Myeloid Leukemia By Inducing Degradation of c-Myc Downstream of the Reprogramming Factor KLF4

Global and MYC-Specific Translation Is Enhanced in Activated Chronic Lymphocytic Leukemia Cells Carrying NOTCH1 C.7541_7542delct Mutations

Acute Myeloid Leukemia Cells Export c-Myc in Extracellular Vesicles Driving a Proliferation of Immune-Suppressive Myeloid-Derived Suppressor Cells

Transition out of HSC Dormancy By a Continuous Upregulation of Metabolism Is Controlled Via Dietary Vitamin A/ Retinoic Acid Signaling

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American Society of Hematology

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American Society of Hematology

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