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Journal Articles

Role Of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) and Its Ligands In The Regulation Of Functional OCT-1 Activity In CML Cells

Jueqiong Wang, PhD, Chung Hoow Kok, PhD, Richard J. D'Andrea, PhD, Timothy P. Hughes, MD, MBBS, Deborah L. White, PhD, FFSc(RCPA)

Blood (2013) 122 (21): 1470.

https://doi.org/10.1182/blood.V122.21.1470.1470

Published: 2013

Journal Articles

Statins Increase Antileukemic Potency of Imatinib Through the Inhibition of MDR/ABCB1 and BCRP/ABCG2 Drug Transporters Activity

Eliza Glodkowska-Mrowka, MD, Piotr Mrowka, M.Sc., Magdalena Winiarska, PhD, Grzegorz Basak, MD, PhD, Joanna Niesiobedzka-Krezel, MD, Ilona Seferynska, MD, PhD, Pawel Krzysztof Wlodarski, MD, PhD, Marek Jakobisiak, MD, PhD, Tomasz Stoklosa, MD, PhD

Blood (2011) 118 (21): 2742.

https://doi.org/10.1182/blood.V118.21.2742.2742

Published: 2011

Journal Articles

Potentiation of the Antileukemic Effects of Imatinib through the Modulation of BCRP/ABCG2 Activity.

Eliza Glodkowska-Mrowka, MD, Magda Winiarska, PhD, Piotr Mrowka, M.Sc., Grzegorz Basak, MD, PhD, Joanna Niesiobedzka-Krezel, MD, Ilona Seferynska, MD, PhD, Tomasz Stoklosa, MD, PhD

Blood (2010) 116 (21): 3400.

https://doi.org/10.1182/blood.V116.21.3400.3400

Published: 2010

Journal Articles

OCT-1 Activity in CML CD34+ Cells Is Not Predictive of Molecular Response to Imatinib Treatment in CP-CML Patients, Despite the Strong Predictive Value of MNC OCT-1 Activity.

Jane R Engler, Amity Frede, Verity A Saunders, Andrew Christopher William Zannettino, BSc, PhD, Deborah L White, Timothy P. Hughes, MD

Blood (2009) 114 (22): 2189.

https://doi.org/10.1182/blood.V114.22.2189.2189

Published: 2009

Journal Articles

Nilotinib concentration in Cell Lines and CML CD34+ Cells Is Not Mediated by Active Uptake or Efflux by Major Drug Transporters

Joanne Mountford, PhD, Andrea Davies, Niove E Jordanides, Athina Giannoudis, Claire M Lucas, Sophia Hatziieremia, Robert J Harris, Heather G Jorgensen, Munir Pirmohamed, Tessa L Holyoake, Richard E Clark

Blood (2008) 112 (11): 3205.

https://doi.org/10.1182/blood.V112.11.3205.3205

Published: 2008

Journal Articles

Reduced Activity of the OCT-1 Protein in Primitive CML Cells: A Likely Determinant of Stem Cell Resistance in Imatinib Treated CML Patients

Jane R Engler, Amity Frede, Andrew C W Zannettino, PhD, Deborah L White, PhD, Timothy P Hughes, MD

Blood (2008) 112 (11): 196.

https://doi.org/10.1182/blood.V112.11.196.196

Published: 2008

Journal Articles

Enhancing the Functional Activity of the OCT-1 Influx Pump May Overcome the Negative Impact of Low OCT-1 Activity in Imatinib Treated CML Patients

Deborah White, PhD, Phuong Dang, Kelvin Groot Obbink, Amity Frede, Chung Kok, Timothy P Hughes, MD, Richard D’Andrea, PhD

Blood (2008) 112 (11): 723.

https://doi.org/10.1182/blood.V112.11.723.723

Published: 2008

Journal Articles

Characterisation of Nilotinib Transport in Chronic Myeloid Leukaemia Cells.

Andrea Davies, PhD, Athina Giannoudis, PhD, Claire M. Lucas, BSc, Robert J. Harris, PhD, Paul W. Manley, PhD, Munir Pirmohamed, PhD, FRCP, FRCP(E), Richard E. Clark, MA, MD, FRCP, FRCPat

Blood (2007) 110 (11): 2364.

https://doi.org/10.1182/blood.V110.11.2364.2364

Published: 2007

Journal Articles

In Contrast to Imatinib, OCT-1 Mediated Influx Has Minimal Impact on Cellular Uptake of Dasatinib in CML Patients at Diagnosis.

Devendra K. Hiwase, MD, Deborah L. White, Verity A. Saunders, Phuong Dang, Amity Venables, Laura Eadie, Steph Zrim, L. Bik To, MD, Junia V. Melo, MD, Timothy P. Hughes, MD

Blood (2007) 110 (11): 1937.

https://doi.org/10.1182/blood.V110.11.1937.1937

Published: 2007

Journal Articles

Unlike Imatinib, Dasatinib Uptake into Chronic Myeloid Leukaemia Cells Is Independent of hOCT1 Expression.

Athina Giannoudis, PhD, Andrea Davies, PhD, Claire M. Lucas, BSc, Robert J. Harris, PhD, Munir Pirmohamed, PhD, FRCP, FRCP(E), Richard E. Clark, MA, MD, FRCP, FRCPat

Blood (2007) 110 (11): 3458.

https://doi.org/10.1182/blood.V110.11.3458.3458

Published: 2007

Journal Articles

Hypoxia Induces Imatinib Resistance in CML Cell Lines.

Daniela Buglio, MD, Piera La Cava, MSc, Fabio Stagno, MD, Annalisa Chiarenza, MD, Salvatore Berretta, MD, Alesandra Aloisi, MSc, Giuseppe A. Palumbo, MD, Paolo Vigneri, MD, Francesco Di Raimondo, MD

Blood (2006) 108 (11): 4387.

https://doi.org/10.1182/blood.V108.11.4387.4387

Published: 2006

Journal Articles

Molecular Response to Imatinib Is Dependent on Dose in CML Patients with Low OCT-1 Influx Activity. Patients with High Activity May Respond Equally Well to Standard or Increased Dose Imatinib.

Deborah White, Verity Saunders, Phuong Dang, Amity Venables, Steph Zrim, John Reynolds, Steven Quinn, Andrew Zannettino, Timothy Hughes

Blood (2006) 108 (11): 738.

https://doi.org/10.1182/blood.V108.11.738.738

Published: 2006

Journal Articles

AMN107 Appears Equipotent and May Synergise with Imatinib at the CML Stem Cell Level through Interaction with ABCG2.

H. Jorgensen, PhD, E. Allan, BSc, N. Jordanides, BSc, A. Hamilton, BSc, J. Mountford, PhD, T. Holyoake, MD, PhD

Blood (2005) 106 (11): 1080.

https://doi.org/10.1182/blood.V106.11.1080.1080

Published: 2005

Journal Articles

Low Baseline Intrinsic Sensitivity to Imatinib (High IC50) in CML Patients Is Due to Reduced Oct-1 Mediated Influx. Intrinsic Sensitivity to AMN107 Does Not Correlate with That of Imatinib and Uptake of AMN107 Is Not Oct-1 Mediated.

Deborah L. White, Verity A. Saunders, Jane Engler, Phuong Dang, Andrew C.W. Zannettino, Antony Cambareri, Steven Quinn, Paul Manley, Timothy P. Hughes

Blood (2005) 106 (11): 1081.

https://doi.org/10.1182/blood.V106.11.1081.1081

Published: 2005

Journal Articles

Functional ABCG2 Is Expressed on CML Stem Cells and Its Inhibition Selectively Depletes CML CD34+ Cells.

Joanne C. Mountford, PhD, Diane Gilmour, BSc, Susan M. Graham, BSc, Niove E. Jordanides, BSC, MSc, Siobhan McMillan, BSc, Tessa L. Holyoake, MD, PhD.

Blood (2004) 104 (11): 716.

https://doi.org/10.1182/blood.V104.11.716.716

Published: 2004

Journal Articles

Effect of adrenergic agents on hematopoiesis after syngeneic bone marrow transplantation in mice

GJ Maestroni, A Conti, E Pedrinis

Blood (1992) 80 (5): 1178–1182.

https://doi.org/10.1182/blood.V80.5.1178.1178

Published: 1992

NARROW

Role Of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) and Its Ligands In The Regulation Of Functional OCT-1 Activity In CML Cells

Statins Increase Antileukemic Potency of Imatinib Through the Inhibition of MDR/ABCB1 and BCRP/ABCG2 Drug Transporters Activity

Potentiation of the Antileukemic Effects of Imatinib through the Modulation of BCRP/ABCG2 Activity.

OCT-1 Activity in CML CD34+ Cells Is Not Predictive of Molecular Response to Imatinib Treatment in CP-CML Patients, Despite the Strong Predictive Value of MNC OCT-1 Activity.

Nilotinib concentration in Cell Lines and CML CD34+ Cells Is Not Mediated by Active Uptake or Efflux by Major Drug Transporters

Reduced Activity of the OCT-1 Protein in Primitive CML Cells: A Likely Determinant of Stem Cell Resistance in Imatinib Treated CML Patients

Enhancing the Functional Activity of the OCT-1 Influx Pump May Overcome the Negative Impact of Low OCT-1 Activity in Imatinib Treated CML Patients

Characterisation of Nilotinib Transport in Chronic Myeloid Leukaemia Cells.

In Contrast to Imatinib, OCT-1 Mediated Influx Has Minimal Impact on Cellular Uptake of Dasatinib in CML Patients at Diagnosis.

Unlike Imatinib, Dasatinib Uptake into Chronic Myeloid Leukaemia Cells Is Independent of hOCT1 Expression.

Hypoxia Induces Imatinib Resistance in CML Cell Lines.

Molecular Response to Imatinib Is Dependent on Dose in CML Patients with Low OCT-1 Influx Activity. Patients with High Activity May Respond Equally Well to Standard or Increased Dose Imatinib.

AMN107 Appears Equipotent and May Synergise with Imatinib at the CML Stem Cell Level through Interaction with ABCG2.

Low Baseline Intrinsic Sensitivity to Imatinib (High IC50) in CML Patients Is Due to Reduced Oct-1 Mediated Influx. Intrinsic Sensitivity to AMN107 Does Not Correlate with That of Imatinib and Uptake of AMN107 Is Not Oct-1 Mediated.

Functional ABCG2 Is Expressed on CML Stem Cells and Its Inhibition Selectively Depletes CML CD34+ Cells.

Effect of adrenergic agents on hematopoiesis after syngeneic bone marrow transplantation in mice

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American Society of Hematology

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American Society of Hematology

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