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Journal Articles

MetAP2 Inhibition Modifies Hemoglobin S (HbS) to Delay Polymerization and Improve Blood Flow in Sickle Cell Disease

Melanie Demers, PhD, Sarah Sturtevant, BSc, Kevin Guertin, PhD, Dipti Gupta, Kunal Desai, MS, Benjamin Vieira, BS, Alexandra Hicks, PhD, Ayman Ismail, PhD, Yukio Nakamura, MD PhD, Bronner Goncalves, MD PhD, Giuseppe Di Caprio, PhD, Ethan Schonbrun, PhD, Scott Hansen, BS, Martin K. Safo, PhD, David K. Wood, PhD, John M. Higgins, MD PhD, David R. Light, PhD

Blood (2019) 134 (Supplement_1): 2260.

https://doi.org/10.1182/blood-2019-128727

Published: 2019

Journal Articles

PP-14, a Novel Structurally-Enhanced Antisickling Allosteric Hemoglobin Effector, Increases Oxygen Affinity and Disrupts Hemoglobin S Polymer Formation

Martin K. Safo, PhD, Piyusha P Pagare, PhD, Mohini Ghatge, PhD, Carla Casu, PhD, Valentina Ghiaccio, PhD, Nancy Anabaraonye, Xiaomeng Xu, MS, Stefano Rivella, PhD, Patrick C. Hines, MD PhD, Ke Liu, PhD, Yan Zhang, PhD, Jürgen Venitz, MD PhD, Osheiza Abdulmalik, DVM

Blood (2019) 134 (Supplement_1): 73.

https://doi.org/10.1182/blood-2019-128646

Published: 2019

Journal Articles

Interest of a New Method for Free Plasma Heme Related Species Dosages in Sickle Cell Disease and Beta Thalassemia

Laurent Kiger, Sandia Adypagavane, Laura Bencheikh, PhD, Nicolas Hebert, Stephane Moutereau, MD, Frédéric Galactéros, MD PhD, Michael Marden, PhD, Yves Beuzard, MD, France Pirenne, MD PhD, Pablo Bartolucci, MD PhD

Blood (2019) 134 (Supplement_1): 3381.

https://doi.org/10.1182/blood-2019-130600

Published: 2019

Journal Articles

Toward a Proteome-Complete Computational Model of the Human Red Blood Cell

James T Yurkovich, PhD, Laurence Yang, PhD, Bernhard O Palsson, PhD

Blood (2018) 132 (Supplement 1): 4888.

https://doi.org/10.1182/blood-2018-99-114969

Published: 2018

Journal Articles

Cerebral Metabolic Alterations in Transgenic and Hemizygous Murine Models of Sickle Cell Disease

Craig A Branch, PhD MS, Min-Hui Cui, PhD, Seetharama Acharya, PhD, Caterina Minniti, MD, Sandra Suzuka, Henny Heisler Billett, MD

Blood (2017) 130 (Supplement 1): 2228.

https://doi.org/10.1182/blood.V130.Suppl_1.2228.2228

Published: 2017

Journal Articles

Low Nocturnal Hemoglobin Oxygen Saturation Does Not Predict Pain or Acute Chest Syndrome Episodes in Children with Sickle Cell Anemia

Shaina Willen Johnson, MD, Susan Redline, MD, Carol Rosen, MD, Mark J. Rodeghier, PhD, Michael DeBaun, MD

Blood (2016) 128 (22): 1320.

https://doi.org/10.1182/blood.V128.22.1320.1320

Published: 2016

Journal Articles

Ischemic Pain Testing Demonstrates Hypoxia Dependent Early Pain and Hypoxia Independent Persistent Pain Responses in Adults with Sickle Cell Anemia

Kathleen Vaughan, BA, Joseph Kim, BS, Daniel Lichy, BS, Nathan S Fishman, BA, Amit Khandhadia, BS, You Keun Kim, Stephen Yoon, BS, Niral Sheth, BS, James Ahad, BS, Hans Ackerman, MD, Inna Belfer, MD PhD, Alexander M. Gorbach, PhD, James G. Taylor, MD

Blood (2016) 128 (22): 3657.

https://doi.org/10.1182/blood.V128.22.3657.3657

Published: 2016

Journal Articles

Moderate Exercise Training Attenuates Inflammation in Transgenic Sickle Cell Mice

Emmanuelle Charrin, Cyril Martin, PhD, John Dube, PhD, Philippe Connes, PhD, Vincent Pialoux, PhD, Solomon Fiifi Ofori-Acquah, PhD

Blood (2015) 126 (23): 976.

https://doi.org/10.1182/blood.V126.23.976.976

Published: 2015

Journal Articles

GBT440 Demonstrates High Specificity for Red Blood Cells in Nonclinical Species

Athiwat Hutchaleelaha, PhD, Mira Patel, PhD, Abel Silva, Donna Oksenberg, PhD, Brian Metcalf, PhD

Blood (2015) 126 (23): 2172.

https://doi.org/10.1182/blood.V126.23.2172.2172

Published: 2015

Journal Articles

Simultaneous Determination of Free Heme and Free Hemoglobin in Biological Samples By Spectral Deconvolution

Jennifer Hamm, MD, Joo-Yeun Oh, PhD, Jeffrey D. Lebensburger, DO, Rakesh P. Patel, PhD

Blood (2014) 124 (21): 4868.

https://doi.org/10.1182/blood.V124.21.4868.4868

Published: 2014

Journal Articles

Erythrocyte Adenosine A2B Receptor-Mediated AMP-Activated Protein Kinase Prevents Hypoxia-Induced Tissue Injury in High Altitude By Inducing 2,3-Bisphosphoglycerate

Hong Liu, MD, Yujin Zhang, PhD, Anren Song, PhD, Harry Karmouty Quintana, PhD, Almut Grenz, MD PhD, Hong Sun, MD PhD, Rodney E. Kellems, PhD, Holger Eltzschig, PhD, Robert Roach, PhD, Michael R. Blackburn, PhD, Yang Xia, MD PhD

Blood (2014) 124 (21): 2664.

https://doi.org/10.1182/blood.V124.21.2664.2664

Published: 2014

Journal Articles

Desaturation Is Related to the Presence of Dense Red Blood Cells in Sickle Cell Patients and Is Reversed By Hydroxyurea

Gaetana Di Liberto, Laurent Kiger, Michael Marden, Laurent Boyer, Marc Conti, Anoosha Habibi, Marie Georgine Rakotoson, Sanam Khorgami, Benoit Vingert, Bernard Maitre, Frédéric Galacteros, France Noizat-Pirenne, Pablo Bartolucci

Blood (2014) 124 (21): 2713.

https://doi.org/10.1182/blood.V124.21.2713.2713

Published: 2014

Journal Articles

Rapid Reversal of Red Blood Cell Sickling Promoted By Pegylated Carboxyhemoglobin Bovine Gas Transfer Properties

Ronald Jubin, PhD, Peter Buontempo, MSc, BSc, Ricardo A Yglesias, BA, MS, Abe Abuchowski, PhD MHS, Yuli Chen, BS, MS, Glenn Kazo, MS, Friedericke Kazo, MS

Blood (2014) 124 (21): 1372.

https://doi.org/10.1182/blood.V124.21.1372.1372

Published: 2014

Journal Articles

Cation Leak in Red Blood Cells of Patients with Wiskott-Aldrich Syndrome Leads to Non-Immunologic Hemolysis

Robert A. Sokolic, MD, Satheesh Chonat, MD, Mary Risinger, RN, Michael Eckhaus, DVM, Elizabeth Garabedian, RN, MSLS, Katherine R. Calvo, MD, PhD, Irina Maric, MD, Theodosia A. Kalfa, MD PhD, Fabio Candotti, MD

Blood (2014) 124 (21): 1338.

https://doi.org/10.1182/blood.V124.21.1338.1338

Published: 2014

Journal Articles

GTx011, a Novel Agent That Improves Rheological Properties Of Sickle Cell Blood By Increasing Oxygen Affinity For Hemoglobin

Mira Patel, PhD, Donna Oksenberg, PhD, Abel Silva, BS, Andreas Betz, PhD, Brian Metcalf, PhD, Uma Sinha, PhD

Blood (2013) 122 (21): 2207.

https://doi.org/10.1182/blood.V122.21.2207.2207

Published: 2013

Journal Articles

Performance Of The Simplified Pesi Score In Patients With Pulmonary Embolism Treated With Rivaroxaban Or Standard Therapy

Petra MG Erkens, PhD, Gregory J Fermann, MD, FACEP, Martin H Prins, MD, Philip S Wells, MD, MSc, Akos F Pap, MSc, Anthonie WA Lensing, MD

Blood (2013) 122 (21): 1139.

https://doi.org/10.1182/blood.V122.21.1139.1139

Published: 2013

Journal Articles

Evaluation of Autonomic Function in Patients with Sickle Cell Disease in Relation to Nighttime Hypoxemia

McGuire Erin, B.S., Roberta Miyeko Kato, MD, Adam M Bush, BS, Heather Zmyewski, Jon Detterich, MD, Daniel Gardner, Michael Khoo, PhD, Herbert J Meiselman, ScD, Thomas D. Coates, MD, John C Wood, MD, Ph.D

Blood (2012) 120 (21): 4764.

https://doi.org/10.1182/blood.V120.21.4764.4764

Published: 2012

Journal Articles

Mechanistic Study of Hemoglobin Induced Platelet Activation

Christine R. Carlisle, PhD, Mary Stahle, Ryan Vest, Roy Hantgan, PhD, Janet Lee, MD, Mark T Gladwin, MD, Daniel Kim-Shapiro, PhD

Blood (2011) 118 (21): 5262.

https://doi.org/10.1182/blood.V118.21.5262.5262

Published: 2011

Journal Articles

Transfusion of Stored Autologous Blood Alters Reactive Hyperemia and Circulating Nitrite Levels in Healthy Volunteers

Lorenzo Berra, Walter Sunny Dzik, MD, Andrea Coppadoro, Kenneth D. Bloch, MD, Binglan Yu, PhD, Ester Spagnolli, Andrea U. Steinbicker, MD, MPH, Martin Feelisch, Bernadette Fernandez, Christopher Stowell, Shaw H Warren, Tian Lin, Warren M. Zapol, MD

Blood (2011) 118 (21): 2327.

https://doi.org/10.1182/blood.V118.21.2327.2327

Published: 2011

Journal Articles

Pulmonary Hypertension During Autologous Transfusion of Stored Blood Is Prevented by Nitric Oxide Inhalation in Lambs

David M. Baron, MD, Binglan Yu, PhD, Chong Lei, MD, PhD, Aranya Bagchi, MD, Arkadi Beloiartsev, MD, Andrea U. Steinbicker, MD, MPH, Christopher P. Stowell, MD, PhD, Rajeev Malhotra, MD, Kenneth D. Bloch, MD, Warren M. Zapol, MD

Blood (2011) 118 (21): 39.

https://doi.org/10.1182/blood.V118.21.39.39

Published: 2011

NARROW

MetAP2 Inhibition Modifies Hemoglobin S (HbS) to Delay Polymerization and Improve Blood Flow in Sickle Cell Disease

PP-14, a Novel Structurally-Enhanced Antisickling Allosteric Hemoglobin Effector, Increases Oxygen Affinity and Disrupts Hemoglobin S Polymer Formation

Interest of a New Method for Free Plasma Heme Related Species Dosages in Sickle Cell Disease and Beta Thalassemia

Toward a Proteome-Complete Computational Model of the Human Red Blood Cell

Cerebral Metabolic Alterations in Transgenic and Hemizygous Murine Models of Sickle Cell Disease

Low Nocturnal Hemoglobin Oxygen Saturation Does Not Predict Pain or Acute Chest Syndrome Episodes in Children with Sickle Cell Anemia

Ischemic Pain Testing Demonstrates Hypoxia Dependent Early Pain and Hypoxia Independent Persistent Pain Responses in Adults with Sickle Cell Anemia

Moderate Exercise Training Attenuates Inflammation in Transgenic Sickle Cell Mice

GBT440 Demonstrates High Specificity for Red Blood Cells in Nonclinical Species

Simultaneous Determination of Free Heme and Free Hemoglobin in Biological Samples By Spectral Deconvolution

Erythrocyte Adenosine A2B Receptor-Mediated AMP-Activated Protein Kinase Prevents Hypoxia-Induced Tissue Injury in High Altitude By Inducing 2,3-Bisphosphoglycerate

Desaturation Is Related to the Presence of Dense Red Blood Cells in Sickle Cell Patients and Is Reversed By Hydroxyurea

Rapid Reversal of Red Blood Cell Sickling Promoted By Pegylated Carboxyhemoglobin Bovine Gas Transfer Properties

Cation Leak in Red Blood Cells of Patients with Wiskott-Aldrich Syndrome Leads to Non-Immunologic Hemolysis

GTx011, a Novel Agent That Improves Rheological Properties Of Sickle Cell Blood By Increasing Oxygen Affinity For Hemoglobin

Performance Of The Simplified Pesi Score In Patients With Pulmonary Embolism Treated With Rivaroxaban Or Standard Therapy

Evaluation of Autonomic Function in Patients with Sickle Cell Disease in Relation to Nighttime Hypoxemia

Mechanistic Study of Hemoglobin Induced Platelet Activation

Transfusion of Stored Autologous Blood Alters Reactive Hyperemia and Circulating Nitrite Levels in Healthy Volunteers

Pulmonary Hypertension During Autologous Transfusion of Stored Blood Is Prevented by Nitric Oxide Inhalation in Lambs

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American Society of Hematology

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American Society of Hematology

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