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Journal Articles

A Combination Strategy Targeting Enhancer Plasticity Exerts Synergistic Lethality Against Beti-Resistant Leukemia Cells

Lei Guo, PhD, Jia Li, PhD, Hongxiang Zeng, PhD, Anna Guzman, Tingting Li, MD, Minjung Lee, MS, Yubin Zhou, PhD, Clifford Stephan, Peter J.A Davies, Margaret Goodell, PhD, Deqiang Sun, PhD, Mark A. Dawson, PhD MBBS, Yun Huang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5053.
https://doi.org/10.1182/blood-2019-130586
Published: 2019
Journal Articles

BCL-2 Inhibitor Venetoclax Enhances Temozolomide Sensitivity in AML

Joseph M Brandwein, MD, Asmaa Basonbul, MSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 2646.
https://doi.org/10.1182/blood-2019-129529
Published: 2019
Journal Articles

Multiple Myeloma Epigenetic Programming Prognostic of Outcome Converges with Loci Reprogrammed in Relapsed/Refractory Disease

Benjamin G Barwick, PhD, Sheri Skerget, PhD, Jonathan J Keats, PhD, Daniel Auclair, Sagar Lonial, Lawrence H. Boise, PhD, Paula M Vertino, PhD, Doris R Powell, MA
Journal: Blood
Blood (2019) 134 (Supplement_1): 858.
https://doi.org/10.1182/blood-2019-124422
Published: 2019
Journal Articles

DNA Repair Genes May Influence Cognitive Outcomes in Adult Patients with Hematologic Malignancies (HM) Treated with Blood or Marrow Transplantation (BMT)

Noha Sharafeldin, MBBCh, MSc, PhD, Alysia Bosworth, BA, Yanjun Chen, MS, Purnima Singh, PhD BS, MSc, Sunita Patel, PhD, Xuexia Wang, PhD, Emily Morse, MA, Molly Mather, MS, Can-Lan Sun, PhD, Liton F. Francisco, BS, Stephen J Forman, F. Lennie Wong, PhD, Smita Bhatia, MD MPH
Journal: Blood
Blood (2018) 132 (Supplement 1): 3411.
https://doi.org/10.1182/blood-2018-99-113043
Published: 2018
Journal Articles

In Vivo Enrichment of Genetically Manipulated Platelets for Murine Haemophilia B Gene Therapy

Yingyu Chen, PhD, Jocelyn A. Schroeder, Jianda Hu, PhD, Qizhen Shi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3483.
https://doi.org/10.1182/blood-2018-99-112245
Published: 2018
Journal Articles

Longitudinal Multilevel Omic Analysis of Pediatric T-ALL Reveals Distinct Mechanisms for Disease Progression in Type 1 and in Type 2 Relapses

Paulina Richter-Pechanska, PhD, Joachim B. Kunz, MD, Tobias Rausch, Busra Erarslan-Uysal, Beat Bornhauser, PhD, Viktoras Frismantas, PhD, Maria Pamela Dobay, PhD, Caroline Von Knebel Doeberitz, Martin Zimmermann, PhD, Stephan Fuhrmann, Martin Stanulla, MD PhD, Martin Schrappe, MD PhD, Gunnar Cario, MD, Gabriele Escherich, Kseniya Bakharevich, Renate Kirschner-Schwabe, PhD, Cornelia Eckert, PhD, Stefan Pfister, Martina U. Muckenthaler, PhD, Jean-Pierre Bourquin, MD PhD, Jan O. Korbel, PhD, Andreas E. Kulozik, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2826.
https://doi.org/10.1182/blood-2018-99-117978
Published: 2018
Journal Articles

Thalassemia Gene Therapy By In Vivo Transduction of Mobilized Hematopoietic Stem Cells (HSCs) with an Integrating Hybrid Adenovirus Vector System

Afrodite Georgakopoulou, PhDstudent, Hongjie Wang, PhD, Chrysi Kapsali, Undergraduate, Nikoleta Psatha, PhD, Angeliki Koufali, Graduate, Chang Li, PhD, Zsuzsanna Izsvak, PhD, Achilles Anagnostopoulos, Thalia Papayannopoulou, MD DrSci, Evangelia Yannaki, MD, Andre Lieber, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2193.
https://doi.org/10.1182/blood-2018-99-116787
Published: 2018
Journal Articles

A Protective Role of DNA Repair Genes Against Acute Graft Versus Host Disease in Children

Patricia Huezo-Diaz, Chakradhara RS Uppugunduri, PhD, Mohamed Aziz Rezgui, MsC, Anuj Tyagi, PhD, Vid Mlakar, PhD, Laurence Lesne, MSc, Tiago Nava, MD, Yves Theoret, PhD, Yves Chalandon, MD PhD, Robbert Bredius, PhD MD, Jean-Hugues Dalle, MD PhD, Peter Bader, MD PhD, Christina Peters, MD, Henrique Bittencourt, MD PhD, Maja Krajinovic, MD PhD, Marc Ansari, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 749.
https://doi.org/10.1182/blood.V130.Suppl_1.749.749
Published: 2017
Journal Articles

Targeting DNA Repair Mechanisms to Overcome Drug Resistance in Diffuse Large B Cell Lymphoma

Julie Devin, Yea-Lih Lin, PhD, Alboukadel Kassambara, PhD, Guillaume Cartron, Olivier Elemento, PhD, Angelos Constantinou, PhD, Philippe Pasero, PhD, Caroline Bret, PhD PharmD, Jerome Moreaux, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1479.
https://doi.org/10.1182/blood.V130.Suppl_1.1479.1479
Published: 2017
Journal Articles

Edo-S101, a Bendamustine (BDM)/ Histone-Deacetylase Inhibitor (HDACi) Fusion Molecule, Demonstrates Potent Preclinical Activity Against T-Cell Malignancies and Overcomes BDM-Resistance

Rosaria De Filippi, MD PhD, Stefania Crisci, ScD, Sara Mele, BS, Serena Zanotta, ScD, Gaetano Corazzelli, MD, Domenico Galati, MD PhD, Davide Coppola, RN, Piera Maiolino, PharmD, Mariangela Saggese, PharmD, Francesco Volzone, MD, Emanuela Morelli, MD, Daniela Donnarumma, MD, Gianpaolo Marcacci, MD, Ferdinando Frigeri, MD, Niels Odum, MD, Thomas Mehrling, MD PhD, Antonio Pinto, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2547.
https://doi.org/10.1182/blood.V130.Suppl_1.2547.2547
Published: 2017
Journal Articles

RNA Sequencing Data-Driven Dissection of Human Plasma Cell Differentiation Reveals New Potential Transcription Regulators

Alboukadel Kassambara, PhD, Laurie Herviou, Michel Jourdan, Coraline Thibaut, Veronika Vikova, Olivier Elemento, PhD, Jerome Moreaux, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4382.
https://doi.org/10.1182/blood.V130.Suppl_1.4382.4382
Published: 2017
Journal Articles

Divergent Epigenomes in Pediatric and Adult Acute Myeloid Leukemia Implicate Cell of Origin and Transcriptional Silencing of Immune Responses As Sources of Clinically Relevant Heterogeneity: A Report from the Children's Oncology Group and NCI/COG Therapeutically Applicable Research to Generate Effective Treatments (TARGET) Initiative

Timothy Junius Triche, Jr., PhD, Jason E Farrar, MD, Hamid Bolouri, PhD, Rhonda E. Ries, MA, Emilia L. Lim, PhD, Todd A. Alonzo, PhD, Yussanne Ma, PhD, Richard Moore, PhD, Andrew J. Mungall, Marco A. Marra, PhD, Jaime M. Guidry Auvil, PhD, Tanja M. Davidsen, PhD, Patee Gesuwan, Leandro C. Hermida, E. Anders Kolb, MD, Alan Gamis, MD, Malcolm A. Smith, MD PhD, Stephen R Piccolo, PhD, Daniela S Gerhard, PhD, Soheil Meshinchi, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1046.
https://doi.org/10.1182/blood.V128.22.1046.1046
Published: 2016
Journal Articles

Multi-Database Description of Primary Splenic Diffuse Large B-Cell Lymphoma

Namratha R Vontela, MD, Kenneth Byrd, Brennan McCullar, MD, Michael G. Martin, MD
Journal: Blood
Blood (2016) 128 (22): 5399.
https://doi.org/10.1182/blood.V128.22.5399.5399
Published: 2016
Journal Articles

Lomeguatrib, a O 6 -Methylguanine-DNA-Methyltransferase (MGMT) Inhibitor, Induces DNA Damage Induced Apoptosis By Targeting Double-Strand DNA Repair in Multiple Myeloma

Dilara Akcora Yildiz, PhD, Tulin Ozkan, PhD, Yunus Yukselten, MS, Nezaket Turkel Sesli, PhD, Seyma Ozkanca, MS, Mehmet Gunduz, MD, Mehmet Ozen, MD, Meral Beksac, MD, Asuman Sunguroglu, PhD
Journal: Blood
Blood (2016) 128 (22): 2103.
https://doi.org/10.1182/blood.V128.22.2103.2103
Published: 2016
Journal Articles

Identification of Anti-Lymphoma Biomarkers of Response to the Anti-CD37 Antibody Drug Conjugate (ADC) IMGN529

Eugenio Gaudio, PhD, Chiara Tarantelli, PhD, Alberto Arribas, PhD, Luciano Cascione, PhD, Ivo Kwee, PhD, Andrea Rinaldi, PhD, Maurilio Ponzoni, MD, Roberta Pittau Bordone, Georg Stussi, MD, Davide Rossi, MD PhD, Emanuele Zucca, Anastasios Stathis, Callum Sloss, PhD Molecular Biology, Francesco Bertoni, MD
Journal: Blood
Blood (2016) 128 (22): 4187.
https://doi.org/10.1182/blood.V128.22.4187.4187
Published: 2016
Journal Articles

A Phase 1 Study of the PARP Inhibitor Veliparib in Combination with Temozolomide in Acute Leukemias

Ivana Gojo, MD, Jan H. Beumer, PharmD, PhD, Keith Pratz, MD, Jiuping Ji, Lihua Wang, PhD, Michelle A. Rudek, PharmD, PhD, Michael A. McDevitt, MD PhD, Maria R. Baer, MD, Amanda Blackford, ScM, B. Douglas Smith, MD, Steven D. Gore, MD, Hetty E. Carraway, MD MBA, Margaret M. Showel, MD, Mark J. Levis, MD PhD, Amy E. DeZern, MD MHS, Douglas Gladstone, MD, Tania Jain, MD, Jackie Greer, RN, Marie Pouquet, PharmD, Ali-walbi Ismail, PharmD, MS, James Herman, MD, Weijie Poh, PhD, Larry Karnitz, PhD, Scott H. Kaufmann, MD PhD, Alice Chen, MD, Judith E Karp, MD
Journal: Blood
Blood (2015) 126 (23): 1361.
https://doi.org/10.1182/blood.V126.23.1361.1361
Published: 2015
Journal Articles

The First-in-Class Alkylating Histone-Deacetylase Inhibitor (HDACi) Fusion Molecule Edo-S101 Exerts Potent Preclinical Activity Against Tumor Cells of Hodgkin Lymphoma (HL) Including Bendamustine-Resistant Clones

Rosaria De Filippi, MD PhD, Stefania Crisci, ScD, Michele Cillo, ScD, Sara Mele, BS, Angela De Monaco, ScD, Domenico Galati, MD, Serena Zanotta, ScD, Gaetana Capobianco, MD, Francesco Volzone, MD, Manuela Arcamone, MD, Piera Maiolino, PharmD, Mariangela Saggese, PharmD, Gaetano Corazzelli, MD, Ferdinando Frigeri, MD PhD, Thomas Mehrling, MD PhD, Antonello Pinto, MD
Journal: Blood
Blood (2015) 126 (23): 2481.
https://doi.org/10.1182/blood.V126.23.2481.2481
Published: 2015
Journal Articles

Cistrome Control of Hematopoieitic Stem/Progenitor Cell Function

Kyle Hewitt, PhD, Kirby D. Johnson, Duk-Hyoung Kim, Prithvia Devadas, Rajalekshmi Prathibha, Chandler Zuo, Colin Dewey, Rajendran Sanalkumar, Jin-Soo Kim, Sunduz Keles, Emery H Bresnick, PhD
Journal: Blood
Blood (2015) 126 (23): 43.
https://doi.org/10.1182/blood.V126.23.43.43
Published: 2015
Journal Articles

Long-Term Increase in Fetal Hemoglobin Expression in Nonhuman Primates Following Transplantation of Autologous Bcl11a Nuclease-Edited HSCs

Olivier Humbert, PhD, Hans-Peter Kiem, MD
Journal: Blood
Blood (2015) 126 (23): 2035.
https://doi.org/10.1182/blood.V126.23.2035.2035
Published: 2015
Journal Articles

Viral Insertion Safety in Patients with Glioblastoma Who Received a Novel Lentiviral MGMT-P140K Gene Therapy to Protect Bone Marrow from Chemotherapy: No Dominant Clonal Evolution Observed with Chemo-Selection

Hua Fung, Andrew E Sloan, Jane Reese, Basem M. William, MD, Karen Lingas, Lisa R Rogers, Heather Embree, Hillard M. Lazarus, Donna Kane, Boro Dropulic, Stanton L. Gerson
Journal: Blood
Blood (2014) 124 (21): 4801.
https://doi.org/10.1182/blood.V124.21.4801.4801
Published: 2014