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Journal Articles

Epigenetic Activation of the pH Regulator MCT4 in Acute Myeloid Leukemia Exploits a Fundamental Metabolic Process of Enhancing Cell Growth through Proton Shifting

Cheuk-Him Man, David T. Scadden, MD, Francois Mercier, MD FRCPC, Nian Liu, Wentao Dong, Gregory Stephanopoulos, PhD, Li Jiang, PhD, Yookyung Jung, PhD, Charles Lin, PhD, Anskar Y.-H. Leung, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3765.
https://doi.org/10.1182/blood-2019-123604
Published: 2019
Journal Articles

Inhibition of Carbonic Anhydrase-IX As a Novel Strategy to Overcome Hypoxia Mediated Drug Resistance in FLT3/ITD Mutated Acute Myeloid Leukemia

Fangli Chen, MD PhD, Adriana Rogozea, George Sandusky, DVM, PhD, Mircea Ivan, MD PhD, Heiko Konig, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2521.
https://doi.org/10.1182/blood.V130.Suppl_1.2521.2521
Published: 2017
Journal Articles

Dematin and Adducin Tether Sodium-Hydrogen Exchanger, NHE1, to Erythrocyte Membrane Cytoskeleton

Yunzhe Lu, PhD, Alicia Rivera, Athar Chishti, PhD
Journal: Blood
Blood (2016) 128 (22): 700.
https://doi.org/10.1182/blood.V128.22.700.700
Published: 2016
Journal Articles

Inhibition of NHE1 Induced Apoptosis in Cytarabine Resistant Leukemia Cell Lines and Primary Leukemia Cells from AML Patients, Which Showed Increased Intracellular pH and NHE1 Activity

Shin Young Hyun, Young Kyung Kim, Ji Eun Jang, MD, Yundeok Kim, MD, Yu Ri Kim, MD PhD, June-Won Cheong, MD,PhD, Kwang Yong Shim, Yoo Hong Min, MD,PhD
Journal: Blood
Blood (2014) 124 (21): 3614.
https://doi.org/10.1182/blood.V124.21.3614.3614
Published: 2014
Journal Articles

Novel Therapeutic Strategy Targeting NHE1 and Its Upstream Activators in Acute Myeloid Leukemia

Cheuk-Him Man, PhD, Chae-Yin Cher, Stephen S.Y. Lam, Eric S.K. Ho, Nelson K.L. Ng, Anskar Y.H. Leung, MD
Journal: Blood
Blood (2014) 124 (21): 913.
https://doi.org/10.1182/blood.V124.21.913.913
Published: 2014
Journal Articles

A Novel Role Of Tescalcin-Sodium/Hydrogen Exchange Axis Underlying Sorafenib Resistance In FLT3-ITD + AML

Cheuk Him Man, Anskar Y.H. Leung, MD, Stephen Sze Yuen Lam, Murphy Ka Hei Sun, Howard Chun Hung Chow, Harinder Gill, MBBS, MRCP (UK), Yok Lam Kwong, MD
Journal: Blood
Blood (2013) 122 (21): 3848.
https://doi.org/10.1182/blood.V122.21.3848.3848
Published: 2013
Journal Articles

Pharmacologic Doses of Amiloride Preferentially Induce Apoptosis and Growth Inhibition of Flt3-ITD Mutation Positive Acute Myeloid Leukemia Cell Lines

Yuliya Linhares, M.D., Jade Dardine, M.D., Siavash Kurdistani, M.D.
Journal: Blood
Blood (2011) 118 (21): 5004.
https://doi.org/10.1182/blood.V118.21.5004.5004
Published: 2011
Journal Articles

Metabolic reprogramming by HIF-1 promotes the survival of bone marrow–derived angiogenic cells in ischemic tissue

Sergio Rey, Weibo Luo, Larissa A. Shimoda, Gregg L. Semenza
Journal: Blood
Blood (2011) 117 (18): 4988–4998.
https://doi.org/10.1182/blood-2010-11-321190
Published: 2011
Journal Articles

Re-Organization of Cardiac Band 3 (cAE1) in Neonatal Cardiomyocytes Submitted to Alkali Loading.

Mariana O. Baratti, Paulo R.M. Lima, PhD, Daniella C. Alberto, PhD, Luciene Borges, Kleber G. Franchini, PhD, Fernando F. Costa, PhD, Sara T.O. Saad, PhD
Journal: Blood
Blood (2006) 108 (11): 3744.
https://doi.org/10.1182/blood.V108.11.3744.3744
Published: 2006
Journal Articles

Treahlose Loaded, Freeze-Dried Rehydrated Human Platelets Maintain and Regulate Their Intracellular pH.

Fern Tablin, VMD, PhD, Minke Tang, PhD, Naomi J. Walker, BS, John H. Crowe, PhD
Journal: Blood
Blood (2004) 104 (11): 3638.
https://doi.org/10.1182/blood.V104.11.3638.3638
Published: 2004
Journal Articles

Metabolic Profile of Imatinib Resistance in CML Cells.

Jelena Miljus, Junia V. Melo, Laszlo Boros, Nora Anderson, Moshe Talpaz, Dieter Leibfritz, Gail S. Eckhardt, Natalie Serkova
Journal: Blood
Blood (2004) 104 (11): 1982.
https://doi.org/10.1182/blood.V104.11.1982.1982
Published: 2004
Journal Articles

Ammonium Transport by the Erythrocyte Rh-Associated Protein.

Connie M. Westhoff, PhD, Binh Dang, MS, Mak Daniel, PhD, Foskett J. Kevin, PhD
Journal: Blood
Blood (2004) 104 (11): 1594.
https://doi.org/10.1182/blood.V104.11.1594.1594
Published: 2004
Journal Articles

Apoptosis of leukemic cells accompanies reduction in intracellular pH after targeted inhibition of the Na + /H + exchanger

Ivan N. Rich, Diana Worthington-White, Oliver A. Garden, Philip Musk
Journal: Blood
Blood (2000) 95 (4): 1427–1434.
https://doi.org/10.1182/blood.V95.4.1427.004k48_1427_1434
Published: 2000
Journal Articles

Influence of pH on Phospholipid Redistribution in Human Erythrocyte Membrane

Jeanette Libera, Thomas Pomorski, Peter Müller, Andreas Herrmann
Journal: Blood
Blood (1997) 90 (4): 1684–1693.
https://doi.org/10.1182/blood.V90.4.1684
Published: 1997