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Journal Articles

The chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability

Free
Zhaowei Tu, Chen Wang, Ashley K. Davis, Mengwen Hu, Chuntao Zhao, Mei Xin, Q. Richard Lu, Yi Zheng
Journal: Blood
Blood (2021) 138 (3): 221–233.
https://doi.org/10.1182/blood.2020009997
Published: 2021
Includes: Supplemental data
Journal Articles

High Burden of Clonal Hematopoiesis in First Responders Exposed to the World Trade Center Disaster

Free
Sakshi Jasra, MD, Orsi Giricz, PhD, Rachel Zeig-Owens, M.P.H, David Goldfarb, M.P.H, Angelica Barreto-Galvez, Kith Pradhan, PhD, Jiahao Chen, PhD, Gaurav S Choudhary, PhD, Srinivas Aluri, Tushar D Bhagat, PhD, Aditi Shastri, MD, Victor Thiruthuvanathan, M.S, Hiroki Goto, MD PhD, Jeannine Gerhardt, PhD, Shanisha Gordon, Arul Veerappan, PhD, Syed Hissam Haider, MD, Matthias Bartenstein, MD, George Nwankwo, Ola Landgren, MD PhD, Michael Weiden, MD, Frederick Fletcher, Lee Greenberger, PhD, Benjamin L. Ebert, MD PhD, Ulrich G. Steidl, MD PhD, Britta Will, PhD, Anna Nolan, MD MS, David Prezant, MD, Advaitha Madireddy, PhD, Amit Verma, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 3720.
https://doi.org/10.1182/blood-2019-129276
Published: 2019
Journal Articles

Dysregulation of Splicing Patterns in MDS Induced By the S100A9/Fto Axis

Free
Erika Adriana Eksioglu, MS PhD, Ling Cen, PhD, Xianghong Chen, PhD, Pingyan Cheng, MD, Kenneth Wright, PhD, Thu Le Trinh, PhD, Danielle Gilvary, BS, Wendy Kandell, BS, Jinhong Liu, MD, Yin-Kai Chen, MD, Amy F McLemore, M.S., Alexandra Calescibetta, John Cleveland, PhD, Alan F. List, MD, Sheng Wei, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4215.
https://doi.org/10.1182/blood-2019-128434
Published: 2019
Journal Articles

Germinal Predisposition in Myelodysplastic Syndromes in Young Adults without a Preexisting Disorder or Organ Dysfunction: Identification of Deleterious Variants in Microsatellite Instability Genes

Free
Tzu Hua Chen-Liang, Ana M Hurtado López, María Zurdo, Esperanza Such, Raul Teruel-Montoya, PhD, Laura Palomo, María-José Jimenez, MD, Rafael Andres del Orbe Barreto, Blanca Navarro, MD PhD, Félix López Cadenas, MD, Eduardo José Salido, MD, Carmen Benet, MD, Begoña Muiña, Raquel de Oña, Nuria de Haro, Fernando Ramos, Montserrat Arnan Sangerman, Francisca Maria Hernandez, MD, Francisco José Ortuño, Leonor Senent, Ana Vicente, María Díez-Campelo, MD PhD, Maria Lourdes Hermosin, MD, Teresa Bernal Del Castillo, MD PhD, Mar Tormo, MD PhD, Beatriz Arrizabalaga, Blanca Xicoy, MD MSc, José Cervera, MD PhD, Francesc Sole, PhD, Guillermo F. Sanz, MD PhD, Andres Jerez
Journal: Blood
Blood (2019) 134 (Supplement_1): 4226.
https://doi.org/10.1182/blood-2019-127204
Published: 2019
Journal Articles

Targeting Polo-like Kinase 4 for Therapeutic Benefit in the Patients with Diffuse Large B-Cell Lymphoma

Free
Yi Zhao, MM, Yang Han, MM, Juan Yang, MM, Shunfeng Hu, Xin Wang, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2568.
https://doi.org/10.1182/blood-2019-129548
Published: 2019
Journal Articles

High-Throughput Immunofluorescence and Electron Tomography to Characterize Centrosomal Aberrations in Plasma Cell Neoplasia

Free
Tobias Dittrich, MD, Martin Schorb, Isabella Haberbosch, MD, Elena Bausch, PhD, Mandy Börmel, Marco Cosenza, PhD, Hartmut Goldschmidt, MD, Carsten Müller-Tidow, MD, Marc S Raab, MD PhD, Ute Hegenbart, MD, Stefan O. Schönland, MD, Yannick Schwab, PhD, Alwin Krämer, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3077.
https://doi.org/10.1182/blood-2019-130713
Published: 2019
Journal Articles

This Is a Title in Title Case: Prediction of CML Evolution By Telomere Length Analysis at the Single-Chromosome Level

Free
Jingyuan Lu, Yingxing Zhou, Xiaomei Yan, Quanyi Lu
Journal: Blood
Blood (2019) 134 (Supplement_1): 2937.
https://doi.org/10.1182/blood-2019-126895
Published: 2019
Journal Articles

Effect of the Unfolded Protein Response and Oxidative Stress on Mutagenesis of CSF3R a Model of Evolution of Severe Congenital Neutropenia to Myelodysplastic Syndrome/Acute Myeloid Leukemia

Free
Adya Sapra, MS, Roman Jaksik, PhD, Sara Biesiadny, Hrishikesh M Mehta, PhD, Marek Kimmel, PhD DSc, Seth J. Corey, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3752.
https://doi.org/10.1182/blood-2019-127401
Published: 2019
Journal Articles

Aurora Kinase a/MDM2-Mediated SETD2 Loss of Function in Chronic Myeloid Leukemia Patients in Blast Crisis Can be Therapeutically Targeted Inducing Apoptotic Cell Death in a Caspase-Dependent Way

Free
Manuela Mancini, PhD, Sara De Santis, Dr, Cecilia Monaldi, Dr, Luana Bavaro, Dr, Margherita Martelli, Dr, Gabriele Gugliotta, MD PhD, Fausto Castagnetti, MD PhD, Gianantonio Rosti, MD, Maria Chiara Fontana, PhD, Samantha Bruno, Dr, Elisa Dan, PhD, Barbara Sinigaglia, Dr, Alessandra Iurlo, MD PhD, Nicola Orofino, MD, Elisabetta Abruzzese, MD, Marzia Salvucci, MD, Patrizia Pregno, Antonella Gozzini, MD, Monica Crugnola, MD, Francesco Albano, MD, Massimiliano Bonifacio, MD, Elisabetta Calistri, MD, Mario Tiribelli, Gianni Binotto, MD, Annalisa Imovilli, Elena Trabacchi, MD, Sara Galimberti, MD PhD, Claudia Baratè, Elena Tenti, Michele Baccarani, MD, Giovanni Martinelli, MD, Michele Cavo, Simona Soverini, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4142.
https://doi.org/10.1182/blood-2019-126500
Published: 2019
Journal Articles

DNA Polymerases Pol θ/Pol η Involved in Error-Prone DNA Repair Are Highly Expressed in Multiple Myeloma and Upregulated By DNA Damage

Free
Masanobu Sunaga, Master, Graduate Student, Tsukasa Oda, PhD, Eiko Yamane, Master, Graduate Student, Rei Ishihara, Master, Graduate Student, Yuki Murakami, Master, Graduate Student, Saki Watanabe, Master, Yuta Asao, Graduate Student, Yuta Masuda, Master, Hisashi Takei, MD, Nobuhiko Kobayashi, MD PhD, Yohei Osaki, MD PhD, Gotoh Nanami, Tetsuhiro Kasamatsu, PhD, Hiromi Koiso, MD PhD, Makiko Takizawa, MD PhD, Hiroaki Shimizu, MD PhD, Takuma Ishizaki, MD PhD, Yoshiyuki Ogawa, MD PhD, Akihiko Yokohama, MD PhD, Norifumi Tsukamoto, MD PhD, Takayuki Saitoh, MD PhD, Hirokazu Murakami, MD PhD, Hiroshi Handa, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4364.
https://doi.org/10.1182/blood-2019-125163
Published: 2019
Journal Articles

1q21 Gain May Challenge the Role of t(4;14) As an Adverse Prognostic Marker of Multiple Myeloma

Free
Chenxing Du, An Gang, MD, Yan Xu, Xuehan Mao, MD, Yuting Yan, Jiahui Liu, Huishou Fan, Weiwei Sui, Shuhui Deng, MD, Li Zengjun, Chengwen Li, Shuhua Yi, MD, Mu Hao, Dehui Zou, MD, Fenghuang Zhan, MD PhD, Yu-Tzu Tai, PhD, Kenneth C. Anderson, MD, Lugui Qiu, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4343.
https://doi.org/10.1182/blood-2019-129739
Published: 2019
Journal Articles

Macrophages Promote DNA Repair of Double Strand Break in Multiple Myeloma Cells By Non-Homologous End Joining(NHEJ), Nevertheless Decrease Its Accuracy

Free
Mengmeng Dong, Enfan Zhang, Haimeng Yan, MD, Ruyi Xu, He Huang, Anyong Xie, Zhen Cai, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3087.
https://doi.org/10.1182/blood-2019-126753
Published: 2019
Journal Articles

Significantly Upregulated Thrombo-Inflammatory Genes Are Normoregulated or Significantly Downregulated during Treatment with Interferon-Alpha2 in Patients with Philadelphia-Negative Chronic Myeloproliferative Neoplasms

Free
Vibe Skov, PhD, Caroline Riley, PhD, Mads Thomassen, PhD, Lasse Kjær, PhD, Thomas Stauffer Larsen, MD PhD, Torben A Kruse, Hans Hasselbalch, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2978.
https://doi.org/10.1182/blood-2019-131698
Published: 2019
Journal Articles

PARP1-Mediated Alt-NHEJ Repair Is a Therapeutic Target in Multiple Myeloma

Free
Daniele Caracciolo, MD, Giada Juli, PhD, Francesca Scionti, PhD, Gaetanina Golino, PhD, Mariamena Arbitrio, MD, Emanuela Altomare, PhD, Katia Todoerti, PhD, Katia Grillone, PhD, Maria Teresa Di Martino, PhD, Marco Rossi, MD, Antonino Neri, MD, Pierosandro Tagliaferri, MD, Pierfrancesco Tassone, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3107.
https://doi.org/10.1182/blood-2019-128245
Published: 2019
Journal Articles

PARP Inhibition Sensitize BCR-ABL1 Positive Cel

Free
Haruka Hiroki, MD, Masatoshi Takagi, MD PhD, Yuko Ishi, MD, Jinhua Piao, Tomohiro Morio, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3367.
https://doi.org/10.1182/blood-2019-127853
Published: 2019
Journal Articles

TET2 Loss Accelerates Leukemogenesis By Disrupting Mismatch Repair Proteins

Free
Ashwin Kishtagari, MBBS, Yihong Guan, PhD, Cassandra M Kerr, MS, Hassan Awada, MD, Jibran Durrani, Edward F Greenberg, MD, Xiaorong Gu, PhD, Feng Pan, PhD, Valeria Visconte, PhD, Dewen You, PhD, Guangbo Qu, PhD, Amy C Graham, BS, MS, Bartlomiej P. Przychodzen, Thomas Laframboise, PhD, Hideki Makishima, MD PhD, Daniel Gackowski, PhD, Ryszard Ólinski, Professor, Yu-Wei Cheng, PhD, Mikkael A. Sekeres, MD MS, Mingjiang Xu, MD PhD, Babal K. Jha, PhD, Jaroslaw P. Maciejewski, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1200.
https://doi.org/10.1182/blood-2019-132005
Published: 2019
Journal Articles

Deletions of 5q Promote Genome Instability in TP53-Mutant MDS/AML

Free
Andreea Reilly, Stephanie Busch, B.S., Janis L. Abkowitz, MD, Pamela S. Becker, MD PhD, Sergei Doulatov, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1244.
https://doi.org/10.1182/blood-2019-127038
Published: 2019
Journal Articles

Targeting Homologous Recombination in Lymphoid Malignancies: Evaluation of Four Small Molecule Inhibitors of RAD51

Free
Melinda Day, PhD, Tyler Maclay, Amber Cyr, Muneer G Hasham, PhD, Kin-hoe Chow, ED Keniston, Kevin Mills, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2080.
https://doi.org/10.1182/blood-2019-131747
Published: 2019
Journal Articles

Telomere Shortening By Terc Knockout in the Eµ-TCL1 Transgenic Murine Model of CLL: Characterization of Disease Development and Survival

Free
Billy Michael Chelliah Jebaraj, PhD, Annika Scheffold, PhD, André Lechel, Sarah-Fee Katz, PhD, Eugen Tausch, Johannes Bloehdorn, MD, Daniela Steinbrecher, PhD, Vanni Torresi, Christof Schneider, MD, Hartmut Döhner, MD, Daniel Mertens, PhD, Lenhard Rudolph, Stephan Stilgenbauer
Journal: Blood
Blood (2019) 134 (Supplement_1): 1732.
https://doi.org/10.1182/blood-2019-126878
Published: 2019
Journal Articles

A Maturation Index Defines Newly Diagnosed Multiple Myeloma Patients with Advanced Immunophenotypic and Molecular Differentiation Profiles Associated with Poor Prognosis

Free
Marina Martello, Rosalinda Termini, Enrica Borsi, Vincenza Solli, Andrea Poletti, Luca Cifarelli, Lakpo Agboyi, Silvia Armuzzi, Lucia Pantani, Serena Rocchi, Katia Mancuso, Elena Zamagni, MD, Paola Tacchetti, Mario Arpinati, MD PhD, Gabriella Chirumbolo, Antonella Orlando, Giulia Marzocchi, Nicoletta Testoni, Pier Luigi Luigi Zinzani, MD, Michele Cavo, Carolina Terragna
Journal: Blood
Blood (2019) 134 (Supplement_1): 1797.
https://doi.org/10.1182/blood-2019-129975
Published: 2019