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Journal Articles

Pralatrexate-Resistant Cell Lines Show Intact Internalization Via RFC1 but Collateral Sensitivity to Nucleoside Analogs

Kana Oiwa, MD, Naoko Hosono, MD, Rie Nishi, PhD, Takanori Ueda, MD PhD, Luigi Scott, PhD, Owen A. O'Connor, MD, PhD, Takahiro Yamauchi, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3961.
https://doi.org/10.1182/blood-2018-99-110147
Published: 2018
Journal Articles

Pralatrexate: Phase 1/2 Study in Japanese Patients with Relapsed or Refractory Peripheral T-Cell Lymphoma (PTCL)

Yoshinobu Maeda, MD PhD, Kensei Tobinai, MD, PhD, Hirokazu Nagai, MD PhD, Takahiko Nakane, MD, PhD, Tatsu Shimoyama, MD, Tomonori Nakazato, Rika Sakai, Takayuki Ishikawa, MD, PhD, Koji Izutsu, MD PhD, Ryuzo Ueda, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4157.
https://doi.org/10.1182/blood.V128.22.4157.4157
Published: 2016
Journal Articles

Spliceosome Inhibitor Meayamycin B As a Novel Potential Chemotherapeutic Agent in ALL and AML

Anna Wojtuszkiewicz, MSc, Yehuda G Assaraf, PhD, Gerrit Jansen, PhD, Kazunori Koide, PhD, Robert K. Bressin, Upamanyu Basu, Edwin Sonneveld, PhD, Elisa Giovannetti, PhD, Gertjan Kaspers, MD PhD, Jacqueline Cloos, PhD
Journal: Blood
Blood (2014) 124 (21): 924.
https://doi.org/10.1182/blood.V124.21.924.924
Published: 2014
Journal Articles

Pre-Clinical Analysis Of The Novel Antifolate Pralatrexate In Multiple Myeloma Reveals Functional Biomarkers Correlated With Response

Michael Mangone, PhD, Anna H Mei, BA, Luigi Scotto, PhD, Michele Visentin, PhD, Enrica Marchi, MD, PhD, I. David Goldman, MD, Constantine S. Mitsiades, MD, PhD, Owen A. O'Connor, MD, PhD, Hearn J. Cho, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 4430.
https://doi.org/10.1182/blood.V122.21.4430.4430
Published: 2013
Journal Articles

Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia

Michal Stark, Chen Wichman, Irit Avivi, Yehuda G. Assaraf
Journal: Blood
Blood (2009) 113 (18): 4362–4369.
https://doi.org/10.1182/blood-2008-08-173799
Published: 2009
Journal Articles

Disparate mechanisms of antifolate resistance provoked by methotrexate and its metabolite 7-hydroxymethotrexate in leukemia cells: implications for efficacy of methotrexate therapy

Kambiz Fotoohi, Gerrit Jansen, Yehuda G. Assaraf, Lilah Rothem, Michal Stark, Ietje Kathmann, Jacek Gregorczyk, Godefridus J. Peters, Freidoun Albertioni
Journal: Blood
Blood (2004) 104 (13): 4194–4201.
https://doi.org/10.1182/blood-2004-04-1493
Published: 2004
Journal Articles

Disparate Mechanisms of Antifolate Resistance Provoked by Methotrexate and Its Metabolite 7-Hydroxymethotrexate in Leukemia Cells: Implications for Efficacy of Methotrexate Therapy.

Freidoun Albertioni, Gerrit Jansen, Kambiz Fotoohi, MD, Yehuda G. Assaraf, Lilah Rothem, PHD, Michal Stark, PHD, Letje Kathmann, PHD, Jacek Gregorczyk, PHD, Godefridus J. Peters
Journal: Blood
Blood (2004) 104 (11): 4369.
https://doi.org/10.1182/blood.V104.11.4369.4369
Published: 2004
Journal Articles

Role of Folylpolyglutamate Synthetase and Folylpolyglutamate Hydrolase in Methotrexate Accumulation and Polyglutamylation in Childhood Leukemia

Marianne G. Rots, Rob Pieters, Godefridus J. Peters, Paul Noordhuis, Christina H. van Zantwijk, Gertjan J.L. Kaspers, Karel Hählen, Ursula Creutzig, Anjo J.P. Veerman, Gerrit Jansen
Journal: Blood
Blood (1999) 93 (5): 1677–1683.
https://doi.org/10.1182/blood.V93.5.1677
Published: 1999
Journal Articles

Disparate Affinities of Antifolates for Folylpolyglutamate Synthetase From Human Leukemia Cells

Giuseppe S.A. Longo, Richard Gorlick, William P. Tong, Emine Ercikan, Joseph R. Bertino
Journal: Blood
Blood (1997) 90 (3): 1241–1245.
https://doi.org/10.1182/blood.V90.3.1241
Published: 1997