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Journal Articles

The Frequency and Effect of Baseline Cross-Reacting and De Novo Inhibitors to Recombinant Porcine FVIII in Patients with Congenital and Acquired Hemophilia a

Carolyne Elbaz, MD, Katerina Pavenski, MD, Hina Chaudhry, BSc, Jerome M. Teitel, MD FRCPC, Michelle Sholzberg, MDBSc,FRCPC,MSc

Blood (2019) 134 (Supplement_1): 1128.

https://doi.org/10.1182/blood-2019-122260

Published: 2019

Journal Articles

Recombinant Porcine Factor VIII Use in Bleed Treatment in Non-Severe Hemophilia a Inhibitor Patients: Dosing Strategies and Efficacy

Patrick Ellsworth, MD, Sheh-Li Chen, PharmD, Yasmina L. Abajas, MD, Stephan Moll, MD, Nigel S. Key, MBChB, FRCP, Alice D. Ma, MD

Blood (2018) 132 (Supplement 1): 1202.

https://doi.org/10.1182/blood-2018-99-119196

Published: 2018

Journal Articles

Surgery in Patients with Factor VIII Inhibitors: A Retrospective Case Series at the Largest Canadian Hemophilia Care Centre

Aditi Khandelwal, MDM, Syed Mahamad, BSc candidate, Jerome M. Teitel, MD, Michelle Sholzberg, MDM, MSc

Blood (2016) 128 (22): 1418.

https://doi.org/10.1182/blood.V128.22.1418.1418

Published: 2016

Journal Articles

Acquired Factor VIII Inhibitors: A Single Institution Retrospective, Observational Study

Lela Ruck, MD, Morey A. Blinder, MD, William Berger, MSW

Blood (2016) 128 (22): 4971.

https://doi.org/10.1182/blood.V128.22.4971.4971

Published: 2016

Journal Articles

An Unusual Case of Acquired Hemophilia a and Factor XIII Consumption

Brett L. Houston, MD, Christine M. Cserti-Gazdewich, MD, Richard Ward, MBBS, Jean St. Louis, MD, Georges E. Rivard, MD, Jerome M. Teitel, MD, Michelle Sholzberg, MD

Blood (2015) 126 (23): 4701.

https://doi.org/10.1182/blood.V126.23.4701.4701

Published: 2015

Journal Articles

Recombinant Porcine Factor VIII, Obi-1, Successfully Controlled Gastrointestinal Bleeding in a Patient with Acquired Hemophilia A

Muhammad Kashif Riaz, MD, Saulius Girnius, MD, Joseph Edward Palascak, MD FACP

Blood (2015) 126 (23): 4676.

https://doi.org/10.1182/blood.V126.23.4676.4676

Published: 2015

Journal Articles

The 1.7 Angstrom X-Ray Crystal Structure of the Porcine Factor VIII C2 Domain and Binding Analysis to Anti-Human C2 Domain Antibodies and Phospholipid Surfaces

Caileen M Brison, B.S., Steven M Mullen, B.S., Kira Podolsky, B.S., Shannon L Meeks, MD, Paul Clinton Spiegel, PhD

Blood (2014) 124 (21): 4235.

https://doi.org/10.1182/blood.V124.21.4235.4235

Published: 2014

Journal Articles

Structural Studies Of The Factor VIII C2 Domain In a Ternary Complex With Two Inhibitory Antibodies Reveals Classical and Non-Classical Epitopes

Justin D Walter, M.S., Rachel A Werther, M.S., Caileen M Brison, B.S., John F. Healey, B.S., Shannon L. Meeks, MD, John (Pete) S. Lollar, III, MD, P. Clint Spiegel, Jr., Ph.D.

Blood (2013) 122 (21): 2358.

https://doi.org/10.1182/blood.V122.21.2358.2358

Published: 2013

Journal Articles

Acquired Hemophilia A in an African-American Male After Stem Cell Transplant for Sickle Cell Disease: Successful Treatment with Recombinant Porcine Factor VIII (OBI-1) and Tolerance Induction with Rituximab and Prednisone

Jay N. Lozier, MD, PhD, Khanh Nghiem, BS, Martin Lee, PhD, Bonnie Hodsdon, BS, Galen Joe, MD, R. Patrick Weitzel, PhD, John F. Tisdale, MD, Matthew Hsieh, MD

Blood (2012) 120 (21): 4631.

https://doi.org/10.1182/blood.V120.21.4631.4631

Published: 2012

Journal Articles

Recombinant B-Domain Deleted Porcine Factor VIII (OBI-1) Safety and Efficacy in the Treatment of Acquired Hemophilia A: Interim Results.

Jean St. Louis, MD, Rebecca Kruse-Jarres, MD/MPH, Anne Greist, MD, Amy D. Shapiro, MD, Hedy Smith, MD PhD, Anja B Drebes, MRCP, FRCPath, Jay N. Lozier, MD, PhD, Edward D. Gomperts, MD

Blood (2012) 120 (21): 2224.

https://doi.org/10.1182/blood.V120.21.2224.2224

Published: 2012

Journal Articles

Recombinant Porcine Factor VIII Corrects Thrombin Generation and Improves Clot Structure In Vitro in Plasma Containing Anti-Factor VIII Inhibitory Antibodies

Claude Negrier, Shannon L. Meeks, MD, Johannes Oldenburg, Uri Martinowitz, Jean-Claude Bordet, Bernd Poetzsch, Raed Al Dieri, Yesim Dargaud, Coen Hemker, Carel Eckmann, Ed Gomperts, Martin Lee

Blood (2011) 118 (21): 2282.

https://doi.org/10.1182/blood.V118.21.2282.2282

Published: 2011

Journal Articles

Differential Engagement of the Unfolded Protein Response by Human and Porcine Factor VIII

Harrison C. Brown, BBA, Bagirath Gangadharan, MS, Christopher Doering, PhD

Blood (2010) 116 (21): 2224.

https://doi.org/10.1182/blood.V116.21.2224.2224

Published: 2010

Journal Articles

High-Expression Porcine FVIII Driven by Erythroid-Specific Promoters for Lentiviral Vector-Mediated Gene Therapy

Nadia Sutherland, MD, Kerry L Dooriss, David A McCarty, Christopher B Doering, PhD, H. Trent Spencer, PhD

Blood (2008) 112 (11): 3544.

https://doi.org/10.1182/blood.V112.11.3544.3544

Published: 2008

Journal Articles

A Phase II Open-Label Study Evaluating Hemostatic Activity, Pharmacokinetics and Safety of Recombinant Porcine Factor VIII (OBI-1) in Hemophilia A Patients with Alloantibody Inhibitors Directed Against Human FVIII.

Johnny Mahlangu, MD, Tatiana A. Andreeva, MD, Donald Macfarlane, MD, PhD, Mark T. Reding, MD, Christopher Walsh, MD, Bruce Ritchie, MD, Nadia Ewing, MD, Craig M. Kessler, MD, Christine Kempton, MD, Edward Libby, MD, Nadezda Zozulya, MD, Amy D. Shapiro, MD, Jean St-Louis, MD, Indira Warrier, MD, W. Keith Hoots, MD, Ralph A. Gruppo, MD, Josef N. Mueksch, MD, MBA

Blood (2007) 110 (11): 783.

https://doi.org/10.1182/blood.V110.11.783.783

Published: 2007

Journal Articles

Hematopoietic stem-cell gene therapy of hemophilia A incorporating a porcine factor VIII transgene and nonmyeloablative conditioning regimens

Lucienne M. Ide, Bagirath Gangadharan, Kuang-Yueh Chiang, Christopher B. Doering, H. Trent Spencer

Blood (2007) 110 (8): 2855–2863.

https://doi.org/10.1182/blood-2007-04-082602

Published: 2007

Includes: Supplemental data

Journal Articles

Post-Transplantation Immunosuppression Facilitates Sustained Expression of Porcine Factor VIII after Reduced-Intensity Transplantation of Genetically-Modified Stem Cells.

Lucienne M. Ide, Bagirath Gangadharan, K.Y. Chiang, MD,PhD, Christopher Doering, PhD, H. Trent Spencer, PhD

Blood (2006) 108 (11): 3280.

https://doi.org/10.1182/blood.V108.11.3280.3280

Published: 2006

Journal Articles

Restoration of Porcine Factor VIII Procoagulant Activity to Hemophilia A Mice with Pre-Existing Immunity to Human Factor VIII.

Christopher B. Doering, PhD, Bagirath Gangadharan, MS, Hillary Z. Dukart, H. Trent Spencer, PhD

Blood (2006) 108 (11): 3284.

https://doi.org/10.1182/blood.V108.11.3284.3284

Published: 2006

Journal Articles

Comparative Immunogenicity of Two Forms of Porcine Factor VIII in Cynomolgus Monkeys.

Garrett E. Bergman, MD, Pete Lollar, MD

Blood (2004) 104 (11): 3079.

https://doi.org/10.1182/blood.V104.11.3079.3079

Published: 2004

Journal Articles

High-Level Expression of Porcine Factor VIII from Murine Mesenchymal Stem Cells.

Bagirath Gangadharan, M.Sc., H. Trent Spencer, Ph.D., Ernest T. Parker, B.S., Christopher B. Doering, Ph.D.

Blood (2004) 104 (11): 5281.

https://doi.org/10.1182/blood.V104.11.5281.5281

Published: 2004

Journal Articles

Differential Immunodominance of Human and Porcine Factor VIII in Hemophilia A Mice.

John F. Healey, B.S., Ernest T. Parker, B.S., Rachel T. Barrow, B.S., Pete Lollar, M.D.

Blood (2004) 104 (11): 40.

https://doi.org/10.1182/blood.V104.11.40.40

Published: 2004

NARROW

The Frequency and Effect of Baseline Cross-Reacting and De Novo Inhibitors to Recombinant Porcine FVIII in Patients with Congenital and Acquired Hemophilia a

Recombinant Porcine Factor VIII Use in Bleed Treatment in Non-Severe Hemophilia a Inhibitor Patients: Dosing Strategies and Efficacy

Surgery in Patients with Factor VIII Inhibitors: A Retrospective Case Series at the Largest Canadian Hemophilia Care Centre

Acquired Factor VIII Inhibitors: A Single Institution Retrospective, Observational Study

An Unusual Case of Acquired Hemophilia a and Factor XIII Consumption

Recombinant Porcine Factor VIII, Obi-1, Successfully Controlled Gastrointestinal Bleeding in a Patient with Acquired Hemophilia A

The 1.7 Angstrom X-Ray Crystal Structure of the Porcine Factor VIII C2 Domain and Binding Analysis to Anti-Human C2 Domain Antibodies and Phospholipid Surfaces

Structural Studies Of The Factor VIII C2 Domain In a Ternary Complex With Two Inhibitory Antibodies Reveals Classical and Non-Classical Epitopes

Acquired Hemophilia A in an African-American Male After Stem Cell Transplant for Sickle Cell Disease: Successful Treatment with Recombinant Porcine Factor VIII (OBI-1) and Tolerance Induction with Rituximab and Prednisone

Recombinant B-Domain Deleted Porcine Factor VIII (OBI-1) Safety and Efficacy in the Treatment of Acquired Hemophilia A: Interim Results.

Recombinant Porcine Factor VIII Corrects Thrombin Generation and Improves Clot Structure In Vitro in Plasma Containing Anti-Factor VIII Inhibitory Antibodies

Differential Engagement of the Unfolded Protein Response by Human and Porcine Factor VIII

High-Expression Porcine FVIII Driven by Erythroid-Specific Promoters for Lentiviral Vector-Mediated Gene Therapy

A Phase II Open-Label Study Evaluating Hemostatic Activity, Pharmacokinetics and Safety of Recombinant Porcine Factor VIII (OBI-1) in Hemophilia A Patients with Alloantibody Inhibitors Directed Against Human FVIII.

Hematopoietic stem-cell gene therapy of hemophilia A incorporating a porcine factor VIII transgene and nonmyeloablative conditioning regimens

Post-Transplantation Immunosuppression Facilitates Sustained Expression of Porcine Factor VIII after Reduced-Intensity Transplantation of Genetically-Modified Stem Cells.

Restoration of Porcine Factor VIII Procoagulant Activity to Hemophilia A Mice with Pre-Existing Immunity to Human Factor VIII.

Comparative Immunogenicity of Two Forms of Porcine Factor VIII in Cynomolgus Monkeys.

High-Level Expression of Porcine Factor VIII from Murine Mesenchymal Stem Cells.

Differential Immunodominance of Human and Porcine Factor VIII in Hemophilia A Mice.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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