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Journal Articles

Glia Maturation Factor-γ Regulates Autophagy in Murine Macrophages

Wulin Aerbajinai, MD PhD, Jianqiong Zhu, MD, Chutima Kumkhaek, PhD, Kyung Chin, Griffin Rodgers, MD

Blood (2019) 134 (Supplement_1): 2318.

https://doi.org/10.1182/blood-2019-130318

Published: 2019

Journal Articles

The Phosphoinositide Kinase Pikfyve Regulates Lysosomal Biogenesis in Macrophages By Modulating the Transcription Factor EB (TFEB)

Francina Gonzalez, MSc, Aae Suzuki, Jessica Guzman, Lynn Spruce, Steven H Seeholzer, PhD, Charles S. Abrams, MD, Sang Hee Min, MDhD

Blood (2017) 130 (Supplement 1): 2276.

https://doi.org/10.1182/blood.V130.Suppl_1.2276.2276

Published: 2017

Journal Articles

Activation of Autophagy in Models of SF3B1 Mutant MDS

Blood (2017) 130 (Supplement 1): 4230.

https://doi.org/10.1182/blood.V130.Suppl_1.4230.4230

Published: 2017

Journal Articles

PIKfyve Inhibitors for the Treatment of Multiple Myeloma

Cecilia Bonolo De Campos, PhD, Yuan Xiao Zhu, PhD, Chang-Xin Shi, PhD, Laura Ann Bruins, BS, Joachim L Petit, PhD, Alysia N Polito, BS, Meaghen E Sharik, BS, Caleb K Stein, MS, Gregory J Ahmann, BS, Ilsel D Lopez Armenta, BS, Nikolai Sepetov, PhD, Sergei Romanov, PhD, P. Leif Bergsagel, MD, Marta Chesi, PhD, Nathalie Meurice, PhD, A. Keith Stewart, MBChB, MBA

Blood (2017) 130 (Supplement 1): 4423.

https://doi.org/10.1182/blood.V130.Suppl_1.4423.4423

Published: 2017

Journal Articles

Targeting Autophagy in Myelodysplastic Syndromes

Valeria Visconte, PhD, Steffan T. Nawrocki, PhD, Bartlomiej P Przychodzen, MSc, Kevin R. Kelly, MD PhD, Mei Yin, Yvonne Parker, Michael J. Clemente, M.S., John Barnard, PhD, Anjali S. Advani, MD, Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Daniel Lindner, Heesun J Rogers, MD PhD, Jaroslaw P Maciejewski, MD PhD FACP, Jennifer S. Carew, PhD

Blood (2016) 128 (22): 4295.

https://doi.org/10.1182/blood.V128.22.4295.4295

Published: 2016

Journal Articles

Development of ROC-325: A Novel Small Molecule Inhibitor of Autophagy with Promising Anti-Leukemic Activity

Steffan T. Nawrocki, PhD, Yingchun Han, MD, Valeria Visconte, PhD, James G Phillips, PhD, Bartlomiej P Przychodzen, MSc, Jaroslaw P Maciejewski, MD PhD FACP, Kevin R. Kelly, MD PhD, Jennifer S. Carew, PhD

Blood (2016) 128 (22): 525.

https://doi.org/10.1182/blood.V128.22.525.525

Published: 2016

Journal Articles

Ubiquitination of the Ferroportin Q248H Mutation Disregulates Autophagy, Hipoxia and Generates Lysosomal and Mitochondrial Damage

Guelaguetza Vazquez-Meves, PhD, Ivanov Andrey, Ph. D., Namita Kumari, PhD, Xionghao Lin, PhD, Sergei A. Nekhai, PhD

Blood (2016) 128 (22): 2454.

https://doi.org/10.1182/blood.V128.22.2454.2454

Published: 2016

Journal Articles

Pikfyve Deficiency Disrupts Lysosomal Maturation and Degradative Function in Macrophages, and Causes Systemic Inflammation in Mice

Sang Hee Min, MD, Aae Suzuki, Jessica Guzman, Lehn Weaver, MD PhD, Charles S. Abrams, MD

Blood (2016) 128 (22): 704.

https://doi.org/10.1182/blood.V128.22.704.704

Published: 2016

Journal Articles

The Proteasome Inhibitor, Ixazomib, Combined with Novel Drug Combinations in T-Cell Lymphoma (TCL) and Hodgkin Lymphoma (HL): Identification of Key Genes and Signaling Pathways Via a Novel Systems Biology Approach

Frank C. Passero, Jr., MD, Ravi Dashnamoorthy, PhD, Afshin Beheshti, PhD, Lynn Hlatky, PhD, Nassera Abermil, MS, PharmD, Michael E Coyle, MD, Jaya Sharma, MD MBBS, Andrew M. Evens, DO, MSc

Blood (2015) 126 (23): 2753.

https://doi.org/10.1182/blood.V126.23.2753.2753

Published: 2015

Journal Articles

Pikfyve Regulates Lysosomal Biogenesis and Functions in Macrophages

Sang H Min, MD, Lehn Weaver, MD PhD, Aae Suzuki, Jessica Guzman, Charles S. Abrams, MD

Blood (2015) 126 (23): 887.

https://doi.org/10.1182/blood.V126.23.887.887

Published: 2015

Journal Articles

Elevated Basal Autophagy in SF3B1 Mutated Myelodysplastic Syndromes: Relationship with Survival Outcomes and Therapeutic Implications

Valeria Visconte, PhD, Kevin R. Kelly, MD PhD, Steffan T. Nawrocki, PhD, Yingchun Han, MD, Hetty E. Carraway, MD MBA, Anjali S. Advani, MD, Jaroslaw P. Maciejewski, MD PhD, Heesun J Rogers, MD PhD, Mikkael A. Sekeres, MD MS, Jennifer S. Carew, PhD

Blood (2015) 126 (23): 1647.

https://doi.org/10.1182/blood.V126.23.1647.1647

Published: 2015

Journal Articles

Pikfyve Is Essential for Lysosomal Homeostasis in Macrophages

Sang H Min, MD, Aae Suzuki, Jessica Guzman, Charles S. Abrams, MD

Blood (2014) 124 (21): 461.

https://doi.org/10.1182/blood.V124.21.461.461

Published: 2014

Journal Articles

Overexpression of BCL-2 Does Not Inhibit Autophagy in Human Follicular and Diffuse Large B-Cell Lymphomas

Aine McCarthy, PhD, Andrew James Clear, BSc, Jacek Marzec, Rita Coutinho, MD, Robert D. Petty, PhD, Janet Matthews, Andrew Wilson, Sameena Iqbal, Maria Calaminici, MD PhD, John G. Gribben, MD DSc, Li Jia, PhD MD

Blood (2014) 124 (21): 3007.

https://doi.org/10.1182/blood.V124.21.3007.3007

Published: 2014

Journal Articles

Evaluation Of Potency and The Associated Biology Of The Investigational Proteasome Inhibitor, Ixazomib: Redox, Autophagic, and MAPK-Dependent Cell Death In T-Cell Lymphoma (TCL) and Hodgkin Lymphoma (HL) Cell Lines and Human Lymphoma Xenograft Models

Ravi Dashnamoorthy, PhD, Irawati Kandela, PhD, Savita Bhalla, PhD, Andrew Mazar, Ph.D., Andrew M Evens, DO, MSc

Blood (2013) 122 (21): 4407.

https://doi.org/10.1182/blood.V122.21.4407.4407

Published: 2013

Journal Articles

Novel Intracranial Xenografts Of CNS Lymphoma Implicate a Role For Cereblon As a Mediator Of Lenalidomide Efficacy

Hua-Xin Gao, Ph.D., Shawn Anderson, Cigall Kadoch, Ph.D., Mekhala Maiti, Ph.D., Lingjing Chen, Ph.D., Dong-Han Yao, Gerd Melkus, Ph.D., Maria Wang, Ph.D., Yan Ren, Ph.D., Michael Breider, Ph.D., Carla Heise, PhD, Clifford A. Lowell, MD, PhD, Colin Collins, Ph.D., James L. Rubenstein, M.D., Ph.D.

Blood (2013) 122 (21): 374.

https://doi.org/10.1182/blood.V122.21.374.374

Published: 2013

Journal Articles

Src Family Kinase Inhibitor PP2 Has Different Effects On ATRA or Arsenic Trioxide-Induced Differentiation of Acute Promyelocytic Leukemia Cell Line

Kyoung Ha Kim, Hee-Jeong Cheong, Sook-Ja Kim, Young Woo Jeon, Jina Yoon, Han Jo Kim, Se Hyung Kim, Hyun Jung Kim, Sang-Cheol Lee, Sang Byung Bae, Chan-Kyu Kim, Namsu Lee, Kyu Taeg Lee, Sung Kyu Park, MD.PhD., Dae Sik Hong, Park Hee-Sook, Jong-Ho Won

Blood (2012) 120 (21): 4800.

https://doi.org/10.1182/blood.V120.21.4800.4800

Published: 2012

Journal Articles

Abrogation of Niche Signals Discovered New Genes Regulating Homing, Expansion and homeostasis of Multiple Myeloma Cells

Yossi Cohen, MD, BsC, Osnat Garach-Jehoshua, PhD, Bar-Chaim Adina, PhD, Abraham Kornberg, MD

Blood (2011) 118 (21): 5080.

https://doi.org/10.1182/blood.V118.21.5080.5080

Published: 2011

Journal Articles

Thrombin Contributes to the Tumor Promalignant Phenotype by Upregulation of Cathepsin D Which Stimulates Angiogenesis.

Liang Hu, MD, Jennifer M. Roth, MD, Peter Brooks, PhD, Simon Karpatkin, MD

Blood (2007) 110 (11): 498.

https://doi.org/10.1182/blood.V110.11.498.498

Published: 2007

Journal Articles

Defective Expression of Neutrophil Serine Proteases in Myeloid Progenitors of Congenital Neutropenia Patients Carrying Either ELA2 or HAX1 Mutations.

Julia Skokowa, MD, PhD, John-Paul Fobiwe, Dan Lan, Manuela Germeshausen, PhD, Karl Welte, MD PhD

Blood (2007) 110 (11): 3299.

https://doi.org/10.1182/blood.V110.11.3299.3299

Published: 2007

Journal Articles

Genes and Proteins Associated with the Tumor Microenvironment Are Differentially Expressed in Cured Versus Primary Chemotherapy-Refractory Diffuse Large B-Cell Lymphoma.

Johan Linderoth, MD, Patrik Edén, PhD, Mats Ehinger, MD PhD, Jeanette Valcich, Mats Jerkeman, MD PhD, Pär-Ola Bendahl, PhD, Mattias Berglund, PhD, Gunilla Enblad, MD PhD, Martin Erlanson, MD PhD, Göran Roos, MD PhD, Eva Cavallin-Ståhl, MD PhD

Blood (2007) 110 (11): 3171.

https://doi.org/10.1182/blood.V110.11.3171.3171

Published: 2007

NARROW

Glia Maturation Factor-γ Regulates Autophagy in Murine Macrophages

The Phosphoinositide Kinase Pikfyve Regulates Lysosomal Biogenesis in Macrophages By Modulating the Transcription Factor EB (TFEB)

Activation of Autophagy in Models of SF3B1 Mutant MDS

PIKfyve Inhibitors for the Treatment of Multiple Myeloma

Targeting Autophagy in Myelodysplastic Syndromes

Development of ROC-325: A Novel Small Molecule Inhibitor of Autophagy with Promising Anti-Leukemic Activity

Ubiquitination of the Ferroportin Q248H Mutation Disregulates Autophagy, Hipoxia and Generates Lysosomal and Mitochondrial Damage

Pikfyve Deficiency Disrupts Lysosomal Maturation and Degradative Function in Macrophages, and Causes Systemic Inflammation in Mice

The Proteasome Inhibitor, Ixazomib, Combined with Novel Drug Combinations in T-Cell Lymphoma (TCL) and Hodgkin Lymphoma (HL): Identification of Key Genes and Signaling Pathways Via a Novel Systems Biology Approach

Pikfyve Regulates Lysosomal Biogenesis and Functions in Macrophages

Elevated Basal Autophagy in SF3B1 Mutated Myelodysplastic Syndromes: Relationship with Survival Outcomes and Therapeutic Implications

Pikfyve Is Essential for Lysosomal Homeostasis in Macrophages

Overexpression of BCL-2 Does Not Inhibit Autophagy in Human Follicular and Diffuse Large B-Cell Lymphomas

Evaluation Of Potency and The Associated Biology Of The Investigational Proteasome Inhibitor, Ixazomib: Redox, Autophagic, and MAPK-Dependent Cell Death In T-Cell Lymphoma (TCL) and Hodgkin Lymphoma (HL) Cell Lines and Human Lymphoma Xenograft Models

Novel Intracranial Xenografts Of CNS Lymphoma Implicate a Role For Cereblon As a Mediator Of Lenalidomide Efficacy

Src Family Kinase Inhibitor PP2 Has Different Effects On ATRA or Arsenic Trioxide-Induced Differentiation of Acute Promyelocytic Leukemia Cell Line

Abrogation of Niche Signals Discovered New Genes Regulating Homing, Expansion and homeostasis of Multiple Myeloma Cells

Thrombin Contributes to the Tumor Promalignant Phenotype by Upregulation of Cathepsin D Which Stimulates Angiogenesis.

Defective Expression of Neutrophil Serine Proteases in Myeloid Progenitors of Congenital Neutropenia Patients Carrying Either ELA2 or HAX1 Mutations.

Genes and Proteins Associated with the Tumor Microenvironment Are Differentially Expressed in Cured Versus Primary Chemotherapy-Refractory Diffuse Large B-Cell Lymphoma.

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American Society of Hematology

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American Society of Hematology

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